WordNet
- mark with lines; "sorrow had lined his face"
- a length (straight or curved) without breadth or thickness; the trace of a moving point
- a single frequency (or very narrow band) of radiation in a spectrum
- reinforce with fabric; "lined books are more enduring"
- a particular kind of product or merchandise; "a nice line of shoes" (同)product line, line of products, line of merchandise, business line, line of business
- the road consisting of railroad track and roadbed (同)railway line, rail line
- a commercial organization serving as a common carrier
- acting in conformity; "in line with"; "he got out of line"; "toe the line"
- something (as a cord or rope) that is long and thin and flexible; "a washing line"
- a conceptual separation or distinction; "there is a narrow line between sanity and insanity" (同)dividing_line, demarcation, contrast
- a formation of people or things one behind another; "the line stretched clear around the corner"; "you must wait in a long line at the checkout counter"
- a formation of people or things one beside another; "the line of soldiers advanced with their bayonets fixed"; "they were arrayed in line of battle"; "the cast stood in line for the curtain call"
- a fortified position (especially one marking the most forward position of troops); "they attacked the enemys line"
- a mark that is long relative to its width; "He drew a line on the chart"
- a spatial location defined by a real or imaginary unidimensional extent
- in games or sports; a mark indicating positions or bounds of the playing area
- persuasive but insincere talk that is usually intended to deceive or impress; "`let me show you my etchings is a rather worn line"; "he has a smooth line but I didnt fall for it"; "that salesman must have practiced his fast line of talk"
- text consisting of a row of words written across a page or computer screen; "the letter consisted of three short lines"; "there are six lines in every stanza"
- be in line with; form a line along; "trees line the riverbank" (同)run along
- cover the interior of; "line the gloves"; "line a chimney"
- fill plentifully; "line ones pockets"
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
- providing something with a surface of a different material (同)facing
- a protective covering that protects an inside surface (同)liner
- the act of attaching an inside lining (to a garment or curtain etc.)
- type genus of the family Cancridae (同)genus Cancer
- the fourth sign of the zodiac; the sun is in this sign from about June 21 to July 22 (同)Cancer the Crab, Crab
- (astrology) a person who is born while the sun is in Cancer (同)Crab
- a small zodiacal constellation in the northern hemisphere; between Leo and Gemini
PrepTutorEJDIC
- 『線』,筋,けい / (色・縫い目などの)『線』,しま;(顔・手などの)しわ(wrinkle) / (物・人の)『列』,行列(row) / 『綱』,糸,針金 / 電線,電話線,電信線 / (文章の)『行』;(詩の)『行』 / 《しばしばa~》《話》『短い手紙』(note) / 《複数形で》輪郭,外形(outline) / 境界線(boundary);限界,限度(limit) / (鉄道・バスなどの)路線;航路,空路 / 《複数形で》せりふ / 進路,道順(course);(考えなどの)筋道,方針 / 《しばしばone's~》(活動の)分野,方面;特意 / 家系,血統,血筋 / 在庫商品,仕入れ品 / 導管,パイプライン / 《しばしば複数形で》戦線,防御線 / …‘に'『線を引く』,筋(しま,しわ)をつける / …‘に'『沿って並ぶ;』(…を)…‘に'沿って並べる《+『名』+『with』+『名』》
- (材料で)〈着物など〉‘に'裏を付ける《+『名』『with』+『名』》 / (…で)…‘を'満たす,(…を)…‘に'詰め込む《+『名』+『with』+『名』》
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
- 〈U〉(服などの)裏張り,裏塗り / 〈U〉裏地,裏材
UpToDate Contents
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- 1. 去勢抵抗性前立腺癌における化学療法 chemotherapy in castrate resistant prostate cancer
- 2. 進行性前立腺癌における骨転移のマネージメント management of bone metastases in advanced prostate cancer
- 3. 播種性前立腺癌に対する治療の概要 overview of the treatment of disseminated prostate cancer
- 4. 新たに診断された前立腺癌の初回の病期分類および評価 initial staging and evaluation of men with newly diagnosed prostate cancer
- 5. 肺外原発小細胞癌 extrapulmonary small cell cancer
English Journal
- Impact of S100A8/A9 expression on prostate cancer progression in vitro and in vivo.
- Grebhardt S1, Müller-Decker K, Bestvater F, Hershfinkel M, Mayer D.Author information 1Hormones and Signal Transduction Group, DKFZ-ZMBH Alliance, German Cancer Research Center, Heidelberg, Germany.AbstractThe proinflammatory S100A8/A9 proteins, which are expressed in myeloid cells under physiological conditions, are strongly expressed in human prostate cancer epithelial cells. Their role in the tumor cells and in tumor progression is largely unclear. We established a prostate cancer epithelial cell line (PC-3 TO-A8/A9) expressing S100A8 and S100A9 simultaneously under doxycycline control, to study the role of S100A8/A9 on tumor growth and infiltration of immune cells in subcutaneous xenografts in male NMRI nu/nu mice. Colonization of distant organs was studied after intracardial injection of the tumor cells in male NOD/SCID mice. PC-3 TO-A8/A9 cells grown in vitro and subcutaneous xenografts in mice not treated with doxycycline expressed high levels of S100A8/A9 mRNA and protein, whereas doxycycline treatment suppressed S100A8/A9 expression. S100A8/A9 expression did not significantly alter growth rate and invasion of the subcutaneous tumors into surrounding tissues. However, S100A8/A9 expression caused increased infiltration of immune cells, especially neutrophils. In intracardially injected mice sporadic tumor settlement was observed in muscle and lymph nodes. Colonies of tumor cells and micro-metastases were observed in the lung of 64.3% (9 out of 14) of mice not treated with doxycycline and in 33.3% (5 out of 15) of mice treated with doxycycline. Our data demonstrate for the first time that S100A8/A9 expression in epithelial cancer cells causes enhanced infiltration of immune cells, especially neutrophils, and stimulates settlement of the cancer cells in the lung.
- Journal of cellular physiology.J Cell Physiol.2014 May;229(5):661-71. doi: 10.1002/jcp.24489.
- The proinflammatory S100A8/A9 proteins, which are expressed in myeloid cells under physiological conditions, are strongly expressed in human prostate cancer epithelial cells. Their role in the tumor cells and in tumor progression is largely unclear. We established a prostate cancer epithelial cell l
- PMID 24122301
- Biochemical characterization of prostate-specific membrane antigen from canine prostate carcinoma cells.
- Wu LY1, Johnson JM, Simmons JK, Mendes DE, Geruntho JJ, Liu T, Dirksen WP, Rosol TJ, Davis WC, Berkman CE.Author information 1Department of Chemistry, Washington State University, Pullman, Washington.AbstractBACKGROUND: Prostate-specific membrane antigen (PSMA) remains an important target for diagnostic and therapeutic application for human prostate cancer. Model cell lines have been recently developed to study canine prostate cancer but their PSMA expression and enzymatic activity have not been elucidated. The present study was focused on determining PSMA expression in these model canine cell lines and the use of fluorescent small-molecule enzyme inhibitors to detect canine PSMA expression by flow cytometry.
- The Prostate.Prostate.2014 May;74(5):451-7. doi: 10.1002/pros.22727. Epub 2014 Jan 21.
- BACKGROUND: Prostate-specific membrane antigen (PSMA) remains an important target for diagnostic and therapeutic application for human prostate cancer. Model cell lines have been recently developed to study canine prostate cancer but their PSMA expression and enzymatic activity have not been elucida
- PMID 24449207
- Prostate cell lines as models for biomarker discovery: Performance of current markers and the search for new biomarkers.
- Johnson IR1, Parkinson-Lawrence EJ, Butler LM, Brooks DA.Author information 1Mechanisms in Cell Biology and Disease Research Group, School of Pharmacy and Medical Sciences, Sansom Institute for Health Research, University of South Australia, Adelaide, SA, Australia.AbstractBACKGROUND: Prostate cancer cell lines have been used in the search for biomarkers that are suitable for prostate cancer diagnosis. Unfortunately, many cell line studies have only involved single cell lines, partially characterized cell lines or were performed without controls, and this may have been detrimental to effective biomarker discovery. We have analyzed a panel of prostate cancer and nonmalignant control cell lines using current biomarkers and then investigated a set of prospective endosomal and lysosomal proteins to search for new biomarkers.
- The Prostate.Prostate.2014 May;74(5):547-60. doi: 10.1002/pros.22777. Epub 2014 Jan 16.
- BACKGROUND: Prostate cancer cell lines have been used in the search for biomarkers that are suitable for prostate cancer diagnosis. Unfortunately, many cell line studies have only involved single cell lines, partially characterized cell lines or were performed without controls, and this may have bee
- PMID 24435746
Japanese Journal
- Preclinical Safety and Efficacy of in Situ REIC/Dkk-3 Gene Therapy for Prostate Cancer
- Kawauchi Keiichiro,Watanabe Masami,Kaku Haruki,Huang Peng,Sasaki Kasumi,Sakaguchi Masakiyo,Ochiai Kazuhiko,Huh Nam-ho,Nasu Yasutomo,Kumon Hiromi
- Acta Medica Okayama 66(1), 7-16, 2012-02
- … The preclinical safety and therapeutic efficacy of adenoviral vectors that express the REIC/Dkk-3 tumor suppressor gene (Ad-REIC) was examined for use in prostate cancer gene therapy. … The Ad-human (h) and mouse (m) REIC were previously demonstrated to induce strong anti-cancer effects in vitro and in vivo, and we herein report the results of two in vivo studies. …
- NAID 120003850603
- IP6含有たいまつ米胚芽発酵液による癌細胞株から分泌される腫瘍関連抗原の抑制
- 池脇 信直,石附 亨,中村 雅彦,高木 隆太郎,金井 美樹,樋口 元剛,近藤 照義
- 九州保健福祉大学研究紀要 12, 189-196, 2011-03
- 本研究では、我々が開発したIP6含有たいまつ米胚芽発酵液(T-IP6)の癌細胞株(MKN-45およびHepG2)から分泌される腫瘍関連抗原(CEAまたはPIVKA-II)に対する影響を化学発光および電気化学発光酵素免疫測定法で解析した。その結果、T-IP6で培養したMKN-45およびHepG2細胞から分泌されるCEAまたはPIVKA-IIは、細胞の形態変化を伴いながら有意に抑制された(P<0 …
- NAID 110008456920
Related Links
- The BC Cancer Research Centre is the research arm of the BC Cancer Agency. Direct links between the research centre and the cancer centres allow researchers and clinicians to quickly translate new discoveries, identified locally ...
- The radiation response of androgen-refractory prostate cancer cell line C4-2 der... The radiation response of androgen-refractory prostate cancer cell line C4-2 derived from androgen-sensitive cell line LNCaP Asian Journal of PMC ...
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★リンクテーブル★
| リンク元 | 「前立腺癌細胞株」「前立腺がん細胞株」 |
| 拡張検索 | 「human prostate cancer cell line」 |
| 関連記事 | 「LINE」「line」「cell line」「lining」「cancer cell」 |
「前立腺癌細胞株」
「前立腺がん細胞株」
「human prostate cancer cell line」
「LINE」
- 日
- 長い散在反復配列、長散在型反復配列、長い散在性反復配列、ライン、広範囲散在反復配列
- 英
- long interspersed nuclear element, long interspersed nucleotide element, long interspersed element, long interspersed repetitive elements, LINEs, long interspersed repeat sequences
- 関
- レトロトランスポゾン
- Long interspersed nuclear elements[8] are a group of genetic elements that are found in large numbers in eukaryotic genomes. They are transcribed (or are the evolutionary remains of what was once transcribed) to an RNA using an RNA polymerase II promoter that resides inside the LINE. LINEs code for the enzyme reverse transcriptase, and many LINEs also code for an endonuclease (e.g. RNase H). The reverse transcriptase has a higher specificity for the LINE RNA than other RNA, and makes a DNA copy of the RNA that can be integrated into the genome at a new site.
- The 5' UTR contains the promoter sequence, while the 3' UTR contains a polyadenylation signal (AATAAA) and a poly-A tail.[10] Because LINEs move by copying themselves (instead of moving, like transposons do), they enlarge the genome. The human genome, for example, contains about 20,000-40,000 LINEs, which is roughly 21% of the genome.
「line」
- n.
- v.
- 裏打ちする
「cell line」
「lining」
- n.