最高濃度、最大濃度、(薬物の)最高血中濃度、最高血漿中濃度、最大血中濃度

関: Cmax、maximal concentration

WordNet

the spatial property of being crowded together (同)density, denseness, tightness, compactness
bringing together military forces
strengthening the concentration (as of a solute in a mixture) by removing diluting material
the strength of a solution; number of molecules of a substance in a given volume
complete attention; intense mental effort (同)engrossment, absorption, immersion
increase in density
the largest possible quantity (同)upper_limit
the point on a curve where the tangent changes from positive on the left to negative on the right
a saying that is widely accepted on its own merits (同)axiom

PrepTutorEJDIC

〈U〉(…への)(光線・注意などの)集中;(仕事などへの)専念,専心《+『on』+『名』》 / 〈C〉(人口などの)集中 / 〈U〉濃縮;〈液体の〉濃度
(量・数・程度の)『最大限』 / (数学で)極大;最大値;極大点 / 最高の,最大の
格言,金言,処世訓

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/04/25 01:33:46」(JST)

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C_max is a term used in pharmacokinetics refers to the maximum (or peak) serum concentration that a drug achieves in a specified compartment or test area of the body after the drug has been administrated and prior to the administration of a second dose. C_max is the opposite of C_min, which is the minimum (or trough) concentration that a drug achieves after dosing.^[1]

T_max is the term used in pharmacokinetics to describe the time at which the C_max is observed.^[2]

After an intravenous administration, C_max and T_max are closely dependent on the experimental protocol, since the concentrations are always decreasing after the dose. But after oral administration,C_max and T_max are dependent on the extent, and the rate of drug absorption and the disposition profile of the drug. They could be used to characterize the properties of different formulations in the same subject.^[3]

Short term drug side effects are most likely to occur at or near the C_max whereas the therapeutic effect of drug with sustained duration of action usually occurs at concentrations slightly above the C_min.

The C_max is often measured in an effort to show bioequivalence between a generic and innovator drug product.^[4] According to FDA, drug quality BA (bioavailability) and BE (bioequivalence) rely on pharmacokinetic measures such as AUC and Cmax that are reflective of systemic exposure.^[5]

References

^ Tracy TS (2004). "Pharmacokinetics". In Stitzel RE, Craig CF. Modern pharmacology with clinical applications. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 49. ISBN 0-7817-3762-1.
^ http://www.lexjansen.com/phuse/2006/st/st03.pdf
^ Urso R, Blardi P, Giorgi G (March 2002). "A short introduction to pharmacokinetics". Eur Rev Med Pharmacol Sci 6 (2-3): 33–44. PMID 12708608.
^ Midha KK, Rawson MJ, Hubbard JW (October 2005). "The bioequivalence of highly variable drugs and drug products". Int J Clin Pharmacol Ther 43 (10): 485–98. doi:10.5414/cpp43485. PMID 16240706.
^ "Bioavailability and Bioequivalence Studies for Orally Administered Drug Products — General Considerations" (PDF). FDA. Retrieved 13 December 2013.

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「最大濃度」

　　[★]

英: maximal concentration、maximum concentration
関: 最大血中濃度、最高血中濃度、最高血漿中濃度、最高濃度

「最大血中濃度」

　　[★]

英: maximum concentration、Cmax
関: 最大濃度、最高血中濃度、最高血漿中濃度、最高濃度

「最高血中濃度」

　　[★]

英: maximum concentration、Cmax
関: 最大血中濃度、最大濃度、最高血漿中濃度、最高濃度

「最高濃度」

　　[★]

英: maximum concentration
関: 最大血中濃度、最大濃度、最高血中濃度、最高血漿中濃度

「最高血漿中濃度」

　　[★]

英: maximum concentration
関: 最大血中濃度、最大濃度、最高血中濃度、最高濃度

「concentration」

　　[★]

n.

濃度、濃縮、(精神の)集中

関: attention、attentive、centralize、conc.、concentrate、concentrated、condensation、enrich、enrichment、focus

「maximum」

　　[★]

n.

最大、極大、最大限、最大値

関: largest、local maximum、maxima、maximal、maximally、maximum value、utmost

[isbn0-7817-3762-1-1] Tracy TS (2004). "Pharmacokinetics". In Stitzel RE, Craig CF. Modern pharmacology with clinical applications. Hagerstwon, MD: Lippincott Williams & Wilkins. p. 49. ISBN 0-7817-3762-1.

[2] ttp://www.lexjansen.com/phuse/2006/st/st03.pdf

[pmid12708608-3] Urso R, Blardi P, Giorgi G (March 2002). "A short introduction to pharmacokinetics". Eur Rev Med Pharmacol Sci 6 (2-3): 33–44. PMID 12708608.

[pmid16240706-4] Midha KK, Rawson MJ, Hubbard JW (October 2005). "The bioequivalence of highly variable drugs and drug products". Int J Clin Pharmacol Ther 43 (10): 485–98. doi:10.5414/cpp43485. PMID 16240706.

[5] "Bioavailability and Bioequivalence Studies for Orally Administered Drug Products — General Considerations" (PDF). FDA. Retrieved 13 December 2013.

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maximum concentration