WordNet

tend to or result in; "This remark lead to further arguments among the guests"
a soft heavy toxic malleable metallic element; bluish white when freshly cut but tarnishes readily to dull grey; "the children were playing with lead soldiers" (同)Pb, atomic number 82
(sports) the score by which a team or individual is winning
the angle between the direction a gun is aimed and the position of a moving target (correcting for the flight time of the missile)
thin strip of metal used to separate lines of type in printing (同)leading
mixture of graphite with clay in different degrees of hardness; the marking substance in a pencil (同)pencil lead
a position of leadership (especially in the phrase `take the lead'
an advantage held by a competitor in a race; "he took the lead at the last turn"
the playing of a card to start a trick in bridge; "the lead was in the dummy"
a news story of major importance (同)lead story
the introductory section of a story; "it was an amusing lead-in to a very serious matter" (同)lead-in, lede
evidence pointing to a possible solution; "the police are following a promising lead"; "the trail led straight to the perpetrator" (同)track, trail
(baseball) the position taken by a base runner preparing to advance to the next base; "he took a long lead off first"
travel in front of; go in advance of others; "The procession was headed by John" (同)head
take somebody somewhere; "We lead him to our chief"; "can you take me to the main entrance?"; "He conducted us to the palace" (同)take, direct, conduct, guide
be ahead of others; be the first; "she topped her class every year" (同)top
cause to undertake a certain action; "Her greed led her to forge the checks"
going or proceeding or going in advance; showing the way; "we rode in the leading car"; "the leading edge of technology"
greatest in importance or degree or significance or achievement; "our greatest statesmen"; "the countrys leading poet"; "a preeminent archeologist" (同)preeminent
indicating the most important performer or role; "the leading man"; "prima ballerina"; "prima donna"; "a star figure skater"; "the starring role"; "a stellar role"; "a stellar performance" (同)prima, star, starring, stellar
treated or mixed with lead; "leaded gasoline"; "leaded zinc"
(of panes of glass) fixed in place by means of thin strips of lead; "leaded windowpanes"
having thin strips of lead between the lines of type
a unit of length of thread or yarn

PrepTutorEJDIC

《方向を表す副詞[句]を伴って》…‘を'『導く』,案内する / 〈道・灯火などが〉…‘に'道筋を示す;(…へ)…‘を'導く《+『名』+『to』(『into』)+『名』》 / …‘の'先頭になる,1番である / …‘の'『率いる』,指揮する / 〈ある人生・生活〉‘を'経験する,生きる,送る / 『先頭に立つ』,(競技・成績などで)リードスル / 〈人が〉『案内する』,先導する / (…に)〈道などが〉『通じている』《+『to』+『名』》 / (…の)結果となる《+『to』+『名』(do『ing』)》 / 〈U〉《the~》『先頭』,首位 / 〈C〉《a~》相手を引き離した点(時間,距離) / 〈C〉模範,手本(example) / 〈C〉(問題解決の)手がかり,ヒント(clue) / 〈C〉(劇・映画などの)主役,主演俳優 / 〈C〉(新聞報道記事などの本文の前におく要約した)前文,前書き,リード / 先頭の,主要な
〈U〉『鉛』(化学記号はは『pb』) / 〈C〉鉛のおもり,測鉛 / 〈C〉《複数形で》(ガラスをはめる)鉛の枠(わく);《英》(屋根をふくのに用いる)鉛板 / 〈U〉〈C〉黒鉛,鉛筆のしん / 〈U〉《集合的に》(鉛の)弾丸 / …‘に'鉛をかぶせる,鉛を詰める,鉛のおもりを付ける
『先導する』,先頭の / 『主要な』,一流の / 指導する / 指導
(ガソリンが)四エチル鉛入りの
草原,牧草地(meadow)

UpToDate Contents

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1. 鉛腎症および鉛関連腎毒性 lead nephropathy and lead related nephrotoxicity
2. 成人における鉛中毒 adult lead poisoning
3. 尿酸による腎疾患 uric acid renal diseases
4. 小児期の鉛中毒：臨床症状および診断 childhood lead poisoning clinical manifestations and diagnosis
5. 無症候性高尿酸血症 asymptomatic hyperuricemia

English Journal

High glucose enhances microRNA-26a to activate mTORC1 for mesangial cell hypertrophy and matrix protein expression.

Dey N1, Bera A1, Das F1, Ghosh-Choudhury N2, Kasinath BS3, Choudhury GG4.
Cellular signalling.Cell Signal.2015 Jul;27(7):1276-85. doi: 10.1016/j.cellsig.2015.03.007. Epub 2015 Mar 20.
High glucose milieu inhibits PTEN expression to activate Akt kinase and induces glomerular mesangial cell hypertrophy and matrix protein expression in diabetic nephropathy. Specific mechanism by which high glucose inhibits PTEN expression is not clear. We found that high glucose increased the expres
PMID 25797045

Calcitriol ameliorates renal damage in a pre‑established proteinuria model.

Maquigussa E1, Arnoni CP1, Pereira LG1, Boim MA1.
Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):1009-15. doi: 10.3892/mmr.2015.3555. Epub 2015 Mar 27.
Proteinuria is critical in the tubulointerstitial changes that ultimately lead to renal insufficiency. Increased protein filtration has direct toxic effects on tubular epithelial cells, leading to epithelial mesenchymal transition (EMT) to a myofibroblast phenotype. Angiotensin II and transforming
PMID 25823676

Japanese Journal

Quantitative Trait Loci for Resistance to the Congenital Nephropathy in Tensin 2-Deficient Mice

Sasaki Hayato,Sasaki Nobuya,Nishino Tomohiro,Nagasaki Ken-ichi,Kitamura Hiroshi,Torigoe Daisuke,Agui Takashi
PLOS ONE 9(6), e99602, 2014-06-26
… Further genetic analysis should lead to identification of CKD modifier gene(s), aiding early diagnosis and providing novel approaches to the discovery of drugs for the treatment and possible prevention of kidney disease. …
NAID 120005468142

リリーインスリン50年賞を受賞した東京女子医科大学糖尿病センター受診の1型糖尿病患者13例の報告

大谷敏嘉,笠原督,内潟安子
糖尿病 57(12), 900-906, 2014
わが国の「リリーインスリン50年賞」は，2003年の第1回表彰開始以来2013年までに66名が受賞している．これら66名のうち東京女子医科大学糖尿病センターの受診患者は16名（24 %）（1型13名，2型2名，その他1名）であった．1型糖尿病患者13名の1983年から2013年のHbA1c平均値は8.4 %，高血圧の合併は10名（77 %），脂質異常症5名（38 %）であった．網膜症については網膜 …
NAID 130004905434