issue or leak, as from a small opening; "Gas escaped into the bedroom"
a plant originally cultivated but now growing wild
an inclination to retreat from unpleasant realities through diversion or fantasy; "romantic novels were her escape from the stress of daily life"; "his alcohol problem was a form of escapism" (同)escapism
the act of escaping physically; "he made his escape from the mental hospital"; "the canary escaped from its cage"; "his flight was an indication of his guilt" (同)flight
a means or way of escaping; "hard work was his escape from worry"; "they installed a second hatch as an escape"; "their escape route"
an avoidance of danger or difficulty; "that was a narrow escape"
the discharge of a fluid from some container; "they tried to stop the escape of gas from the damaged pipe"; "he had to clean up the leak" (同)leak, leakage, outflow
remove oneself from a familiar environment, usually for pleasure or diversion; "We escaped to our summer house for a few days"; "The president of the company never manages to get away during the summer" (同)get away
run away from confinement; "The convicted murderer escaped from a high security prison" (同)get away, break loose
money that is invested with an expectation of profit (同)investment funds
the ceremonial act of clothing someone in the insignia of an office; the formal promotion of a person to an office or rank (同)investiture
outer layer or covering of an organ or part or organism
the act of putting on robes or vestments
the commitment of something other than money (time, energy, or effort) to a project with the expectation of some worthwhile result; "this job calls for the investment of some hard thinking"; "he made an emotional investment in the work"
nonperformance of something distasteful (as by deceit or trickery) that you are supposed to do; "his evasion of his clear duty was reprehensible"; "that escape from the consequences is possible but unattractive" (同)escape, dodging
the deliberate act of failing to pay money; "his evasion of all his creditors"; "he was indicted for nonpayment" (同)nonpayment
the act of physically escaping from something (an opponent or a pursuer or an unpleasant situation) by some adroit maneuver
a statement that is not literally false but that cleverly avoids an unpleasant truth (同)equivocation
provide with power and authority; "They vested the council with special rights" (同)vest, enthrone
furnish with power or authority; of kings or emperors (同)clothe, adorn
make an investment; "Put money into bonds" (同)put, commit, place
escape, either physically or mentally; "The thief eluded the police"; "This difficult idea seems to evade her"; "The event evades explanation" (同)evade, bilk
be incomprehensible to; escape understanding by; "What you are seeing in him eludes me" (同)escape
Substrate channeling and enzyme complexes for biotechnological applications.
Zhang YH.AbstractSubstrate channeling is a process of transferring the product of one enzyme to an adjacent cascade enzyme or cell without complete mixing with the bulk phase. Such phenomena can occur in vivo, in vitro, or ex vivo. Enzyme-enzyme or enzyme-cell complexes may be static or transient. In addition to enhanced reaction rates through substrate channeling in complexes, numerous potential benefits of such complexes are protection of unstable substrates, circumvention of unfavorable equilibrium and kinetics imposed, forestallment of substrate competition among different pathways, regulation of metabolic fluxes, mitigation of toxic metabolite inhibition, and so on. Here we review numerous examples of natural and synthetic complexes featuring substrate channeling. Constructing synthetic in vivo, in vitro or ex vivo complexes for substrate channeling would have great biotechnological potentials in metabolic engineering, multi-enzyme-mediated biocatalysis, and cell-free synthetic pathway biotransformation (SyPaB).
Biotechnology advances.Biotechnol Adv.2011 Nov;29(6):715-25. Epub 2011 Jun 7.
Substrate channeling is a process of transferring the product of one enzyme to an adjacent cascade enzyme or cell without complete mixing with the bulk phase. Such phenomena can occur in vivo, in vitro, or ex vivo. Enzyme-enzyme or enzyme-cell complexes may be static or transient. In addition to enh
Colocalization of gadolinium-diethylene triamine pentaacetic acid with high-molecular-weight molecules after intracerebral convection-enhanced delivery in humans.
Sampson JH, Brady M, Raghavan R, Mehta AI, Friedman AH, Reardon DA, Petry NA, Barboriak DP, Wong TZ, Zalutsky MR, Lally-Goss D, Bigner DD.SourceDivision of Neurosurgery, Department of Surgery, Duke University Medical Center, Durham, North Carolina 27710, USA. john.sampson@duke.edu
Neurosurgery.Neurosurgery.2011 Sep;69(3):668-76.
BACKGROUND: Convection-enhanced delivery (CED) permits site-specific therapeutic drug delivery within interstitial spaces at increased dosages through circumvention of the blood-brain barrier. CED is currently limited by suboptimal methodologies for monitoring the delivery of therapeutic agents that
Effects of capsid-modified oncolytic adenoviruses and their combinations with gemcitabine or silica gel on pancreatic cancer.
Kangasniemi L, Parviainen S, Pisto T, Koskinen M, Jokinen M, Kiviluoto T, Cerullo V, Jalonen H, Koski A, Kangasniemi A, Kanerva A, Pesonen S, Hemminki A.SourceCancer Gene Therapy Group, Molecular Cancer Biology Program, Transplantation Laboratory, Haartman Institute and Finnish Institute of Molecular Medicine, University of Helsinki, Finland; HUSLAB, Helsinki University Central Hospital, Finland; Oncos Therapeutics, Helsinki, Finland.
International journal of cancer. Journal international du cancer.Int J Cancer.2011 Aug 10. doi: 10.1002/ijc.26370. [Epub ahead of print]
Conventional cancer treatments often have little impact on the course of advanced pancreatic cancer. Although cancer gene therapy with adenoviruses is a promising developmental approach, the primary receptor is poorly expressed in pancreatic cancers which might compromise efficacy and thus targeting
Anti-circumvention refers to laws which prohibit the circumvention of technological barriers for using a digital good in certain ways which the rightsholders do not wish to allow. The requirement for anti-circumvention laws was globalized in ...
tr.v. cir・cum・vent・ed, cir・cum・vent・ing, cir・cum・vents. 1. To surround (an enemy, for example); enclose or entrap. 2. To go around; bypass: circumvented the city. 3. To avoid or get around by artful maneuvering: She planned a way to circumvent ...