English Journal

Safety and efficacy of bilateral topical application of rocuronium bromide for mydriasis in European kestrels (Falco tinnunculus).

Barsotti G1, Briganti A, Spratte JR, Ceccherelli R, Breghi G.
Journal of avian medicine and surgery.J Avian Med Surg.2012 Mar;26(1):1-5.
The avian iris is mainly composed of striated muscle fibers, and the topical parasympatholytic drugs used in mammals to induce pupil dilation are ineffective in birds. The achievement of mydriasis in conscious birds is only possible by using neuromuscular blocking agents such as curariform drugs. To
PMID 22645832

Mydriatic effect of topically applied rocuronium bromide in tawny owls (Strix aluco): comparison between two protocols.

Barsotti G1, Briganti A, Spratte JR, Ceccherelli R, Breghi G.
Veterinary ophthalmology.Vet Ophthalmol.2010 Sep;13 Suppl:9-13. doi: 10.1111/j.1463-5224.2010.00773.x.
OBJECTIVE: To evaluate the mydriatic efficacy of a neuromuscular blocking agent (rocuronium bromide) applied topically to only one eye of nocturnal birds of prey and to assess for any general and/or local adverse effects due to its use. Animal studied Twelve healthy adult tawny owls (Strix aluco)
PMID 20840085

Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain.

Wang HL1, Gao F, Bren N, Sine SM.
The Journal of biological chemistry.J Biol Chem.2003 Aug 22;278(34):32284-91. Epub 2003 Jun 10.
Curariform alkaloids competitively inhibit muscle acetylcholine receptors (AChR) by bridging the alpha and non-alpha subunits that form the ligand-binding site. Here we delineate bound orientations of d-tubocurarine (d-TC) and its methylated derivative metocurine using mutagenesis, ligand binding me
PMID 12799358