WordNet

unusually great in degree or quantity or number; "heavy taxes"; "a heavy fine"; "heavy casualties"; "heavy losses"; "heavy rain"; "heavy traffic"
a serious (or tragic) role in a play
an actor who plays villainous roles
slowly as if burdened by much weight; "time hung heavy on their hands" (同)heavily
requiring or showing effort; "heavy breathing"; "the subject made for labored reading" (同)labored, laboured
lacking lightness or liveliness; "heavy humor"; "a leaden conversation" (同)leaden
darkened by clouds; "a heavy sky" (同)lowering, sullen, threatening
slow and laborious because of weight; "the heavy tread of tired troops"; "moved with a lumbering sag-bellied trot"; "ponderous prehistoric beasts"; "a ponderous yawn" (同)lumbering, ponderous
(of sleep) deep and complete; "a heavy sleep"; "fell into a profound sleep"; "a sound sleeper"; "deep wakeless sleep" (同)profound, sound, wakeless
full and loud and deep; "heavy sounds"; "a herald chosen for his sonorous voice" (同)sonorous
full of; bearing great weight; "trees heavy with fruit"; "vines weighed down with grapes" (同)weighed down
(of an actor or role) being or playing the villain; "Iago is the heavy role in `Othello"
(physics, chemistry) being or containing an isotope with greater than average atomic mass or weight; "heavy hydrogen"; "heavy water"
dense or inadequately leavened and hence likely to cause distress in the alimentary canal; "a heavy pudding"
large and powerful; especially designed for heavy loads or rough work; "a heavy truck"; "heavy machinery"
made of fabric having considerable thickness; "a heavy coat"
marked by great psychological weight; weighted down especially with sadness or troubles or weariness; "a heavy heart"; "a heavy schedule"; "heavy news"; "a heavy silence"; "heavy eyelids"
of comparatively great physical weight or density; "a heavy load"; "lead is a heavy metal"; "heavy mahogany furniture"
of great intensity or power or force; "a heavy blow"; "the fighting was heavy"; "heavy seas"
of relatively large extent and density; "a heavy line"
of the military or industry; using (or being) the heaviest and most powerful armaments or weapons or equipment; "heavy artillery"; "heavy infantry"; "a heavy cruiser"; "heavy guns"; "heavy industry involves large-scale production of basic products (such as steel) used by other industries"
sharply inclined; "a heavy grade"
fasten or secure with chains; "Chain the chairs together"
a unit of length
a necklace made by a stringing objects together; "a string of beads"; "a strand of pearls"; (同)string, strand
a linked or connected series of objects; "a chain of daisies"
a series of (usually metal) rings or links fitted into one another to make a flexible ligament
anything that acts as a restraint
(chemistry) a series of linked atoms (generally in an organic molecule) (同)chemical chain
a series of things depending on each other as if linked together; "the chain of command"; "a complicated concatenation of circumstances" (同)concatenation
(business) a number of similar establishments (stores or restaurants or banks or hotels or theaters) under one ownership
connect or arrange into a chain by linking
the act of deleting something written or printed
the omission that is made when an editorial change shortens a written passage; "an editors deletions frequently upset young authors"; "both parties agreed on the excision of the proposed clause" (同)excision, cut
(genetics) the loss or absence of one or more nucleotides from a chromosome
a class of proteins produced in lymph tissue in vertebrates and that function as antibodies in the immune response (同)Ig, immune serum globulin, immune gamma globulin, immune_globulin

PrepTutorEJDIC

『重い』,重量のある / (分量・程度・規模・強さなどが)『激しい』,大きい, / 『厳しい』,耐えがたい,つらい / 悲しい,陰気な / (動作が)のろい,ぎこちない / ものうい,だるい / (空が)曇った,うっとうしい,(海が)荒れた / (食物が)消化の悪い / 敵役,悪役
『鎖』;(装飾用の)鎖 / 《複数形で》『束縛』,拘束;囚人をつなぐ鎖 / (物事の)『連続』,つながり《+『of』+『名』》 / (商店・銀行・ホテルなどの)チェーン(一連の店が同一資本のもとで連携して経営される方式;その店) / チェーン(測量で用いられる単位;約21.7m) / …'を'『鎖でつなぐ』《+『up』(『together』)+『名,』+『名』+『up』(『together』)》
削除;〈C〉削除箇所

UpToDate Contents

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1. 多発性骨髄腫の病理生物学 pathobiology of multiple myeloma
2. B細胞前リンパ球性白血病 b cell prolymphocytic leukemia
3. 慢性リンパ性白血病に対する治療の概要 overview of the treatment of chronic lymphocytic leukemia
4. 慢性リンパ性白血病の病期分類および予後 staging and prognosis of chronic lymphocytic leukemia
5. 染色体の転座、欠失、および逆位 chromosomal translocations deletions and inversions

English Journal

Del(20q) in patients with chronic lymphocytic leukemia: a therapy-related abnormality involving lymphoid or myeloid cells.

Yin CC1, Tang G1, Lu G1, Feng X1, Keating MJ2, Medeiros LJ1, Abruzzo LV1.
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc.Mod Pathol.2015 May 8. doi: 10.1038/modpathol.2015.58. [Epub ahead of print]
Deletion 20q (Del(20q)), a common cytogenetic abnormality in myeloid neoplasms, is rare in chronic lymphocytic leukemia. We report 64 patients with chronic lymphocytic leukemia and del(20q), as the sole abnormality in 40, a stemline abnormality in 21, and a secondary abnormality in 3 cases. Fluoresc
PMID 25953391

Deletion of the collagen-specific molecular chaperone Hsp47 causes endoplasmic reticulum stress-mediated apoptosis of hepatic stellate cells.

Kawasaki K1, Ushioda R2, Ito S1, Ikeda K3, Masago Y1, Nagata K4.
The Journal of biological chemistry.J Biol Chem.2015 Feb 6;290(6):3639-46. doi: 10.1074/jbc.M114.592139. Epub 2014 Dec 18.
Chronic liver injury, often caused by alcoholism and viral hepatitis, causes liver fibrosis via the induction of collagen production. In liver fibrosis, hepatic stellate cells (HSCs) are activated and transform into myofibroblasts, which actively produce and secrete collagen into the extracellular m
PMID 25525267

Genomic and epigenomic co-evolution in follicular lymphomas.

Loeffler M1, Kreuz M1, Haake A2, Hasenclever D1, Trautmann H3, Arnold C4, Winter K5, Koch K6, Klapper W6, Scholtysik R7, Rosolowski M1, Hoffmann S8, Ammerpohl O2, Szczepanowski M6, Herrmann D3, Küppers R7, Pott C3, Siebert R2; HaematoSys-Project.
Leukemia.Leukemia.2015 Feb;29(2):456-63. doi: 10.1038/leu.2014.209. Epub 2014 Jul 16.
Follicular lymphoma (FL) with a t(14;18) is a B-cell neoplasm clinically characterized by multiple recurrencies. In order to investigate the clonal evolution of this lymphoma, we studied paired primary and relapse tumor samples from 33 patients with recurrent non-transformed t(14;18)-positive FL. We
PMID 25027518

Japanese Journal

HTLV-Iウイルス関連リンパ節炎

大島孝一,菊池昌弘
日本リンパ網内系学会会誌 = The journal of the Japanese Society of Lymphoreticular Tissue 39(1), 27-32, 1999-03-20
… The proviral DNA of HTLV-I was detected by Southern blot analysis, in situ hybridization technique, and/or polymerase chain reaction. … The infiltrating lymphocytes were positive for CD4, but neither rearrangement nor deletion of T-cell receptors and immunoglobulin heavy chain genes was detected. …
NAID 10010347553

Acute Myelomonocytic Leukemia in a Patient with Multiple Myeloma: Evidence for Different Clonal Origin

NAKASE Kazunori,TSUJI Kota,HASEGAWA Masaki,SUZUKI Yoshinori,TAMAKI Shigehisa,TANIGAWA Motoaki,IKEDA Takeshi,MIYANISHI Eiki
Internal medicine 34(6), 546-549, 1995-06
… Cytogenetic analysis revealed a chromosome deletion -7. … Analysis of immunoglobulin genes showed the heavy chain genes in germ line configuration. …
NAID 10006168233

Analysis of homozygous mutant chimeric mice: deletion of the immunoglobulin heavy-chain joining region blocks B-cell development and antibody production.

JAKOBOVITS A.
Proc. Natl Acad. Sci. USA 90, 2551, 1993
NAID 30016296052

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