WordNet

of or relating to interstices
not caused by a specific agent; used also of staining in making microscope slides; "nonspecific enteritis"
respiratory disease characterized by inflammation of the lung parenchyma (excluding the bronchi) with congestion caused by viruses or bacteria or irritants

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肺炎

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/12 16:47:25」(JST)

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Non-specific interstitial pneumonia (NSIP) is a form of idiopathic interstitial pneumonia.^[1]^[2]^[3]

Patients with an NSIP histologic pattern on biopsy have a better prognosis than those with usual interstitial pneumonia (UIP). There are two variants of NSIP: cellular and fibrosing. The cellular variant features chronic inflammatory cells with minimal collagen deposition while the fibrosing pattern consists of diffuse interstitial fibrosis with fewer inflammatory cells. In contrast to UIP, NSIP has little or no honeycomb change, and fibroblast foci are scant or absent.^[4]^[5]

References[edit]

^ "Idiopathic Interstitial Pneumonias: Interstitial Lung Diseases: Merck Manual Professional". Retrieved 2008-12-09.
^ Katzenstein AL, Fiorelli RF (February 1994). "Nonspecific interstitial pneumonia/fibrosis. Histologic features and clinical significance". Am. J. Surg. Pathol. 18 (2): 136–47. doi:10.1097/00000478-199402000-00003. PMID 8291652.
^ Martinez FJ (2006). "Idiopathic interstitial pneumonias: usual interstitial pneumonia versus nonspecific interstitial pneumonia". Proc Am Thorac Soc 3 (1): 81–95. doi:10.1513/pats.200511-123JH. PMID 16493155.
^ Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 731. ISBN 0-7216-0187-1.
^ Leslie KO (November 2005). "Historical perspective: a pathologic approach to the classification of idiopathic interstitial pneumonias". Chest 128 (5 Suppl 1): 513S–519S. doi:10.1378/chest.128.5_suppl_1.513S. PMID 16304241.

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1. 非特異的間質性肺炎 nonspecific interstitial pneumonia
2. 特発性間質性肺炎：臨床症状および病理 idiopathic interstitial pneumonias clinical manifestations and pathology
3. 間質性肺疾患における肺生検結果の解釈 interpretation of lung biopsy results in interstitial lung disease
4. シェーグレン症候群関連間質性肺疾患：管理と予後 interstitial lung disease associated with sjogrens syndrome management and prognosis
5. 未分化型の全身性リウマチ性（結合組織）疾患およびオーバーラップ症候群 undifferentiated systemic rheumatic connective tissue diseases and overlap syndromes

English Journal

Diffuse pulmonary lymphatic disease presenting as interstitial lung disease in adulthood: report of 3 cases.

Boland JM, Tazelaar HD, Colby TV, Leslie KO, Hartman TE, Yi ES.SourceDepartments of *Laboratory Medicine and Pathology ‡Radiology, Mayo Clinic, Rochester, MN †Mayo Clinic, Scottsdale, AZ.
The American journal of surgical pathology.Am J Surg Pathol.2012 Oct;36(10):1548-54.
Diffuse pulmonary lymphatic diseases are typically diagnosed shortly after birth or in childhood, but rarely may become evident in adulthood. We report 3 adult patients who presented with diffuse interstitial lung disease clinically and radiologically but on biopsy were found to have diffuse pulmona
PMID 22982897

Usual interstitial pneumonia and nonspecific interstitial pneumonia: Correlation between CT findings at the site of biopsy with pathological diagnoses.

Sumikawa H, Johkoh T, Fujimoto K, Ichikado K, Colby TV, Fukuoka J, Taniguchi H, Kondoh Y, Kataoka K, Yanagawa M, Koyama M, Honda O, Tomiyama N.SourceDepartment of Radiology, Osaka University Graduate School of Medicine, 2-2 Yamadaoka, Suita, Osaka 565-0825, Japan.
European journal of radiology.Eur J Radiol.2012 Oct;81(10):2919-24. Epub 2011 Dec 12.
OBJECTIVES: The aim of this study was to correlate high-resolution CT (HRCT) findings at the site of biopsy with the whole lung CT and pathologic diagnoses in usual interstitial pneumonia (UIP) and nonspecific interstitial pneumonia (NSIP).METHODS: The study included 35 patients (25 UIP and 10 NSIP)
PMID 22169358

Japanese Journal

気管支肺胞洗浄液中の好中球・好酸球増多を認め、胸腔鏡下肺生検にて診断した特発性非特異性門質性肺炎の１例

磯部全,前野敏孝,折居美波,倉林正彦,Isobe Zen,Maeno Toshitaka,Orii Minami,Masahiko Kurabayashi
The Kitakanto medical journal = 北関東医学 63(4), 369-373, 2013-11-01
要旨症例は60歳女性. 2007年9 月頃より乾性咳嗽, 労作時呼吸困難(F-H-J 度) が出現し, 同年11月当科へ精査目的にて入院した. また両手指の腫脹と関節痛, 朝の手指のこわばりも認めた. 安静時動脈血液ガス分析ではPaO2 64.8 torrと低酸素血症が認められた. 胸部単純レントゲンにて両下肺野のスリガラス陰影, 胸部CT では両下葉優位の気管支血管束に沿うスリガラス陰影, 網状 …
NAID 120005345409

気管支肺胞洗浄液中の好中球・好酸球増多を認め,胸腔鏡下肺生検にて診断した特発性非特異性間質性肺炎の1例

磯部全,前野敏孝,折居美波 [他]
北関東医学 63(4), 369-373, 2013-11
NAID 40019875639

Interstitial Pneumonia Associated with Linear Immunoglobulin A/Immunoglobulin G Bullous Dermatosis

Kakugawa Tomoyuki,Tomimura Saori,Hayashi Tomayoshi,Sakamoto Noriho,Ishimatsu Yuji,Mukae Hiroshi,Kohno Shigeru
Respiration 86(4), 347-351, 2013-10
… A 76-year-old man with interstitial lung disease was admitted to our institution after developing persistent dyspnea upon effort. … Chest computed tomography, bronchoalveolar lavage and transbronchial lung biopsy findings suggested nonspecific interstitial pneumonia. …
NAID 120005353326

Related Pictures

Non-specific interstitial pneumonia | Radiology Case | Radiopaedia.org Non specific interstitial pneumonia (NSIP) | Image | Radiopaedia.org

★リンクテーブル★

リンク元	「非特異性間質性肺炎」「非特異型間質性肺炎」
関連記事	「interstitial」「nonspecific」

「非特異性間質性肺炎」

　　[★]

英: nonspecific interstitial pneumonia NSIP, ~~nonspecific interstitial pneumonitis~~
同: 非特異性間質性肺炎・肺線維症 nonspecific interstitial pneumonia/fibrosis
関: 間質性肺炎

[show details]

非特異型間質性肺炎 : 43 件
非特異性間質性肺炎 : 約 27,300 件
非特異的間質性肺炎 : 98 件

特徴

臨床診断名	IPF	NSIP	BOOP/COP
病理組織像	UIP	NSIP	OP
発症様式	慢性	慢性/亜急性	亜急性
BALF所見	リンパ球±	CD8↑	CD8↑
予後	不良	良好(時に不良)	良好
分布	斑状,不均質, 胸膜下･小葉辺縁	びまん性,均質	小葉中心性
時相	多様	均質	均質
間質への細胞浸潤	少ない	通常多い	やや多い
胞隔の炎症	軽度,斑状	びまん性,多彩	軽度
線維芽細胞巣	多数	まれ	なし
肺胞内マクロファージ集積	巣状	巣状	なし
肺胞腔内線維化	まれ	しばしば	多数
顕微鏡的蜂巣肺(肺胞虚説)	高頻度	通常なし(一部に認める)	なし
硝子膜	なし	なし	なし

概念

UIPとBOOPの様な病理像とステロイド反応性を呈する
病変のほぼ一様な慢性間質性肺炎で、びまん性肺胞傷害(DAD)、閉塞性細気管支炎性器質化肺炎(BOOP)、通常型間質性肺炎(UIP)、剥離型間質性肺炎(DIP)、リンパ球様間質性肺炎(LIP)、巨細胞性間質性肺炎(GIP)のいずれとも病理組織所見上、判断できない症例群に対する暫定的な病理組織学的概念(Katzenstein、et　al、1984)。(医学用語辞書)

分類

I群：細胞性間質性肺炎。間質の炎症性病変が主体。線維化病変は低頻度。
II群：リンパ球、形質細胞の間質浸潤。肺胞構造の消失を伴う線維化病変。
III型：病期の揃ったびまん性/斑状線維化病変。蜂巣肺。

疫学

40歳以上で女性に多い(YN.I-81)

症状

呼吸困難、乾性咳嗽、発熱
亜急性に発症

検査

血液検査

CRP↑、LDH↑、低酸素血症、SP-A↑、SP-B↑、KL-6↑

聴診

捻髪音 fine crackle

胸部X線写真

BALF

リンパ球%↑、CD8↑

治療

ステロイドに対する反応性良好

予後

良好、一部に予後不良。

「非特異型間質性肺炎」

　　[★]

英: non-specific interstitial pneumonia, nonspecific interstitial pneumonia, non-specific interstitial pneumonitis, nonspecific interstitial pneumonitis
関: 間質性肺炎

「interstitial」

　　[★]

adj.

間質性の、間質内の、侵入型の、組織内の、介在の、介在性の、中間部の、間質の

関: intercalary、intermediate、internuncial、interstitial tissue、interstitium、intervene、intervening、interzonal、invasive、stroma、stromal、stromata

「nonspecific」

　　[★]

adj.

非特異的な、非特異性の

関: non-specific、nonspecifically、nonspecificity、off-target、unspecific

[urlIdiopathic_Interstitial_Pneumonias:_Interstitial_Lung_Diseases:_Merck_Manual_Professional-1] "Idiopathic Interstitial Pneumonias: Interstitial Lung Diseases: Merck Manual Professional". Retrieved 2008-12-09.

[pmid8291652-2] Katzenstein AL, Fiorelli RF (February 1994). "Nonspecific interstitial pneumonia/fibrosis. Histologic features and clinical significance". Am. J. Surg. Pathol. 18 (2): 136–47. doi:10.1097/00000478-199402000-00003. PMID 8291652.

[pmid16493155-3] Martinez FJ (2006). "Idiopathic interstitial pneumonias: usual interstitial pneumonia versus nonspecific interstitial pneumonia". Proc Am Thorac Soc 3 (1): 81–95. doi:10.1513/pats.200511-123JH. PMID 16493155.

[isbn0-7216-0187-1-4] Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Robbins and Cotran pathologic basis of disease. St. Louis, Mo: Elsevier Saunders. p. 731. ISBN 0-7216-0187-1.

[pmid16304241-5] Leslie KO (November 2005). "Historical perspective: a pathologic approach to the classification of idiopathic interstitial pneumonias". Chest 128 (5 Suppl 1): 513S–519S. doi:10.1378/chest.128.5_suppl_1.513S. PMID 16304241.

匿名

検索

案内

案内

nonspecific interstitial pneumonia