中性アミノ酸トランスポーター、中性アミノ酸輸送体

関: neutral amino acid transport system

WordNet

move something or somebody around; usually over long distances
an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
transport commercially (同)send, ship
possessing no distinctive quality or characteristics
one who does not side with any party in a war or dispute
having no net electric charge (同)electroneutral
lacking distinguishing quality or characteristics; "a neutral personality that made no impression whatever"
not supporting or favoring either side in a war, dispute, or contest
street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
having the characteristics of an acid; "an acid reaction"
a long truck for carrying motor vehicles (同)car transporter
a crane for moving material with dispatch as in loading and unloading ships
pertaining to or containing any of a group of organic compounds of nitrogen derived from ammonia (同)aminic
the radical -NH2 (同)amino_group

PrepTutorEJDIC

(ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
『中立の』;中立国の / 『公平な』,不偏不党の / (人・物が)特色のはっきりしない;(色が)はっきりしない,くすんだ / (酸性でもアルカリ性でもない)中性の / (電気が)中性の,(物体が)帯電していない / (自動車などのギアが)ニュートラルの / (文法で)中性の / 〈C〉(戦争・論争などで)中立の人;中立国民;中立国 / 〈C〉くすんだ色,灰色 / 〈U〉(自動車などのギヤの)ニュートラル(動力のかかっていない状態・位置)
酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
自動車運搬用大型トラック

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/10/10 00:12:44」(JST)

wiki en

[Wiki en表示]

An amino acid transporter is a membrane transport protein that transports amino acids. They are mainly of the solute carrier family.

Solute carrier family examples

(1) high affinity glutamate and neutral amino acid transporter^[1]
(3) heavy subunits of heteromeric amino acid transporters^[2]
(7) cationic amino acid transporter/glycoprotein-associated^[3]
(15) proton oligopeptide cotransporter^[4]
(17) vesicular glutamate transporter^[5]
(18) vesicular amine transporter^[6]
(25) some mitochondrial carriers^[7]
(26) multifunctional anion exchanger^[8]
(32) vesicular inhibitory amino acid transporter^[9]
(36) proton-coupled amino acid transporter^[10]
(38) System A & N, sodium-coupled neutral amino acid transporter^[11]

VIAAT

Vesicular inhibitory amino acid transporter (VIAAT) is responsible for the storage of GABA and glycine in neuronal synaptic vesicles.^[12]

Human proteins containing this domain

ATA2; SLC32A1; SLC36A1; SLC36A2; SLC36A3; SLC36A4; SLC38A1; SLC38A2; SLC38A3; SLC38A4; SLC38A5; SLC38A6;

References

^ Kanai Y, Hediger MA (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflugers Arch 447 (5): 469–479. doi:10.1007/s00424-003-1146-4. PMID 14530974.
^ Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309.
^ Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310.
^ Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflugers Arch 447 (5): 610–618. doi:10.1007/s00424-003-1101-4. PMID 12905028.
^ Reimer RJ, Edwards RH (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflugers Arch 447 (5): 629–635. doi:10.1007/s00424-003-1087-y. PMID 12811560.
^ Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflugers Arch 447 (5): 636–640. doi:10.1007/s00424-003-1100-5. PMID 12827358.
^ Palmieri F (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflugers Arch 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172.
^ Mount DB, Romero MF (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflugers Arch 447 (5): 710–721. doi:10.1007/s00424-003-1090-3. PMID 12759755.
^ Gasnier B (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflugers Arch 447 (5): 752–755. doi:10.1007/s00424-003-1091-2. PMID 12750892.
^ Boll M, Daniel H, Gasnier B (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflugers Arch 447 (5): 776–779. doi:10.1007/s00424-003-1073-4. PMID 12748860.
^ Mackenzie B, Erickson JD (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflugers Arch 447 (5): 784–795. doi:10.1007/s00424-003-1117-9. PMID 12845534.
^ [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003

UpToDate Contents

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English Journal

Suppression of network activity in dorsal horn by gabapentin permeation of TRPV1 channels: Implications for drug access to cytoplasmic targets.

Biggs JE1, Stemkowski PL1, Knaus EE2, Chowdhury MA2, Ballanyi K3, Smith PA4.
Neuroscience letters.Neurosci Lett.2015 Jan 1;584:397-402. doi: 10.1016/j.neulet.2014.07.033. Epub 2014 Jul 29.
The effectiveness of gabapentin (GBP) in the treatment of neuropathic pain depends on access to the α2δ-1 accessory subunit of voltage-gated Ca(2+) channels. Access may be limited by its rate of entry via the neuronal system L-neutral amino acid transporter. The open pore of capsaicin-activated TR
PMID 25079903

Essential amino acid transporter Lat4 (Slc43a2) is required for mouse development.

Guetg A1, Mariotta L1, Bock L1, Herzog B1, Fingerhut R2, Camargo SM1, Verrey F3.
The Journal of physiology.J Physiol.2014 Dec 5. [Epub ahead of print]
Amino acid uniporter Lat4 (Slc43a2) mediates facilitated diffusion of branched-chain amino acids, methionine and phenylalanine, but its physiological role and subcellular localization are not known. We report here that Slc43a2 knock-out mice were born at expected Mendelian frequency but displayed an
PMID 25480797

Leucine stimulates ASCT2 amino acid transporter expression in porcine jejunal epithelial cell line (IPEC-J2) through PI3K/Akt/mTOR and ERK signaling pathways.

Zhang S1, Ren M, Zeng X, He P, Ma X, Qiao S.
Amino acids.Amino Acids.2014 Dec;46(12):2633-42. doi: 10.1007/s00726-014-1809-9. Epub 2014 Jul 26.
Leucine has been shown to influence intestinal protein metabolism, cell proliferation and migration. Furthermore, our previous study demonstrated that branched-chain amino acids could modulate the intestinal amino acid and peptide transporters in vivo. As the possible mechanisms are still largely un
PMID 25063204

Japanese Journal

The role of L-type amino acid transporter 1 in human tumors

Intractable & Rare Diseases Research 4(4), 165-169, 2015
NAID 130005109603

The role of L-type amino acid transporter 1 in human tumors

Intractable & Rare Diseases Research advpub(0), 2015
NAID 130005098728

In Vitro Study of L-Glutamate and L-Glutamine Transport in Retinal Pericytes: Involvement of Excitatory Amino Acid Transporter 1 and Alanine–Serine–Cysteine Transporter 2

Biological and Pharmaceutical Bulletin 38(6), 901-908, 2015
NAID 130005072672

「中性アミノ酸輸送体」

Transmembrane amino acid transporter protein
Identifiers
Symbol	Aa_trans
Pfam	PF01490
InterPro	IPR013057
TCDB	2.A.18
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

　　[★]

英: neutral amino acid transporter
関: 中性アミノ酸輸送系、中性アミノ酸トランスポーター

「中性アミノ酸トランスポーター」

　　[★]

英: neutral amino acid transporter
関: 中性アミノ酸輸送体

「neutral amino acid transport system」

　　[★]

中性アミノ酸輸送系

関: neutral amino acid transporter

「large neutral amino acid-transporter 1」

　　[★]

大型中性アミノ酸輸送体1、大型中性アミノ酸トランスポータ1

関: LAT1、SLC7A5

「transport」

　　[★]

n.

輸送、運搬

v.

輸送する、運搬する、運ぶ

関: bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

「transporter」

　　[★] トランスポーター

関: translocator、transport protein、transporter protein

「neutral」

　　[★]

adj.

中性の、中立の

[Kanai_2004-0] Kanai Y, Hediger MA (2004). "The glutamate/neutral amino acid transporter family SLC1: molecular, physiological and pharmacological aspects". Pflugers Arch 447 (5): 469–479. doi:10.1007/s00424-003-1146-4. PMID 14530974.

[Palacin_2004-1] Palacin M, Kanai Y (2004). "The ancillary proteins of HATs: SLC3 family of amino acid transporters". Pflugers Arch 447 (5): 490–494. doi:10.1007/s00424-003-1062-7. PMID 14770309.

[Verrey_2004-2] Verrey F, Closs EI, Wagner CA, Palacin M, Endou H, Kanai Y (2004). "CATs and HATs: the SLC7 family of amino acid transporters". Pflugers Arch 447 (5): 532–542. doi:10.1007/s00424-003-1086-z. PMID 14770310.

[Daniel_2004-3] Daniel H, Kottra G (2004). "The proton oligopeptide cotransporter family SLC15 in physiology and pharmacology". Pflugers Arch 447 (5): 610–618. doi:10.1007/s00424-003-1101-4. PMID 12905028.

[Reimer_2004-4] Reimer RJ, Edwards RH (2004). "Organic anion transport is the primary function of the SLC17/type I phosphate transporter family". Pflugers Arch 447 (5): 629–635. doi:10.1007/s00424-003-1087-y. PMID 12811560.

[Eiden_2004-5] Eiden LE, Schafer MK, Weihe E, Schutz B (2004). "The vesicular amine transporter family (SLC18): amine/proton antiporters required for vesicular accumulation and regulated exocytotic secretion of monoamines and acetylcholine". Pflugers Arch 447 (5): 636–640. doi:10.1007/s00424-003-1100-5. PMID 12827358.

[Palmieri_2004-6] Palmieri F (2004). "The mitochondrial transporter family (SLC25): physiological and pathological implications". Pflugers Arch 447 (5): 689–709. doi:10.1007/s00424-003-1099-7. PMID 14598172.

[Mount_2004-7] Mount DB, Romero MF (2004). "The SLC26 gene family of multifunctional anion exchangers". Pflugers Arch 447 (5): 710–721. doi:10.1007/s00424-003-1090-3. PMID 12759755.

[Gasnier_2004-8] Gasnier B (2004). "The SLC32 transporter, a key protein for the synaptic release of inhibitory amino acids". Pflugers Arch 447 (5): 752–755. doi:10.1007/s00424-003-1091-2. PMID 12750892.

[Boll_2004-9] Boll M, Daniel H, Gasnier B (2004). "The SLC36 family: proton-coupled transporters for the absorption of selected amino acids from extracellular and intracellular proteolysis family". Pflugers Arch 447 (5): 776–779. doi:10.1007/s00424-003-1073-4. PMID 12748860.

[Mackenzie_2004b-10] Mackenzie B, Erickson JD (2004). "Sodium-coupled neutral amino acid (System N/A) transporters of the SLC38 gene family". Pflugers Arch 447 (5): 784–795. doi:10.1007/s00424-003-1117-9. PMID 12845534.

[11] [Vesicular Inhibitory Amino Acid Transporter Is Present in Glucagon-Containing Secretory Granules in {alpha}TC6 Cells, Mouse Clonal {alpha}-Cells, and {alpha}-Cells of Islets of Langerhans] Diabetes 52:2066-2074, 2003

リンク元	「中性アミノ酸輸送体」「中性アミノ酸トランスポーター」「neutral amino acid transport system」
拡張検索	「large neutral amino acid-transporter 1」
関連記事	「transport」「transporter」「neutral」

匿名

検索

案内

案内

neutral amino acid transporter