perinuclear antineutrophil cytoplasmic antibody

MPO-ANCA

WordNet

1. of or relating to cytoplasm (同)cytoplasmatic
2. any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
3. the protoplasm of a cell excluding the nucleus; is full of proteins that control cell metabolism (同)cytol

PrepTutorEJDIC

1. 細胞質の
2. 抗体,免疫体,抗毒素
3. 細胞質

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• 1. 抗好中球細胞質抗体の臨床的な意味 clinical spectrum of antineutrophil cytoplasmic antibodies
• 2. 多発血管炎性肉芽腫症を伴う肉芽腫症および関連血管炎の病因 pathogenesis of granulomatosis with polyangiitis and related vasculitides
• 3. 自己免疫性肝炎の血清学的マーカー serologic markers of autoimmune hepatitis
• 4. 薬物誘発性ループス drug induced lupus
• 5. 好酸球性肉芽腫性多発血管炎(チャーグ・ストラウス症候群）の臨床的特徴および診断 clinical features and diagnosis of eosinophilic granulomatosis with polyangiitis churg strauss

English Journal

• The role of conjunctival biopsy in the diagnosis of granulomatosis with polyangiitis.

• Ursea R1, De Castro D2, Bowen TJ3, Chan CC4.
• Journal of ophthalmic inflammation and infection.J Ophthalmic Inflamm Infect.2015 Jan 23;5(1):1. doi: 10.1186/s12348-014-0033-9. eCollection 2015.
• BACKGROUND: The purpose of this study is to describe a patient who was diagnosed with granulomatosis with polyangiitis based on conjunctival biopsy. This study is a case report and review of the literature.FINDINGS: A 48-year-old Caucasian woman presented with a 2-week history of a left eye peripher
• PMID 25632308

• Association of Anti-glycan Antibodies and Inflammatory Bowel Disease Course.

• Paul S1, Boschetti G2, Rinaudo-Gaujous M1, Moreau A1, Del Tedesco E3, Bonneau J1, Presles E4, Mounsef F5, Clavel L3, Genin C1, Flourié B2, Phelip JM3, Nancey S2, Roblin X6.
• Journal of Crohn's & colitis.J Crohns Colitis.2015 Jun;9(6):445-51. doi: 10.1093/ecco-jcc/jjv063. Epub 2015 Apr 19.
• BACKGROUND AND AIMS: The usefulness of anti-glycan antibodies alone or combined with anti-Saccharomyces cerevisiae [ASCA] or perinuclear antineutrophil cytoplasmic [pANCA] antibodies for diagnosis of inflammatory bowel disease [IBD], differentiation between Crohn's disease [CD] and ulcerative coliti
• PMID 25895876

• Craniovertebral junction instability as an extension of cocaine-induced midline destructive lesions: case report.

• Brembilla C1, Lanterna LA, Risso A, Bombana E, Gritti P, Trezzi R, Bonaldi G, Biroli F.
• Journal of neurosurgery. Spine.J Neurosurg Spine.2015 May 8:1-7. [Epub ahead of print]
• With the increasingly widespread illicit use of cocaine, a broad spectrum of clinical pathologies related to this form of drug abuse is emerging. The most frequently used method of administration of powdered cocaine is intranasal inhalation, or "snorting." Consequently, adverse effects of cocaine on
• PMID 25955800

Japanese Journal

• Clinical investigations: Eye manifestations in patients with perinuclear antineutrophil cytoplasmic antibody-associated vasculitis: case series and literature review

• Matsuo Toshihiko
• Japanese journal of ophthalmology 51(2), 131-138, 2007-03
• NAID 40015324641

• Isolated Oculomotor Nerve Palsy in Churg-Strauss Syndrome

• Tsuda Hiromasa,Ishikawa Hiroshi,Majima Toru [他],SAWADA Umihiko,MIZUTANI Tomohiko
• Internal medicine 44(6), 638-640, 2005-06-01
• … Based on bronchial asthma, hypereosinophilia, mononeuropathy multiplex, pulmonary eosinophilia and positive perinuclear antineutrophil cytoplasmic antibody in the serum, the patient was diagnosed as having Churg-Strauss syndrome. …
• NAID 10016451291

• Idiopathic hypertrophic pachymeningitis

• RIKU Shigeo,KATO Shigenori
• Neuropathology : official journal the Japanese Society of Neuropathology 23(4), 335-344, 2003-12-01
• NAID 10013405032

Related Links

• ANCA - Overview: Cytoplasmic Neutrophil Antibodies, Serum

ACPA (Anti-Neutrophil Cytoplasmic Antibodies) ANCA (Antineutrophil Cytoplasmic Antibodies) ANCA (Wegener's) Anti-Neutrophil Cytoplasmic Ab Test Anti-Neutrophil Cytoplasmic Antibodies Anticytoplasmic Antibody Anticytoplasmic Autoantibodies ...

• Antineutrophil Cytoplasmic Antibodies, Autoimmune ...

Objectives Reports of an association between antineutrophil cytoplasmic antibodies (ANCA) and autoimmune neutropenia have rarely included cases of proven vasculitis. A case of ANCA-associated vasculitis (AAV) with ...

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★リンクテーブル★

リンク元	「MPO-ANCA」
関連記事	「cytoplasmic」

「MPO-ANCA」

　　[★]

英

myeloperoxidase antineutrophil cytoplasmic antibody, myeloperoxidase-anti-neutrophil cytoplasmic antibody

perinuclear antineutrophil cytoplasmic antibody, perinuclear-anti-neutrophil cytoplasmic antibody, p-ANCA

関

PR3-ANCA=C-ANCA

鑑別疾患

• 顕微鏡的多発血管炎(MPA)
• 半月体形成性糸球体腎炎(急速進行性糸球体腎炎 RPGN)
• アレルギー性肉芽腫性血管炎 Churg-Strauss症候群

顕微鏡的多発血管炎(MPA)

YN.F-62

• 全身の小血管に炎症を来たし、全身症状が見られるが特に肺(間質性肺炎)、腎(半月体形成性糸球体腎炎)に病変が認められる。全身症状としては発熱、体重減少、多発関節炎、筋肉痛が見られ、肺出血(血痰)、進行性腎機能低下を来たし、尿検査では血尿、蛋白尿、円柱が認められる。治療はステロイドと免疫抑制薬である。重症例では血漿交換も適応となる。死因は腎不全が多い。

アレルギー性肉芽腫性血管炎 Churg-Strauss症候群

• 主に中動脈以下の動脈を好発部位とする壊死性肉芽腫性血管炎。高率に肺病変と好酸球増多症を認め、また好酸球の組織浸潤も著明。気管支喘息、好酸球増加、血管炎をみとめる場合、チャーグ・ストラウス症候群である。典型的組織像が見とめられればアレルギー性肉芽腫性血管炎と呼ばれる。検査では、白血球増加、血小板数増加、血清IgE増加、MPO-ANCA陽性、リウマトイド因子陽性、肺浸潤陰影が認められる。治療はステロイドや免疫抑制薬である。結節性多発動脈炎より予後良好であるが脳血管障害、呼吸不全、腸管出血、感染が死因となりうる。

「cytoplasmic」

　　[★]

• 細胞質の、細胞質内の、細胞質側の、原形質の

関

cytoplasm、cytoplasma、intracytoplasmic、protoplasm、protoplasmic