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the formation of blood cells in the living body (especially in the bone marrow) (同)haematopoiesis, hemopoiesis, haemopoiesis, hemogenesis, haemogenesis, hematogenesis, haematogenesis, sanguification

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/05/16 13:22:52」(JST)

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Micrograph showing nucleated red blood cells (bottom left of image), one of the elements necessary to call extramedullary hematopoiesis, in an endometrial polyp. H&E stain.

Extramedullary hematopoiesis refers to hematopoiesis occurring outside of the medulla of the bone.

In some cases, it may be physiologic. For example, during fetal development, hematopoiesis occurs at many different locations, such as the liver and spleen.^[1]

However, it is more frequently associated with pathologic processes. For example, it can be caused by myelofibrosis.^[2]

It can sometimes be identified via computed tomography.^[3]

References [edit]

^ "hematopoiesis". Retrieved 2009-02-25. ^{[dead link]}
^ Chunduri S, Gaitonde S, Ciurea SO, Hoffman R, Rondelli D (October 2008). "Pulmonary extramedullary hematopoiesis in patients with myelofibrosis undergoing allogeneic stem cell transplantation. Can induce penile lesions.". Haematologica 93 (10): 1593–5. doi:10.3324/haematol.13203. PMID 18641018.
^ Marchiori E, Escuissato DL, Irion KL, et al. (October 2008). "Extramedullary hematopoiesis: findings on computed tomography scans of the chest in 6 patients". J Bras Pneumol 34 (10): 812–6. PMID 19009214.

Calvin SH Ng, Song Wan, Tak Wai Lee, Alan DL Sihoe, Innes YP Wan, Ahmed A Arifi, Anthony PC Yim. Video assisted thoracoscopic surgery for mediastinal extramedullary haematopoiesis. Ann R Coll Surg Engl 2002;84:161-163

External links [edit]

Berkmen YM, Zalta BA (December 2007). "Case 126: extramedullary hematopoiesis". Radiology 245 (3): 905–8. doi:10.1148/radiol.2453040715. PMID 18024458.

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1. 原発性骨髄線維症の臨床症状および診断 clinical manifestations and diagnosis of primary myelofibrosis
2. サラセミアの臨床症状および診断 clinical manifestations and diagnosis of the thalassemias
3. 原発性骨髄線維症における病態 pathogenetic mechanisms in primary myelofibrosis
4. 原発性骨髄線維症の予後および治療 prognosis and treatment of primary myelofibrosis
5. 赤血球産生低下による貧血 anemias due to decreased red cell production

English Journal

Extramedullary Hematopoiesis Generates Ly-6Chigh Monocytes that Infiltrate Atherosclerotic Lesions.

Robbins CS, Chudnovskiy A, Rauch PJ, Figueiredo JL, Iwamoto Y, Gorbatov R, Etzrodt M, Weber GF, Ueno T, van Rooijen N, Mulligan-Kehoe MJ, Libby P, Nahrendorf M, Pittet MJ, Weissleder R, Swirski FK.Source1 Massachusetts General Hospital & Harvard Medical School, Boston, MA;
Circulation.Circulation.2011 Dec 5. [Epub ahead of print]
BACKGROUND: Atherosclerotic lesions are believed to grow via the recruitment of bone marrow-derived monocytes. Among the known murine monocyte subsets, Ly-6C(high) monocytes are inflammatory, accumulate in lesions preferentially, and differentiate. Here we hypothesized that the bone marrow outsource
PMID 22144566

Comparative virulence of three Trypanosoma evansi isolates from water buffaloes in the Philippines.

Verdillo JC, Lazaro JV, Abes NS, Mingala CN.SourceCollege of Veterinary Science and Medicine, Central Luzon State University, Science City of Munoz, 3120 Nueva Ecija, Philippines.
Experimental parasitology.Exp Parasitol.2011 Dec 4. [Epub ahead of print]
The virulence of three Trypanosoma evansi isolates in Luzon, Visayas and Mindanao water buffaloes was compared determining the mortality rate, parasitemia level, clinical signs, and lesions on mice. A total of 51 inbred Balb/c mice (5-6weeks old) were used and divided into two sets. Set A had three
PMID 22154978

Japanese Journal

原発性肺癌に併発した多発性後縦隔骨髄脂肪腫の1例

藤原隆行,朝戸裕二,清嶋護之,佐藤始広,飯嶋達生,雨宮隆太
肺癌 51(3), 207-211, 2011
背景．骨髄脂肪腫は骨髄成分と成熟脂肪組織からなる稀な良性腫瘍である．副腎原発が多く，後縦隔原発例は稀である．症例．既往に多血症，高血圧症，糖尿病を有する71歳男性である．食欲不振を主訴に近医受診し，胸部X線および胸部CTにおいて肺および縦隔の異常陰影を指摘され，当院を紹介受診した．胸部CTにおいて，右肺S1に15 mm大の結節影，両側後縦隔の第3胸椎に接し腫瘤性病変を認めた．FDG-PETでは右肺 …
NAID 130000761275

A Long Course of Leukocytopenia and Splenomegaly with Extramedullary Hematopoiesis in the Absence of Clinically Manifested Rheumatoid Arthritis

MUROI Kazuo,SAKUMA Yasunaru,IZUMI Tohru,SATO Kazuya,TANAKA Akira,OZAWA Keiya
Journal of clinical and experimental hematopathology 50(2), 163-166, 2010-11-01
… Histology of the splenectomized spleen showed follicular hyperplasia with plasmacyte infiltration and extramedullary hematopoeisis. …
NAID 10027648057