WordNet

of or relating to cytoplasm (同)cytoplasmatic
any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response
the protoplasm of a cell excluding the nucleus; is full of proteins that control cell metabolism (同)cytol

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Clinical Implication of Proteinase-3-antineutrophil Cytoplasmic Antibody in Patients with Idiopathic Interstitial Pneumonias.

Hozumi H1,2, Enomoto N3, Oyama Y3, Kono M3, Fujisawa T3, Inui N4, Nakamura Y3, Suda T3.
Lung.Lung.2016 Apr;194(2):235-42. doi: 10.1007/s00408-016-9851-x. Epub 2016 Feb 12.
PURPOSE: The clinical significance of proteinase-3-antineutrophil cytoplasmic antibody (PR3-ANCA) positivity is not well established in idiopathic interstitial pneumonia (IIP) patients. We aimed to determine the clinical features of PR3-ANCA-positive IIP patients.METHODS: We retrospectively reviewed
PMID 26873743

[Clinical analysis of 43 patients with eosinophilic granulomatosis with polyangiitis].

Li J1, Zhang LM, Zhao W, Zhu M, Xue Y, Dai HP.
Zhonghua yi xue za zhi.Zhonghua Yi Xue Za Zhi.2016 Mar 15;96(10):787-91. doi: 10.3760/cma.j.issn.0376-2491.2016.10.008.
OBJECTIVE: To describe the clinical features of eosinophilic granulomatosis with polyangiitis (EGPA).METHODS: Patients who fulfilled the criteria for EGPA managed at the Beijing Chaoyang Hospital of Capital Medical University between May 2005 and Feb 2014 were retrospectively investigated. Patients'
PMID 27055639

Prevalence and Responsiveness to Treatment of Lung Abnormalities on Chest Computed Tomography in Patients With Microscopic Polyangiitis: A Multicenter, Longitudinal, Retrospective Study of One Hundred Fifty Consecutive Hospital-Based Japanese Patients.

Yamagata M1, Ikeda K1, Tsushima K1, Iesato K1, Abe M1, Ito T2, Kashiwakuma D3, Kagami S3, Iwamoto I3, Nakagomi D4, Sugiyama T4, Maruyama Y5, Furuta S6, Jayne D7, Uno T1, Tatsumi K1, Nakajima H1.
Arthritis & rheumatology (Hoboken, N.J.).Arthritis Rheumatol.2016 Mar;68(3):713-23. doi: 10.1002/art.39475.
OBJECTIVE: To determine the prevalence of lung abnormalities on chest computed tomography (CT) in patients with microscopic polyangiitis (MPA), to assess the responsiveness of such abnormalities to initial treatment, and to assess associations between these abnormalities and patient and disease char
PMID 26474081

Diffuse Alveolar Hemorrhage Emerging One Week after Starting High-dose Corticosteroid Therapy for Granulomatosis with Polyangiitis (GPA) with Systemic Lupus Erythematosus (SLE)

英: myeloperoxidase antineutrophil cytoplasmic antibody, myeloperoxidase-anti-neutrophil cytoplasmic antibody; perinuclear antineutrophil cytoplasmic antibody, perinuclear-anti-neutrophil cytoplasmic antibody, p-ANCA
関: PR3-ANCA=C-ANCA

YN.F-62

全身の小血管に炎症を来たし、全身症状が見られるが特に肺(間質性肺炎)、腎(半月体形成性糸球体腎炎)に病変が認められる。全身症状としては発熱、体重減少、多発関節炎、筋肉痛が見られ、肺出血(血痰)、進行性腎機能低下を来たし、尿検査では血尿、蛋白尿、円柱が認められる。治療はステロイドと免疫抑制薬である。重症例では血漿交換も適応となる。死因は腎不全が多い。

主に中動脈以下の動脈を好発部位とする壊死性肉芽腫性血管炎。高率に肺病変と好酸球増多症を認め、また好酸球の組織浸潤も著明。気管支喘息、好酸球増加、血管炎をみとめる場合、チャーグ・ストラウス症候群である。典型的組織像が見とめられればアレルギー性肉芽腫性血管炎と呼ばれる。検査では、白血球増加、血小板数増加、血清IgE増加、MPO-ANCA陽性、リウマトイド因子陽性、肺浸潤陰影が認められる。治療はステロイドや免疫抑制薬である。結節性多発動脈炎より予後良好であるが脳血管障害、呼吸不全、腸管出血、感染が死因となりうる。