post-transfusion purpura

輸血後紫斑病

WordNet

1. ride Western style and bob up and down in the saddle in rhythm with a horses trotting gait
2. an upright consisting of a piece of timber or metal fixed firmly in an upright position; "he set a row of posts in the ground and strung barbwire between them"
3. the delivery and collection of letters and packages; "it came by the first post"; "if you hurry youll catch the post"
4. a pole or stake set up to mark something (as the start or end of a race track); "a pair of posts marked the goal"; "the corner of the lot was indicated by a stake" (同)stake
5. the position where someone (as a guard or sentry) stands or is assigned to stand; "a soldier manned the entrance post"; "a sentry station" (同)station
6. mark or expose as infamous; "She was branded a loose woman" (同)brand
7. transfer (entries) from one account book to another (同)carry
8. place so as to be noticed; "post a sign"; "post a warning at the dump" (同)put_up
9. affix in a public place or for public notice; "post a warning"
10. assign to a post; put into a post; "The newspaper posted him in Timbuktu"
11. display, as of records in sports games
12. enter on a public list
13. publicize with, or as if with, a poster; "Ill post the news on the bulletin board"
14. United States manufacturer of breakfast cereals and Postum (1854-1914) (同)C. W. Post, Charles William Post
15. United States female author who wrote a book and a syndicated newspaper column on etiquette (1872-1960) (同)Emily Post, Emily Price Post
16. United States aviator who in 1933 made the first solo flight around the world (1899-1935) (同)Wiley Post
17. the introduction of blood or blood plasma into a vein or artery (同)blood_transfusion
18. the action of pouring a liquid from one vessel to another
19. (bookkeeping) a listing on the companys records; "the posting was made in the cash account"
20. any of several blood diseases causing subcutaneous bleeding (同)peliosis

PrepTutorEJDIC

1. 〈C〉(木・金属・石などの)『柱』,『支柱』,くい / 《the ~》(競馬の)出発標,決勝標 / 〈C〉《話》(ラグビーなどの)ゴールポスト(goalpost) / (柱・壁などに)〈掲示物〉‘を'『張る』,張り出す《+『名』〈掲示物〉+『on』+『名』》;(掲示物を)〈柱・壁など〉‘に'張る《+『名』+『with』+『名』〈掲示物〉》 / (掲示して)…‘を'公表する,公示する / 《通例受動態で》(…として)…‘を'掲示(発表)する《+『名』+『as』+『現分』(過分)》
2. (兵士・警官・看護婦などの)『部署』,『持ち場』 / (軍隊の)駐屯(ちゅうとん)地,駐留地,兵営地 / (指名・任命された)『地位』,職 / (またtrading post)(未開地などの)交易所 / 〈兵士・警官・看護婦など〉‘を'配置する / 《通例受動態で》《おもに英》(…に)〈人〉‘を'任命する《+『名』+『to』+『名』》
3. 〈U〉《おもに英》『郵便』[制度] / 《おもに英》《単数形で》(郵便物の1回の)『集配』,『配達』,便;(1回で集配・配達される)郵便物(《米》mail) / 《the ~》《おもに英》郵便局(post office);ポスト,郵便箱(《米》mailbox) / 〈C〉(昔,郵便物の中断所にした)駅,宿,宿場 / 《おもに英》〈郵便物〉‘を'郵便局に出す,ポストに入れる(《米》mail)《+『off』+『名』+『,』『名』+『off』》 / 《『post』+『名』〈間〉〈人〉+『名』〈直〉=『post』+『名』+『to』+『名』〈人〉》〈人〉‘に'〈手紙など〉‘を'郵便で送る(《米》mail)
4. 輸血
5. 《おもに英》(特に軍職に)任命すること

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/03/10 02:55:46」(JST)

wiki en

[Wiki en表示]

Post-transfusion purpura (PTP) is an adverse reaction to a blood transfusion or platelet transfusion that occurs when the body produces alloantibodies to the introduced platelets' antigens. These alloantibodies destroy the patient's platelets leading to thrombocytopenia, a rapid decline in platelet count. PTP usually presents 5–12 days after transfusion, and is a potentially fatal condition.

Mechanism and treatment

PTP is rare, but usually occurs in women who have had multiple pregnancies or in people who have undergone previous transfusions. The precise mechanism leading to PTP is unknown, but it most commonly occurs in individuals whose platelets lack the HPA-1a antigen (old name: PL^A1). The patient develops antibodies to the HPA-1a antigen leading to platelet destruction. In some cases, HPA-5b has also been implicated. It is unclear why alloantibodies attack the patient's own, as well as the introduced platelets. Probable explanation for this is that the recipient's platelet acquire the phenotype of donor's platelet by binding of the soluble antigens from the donor onto the recipient's platelet. It is usually self-limiting, but IVIG therapy is the primary treatment. Plasmapheresis is also an option for treatment.

See also

• Blood transfusion
• Neonatal alloimmune thrombocytopenia

References

UpToDate Contents

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• 1. 免疫学的輸血反応 immunologic blood transfusion reactions
• 2. 原因不明の血小板減少症を有する成人に対するアプローチ approach to the adult with unexplained thrombocytopenia
• 3. 血液疾患における免疫グロブリンの静脈内投与 intravenous immune globulin in hematologic disorders
• 4. 重症患者における血液製剤の使用 use of blood products in the critically ill
• 5. 血小板輸血療法の臨床上および検査上の特徴 clinical and laboratory aspects of platelet transfusion therapy

English Journal

• Post-Transfusion Purpura Following Cardiac Surgery.

• Demir T1, Sahin M, El H, Sezer H.
• Journal of cardiac surgery.J Card Surg.2014 Oct 17. doi: 10.1111/jocs.12462. [Epub ahead of print]
• Post-transfusion purpura (PTP) is a rare disorder characterized by severe thrombocytopenia developing after a blood component transfusion. Ninety percent of the reported cases are women. In this article, we present a case of PTP in a male patient who underwent coronary artery bypass grafting and dis
• PMID 25327777

• Molecular typing of human platelet and neutrophil antigens (HPA and HNA).

• Veldhuisen B1, Porcelijn L2, Ellen van der Schoot C3, de Haas M2.
• Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis.Transfus Apher Sci.2014 Apr;50(2):189-99. doi: 10.1016/j.transci.2014.02.014. Epub 2014 Mar 6.
• Genotyping is an important tool in the diagnosis of disorders involving allo-immunisation to antigens present on the membranes of platelets and neutrophils. To date 28 human platelet antigens (HPAs) have been indentified on six polymorphic glycoproteins on the surface of platelets. Antibodies agains
• PMID 24685245

• Studies on CD36 deficiency in South China: Two cases demonstrating the clinical impact of anti-CD36 antibodies.

• Xu X1, Ye X, Xia W, Liu J, Ding H, Deng J, Chen Y, Shao Y, Wang J, Fu Y, Santoso S.
• Thrombosis and haemostasis.Thromb Haemost.2013 Dec;110(6):1199-206. doi: 10.1160/TH13-05-0435. Epub 2013 Aug 22.
• CD36 (also known as GPIV) deficiency is known to be responsible for the production of anti-Nak(a) antibodies in different clinical settings such as fetal/neonatal alloimmune thrombocytopenia (FNAIT), platelet transfusion refractoriness (PTR) and post-transfusion purpura (PTP). However, no data regar
• PMID 23966019

Japanese Journal

• 日本人におけるＧｏＶ血小板同種抗原の遺伝子頻度

• 日本輸血学会雑誌 49(6), 757-760, 2003
• NAID 130003853203

• Post-transfusion purpura-like syndrome associated with CD36 (Nak^a) isoimmunization

• Transfusion
• NAID 30015003087

• ＭＰＨＡ法のショ糖生食水によるＨＰＡ‐２ａ，２ｂ抽出抗原の確立

• 日本輸血学会雑誌 38(3), 467-474, 1992
• NAID 130003852820

Related Links

• Post-transfusion purpura. - National Center for Biotechnology ...

1. J Am Board Fam Pract. 1991 May-Jun;4(3):175-7. Post-transfusion purpura. Vincent EC(1), Willett T. Author information: (1)Swedish Family Practice Residency, Swedish Hospital Medical Center, Seattle ...

• Post-transfusion purpura (PTP) | Australian Red Cross Blood ...

This is a delayed (>24 hours), immunological transfusion reaction. When to suspect this adverse reaction? PTP is a rare delayed transfusion reaction where a patient develops dramatic, sudden and self-limiting thrombocytopenia ...

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★リンクテーブル★

リンク元	「輸血後紫斑病」
関連記事	「post」「transfusion」「purpura」

「輸血後紫斑病」

　　[★]

英

posttransfusion purpura, post-transfusion purpura

同

シュルマン症候群 Shulman syndrome

関

輸血後合併症

• Sabiston Textbook of Surgery, 18th ed.
• Table 6-4 -- Categories and Management of Adverse Transfusion Reactions

Delayed (>24 Hours) Transfusion Reactions?Immunologic
TYPE	INCIDENCE	ETIOLOGY	MANIFESTATION	DIAGNOSTIC TESTING	THERAPEUTIC/PROPHYLACTIC APPROACH
Post-transfusion purpura	Rare	Recipient platelet antibodies (apparent alloantibody, usually anti? HPA-1) destroy autologous platelets	Thrombocytopenic purpura, bleeding 8-10 days after transfusion	Platelet antibody screen and identification	IGIV|HPA-1?negative platelets|Plasmapheresis

「post」

　　[★]

• comb form.

• ポスト、後

• v.

• ポストする

関

after、afterward、afterwards、behind、following、late、posterior、subsequent

　 　 　 　 　 　 　 　 　 　 　 　 　 　 　 　

「transfusion」

　　[★]

• n.

• 注入、移注。(医)輸液、輸注、輸血

　 　 　

「purpura」

　　[★]

• n.

• 紫斑、紫斑病