無汗症
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/04/07 17:37:44」(JST)
[Wiki en表示]
Hypohidrosis |
Classification and external resources |
Specialty |
dermatology |
ICD-10 |
L74.4 |
ICD-9-CM |
705.0 |
DiseasesDB |
21064 |
[edit on Wikidata]
|
Hypohidrosis is diminished sweating in response to appropriate stimuli. While hyperhidrosis is a socially troubling but benign condition, hypohidrosis can lead to hyperthermia, heat exhaustion, heat stroke and potentially death.[1] An extreme case of hypohydrosis in which there is a complete absence of sweating and the skin is dry is termed anhidrosis.
Contents
- 1 Causes
- 1.1 Medications
- 1.2 Physical agents
- 1.3 Dermatological
- 1.4 Neuropathic
- 2 Diagnosis
- 3 Management
- 4 References
- 5 Notes
Causes
Medications
- Anticholinergic agents
- Opioids
- Botulinum toxin
- Alpha-2 receptor antagonists
- Clonidine
- Barbiturates
- Zonisamide
Physical agents
- Tumors
- Burns
- Radiation
- Surgery
- Scars
- Sores
Dermatological
- X-linked hypohidrotic ectodermal dysplasia
- Incontinentia pigmenti
- Bazex disease
- Fabry disease
- Miliaria
- Sjogren syndrome
- Systemic sclerosis
- Graft-versus-host disease
Neuropathic
- Multiple system atrophy
- Dementia with Lewy bodies
- Multiple sclerosis
- Cerebrovascular accident
- Tumour
- Encephalitis
- Cervical myelopathy
- Diabetes mellitus
- Guillain–Barré syndrome
- Hereditary sensory and autonomic neuropathy
- Alcoholism
- Amyloidosis
- Ross syndrome
- Pure autonomic failure
- Horner's syndrome
Diagnosis
Sweat is readily visualized by a topical indicator such as iodinated starch (Minor test) or sodium alizarin sulphonate, both of which undergo a dramatic colour change when moistened by sweat. A thermoregulatory sweat test can evaluate the body’s response to a thermal stimulus by inducing sweating through a hot box ⁄ room, thermal blanket or exercise. Failure of the topical indicator to undergo a colour change during thermoregulatory sweat testing indicates hypohidrosis, and further tests may be required to localize the lesion.
Magnetic resonance imaging of the brain and ⁄ or spinal cord is the best modality for evaluation when the lesion is suspected to be localized to the central nervous system.
Skin biopsies are useful when anhidrosis occurs as part of a dermatological disorder. Biopsy results may reveal the sweat gland destruction, necrosis or fibrosis, in addition to the findings of the primary dermatological disorder.
Management
The treatment options for hypohidrosis and anhidrosis is limited. Those with hypohidrosis should avoid drugs that can aggravate the condition (see medication-causes). They should limit activities that raise the core body temperature and if exercises are to be performed, they should be supervised and be performed in a cool, sheltered and well-ventilated environment. In instances where the cause is known, treatment should be directed at the primary pathology. In autoimmune diseases, such as Sjogren syndrome and systemic sclerosis, treatment of the underlying disease using immunosuppressive drugs may lead to improvement in hypohidrosis. In neurological diseases, the primary pathology is often irreversible. In these instances, prevention of further neurological damage, such as good glycaemic control in diabetes, is the cornerstone of management. In acquired generalized anhidrosis, spontaneous remission may be observed in some cases. Numerous cases have been reported to respond effectively to systemic corticosteroids. Although an optimum dose and regime has not been established, pulse methylprednisolone (up to 1000 mg ⁄ day) has been reported to have good effect.
References
- ^ Chia, K. Y.; Tey, H. L. (2012). "Approach to hypohidrosis". Journal of the European Academy of Dermatology and Venereology. 27 (7): 799–804. doi:10.1111/jdv.12014. PMID 23094789.
Notes
- http://www.mayoclinic.com/health/anhidrosis/DS01050[full citation needed]
- MedlinePlus Encyclopedia Sweating - absent
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Thoracolumbar Arachnoid Cyst with Horner Syndrome: A Case Report and Review of the Literature.
- Gao Y1, Zhang H, Yang J, Fu Q, Zheng J, Shuai M, Hu Z, Tan W, Cao W, Yang X, Jin A, Zhou R, Lu H.
- Cell biochemistry and biophysics.Cell Biochem Biophys.2014 Dec 9. [Epub ahead of print]
- Horner syndrome (HS) results from the interruption of sympathic pathway, and the patients have a group of signs including miosis, ptosis, enophthalmos, and anhydrosis. While HS is mainly caused by cervical sympathetic nerve injury such as sympathetic chain tumor, we report here a HS case caused by a
- PMID 25486904
- A heterozygous female with Fabry disease due to a novel alpha-galactosidase A mutation exhibits a unique synaptopodin distribution in vacuolated podocytes.
- Takahashi N, Yokoi S, Kasuno K, Kogami A, Tsukimura T, Togawa T, Saito S, Ohno K, Hara M, Kurosawa H, Hirayama Y, Kurose T, Yokoyama Y, Mikami D, Kimura H, Naiki H, Sakuraba H, Iwano M.
- Clinical nephrology.Clin Nephrol.2014 Oct 8. [Epub ahead of print]
- We report the case of a 42-yearold woman diagnosed with heterozygous Fabry disease (FD) due to a novel alpha-galactosidase A Pro210Ser mutation and exhibiting a unique distribution of synaptopodin within podocytes. The patient was referred to our hospital with moderate proteinuria, and a renal biops
- PMID 25295576
- Atopic Diathesis in Hypohidrotic/Anhidrotic Ectodermal Dysplasia.
- Koguchi-Yoshioka H1, Wataya-Kaneda M, Yutani M, Murota H, Nakano H, Sawamura D, Katayama I.
- Acta dermato-venereologica.Acta Derm Venereol.2014 Oct 1. doi: 10.2340/00015555-1978. [Epub ahead of print]
- Recently, patients with hypohidrotic/anhidrotic ectodermal dysplasia (H/AED) have been reported to have a higher prevalence of symptoms suggestive of atopic disorders than the general population. To better understand atopic diathesis in H/AED, 6 cases of clinically or genetically diagnosed H/AED wer
- PMID 25270765
Japanese Journal
- 脳神経障害を合併しMRI にて三叉神経の腫大・造影効果を呈した急性自律性感覚性運動性ニューロパチーの1例
- コリン性蕁麻疹 (特集 特異なアレルギーの発症機序 : 最近の知見)
- 大腿骨骨折に対して観血的治療を要した先天性無痛無汗症の1例
Related Links
- Anhydrosis' definition, the deficiency or absence of perspiration; adiaphoresis. See more. Thesaurus Translate Puzzles & Games Reference Word of the Day Blog Slideshows Apps by Dictionary My Account Log Out Log In ...
- Thesaurus Antonyms Related Words Synonyms Legend: Noun 1. anhydrosis - failure of the sweat glands anhidrosis physical condition, physiological condition, physiological ... Disclaimer All content on this website, including ...
Related Pictures
★リンクテーブル★
[★]
- 英
- anhidrosis、anhydrosis, anidrosis, adiaphoresis
- 同
- 無発汗症
- 関
- 発汗低下、乏汗症 oligohidrosis、減汗症 hypohidrosis
- 発汗刺激があっても発汗がまったくない状態である
- 全身性のものと局所性のもの、原因により先天性、後天性(続発性)のものがある。
- 皮膚は乾燥して粗造化し、鱗屑を付着する。掻痒感を呈することもある。
- これらは汗腺の機能的変化あるいは汗腺およびその周囲組織の器質的変化によって起こる。
- 病態からの分類