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1. 認知症患者における睡眠覚醒障害および睡眠障害 sleep wake disturbances and sleep disorders in patients with dementia
2. 止血の概要 overview of hemostasis
3. 皮膚病変のダーモスコピー評価 dermoscopic evaluation of skin lesions
4. スポーツ医療の最新情報（プライマリケア） whats new in sports medicine primary care
5. せん妄および急性錯乱状態：予防、治療、および予後 delirium and acute confusional states prevention treatment and prognosis

English Journal

Chitosan Decorated Copper Nanoparticles as Efficient Catalyst for Synthesis of Novel Quinoline Derivatives.

Alghamdi KS, Ahmed NSI, Bakhotmah D, Mokhtar M.
Journal of nanoscience and nanotechnology. 2020 Feb;20(2)890-899.
Chitosan decorated copper nanoparticles (CS/CuNPs) catalysts were synthesized via reduction methods utilizing green protocol. The CS/CuNPs hybrid catalysts were tested for the synthesis of quinoline derivatives utilizing one-pot multicomponent reaction (MCR) under ultrasonic irradiation. The optimiz
PMID 31383084

Donepezil + chromone + melatonin hybrids as promising agents for Alzheimer's disease therapy.

Pachón-Angona I, Refouvelet B, Andrýs R, Martin H, Luzet V, Iriepa I, Moraleda I, Diez-Iriepa D, Oset-Gasque MJ, Marco-Contelles J, Musilek K, Ismaili L.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)479-489.
We describe herein the design, multicomponent synthesis and biological studies of new donepezil + chromone + melatonin hybrids as potential agents for Alzheimer's disease (AD) therapy. We have identified compound 14n as promising multitarget small molecule showing strong BuChE inhibition (IC
PMID 30712420

Synthesis and biological evaluation of benzothiazin-4-ones: a possible new class of acetylcholinesterase inhibitors.

Berwaldt GA, Gouvêa DP, da Silva DS, das Neves AM, Soares MSP, Azambuja JH, Siqueira GM, Spanevello RM, Cunico W.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)197-203.
A series of nineteen benzothiazin-4-ones from N-(3-aminopropyl) piperidine, 4-(2-aminoethyl)morpholine or 1-(2-aminoethyl)piperidine, aliphatic or aromatic aldehyde and thiosalicylic acid, were synthesized in good yields by multicomponent one-pot reactions. The solvent was toluene and this efficient
PMID 30482059