WordNet
- (genetics) the process of expressing a gene
- the feelings expressed on a persons face; "a sad expression"; "a look of triumph"; "an angry face" (同)look, aspect, facial_expression, face
- the act of forcing something out by squeezing or pressing; "the expression of milk from her breast"
- expression without words; "tears are an expression of grief"; "the pulse is a reflection of the hearts condition" (同)manifestation, reflection, reflexion
- the communication (in speech or writing) of your beliefs or opinions; "expressions of good will"; "he helped me find verbal expression for my ideas"; "the idea was immediate but the verbalism took hours" (同)verbal expression, verbalism
- a process of becoming larger or longer or more numerous or more important; "the increase in unemployment"; "the growth of population" (同)increment, growth
- become bigger or greater in amount; "The amount of work increased"
- make bigger or more; "The boss finally increased her salary"; "The university increased the number of students it admitted"
- the amount by which something increases; "they proposed an increase of 15 percent in the fare" (同)increment
- the act of increasing something; "he gave me an increase in salary" (同)step-up
- a change resulting in an increase; "the increase is scheduled for next month"
- made greater in size or amount or degree
PrepTutorEJDIC
- 〈U〉〈C〉(思想・意見・考えなどを)『言葉で表すこと』,(…の)『表現』《+『of』+『名』》 / 〈C〉(考え・気持ちなどの)『現れ』,印《+『of』+『名』》 / 〈C〉(考え・気持ちなどを表す)『顔つき』,表情《+『of』+『名』》 / 〈U〉(考え・気持ちなどを表す)声の調子 / 〈C〉語句,言い回し,表現法 / 〈C〉(数量・運算などを示す)式
- 『増える』,『増大する』 / (…に)…‘を'『増やす』《+『名』+『to』+『名』》 / (…の)『増加』,増大;〈C〉増加量(額)《+『of』(『in』,『on』)+『名』》
UpToDate Contents
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- 1. 早産児のための搾乳 breast milk expression for the preterm infant
- 2. 遺伝学およびゲノミクスのためのツール：遺伝子発現プロファイリング tools for genetics and genomics gene expression profiling
- 3. 糖尿病性腎症の概要 overview of diabetic nephropathy
- 4. 急性心臓同種移植拒絶反応：診断 acute cardiac allograft rejection diagnosis
- 5. 臨床腫瘍学における遺伝子発現プロファイリング、プロテオミクス、およびマイクロRNAプロファイリングの概要 overview of gene expression profiling proteomics and microrna profiling in clinical oncology
English Journal
- Underexpressed CNDP2 Participates in Gastric Cancer Growth Inhibition through Activating the MAPK Signaling Pathway.
- Zhang Z1, Miao L2, Xin X3, Zhang J4, Yang S4, Miao M4, Kong X5, Jiao B4.Author information 1Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Guangzhou, China.2Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China.3Department of Pharmacology, School of Pharmacy and Institute of Biomedical Sciences, Fudan University, Shanghai, China Department of Pharmacology, Taishan Medical University, Shandong Province, China.4Department of Biochemistry and Molecular Biology, Second Military Medical University, Shanghai, China.5Key Laboratory of Liver Disease, Center of Infectious Diseases, Guangzhou 458 Hospital, Guangzhou, China.AbstractIncreasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric cancer tissues. The ectopic expression of CNDP2 resulted in significant inhibition of cell proliferation, induction of cell apoptosis and cell cycle arrest, and suppressed gastric tumor growth in nude mice. We further revealed that the reintroduction of CNDP2 transcriptionally upregulated p38 and activated c-Jun NH2-terminal kinase (JNK), whereas the loss of CNDP2 increased the phosphorylation of extracellular signal-related kinase (ERK). These results suggest that CNDP2 acts as a functional tumor suppressor in gastric cancer via activation of the mitogen-activated protein kinase (MAPK) pathway.
- Molecular medicine (Cambridge, Mass.).Mol Med.2014 Dec 24;20(1):17-28. doi: 10.2119/molmed.2013.00102.
- Increasing evidence suggests that cytosolic non-specific dipeptidase 2 (CNDP2) appears to do more than just perform an enzymatic activity; it is functionally important in cancers as well. Here, we show that the expression of CNDP2 is commonly down-regulated in gastric cancer tissues. The ectopic exp
- PMID 24395568
- Thymoquinone overcomes chemoresistance and enhances the anticancer effects of bortezomib through abrogation of NF-κB regulated gene products in multiple myeloma xenograft mouse model.
- Siveen KS, Mustafa N, Li F, Kannaiyan R, Ahn KS, Kumar AP, Chng WJ, Sethi G.Author information Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.AbstractMultiple myeloma (MM) is a B cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow. With the advent of novel targeted agents, the median survival rate has increased to 5 -7 years. However, majority of patients with myeloma suffer relapse or develop chemoresistance to existing therapeutic agents. Thus, there is a need to develop novel alternative therapies for the treatment of MM. Thus in the present study, we investigated whether thymoquinone (TQ), a bioactive constituent of black seed oil, could suppress the proliferation and induce chemosensitization in human myeloma cells and xenograft mouse model. Our results show that TQ inhibited the proliferation of MM cells irrespective of their sensitivity to doxorubicin, melphalan or bortezomib. Interestingly, TQ treatment also resulted in a significant inhibition in the proliferation of CD138+ cells isolated from MM patient samples in a concentration dependent manner. TQ also potentiated the apoptotic effects of bortezomib in various MM cell lines through the activation of caspase-3, resulting in the cleavage of PARP. TQ treatment also inhibited chemotaxis and invasion induced by CXCL12 in MM cells. Furthermore, in a xenograft mouse model, TQ potentiated the antitumor effects of bortezomib (p<0.05, vehicle versus bortezomib + TQ; p<0.05, bortezomib versus bortezomib + TQ), and this correlated with modulation of various markers for survival and angiogenesis, such as Ki-67, vascular endothelial growth factor (VEGF), Bcl-2 and p65 expression. Overall, our results demonstrate that TQ can enhance the anticancer activity of bortezomib in vitro and in vivo and may have a substantial potential in the treatment of MM.
- Oncotarget.Oncotarget.2014 Dec 18. [Epub ahead of print]
- Multiple myeloma (MM) is a B cell malignancy characterized by clonal proliferation of plasma cells in the bone marrow. With the advent of novel targeted agents, the median survival rate has increased to 5 -7 years. However, majority of patients with myeloma suffer relapse or develop chemoresistance
- PMID 24504138
- Histometric changes and epidermal FGF9 expression in carbon photoenhancer-assisted Nd:YAG laser treatment.
- Zheng Z, Kim J, Choi MJ, Goo B, Chun SI, Cho SB.Author information Department of Dermatology and Cutaneous Biology Research Institute, Yonsei University College of Medicine , Seoul , Korea.AbstractFibroblast growth factor (FGF)-9 plays an important role in wound healing. However, the effects of non-ablative laser treatment on the expression of FGF9 have not been fully investigated. Non-ablative 1064-nm quasi-long pulsed and Q-switched Nd:YAG laser treatments were delivered to hairless mice with and without a carbon photoenhancer. For histological and immunohistochemical analyses, sections were stained with hematoxylin and eosin as well as FGF9 antibody. Significantly, increased epidermal and dermal thickness was noted in mice treated with carbon photoenhancer-assisted quasi-long pulsed or Q-switched laser treatments compared to those treated without a carbon photoenhancer. Expression of FGF9 was observed in both the epidermis and dermis in all groups of mice during the healing process. Earlier and more pronounced expression of FGF9 was detected in mice treated with carbon photoenhancer-assisted quasi-long pulsed laser therapy. In addition, two peaks of pronounced FGF9 expression were observed, especially in mice that underwent carbon photoenhancer-assisted 1064-nm quasi-long pulsed Nd:YAG laser treatment. A carbon photoenhancer seems to enhance the effect of quasi-long pulsed and Q-switched Nd:YAG laser treatment. In addition, expression of FGF9 may play an important role in the healing process after laser treatments and could contribute to histometric changes.
- The Journal of dermatological treatment.J Dermatolog Treat.2014 Aug;25(4):278-82. doi: 10.3109/09546634.2012.723121. Epub 2012 Sep 19.
- Fibroblast growth factor (FGF)-9 plays an important role in wound healing. However, the effects of non-ablative laser treatment on the expression of FGF9 have not been fully investigated. Non-ablative 1064-nm quasi-long pulsed and Q-switched Nd:YAG laser treatments were delivered to hairless mice wi
- PMID 22905667
Japanese Journal
- The c-MYC-ABCB5 axis plays a pivotal role in 5-fluorouracil resistance in human colon cancer cells
- Kugimiya Naruji,Nishimoto Arata,Hosoyama Tohru,Ueno Koji,Enoki Tadahiko,Li Tao-Sheng,Hamano Kimikazu
- Journal of Cellular and Molecular Medicine 19(7), 1569-1581, 2015-07
- … In this study, we found that the c-MYC expression level in primary colorectal cancer tissues correlated with the recurrence rate following 5-fluorouracil (5-FU)-based adjuvant chemotherapy. … Supporting this finding, overexpression of exogenous c-MYC increased the survival rate following 5-FU treatment in human colon cancer cells, and knockdown of endogenous c-MYC decreased it. … Furthermore, c-MYC knockdown decreased the expression level of ABCB5, which is involved in 5-FU resistance. …
- NAID 120005624101
- Ninjurin1 Is a Novel Factor to Regulate Angiogenesis Through the Function of Pericytes
- 松木 考樹,鹿原 真樹,齊藤 幸裕,島村 浩平,簑島 暁帆,西村 正人,青沼 達也,竹原 有史,長谷部 直幸,川辺 淳一
- Circulation Journal 79(6), 1363-1371, 2015-06
- … Hypoxia induced the gene expression of Ninj1 in addition of vascular endothelial growth factor (VEGF) in cPCs. … When cPCs were co-incubated with a thoracic aorta in a three-dimensional Matrigel system, the length of the EC-tubes sprouting from the aorta was increased. …
- NAID 120005624086
- Characterization of cooperative bicarbonate uptake into chloroplast stroma in the green alga Chlamydomonas reinhardtii.
- Yamano Takashi,Sato Emi,Iguchi Hiro,Fukuda Yuri,Fukuzawa Hideya
- Proceedings of the National Academy of Sciences of the United States of America, 2015-05-26
- … HLA3 and LCIA formed protein complexes independently, and the absence of LCIA decreased HLA3 mRNA accumulation, suggesting the presence of unidentified retrograde signals from the chloroplast to the nucleus to maintain HLA3 mRNA expression. … Furthermore, although single overexpression of HLA3 or LCIA in high CO2 conditions did not affect Ci affinity, simultaneous overexpression of HLA3 with LCIA significantly increased Ci affinity/accumulation. …
- NAID 120005611393
Related Links
- Structured knowledge about Increased expression, which is a Differential expression. Synonyms: Up-regulated, Upregulated, Up-regulated expression, Upregulated expression. Date: 11-24-2010. ... Name: Increased expression
- The increased expression of mgtA did not result in a statistically significant increase in the total Mg 2+ content of the cells compared with that measured in the WT. However, because Mg 2+ inside the cells is largely bound to 2+ ...
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★リンクテーブル★
| リンク元 | 「up-regulation」「発現増加」「up-regulate」 |
| 関連記事 | 「increase」「expression」 |
「up-regulation」
- 上方制御、上向き調節、発現上昇、発現増加、(発現量などの)増加、アップレギュレーション
- 関
- elevate、gain、increase、increased expression、increment、multiply、receptor up-regulation、rise、up-regulate、up-regulated、upregulate、upregulation
「発現増加」
「up-regulate」
上方制御する、アップレギュレートする、発現増加させる
「increase」
- n.
- v.
- 増加する、増える
- 関
- ascending、ascent、augment、augmentation、elevate、elevation、enlarge、escalate、escalation、expansion、gain、increment、multiply、raise、rise、rose、up-regulation、upregulation
「expression」
- n.
- 関
- Eq.、equation、exert、express、facial expression、formula、formulae、level of expression、manifestation、represent、representation、representational