WordNet

cultivate by growing, often involving improvements by means of agricultural techniques; "The Bordeaux region produces great red wines"; "They produce good ham in Parma"; "We grow wheat here"; "We raise hogs here" (同)raise, farm, produce
come to have or undergo a change of (physical features and attributes); "He grew a beard"; "The patient developed abdominal pains"; "I got funny spots all over my body"; "Well-developed breasts" (同)develop, produce, get, acquire
become attached by or as if by the process of growth; "The tree trunks had grown together"
become larger, greater, or bigger; expand or gain; "The problem grew too large for me"; "Her business grew fast"
cause to grow or develop; "He grows vegetables in his backyard"
increase in size by natural process; "Corn doesnt grow here"; "In these forests, mushrooms grow under the trees"; "her hair doesnt grow much anymore"
(biology) the process of an individual organism growing organically; a purely biological unfolding of events involved in an organism changing gradually from a simple to a more complex level; "he proposed an indicator of osseous development in children" (同)growing, maturation, development, ontogeny, ontogenesis
(pathology) an abnormal proliferation of tissue (as in a tumor)
a progression from simpler to more complex forms; "the growth of culture"
something grown or growing; "a growth of hair"
vegetation that has grown; "a growth of trees"; "the only growth was some salt grass"
be a contributing factor; "make things factor into a companys profitability"
any of the numbers (or symbols) that form a product when multiplied together
an independent variable in statistics
anything that contributes causally to a result; "a number of factors determined the outcome"
consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
a concept whose truth can be proved; "scientific hypotheses are not facts"
a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"

PrepTutorEJDIC

『成長する』,育つ,〈植物が〉生える,茂る / (類・量・程などにおいて)『増大する』,大きくなる / 『しだいになる』 / …‘を'成長させる,大きくする,育てる / …から生じる(起こる)
〈U〉(…の)『成長』,発育;『発達』,発展《+『of』+『名』》 / 〈U〉(数・量,重要性・力などの)『増加』,増大,拡張《+『of』+『名』》 / 〈U〉《修飾語[句]を伴って》栽培,生産,…産 / 〈C〉成育した物,(草,木,髪,ひげなどの)生えたもの / 〈C〉腫瘍(しゅよう)
(…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/12/13 06:17:34」(JST)

wiki en

[Wiki en表示]

Hepatocyte growth factor/scatter factor (HGF/SF) is a paracrine cellular growth, motility and morphogenic factor. It is secreted by mesenchymal cells and targets and acts primarily upon epithelial cells and endothelial cells, but also acts on haemopoietic progenitor cells. It has been shown to have a major role in embryonic organ development, specifically in myogenesis, in adult organ regeneration and in wound healing.^[1]

Function[edit]

Hepatocyte growth factor regulates cell growth, cell motility, and morphogenesis by activating a tyrosine kinase signaling cascade after binding to the proto-oncogenic c-Met receptor.^[2] Hepatocyte growth factor is secreted by mesenchymal cells and acts as a multi-functional cytokine on cells of mainly epithelial origin. Its ability to stimulate mitogenesis, cell motility, and matrix invasion gives it a central role in angiogenesis, tumorogenesis, and tissue regeneration.^[3]

Structure[edit]

It is secreted as a single inactive polypeptide and is cleaved by serine proteases into a 69-kDa alpha-chain and 34-kDa beta-chain. A disulfide bond between the alpha and beta chains produces the active, heterodimeric molecule. The protein belongs to the plasminogen subfamily of S1 peptidases but has no detectable protease activity.^[3]

Clinical significance[edit]

Human HGF plasmid DNA therapy of cardiomyocytes is being examined as a potential treatment for coronary artery disease as well as treatment for the damage that occurs to the heart after myocardial infarction.^[4]^[5]

HGF may further play a role as an indicator for prognosis of chronicity for Chikungunya virus induced arthralgia. High HGF levels correlate with high rates of recovery.^[6]

Interactions[edit]

Hepatocyte growth factor has been shown to interact with C-Met.^[2]^[7]^[8]

References[edit]

^ Gallagher, J.T., Lyon, M. (2000). "Molecular structure of Heparan Sulfate and interactions with growth factors and morphogens". In Iozzo, M, V. Proteoglycans: structure, biology and molecular interactions. Marcel Dekker Inc. New York, New York. pp. 27–59.
^ ^a ^b Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA (February 1991). "Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product". Science 251 (4995): 802–4. doi:10.1126/science.1846706. PMID 1846706.
^ ^a ^b "Entrez Gene: HGF hepatocyte growth factor (hepapoietin A; scatter factor)".
^ Yang, Z. J.; Zhang, Y. R.; Chen, B.; Zhang, S. L.; Jia, E. Z.; Wang, L. S.; Zhu, T. B.; Li, C. J.; Wang, H.; Huang, J.; Cao, K. J.; Ma, W. Z.; Wu, B.; Wang, L. S.; Wu, C. T. (2008). "Phase I clinical trial on intracoronary administration of Ad-hHGF treating severe coronary artery disease". Molecular Biology Reports 36 (6): 1323–1329. doi:10.1007/s11033-008-9315-3. PMID 18649012.
^ Hahn, W.; Pyun, W. B.; Kim, D. S.; Yoo, W. S.; Lee, S. D.; Won, J. H.; Shin, G. J.; Kim, J. M.; Kim, S. (2011). "Enhanced cardioprotective effects by coexpression of two isoforms of hepatocyte growth factor from naked plasmid DNA in a rat ischemic heart disease model". The Journal of Gene Medicine 13 (10): 549–555. doi:10.1002/jgm.1603. PMID 21898720.
^ Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF (January 2011). "Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor". J. Infect. Dis. 203 (2): 149–57. doi:10.1093/infdis/jiq042. PMC 3071069. PMID 21288813.
^ Comoglio PM (1993). "Structure, biosynthesis and biochemical properties of the HGF receptor in normal and malignant cells". EXS 65: 131–65. PMID 8380735.
^ Naldini L, Weidner KM, Vigna E, Gaudino G, Bardelli A, Ponzetto C, Narsimhan RP, Hartmann G, Zarnegar R, Michalopoulos GK (October 1991). "Scatter factor and hepatocyte growth factor are indistinguishable ligands for the MET receptor". EMBO J. 10 (10): 2867–78. PMC 452997. PMID 1655405.

External links[edit]

Hepatocyte growth factor at the US National Library of Medicine Medical Subject Headings (MeSH)
Hepatocyte growth factor on the Atlas of Genetics and Oncology
UCSD Signaling Gateway Molecule Page on HGF

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UpToDate Contents

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English Journal

Co-expression of hepatocyte growth factor and c-met in epithelial odontogenic tumors.

Poomsawat S, Punyasingh J, Vejchapipat P, Larbcharoensub N.SourceDepartment of Oral and Maxillofacial Pathology, Faculty of Dentistry, Mahidol University, Bangkok, Thailand.
Acta histochemica.Acta Histochem.2012 Jul;114(4):400-5. Epub 2011 Sep 8.
Hepatocyte growth factor (HGF) and its receptor, c-met, have been shown to regulate cell proliferation, motility and morphology in a variety of cell types. A significant role of the HGF/c-met pathway has been demonstrated in various tumors, however, little is known about the role of HGF/c-met pathwa
PMID 21855117

A novel human hepatoma cell line, FLC-4, exhibits highly enhanced liver differentiation functions through the three-dimensional cell shape.

Laurent T, Murase D, Tsukioka S, Matsuura T, Nagamori S, Oda H.SourceLaboratory of Nutritional Biochemistry, Department of Applied Molecular Biosciences, Nagoya University, Nagoya, Japan.
Journal of cellular physiology.J Cell Physiol.2012 Jul;227(7):2898-906. doi: 10.1002/jcp.23033.
We characterized three-dimensional human hepatoma cell lines, functional liver cell (FLC) cell lines, to establish a highly differentiated hepatoma cell line. We investigated the effect of extracellular matrix and cell morphology on liver-specific gene expression in FLC cells. The hepatocyte nuclear
PMID 21960466

Japanese Journal

Hepatocyte growth factor and Met in drug discovery

Sakai Katsuya,Aoki Shunsuke,Matsumoto Kunio
The journal of biochemistry 157(5), 271-284, 2015-05
NAID 40020461372

マウスメッケル軟骨の発生と消失における肝細胞増殖因子(HGF)の局在と役割

徳永寛司,坂東康彦,﨑山浩司 [他]
明海歯科医学 44(1), 74-86, 2015
NAID 40020368595

Upregulation of Bcl-2 enhances secretion of growth factors by adipose-derived stem cells deprived of oxygen and glucose

, , , , ,
BioScience Trends 9(2), 122-128, 2015
… There is an increasing recognition that beneficial effects of adipose-derived stem cell (ADSC) therapy may depend largely on the secretion of multiple growth factors. … This study modified ADSCs with the Bcl-2 gene in order to increase the secretion of growth factors during oxygen-glucose deprivation (OGD). …
NAID 130005070480

Related Pictures

★リンクテーブル★

リンク元	「hepatopoietin」「HGF」「肝細胞増殖因子」
関連記事	「grow」「fact」「factor」「growth」

「hepatopoietin」

Hepatocyte growth factor (hepapoietin A; scatter factor)
	; PDB rendering based on 1bht.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1BHT, 1GMN, 1GMO, 1GP9, 1NK1, 1SHY, 1SI5, 2HGF, 2QJ2, 3HMS, 3HMT, 3HN4, 3MKP, 3SP8, 4K3J
Identifiers
Symbols	HGF; DFNB39; F-TCF; HGFB; HPTA; SF
External IDs	OMIM: 142409 MGI: 96079 HomoloGene: 503 ChEMBL: 5479 GeneCards: HGF Gene
Gene Ontology
Molecular function	• serine-type endopeptidase activity; • protein binding; • growth factor activity; • chemoattractant activity; • identical protein binding; • protein heterodimerization activity;
Cellular component	• extracellular region; • extracellular space; • platelet alpha granule lumen;
Biological process	• activation of MAPK activity; • epithelial to mesenchymal transition; • liver development; • platelet degranulation; • proteolysis; • mitosis; • blood coagulation; • positive regulation of phosphatidylinositol 3-kinase cascade; • platelet activation; • positive regulation of cell migration; • organ regeneration; • cellular response to hepatocyte growth factor stimulus; • negative regulation of apoptotic process; • negative regulation of cysteine-type endopeptidase activity involved in apoptotic process; • positive regulation of osteoblast differentiation; • positive regulation of transcription from RNA polymerase II promoter; • hepatocyte growth factor receptor signaling pathway; • positive regulation of peptidyl-tyrosine phosphorylation; • positive chemotaxis; • myoblast proliferation; • cell chemotaxis; • regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling; • negative regulation of release of cytochrome c from mitochondria; • negative regulation of hydrogen peroxide-mediated programmed cell death; • positive regulation of DNA biosynthetic process;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
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