English Journal

Geographical venom variations of the Southeast Asian monocled cobra (Naja kaouthia): venom-induced neuromuscular depression and antivenom neutralization.

Tan KY1, Tan CH2, Sim SM3, Fung SY1, Tan NH1.
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP.Comp Biochem Physiol C Toxicol Pharmacol.2016 Mar 10;185-186:77-86. doi: 10.1016/j.cbpc.2016.03.005. [Epub ahead of print]
The Southeast Asian monocled cobras (Naja kaouthia) exhibit geographical variations in their venom proteomes, especially on the composition of neurotoxins. This study compared the neuromuscular depressant activity of the venoms of N. kaouthia from Malaysia (NK-M), Thailand (NK-T) and Vietnam (NK-V),
PMID 26972756

How do short neurotoxins bind to a muscular-type nicotinic acetylcholine receptor?

Teixeira-Clerc F1, Ménez A, Kessler P.
The Journal of biological chemistry.J Biol Chem.2002 Jul 12;277(28):25741-7. Epub 2002 May 2.
We investigated the interacting surface between a short curarimimetic toxin and a muscular-type nicotinic acetylcholine receptor, looking for the ability of various biotinylated Naja nigricollis alpha-neurotoxin analogues to bind simultaneously the receptor and streptavidin. All these derivatives, m
PMID 12006581

Molecular determinants by which a long chain toxin from snake venom interacts with the neuronal alpha 7-nicotinic acetylcholine receptor.

Antil-Delbeke S1, Gaillard C, Tamiya T, Corringer PJ, Changeux JP, Servent D, Ménez A.
The Journal of biological chemistry.J Biol Chem.2000 Sep 22;275(38):29594-601.
Long chain curarimimetic toxins from snake venom bind with high affinities to both muscular type nicotinic acetylcholine receptors (AChRs) (K(d) in the pm range) and neuronal alpha 7-AChRs (K(d) in the nm range). To understand the molecular basis of this dual function, we submitted alpha-cobratoxin
PMID 10852927

Japanese Journal

Stereochemical preferences for curarimimetic neuromuscular junction blockade I: enantiomeric monoquaternary amines as probes

大味谷輝男
日本薬理学雑誌 49(4), 159-168,en21, 1953
… The curarimimetic and anticonvulsant activity activity of 3- (1, 2, 3, 4-tetrahydro-8-naphthyloxy) propane-1, 2-diol (=ar.α-Tetralyl glycerol ether, abbreviated as α-TNP and 3- (1, 2, 3, 4-tetrahydro-7-naphthyloxy) propane-1, 2-diol (=ar.β-Tetralyl glycerol ether, abbreviated as β-TNP) has been studied and the latter was found to have a stronger power and a longer duration than those hitherto tested including Myanesin. …
NAID 130001507983

大味谷輝男,藤竹信英
日本薬理学雑誌 49(2), 84-88,en11, 1953
… The toxicology and curarimimetic properties of 27 aromatic glucosides were studied in mice and compared with Myanesin, each of which, however, has been proved inferior to the latter. …
NAID 130001507938

英: nondepolarizing muscle relaxant non-depolarizing muscle relaxant
同: 競合的神経筋遮断薬 competitive neuromuscular blocker、競合的筋弛緩薬 competitive muscle relaxant、非脱分極性神経筋遮断薬 non-depolarizing neuromuscular blocker、非脱分極性遮断薬 nondepolarizing blocking drugs、クラーレ様作用薬 curarimimetic、クラーレ様物質
関: 脱分極性筋弛緩薬、筋弛緩薬、Train of four monitor、脱分極性遮断薬、神経筋接合部遮断薬

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