ovarian hypoplasia

卵巣形成不全

WordNet

1. underdevelopment of an organ because of a decrease in the number of cells
2. of or involving the ovaries; "ovarian cancer"

PrepTutorEJDIC

1. 卵巣の / 子房(しぼう)の

UpToDate Contents

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• 1. 幼児、小児および思春期における卵巣嚢腫、および腫瘍 ovarian cysts and neoplasms in infants children and adolescents
• 2. 卵巣癌のスクリーニング screening for ovarian cancer
• 3. Overview of the approach to survivors of epithelial ovarian, fallopian tube, or peritoneal carcinoma
• 4. 自己免疫性原発性卵巣不全（早発卵巣不全）の臨床的特徴および診断 clinical features and diagnosis of autoimmune primary ovarian insufficiency premature ovarian failure
• 5. 上皮性卵巣癌の早期発見：症状認識の役割 early detection of epithelial ovarian cancer role of symptom recognition

English Journal

• Exploring the roles of PALB2 at the crossroads of DNA repair and cancer.

• Pauty J, Rodrigue A, Couturier A, Buisson R1, Masson JY.
• The Biochemical journal.Biochem J.2014 Jun 15;460(3):331-42. doi: 10.1042/BJ20140208.
• PALB2 [partner and localizer of BRCA2 (breast cancer early-onset 1)] has emerged as a key player in the maintenance of genome integrity. Biallelic mutations in PALB2 cause FA (Fanconi's anaemia) subtype FA-N, a devastating inherited disorder marked by developmental abnormalities, bone marrow failure
• PMID 24870022

• Metformin in women with PCOS, Pros.

• Renato P.
• Endocrine.Endocrine.2014 Jun 10. [Epub ahead of print]
• Metformin is an old insulin sensitizer that has been widely used in women with polycystic ovary syndrome (PCOS) to treat metabolic comorbidities and may also improve ovarian dysfunction in women with PCOS. In fact, metformin may improve insulin resistance, a common finding of PCOS, and reduce insuli
• PMID 24913417

• Neurovascular Complications of Ovarian Hyperstimulation Syndrome (OHSS): From Pathophysiology to Recent Treatment Options.

• Calabrò RS, Gervasi G, Leo A, Luca RD, Balletta T, Casella C, Triolo O, Bramanti P1.
• Recent patents on endocrine, metabolic & immune drug discovery.Recent Pat Endocr Metab Immune Drug Discov.2014 Jun 6. [Epub ahead of print]
• Ovarian hyperstimulation syndrome (OHSS) is a severe iatrogenic complication of ovulation induction, which has a very serious impact on the patient's health, as it is often associated with a high morbidity and mortality risk. Indeed, patients classified as having severe OHSS presented with liquid im
• PMID 24902709

Japanese Journal

• (1)卵巣癌における化学療法感受性バイオマーカーの開発と組織型による分子標的の同定 : 治療個別化に向けたBioinformaticsの応用(<特集>第61回学術講演会シンポジウム3「卵巣癌の新たな治療戦略-基礎から,そして臨床から-」)

• 松村 謙臣
• 日本産科婦人科學會雜誌 61(11), 2013-2026, 2009-11-01
• … In order to link findings of basic research with the treatment of ovarian cancer, genome-wide analysis using bioinformatics is thought to be necessary. … In this research, we analyzed the following three subjects using bioinformatics to improve drug treatment against ovarian cancer. … 1) Biomarker of chemo-sensitivity A transcript factor YY1 was one of genes that discriminate between good and poor prognosis in patients with serous ovarian cancer. …
• NAID 110007467573

• Influence of the hypogonadism (hgn) locus on female reproduction and ovarian development in an altered genetic background

• SUZUKI HIROETSU,DAIGO KUMI,OKADA MIKA,YAGI MIO,NAKAMIYA EIJIRO,SAITO KENICHI,SUZUKI KATSUSHI
• Reproductive medicine and biology 5(3), 227-234, 2006-09-01
• NAID 10019285801

• EVALUATION OF A TWO-GENERATION REPRODUCTION TOXICITY STUDY ADDING ENDOPOINTS TO DETECT ENDOCRINE DISRUPTING ACTIVITY USING VINCLOZOLIN

• MATSUURA Ikuo,SAITOH Tetsuji,ASHINA Michiko,WAKO Yumi,IWATA Hiroshi,TOYOTA Naoto,ISHIZUKA Yoshihito,NAMIKI Masato,HOSHINO Nobuhito,TSUCHITANI Minoru,IKEDA Yasuo
• Journal of toxicological sciences 30(Special_Issue), 163-188, 2006-02-22
• … Histopathological examination revealed centrilobular hepatocellular hypertrophy in males at 200 and 1000 ppm and in females at 1000 ppm, increased lipid droplets in the adrenal zona fasciculata and zona glomerulosa in males at 200 and 1000 ppm and in females at 40 ppm and above, and hyperplasia of ovarian interstitial cells and vacuolation of lutein cells in females at 1000 ppm in both generations. …
• NAID 110004471433

Related Links

• ovarian hypoplasia - definition of ovarian hypoplasia in the ...

ovarian /ovar·i·an/ (o-var´e-an) pertaining to an ovary or ovaries. ovarian [ōver′ē·ən] Etymology: L, ovum, egg pertaining to the ovary. ovarian ovarian adjective Referring to one or more ovaries ovarian [o-var´e-an] pertaining to an ovary. ...

• Ovarian Hypoplasia | Calfology - Calfology | Official Sponsor of ...

Description: Ovarian hypoplasia is a condition in which one or both ovaries are smaller than normal. It is much more common for the left ovary to be hypoplastic than the left, but both may be adversely affected. This condition is ...

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★リンクテーブル★

リンク元	「ターナー症候群」「卵巣形成不全」「卵巣形成障害」
関連記事	「hypoplasia」「ovarian」

「ターナー症候群」

　　[★]

英

Turner syndrome, Turner's syndrome

同

XO症候群 XO syndrome, 卵巣形成不全 ovarian hypoplasia、Ullrich-Turner症候群

関

モノソミー、ヌーナン症候群

概念

• 性腺発育不全、翼状頸、外反肘、低身長を主徴とする性染色体異常症候群。

病因

• 染色体異常

• 核型：45X(約50%)、45X/46XX (モザイク)、46XXq、46XXp
• X染色体の長腕・短腕は卵巣機能に関係、X染色体の短腕は身長に関連

疫学

• 新生児発生頻度：1/2,000。出生女児数1,000人対1人

症候

• 全身:低身長：3歳ごろまでは正常。以降低下し、日本人では平均成人身長は138cm。(SPE.223)
• 知能：正常。まれだが、環状X染色体を有する場合は重度の精神遅滞を呈する。(参考1)
• 頚部:翼状頚
• 胸部:盾状胸
• 上肢:外反肘
• 生殖器

• 外生殖器：形成は正常だが、エストロゲン低値により外観は小児様外性器を呈する。
• 内生殖器

• 子宮、卵管は特に問題なし
• 性腺(卵巣)：卵巣形成不全(索状卵巣 streak gonad)　→　二次性徴の欠如、卵巣性無月経、貧毛症、不妊症、高ゴナドトロピン性性腺機能低下症。

• 内分泌

• 糖尿病
• 甲状腺機能障害

• 循環器：本態性高血圧、心・血管奇形
• 胎児：

• 子宮内発達遅延

奇形

• 心奇形、大動脈縮窄症、腎奇形(馬蹄腎など)、腸回転異常症

治療

• 低身長：成長ホルモン

参考

• 1. [charged] Clinical manifestations and diagnosis of Turner syndrome (gonadal dysgenesis) - uptodate [1]

国試

• 105I050

「卵巣形成不全」

　　[★]

英

ovarian hypoplasia

関

ターナー症候群

「卵巣形成障害」

　　[★]

関

卵巣形成不全 ovarian hypoplasia

「hypoplasia」

　　[★]

• n.

• 発育不全、形成不全、低形成

関

abortion、abortive、agenesis、、dysgenesis、hypotrophy

無形成、aplasia、aplastic

　

「ovarian」

　　[★]

• adj.

• 卵巣の、(植物)子房の

関

ovary