WordNet

seek or achieve an end by using to ones advantage; "She uses her influential friends to get jobs"; "The presidents wife used her good connections"
the act of using; "he warned against the use of narcotic drugs"; "skilled in the utilization of computers" (同)usage, utilization, utilisation, employment, exercise
a particular service; "he put his knowledge to good use"; "patrons have their uses"
(law) the exercise of the legal right to enjoy the benefits of owning property; "we were given the use of his boat" (同)enjoyment
use up, consume fully; "The legislature expended its time on school questions" (同)expend
take or consume (regularly or habitually); "She uses drugs rarely" (同)habituate
put into service; make work or employ for a particular purpose or for its inherent or natural purpose; "use your head!"; "we only use Spanish at home"; "I cant use this tool"; "Apply a magnetic field here"; "This thinking was applied to many projects"; "How do you utilize this tool?"; "I apply this rule to get good results"; "use the plastic bags to store the food"; "He doesnt know how to use a computer" (同)utilize, utilise, apply, employ
habitually do something (use only in the past tense); "She used to call her mother every week but now she calls only occasionally"; "I used to get sick when I ate in that dining hall"; "They used to vacation in the Bahamas"
of the transmission gear causing backward movement in a motor vehicle; "in reverse gear"
a relation of direct opposition; "we thought Sue was older than Bill but just the reverse was true" (同)contrary, opposite
the gears by which the motion of a machine can be reversed (同)reverse gear
the side of a coin or medal that does not bear the principal design (同)verso
(American football) a running play in which a back running in one direction hands the ball to a back running in the opposite direction
an unfortunate happening that hinders or impedes; something that is thwarting or frustrating (同)reversal, setback, blow, black_eye
relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
contingent on something else (同)dependant, qualified
(of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
a lapel on a womans garment; turned back to show the reverse side (同)revere

PrepTutorEJDIC

〈道具など〉‘を'『使う』,用いる / …‘を'『費す』,消費する / 《副詞[句]を伴って》〈人など〉‘を'『扱う』 / …‘を'自分の都合のいいように合用する / 〈U〉『使用』,利用 / 〈U〉『役に立つこと』,効用,利益(usefulness) / 〈U〉使う必要(場合),使用する機会,入り用 / 〈C〉〈U〉使用の目的,用途 / 〈U〉使用する権利 / 〈U〉使い方 / 〈U〉(身体などを)使う能力
(位置・方向・順序などにおいて)『逆の』;裏側の』 / 逆に動かす(動く),バックの / 〈U〉《the reverse》(…の)『反対』,『逆』《+『of』+『名』(『wh』‐節)》》 / 〈U〉《the reverse》(貨幣・メダルなどの)『裏側』,(一般に)(…の)裏面《+『of』+『名』》 / 〈C〉(運命などの)逆転,不運 / 〈U〉後退[装置],逆転[装置] / …‘を'『逆にする』,反対にする;…‘を'裏返す / 〈機械など〉‘を'逆転させる,逆方向に動かす / 〈判決など〉‘を'取り消す,破棄する / (ダンスで)逆に回る / 〈機械などが〉逆方向に動く
『頼っている』,依存している,従属している / 扶養される人(家族)
『使い古しの』,使用した
(…に)『慣れている』《+to+名(doing)》
『…するのが常だった』,よく…したものだ / 『以前は…した』
（フランス語）(えりの)裏出し,折り返し

UpToDate Contents

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1. ソタロールの治療使用および主な副作用 therapeutic use and major side effects of sotalol
2. 後天性ＱＴ延長症候群 acquired long qt syndrome
3. 心筋活動電位および抗不整脈剤の作用 myocardial action potential and action of antiarrhythmic drugs
4. ドフェチリドの治療使用 therapeutic use of dofetilide
5. イブチリドの治療使用 therapeutic use of ibutilide

English Journal

Reversed synaptic effects of hypocretin and NPY mediated by excitatory GABA-dependent synaptic activity in developing MCH neurons.

Li Y1, Xu Y, van den Pol AN.
Journal of neurophysiology.J Neurophysiol.2013 Mar;109(6):1571-8. doi: 10.1152/jn.00522.2012. Epub 2012 Dec 19.
In mature neurons, GABA is the primary inhibitory neurotransmitter. In contrast, in developing neurons, GABA exerts excitatory actions, and in some neurons GABA-mediated excitatory synaptic activity is more prevalent than glutamate-mediated excitation. Hypothalamic neuropeptides that modulate cognit
PMID 23255725

3α5β-Pregnanolone glutamate, a use-dependent NMDA antagonist, reversed spatial learning deficit in an animal model of schizophrenia.

Vales K1, Rambousek L, Holubova K, Svoboda J, Bubenikova-Valesova V, Chodounska H, Vyklicky L, Stuchlik A.
Behavioural brain research.Behav Brain Res.2012 Nov 1;235(1):82-8. doi: 10.1016/j.bbr.2012.07.020. Epub 2012 Jul 20.
Neuroactive steroids modulate receptors for neurotransmitters in the brain and thus might be efficacious in the treatment of various diseases of the central nervous system such as schizophrenia. We have designed and synthetized a novel use-dependent NMDA receptor antagonist 3α5β-pregnanolone gluta
PMID 22820236

Pretreatment with intrathecal amitriptyline potentiates anti-hyperalgesic effects of post-injury intra-peritoneal amitriptyline following spinal nerve ligation.

Cheng KI1, Wang HC, Chang LL, Wang FY, Lai CS, Chou CW, Tsai HP, Kwan AL.
BMC neurology.BMC Neurol.2012 Jun 21;12:44. doi: 10.1186/1471-2377-12-44.
BACKGROUND: Amitriptyline, a tricyclic antidepressant and potent use-dependent blocker of sodium channels, has been shown to attenuate acute and chronic pain in several preclinical modes. The purpose of this study was to investigate whether intrathecal pretreatment with amitriptyline combined with p
PMID 22720761

Japanese Journal

Ionic and Cellular Mechanisms Underlying the Development of Acquired Brugada Syndrome in Patients Treated with Antidepressants

Minoura Yoshino,M. Di Diego Jose,Barajas-Martinez Hector,C. Zygmunt Andrew,Hu Dan,Sicouri Serge,Antzelevitch Charles
Journal of Arrhythmia 27(Supplement), CP2_01-CP2_01, 2011
… Isoproterenol (100 nM) or quinidine (10 µM) reversed the effects of amitriptyline. … Using voltage-clamp techniques applied to isolated cardiomyocytes, 0.2 µM amitriptyline was shown to produce use-dependent inhibition of sodium channel current (I<SUB>Na</SUB>), without significantly affecting I<SUB>to</SUB> …
NAID 130002130143

Use-dependent Electrophysiologic Effects of DL-sotalol and Modulation by Isoproterenol in the Human Ventricle.

NAITOH Naoki,FURUSHIMA Hiroshi,OHIRA Koji,TANEDA Koji,AIZAWA Yoshifusa
Japanese Heart Journal 39(2), 153-161, 1998
… The VERP was significantly prolonged after dl-sotalol treatment at paced cycle lengths of 600 (241±16 to 302±28msec, p<0.001), 400 (223±21 to 280±23msec, p<0.001) and 300msec (202±16 to 256±24msec, p<0.005), but there was a parallel shift of the VERP, suggesting the absence of use-dependent effects on the VERP. …
NAID 130000766746