ovarian

• adj.

• 卵巣の、(植物)子房の

関

ovary

　 　

WordNet

1. of or involving the ovaries; "ovarian cancer"
2. the organ that bears the ovules of a flower
3. (vertebrates) one of usually two organs that produce ova and secrete estrogen and progesterone

PrepTutorEJDIC

1. 卵巣の / 子房(しぼう)の
2. 卵巣 / (花の)子房

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/01 19:42:59」(JST)

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For ovary as part of plants, see Ovary (botany).

"Ovaria" redirects here. This is also a proposed section and a synonym of Solanum.

Ovary
Blood supply of the human female reproductive organs. The left ovary is visible above the label "ovarian arteries".
Latin	ovarium
Gray's	subject #266 1254
Artery	ovarian artery, uterine artery
Vein	ovarian vein
Nerve	ovarian plexus
Lymph	Paraaortic lymph node
MeSH	Ovary
Dorlands/Elsevier	Ovary

The ovary (From Latin: ovarium, literally “egg” or “nut”) is an ovum-producing reproductive organ, often found in pairs as part of the vertebrate female reproductive system. Ovaries in female individuals are analogous to testes in male individuals, in that they are both gonads and endocrine glands.

Structure

Each ovary is dark-black in color and located alongside the lateral wall of the Uterus in a region called the ovarian fossa. The fossa usually lies beneath the external iliac artery and in front of the ureter and the internal iliac artery. It is about 4 cm x 3 cm x 2 cm in size.

Usually each ovary takes turns releasing an egg every month; however, if there was a case where one ovary was absent or dysfunctional then the other ovary would continue providing eggs to be released.

Ligaments

In the human the paired ovaries lie within the pelvic cavity, on either side of the uterus, to which they are attached via a fibrous cord called the ovarian ligament. The ovaries are uncovered in the peritoneal cavity but are tethered to the body wall via the suspensory ligament of the ovary. The part of the broad ligament of the uterus that covers the ovary is known as the mesovarium. Thus, the ovary is the only organ in the human body which is totally invaginated into the peritonium, making it the only intraperitoneal organ (not to be confused with interperitoneal).

Extremities

There are two extremities to the ovary:

• The end to which the fallopian tube attaches is called the tubal extremity and ovary is connected to it by infundibulopelvic ligament.
• The other extremity is called the uterine extremity. It points downward, and it is attached to the uterus via the ovarian ligament.

Histology

• Follicular cells flat epithelial cells that originate from surface epithelium covering the ovary
• Granulosa cells - surrounding follicular cells have changed from flat to cuboidal and proliferated to produce a stratified epithelium
• Gametes

Section of the ovary of a newly born child. Germinal epithelium is seen at top. Primitive ova are seen in their cell-nests. The Genital cord or genital ridge is still discernible in this young child. A blood vessel and an ovarian follicle is also seen. Formation of about 30 primordial follicles in the ovarian cortex region during 5-7 month of embryonic development.

• The outermost layer is called the ovarian surface epithelium (previously known as the germinal epithelium).
• The ovarian cortex consists of ovarian follicles and stroma in between them. Included in the follicles are the cumulus oophorus, membrana granulosa (and the granulosa cells inside it), corona radiata, zona pellucida, and primary oocyte. The zona pellucida, theca of follicle, antrum and liquor folliculi are also contained in the follicle. Also in the cortex is the corpus luteum derived from the follicles.
• The innermost layer is the ovarian medulla. It can be hard to distinguish between the cortex and medulla, but follicles are usually not found in the medulla.

The ovary also contains blood vessels and lymphatics.

Function

Hormones

Ovaries secrete estrogen, testosterone and progesterone. In women, fifty per cent of testosterone is produced by the ovaries and adrenal glands and released directly into the blood stream. Estrogen is responsible for the appearance of secondary sex characteristics for females at puberty and for the maturation and maintenance of the reproductive organs in their mature functional state. Progesterone prepares the uterus for pregnancy, and the mammary glands for lactation. Progesterone functions with estrogen by promoting menstrual cycle changes in the endometrium.

Ovarian aging

As women age, they experience a decline in reproductive performance leading to menopause. This decline is tied to a decline in the number of ovarian follicles. Although about 1 million oocytes are present at birth in the human ovary, only about 500 (about 0.05%) of these ovulate, and the rest are wasted. The decline in ovarian reserve appears to occur at a constantly increasing rate with age, and leads to nearly complete exhaustion of the reserve by about age 52. As ovarian reserve and fertility decline with age, there is also a parallel increase in pregnancy failure and meiotic errors resulting in chromosomally abnormal conceptions.

Women with an inherited mutation in the DNA repair gene BRCA1 undergo menopause prematurely, suggesting that naturally occurring DNA damages in oocytes are repaired less efficiently in these women, and this inefficiency leads to early reproductive failure. The BRCA1 protein plays a key role in a type of DNA repair termed homologous recombinational repair that is the only known cellular process that can accurately repair DNA double-strand breaks. Titus et al. showed that DNA double-strand breaks accumulate with age in humans and mice in primordial follicles. Primodial follicles contain oocytes that are at an intermediate (prophase I) stage of meiosis. Meiosis is the general process in eukaryotic organisms by which germ cells are formed, and it is likely an adaptation for removing DNA damages, especially double-strand breaks, from germ line DNA. (see Meiosis and Origin and function of meiosis). Homologous recombinational repair is especially promoted during meiosis. Titus et al. also found that expression of 4 key genes necessary for homologous recombinational repair of DNA double-strand breaks (BRCA1, MRE11, RAD51 and ATM) decline with age in the oocytes of humans and mice. They hypothesized that DNA double-strand break repair is vital for the maintenance of oocyte reserve and that a decline in efficiency of repair with age plays a key role in ovarian aging.

Society and culture

Cryopreservation

Cryopreservation of ovarian tissue, often called Ovarian Tissue Cryopreservation, is of interest to women who want to preserve their reproductive function beyond the natural limit, or whose reproductive potential is threatened by cancer therapy, for example in hematologic malignancies or breast cancer. The procedure is to take a part of the ovary and carry out slow freezing before storing it in liquid nitrogen whilst therapy is undertaken. Tissue can then be thawed and implanted near the fallopian, either orthotopic (on the natural location) or heterotopic (on the abdominal wall), where it starts to produce new eggs, allowing normal conception to take place. A study of 60 procedures concluded that ovarian tissue harvesting appears to be safe. The ovarian tissue may also be transplanted into mice that are immunocompromised (SCID mice) to avoid graft rejection, and tissue can be harvested later when mature follicles have developed.

Disease

Ovarian diseases can be classified as endocrine disorders or as a disorders of the reproductive system.

If the egg fails to release from the follicle in the ovary an ovarian cyst may form. Small ovarian cysts are common in healthy women. Some women have more follicles than usual (polycystic ovary syndrome), which inhibits the follicles to grow normally and this will cause cycle irregularities.

In other animals

Ovaries of some kind are found in the female reproductive system of many animals that employ sexual reproduction, including invertebrates. However, they develop in a very different way in most invertebrates than they do in vertebrates, and are not truly homologous.

Many of the features found in human ovaries are common to all vertebrates, including the presence of follicular cells, tunica albuginea, and so on. However, many species produce a far greater number of eggs during their lifetime than do humans, so that, in fish and amphibians, there may be hundreds, or even millions of fertile eggs present in the ovary at any given time. In these species, fresh eggs may be developing from the germinal epithelium throughout life. Corpora lutea are found only in mammals, and in some elasmobranch fish; in other species, the remnants of the follicle are quickly resorbed by the ovary. In birds, reptiles, and monotremes, the egg is relatively large, filling the follicle, and distorting the shape of the ovary at maturity.

Amphibians and reptiles have no ovarian medulla; the central part of the ovary is a hollow, lymph-filled space. The ovary of teleosts is also often hollow, but in this case, the eggs are shed into the cavity, which opens into the oviduct.

Although most normal female vertebrates have two ovaries, this is not the case in all species. In most birds and in platypuses, the right ovary never matures, so that only the left is functional. (Exceptions include the Kiwi and some, but not all raptors, in which both ovaries persist.) In some elasmobranchs, only the right ovary develops fully. In the primitive jawless fish, and some teleosts, there is only one ovary, formed by the fusion of the paired organs in the embryo.

Other conditions include

• Ovarian cancer
• Luteoma
• Hypogonadism
• Hyperthecosis

Additional Images

• Left Ovary

• Ovaries

• Uterus

See also

• Ovarian reserve
• Folliculogenesis
• Oophorectomy
• Menopause
• Ovum

References

External links

• From the American Medical Association
• Merck Online Medical Library: Female Reproductive System

UpToDate Contents

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• 1. 卵巣癌のスクリーニング screening for ovarian cancer
• 2. 付属器腫瘤のマネージメント management of an adnexal mass
• 3. 上皮性卵巣癌、卵管癌、または腹膜癌の再発に対する薬物療法：プラチナ製剤抵抗性癌 medical treatment for relapsed epithelial ovarian fallopian tubal or peritoneal cancer platinum resistant disease
• 4. 進行（ステージIIIまたはIV）上皮性卵巣癌、卵管癌、および腹膜癌に対する初回化学療法 first line chemotherapy for advanced stage iii or iv epithelial ovarian fallopian tubal and peritoneal cancer
• 5. 上皮性卵巣癌、卵管癌、または腹膜癌の再発に対する薬物療法：プラチナ製剤感受性癌 medical treatment for relapsed epithelial ovarian fallopian tubal or peritoneal cancer platinum sensitive disease

English Journal

• Panobinostat: The Small Molecule Metalloenzyme Inhibitor with Marvelous Anticancer Activity.

• Ganai SA1.
• Current topics in medicinal chemistry.Curr Top Med Chem.2016;16(4):427-34.
• Histone acetyl transferases (HATs) and histone deacetylases (HDACs) are antagonistic enzymes regulating the turnover of histone acetylation thereby governing gene expression in a precise manner. Histone acetylation deregulation caused by aberrant expression of classical HDACs plays a crucial role in
• PMID 26268342

• Currently recognized clinically relevant and known genes for human reproduction and related infertility with representation on high-resolution chromosome ideograms.

• Butler MG1, Rafi SK2, McGuire A2, Manzardo AM2.
• Gene.Gene.2016 Jan 1;575(1):149-59. doi: 10.1016/j.gene.2015.08.057. Epub 2015 Sep 2.
• OBJECTIVE: To provide an update of currently recognized clinically relevant candidate and known genes for human reproduction and related infertility plotted on high resolution chromosome ideograms (850 band level) and represented alphabetically in tabular form.METHOD: Descriptive authoritative compu
• PMID 26341055

• ABO (histo) blood group phenotype development and human reproduction as they relate to ancestral IgM formation: A hypothesis.

• Arend P1.
• Immunobiology.Immunobiology.2016 Jan;221(1):116-27. doi: 10.1016/j.imbio.2015.07.003. Epub 2015 Aug 1.
• The formation of a histo (blood) group) ABO phenotype and the exclusion of an autoreactive IgM or isoagglutinin activity arise apparently in identical glycosylation of complementary domains on cell surfaces and plasma proteins. The fundamental O-glycan emptiness of the circulating IgM, which during
• PMID 26433867

Japanese Journal

• Ovarian structure and mode of egg production in the seaweed pipefish Syngnathus schlegeli (Syngnathidae)

• Sogabe Atsushi,Takata Hiromi,Kobayashi Yasuhisa
• Ichthyological research : an official journal of the Ichthyological Society of Japan 60(1), 85-88, 2013-01-25
• NAID 40019557044

• 超音波画像検査による卵胞数の計測に基づく供胚牛の選定技術の開発

• 葉棚 幸輝,木村 健一,柳澤 克可 [他]
• 家畜診療 = Journal of livestock medicine 60(1), 29-34, 2013-01
• NAID 40019553227

• The ex vivo effects of eyestalk peptides on ovarian vitellogenin gene expression in the kuruma prawn Marsupenaeus japonicus

• Tsutsui Naoaki,Nagakura-Nakamura Ayano,Nagai Chiaki [他]
• Fisheries science 79(1), 33-38, 2013-01
• NAID 40019552229

Related Links

• National Ovarian Cancer Coalition (NOCC) | Your National ...

Our mission is to raise awareness of ovarian cancer and provide information on symptoms, diagnosis, treatment and support through national programs and local chapter initiatives. ... * SOURCE: Society of Gynecologic Oncology ...

• Ovarian Cancer: Facts on Symptoms and Treatment

Get information on ovarian cancer symptoms, treatment, stages, survival rates, prognosis, diagnosis, causes, and more. Ovarian cancer has often metastasized by the time it is detected. ... Epithelial ovarian cancer (EOC) accounts ...

Related Pictures

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★リンクテーブル★

リンク元	「子房」
拡張検索	「ovarian cancer cell」「ovarian disease」

「子房」

　　[★]

英

ovary、ovarian

関

卵巣

「ovarian cancer cell」

　　[★]

• 卵巣癌細胞、卵巣がん細胞

「ovarian disease」

　　[★]

• 卵巣疾患、卵巣病