English Journal
- Amino-terminal propeptide of type III procollagen is associated with restrictive mitral filling pattern in patients with dilated cardiomyopathy: a possible link between diastolic dysfunction and prognosis.
- Rossi A1, Cicoira M, Golia G, Zanolla L, Franceschini L, Marino P, Graziani M, Zardini P.
- Heart (British Cardiac Society).Heart.2004 Jun;90(6):650-4.
- PMID 15145870
- Transforming growth factor-beta induces secretion of activated ADAMTS-2. A procollagen III N-proteinase.
- Wang WM1, Lee S, Steiglitz BM, Scott IC, Lebares CC, Allen ML, Brenner MC, Takahara K, Greenspan DS.
- The Journal of biological chemistry.J Biol Chem.2003 May 23;278(21):19549-57. Epub 2003 Mar 19.
- PMID 12646579
Related Links
- Collagen is the most abundant mammalian protein and the main component of connective tissues. Typically collagen is first synthesized as individual glycine-rich preprocollagen monomeric strands from the ribosomes in the rough endoplasmic reticulum (RER).
- Collagen is the most abundant mammalian protein and the main component of connective tissues. Typically collagen is first synthesized as individual glycine-rich preprocollagen monomeric strands from the ribosomes in the rough endoplasmic reticulum (RER). After transport to the lumen of the RER signal peptides are cleaved to yield procollagen.
- アプリケーション. 1/5000 - 1/10000. Detects a band of approximately 180 kDa (predicted molecular weight: 180 kDa). Native conditions are recommended. Use at an assay dependent concentration. Can be used with a suitable biotinylated detection antibody such as Rabbit polyclonal to Collagen V (Biotin) ( ab6582 ). 1/50 - 1/200.
Related Pictures
★リンクテーブル★
| リンク元 | 「コラーゲン」 |
「コラーゲン」
- first aid step1 2006 p.85,86,114,288,291,292,301,306,319,321,385,427
遺伝子
- COL1A1 17q22
- COL1A2 7q22.1
- COL2A1 12q13
- COL11A2 6p21.3
- これらの遺伝子の変異による結合組織疾患はdominant negative mutationである。
臨床関連
コラーゲンの種類
- HIS.97 NDE.5
| 場所 | |
| I型コラーゲン | 狭義の結合組織、骨、歯の象牙質とセメント質に存在 |
| II型コラーゲン | 硝子軟骨、弾性軟骨 |
| III型コラーゲン | 細網線維 |
| IV型コラーゲン | 基底板の緻密板を作る |
| V型コラーゲン | I型コラーゲンと関連。胎盤に存在 |
| VII型コラーゲン | 基底板を細網線維に付着。anchoring fibril |
| XVII型コラーゲン | ヘミデスモソームと基底板を連結 |
生合成
- first aid step1 2006 p.85
- ER：ER内でOH化(Pro, Lys)：preprocollagen
- Golgi：Lysの糖鎖付加：procollagen(triple helix of 3 collagen α chains)
- EM：procollagen －procollagen peptidase→ tropocollagen
- ：tropocollagen －covalent lysine-hydroxylysine cross-linkage by lysyl oxidase → collagen fibrils