WordNet
- something that people do or cause to happen (同)deed, human action, human_activity
- behave in a certain manner; show a certain behavior; conduct or comport oneself; "You should act like an adult"; "Dont behave like a fool"; "What makes her do this way?"; "The dog acts ferocious, but he is really afraid of people" (同)behave, do
- pretend to have certain qualities or state of mind; "He acted the idiot"; "She plays deaf when the news are bad" (同)play, act_as
- a legal document codifying the result of deliberations of a committee or society or legislative body (同)enactment
- a short theatrical performance that is part of a longer program; "he did his act three times every evening"; "she had a catchy little routine"; "it was one of the best numbers he ever did" (同)routine, number, turn, bit
- a manifestation of insincerity; "he put on quite an act for her benefit"
- a subdivision of a play or opera or ballet
- discharge ones duties; "She acts as the chair"; "In what capacity are you acting?"
- perform an action, or work out or perform (an action); "think before you act"; "We must move quickly"; "The governor should act on the new energy bill"; "The nanny acted quickly by grabbing the toddler and covering him with a wet towel" (同)move
- play a role or part; "Gielgud played Hamlet"; "She wants to act Lady Macbeth, but she is too young for the role"; "She played the servant to her husbands master" (同)play, represent
- perform on a stage or theater; "She acts in this play"; "He acted in `Julius Caesar"; "I played in `A Christmas Carol" (同)play, roleplay, playact
- be engaged in an activity, often for no particular purpose other than pleasure
- be suitable for theatrical performance; "This scene acts well"
- a simple compound whose molecules can join together to form polymers
- one of the proteins into which actomyosin can be split; can exist in either a globular or a fibrous form
PrepTutorEJDIC
- 『行い』,『行為』 / 《しばしばA-》法令,条令 / 《しばしばA-》(芝居の1つの)『幕』;(演芸などの)出し物の一つ / (見せかけの)お芝居,演技 / 『行動する』,行う / 《様態を表す副詞[句]を伴って》わざとふるまう,見せかける / 〈人・物が〉(…として)動く,役割をはたす《+『as』+『名』》 / 〈薬が〉『作用する』,きく / 舞台に立つ,出演する / 〈…の役〉'を'『演ずる』;〈劇〉'を'上演する / …‘に'ふさわしくふるまう / …‘に'見せかける,‘の'ふりをする
- 単量体(異種の分子と反応し重合体を構成する)
- 純蛋白質(筋肉生成に役立つ)
UpToDate Contents
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- 1. リステリア菌感染の疫学および病因 epidemiology and pathogenesis of listeria monocytogenes infection
- 2. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
- 3. 糸球体足細胞のバイオロジー biology of glomerular podocytes
- 4. ウィスコット・オルドリック症候群 wiskott aldrich syndrome
- 5. 赤血球細胞膜の動態および機構 red blood cell membrane dynamics and organization
English Journal
- Mechanisms of nuclear actin in chromatin-remodeling complexes.
- Kapoor P1, Shen X2.Author information 1Department of Molecular Carcinogenesis, Science Park Research Division, The University of Texas M.D. Anderson Cancer Center, Smithville, TX 78957, USA.2Department of Molecular Carcinogenesis, Science Park Research Division, The University of Texas M.D. Anderson Cancer Center, Smithville, TX 78957, USA. Electronic address: snowshen@mac.com.AbstractThe mystery of nuclear actin has puzzled biologists for decades largely due to the lack of defined experimental systems. However, the development of actin-containing chromatin-modifying complexes as a defined genetic and biochemical system in the past decade has provided an unprecedented opportunity to dissect the mechanism of actin in the nucleus. Although the established functions of actin mostly rely on its dynamic polymerization, the novel finding of the mechanism of action of actin in the INO80 chromatin-remodeling complex suggests a conceptually distinct mode of actin that functions as a monomer. In this review we highlight the new paradigm and discuss how actin interaction with chromatin suggests a fundamental divergence between conventional cytoplasmic actin and nuclear actin. Furthermore, we provide how this framework could be applied to investigations of nuclear actin in other actin-containing chromatin-modifying complexes.
- Trends in cell biology.Trends Cell Biol.2014 Apr;24(4):238-246. doi: 10.1016/j.tcb.2013.10.007. Epub 2013 Nov 16.
- The mystery of nuclear actin has puzzled biologists for decades largely due to the lack of defined experimental systems. However, the development of actin-containing chromatin-modifying complexes as a defined genetic and biochemical system in the past decade has provided an unprecedented opportunity
- PMID 24246764
- The β-actin mRNA zipcode regulates epithelial adherens junction assembly but not maintenance.
- Gutierrez N1, Eromobor I, Petrie RJ, Vedula P, Cruz L, Rodriguez AJ.Author information 1Department of Biological Sciences, Rutgers University Newark, Newark, New Jersey 07102, USA.AbstractEpithelial cell-cell contact stimulates actin cytoskeleton remodeling to down-regulate branched filament polymerization-driven lamellar protrusion and subsequently to assemble linear actin filaments required for E-cadherin anchoring during adherens junction complex assembly. In this manuscript, we demonstrate that de novo protein synthesis, the β-actin 3' UTR, and the β-actin mRNA zipcode are required for epithelial adherens junction complex assembly but not maintenance. Specifically, we demonstrate that perturbing cell-cell contact-localized β-actin monomer synthesis causes epithelial adherens junction assembly defects. Consequently, inhibiting β-actin mRNA zipcode/ZBP1 interactions with β-actin mRNA zipcode antisense oligonucleotides, to intentionally delocalize β-actin monomer synthesis, is sufficient to perturb adherens junction assembly following epithelial cell-cell contact. Additionally, we demonstrate active RhoA, the signal required to drive zipcode-mediated β-actin mRNA targeting, is localized at epithelial cell-cell contact sites in a β-actin mRNA zipcode-dependent manner. Moreover, chemically inhibiting Src kinase activity prevents the local stimulation of β-actin monomer synthesis at cell-cell contact sites while inhibiting epithelial adherens junction assembly. Together, these data demonstrate that epithelial cell-cell contact stimulates β-actin mRNA zipcode-mediated monomer synthesis to spatially regulate actin filament remodeling, thereby controlling adherens junction assembly to modulate cell and tissue adhesion.
- RNA (New York, N.Y.).RNA.2014 Mar 28. [Epub ahead of print]
- Epithelial cell-cell contact stimulates actin cytoskeleton remodeling to down-regulate branched filament polymerization-driven lamellar protrusion and subsequently to assemble linear actin filaments required for E-cadherin anchoring during adherens junction complex assembly. In this manuscript, we d
- PMID 24681968
- Autonomous and in trans functions for the two halves of Srv2/CAP in promoting actin turnover.
- Chaudhry F1, Jansen S, Little K, Suarez C, Boujemaa-Paterski R, Blanchoin L, Goode BL.Author information 1Department of Biology, Rosenstiel Basic Medical Science Research Center, Brandeis University, Waltham, MA, 02454, U.S.A.AbstractRecent evidence has suggested that Srv2/CAP (cyclase-associated protein) has two distinct functional roles in regulating actin turnover, with its N-terminus enhancing cofilin-mediated severing of actin filaments and its C-terminus catalyzing actin monomer recycling. However, it has remained unclear to what degree these two activities are coordinated by being linked in one molecule, or whether they can function autonomously. To address this, we physically divided the protein into two separate halves, N-Srv2 and C-Srv2, and asked whether they are able to function in trans both in living cells and in reconstituted assays for F-actin turnover and actin-based motility. Remarkably, in F-actin turnover assays the stimulatory effects of N-Srv2 and C-Srv2 functioning in trans were quantitatively similar to those of intact full-length Srv2. Further, in bead motility assays and in vivo, the fragments again functioned in trans, although not with the full effectiveness of intact Srv2. From these data, we conclude that the functions of the two halves of Srv2/CAP are largely autonomous, although their linkage improves coordination of the two functions in specific settings, possibly explaining why the linkage is conserved across distant plant, animal, and fungal species. © 2014 Wiley Periodicals, Inc.
- Cytoskeleton (Hoboken, N.J.).Cytoskeleton (Hoboken).2014 Mar 11. doi: 10.1002/cm.21170. [Epub ahead of print]
- Recent evidence has suggested that Srv2/CAP (cyclase-associated protein) has two distinct functional roles in regulating actin turnover, with its N-terminus enhancing cofilin-mediated severing of actin filaments and its C-terminus catalyzing actin monomer recycling. However, it has remained unclear
- PMID 24616256
Japanese Journal
- Swelling-induced long-range ordered structure formation in polyelectrolyte hydrogel
- Arifuzzaman Md.,Wu Zi Liang,Kurokawa Takayuki,Kakugo Akira,Gong Jian Ping
- Soft Matter 8(31), 8060-8066, 2012-08-21
- … The hydrogel is synthesized from a cationic monomer, N-[3-(N,N-dimethylamino)propyl] acrylamide methyl chloride quaternary (DMAPAA-Q), in the presence of a small amount of the oppositely charged poly(2,2'-disulfonyl-4,4'-benzidine terephthalamide) (PBDT) that has a semi-rigid nature. … This sort of non-equilibrium structure formation mechanism may help understand how biomacromolecules that are rigid polyelectrolytes, such as microtubules and actin filaments, form rich architectures during the growth of biological organs. …
- NAID 120005228646
- カーネーションのユビキチン遺伝子のクローニングと性質，発現解析，および老化花弁の遺伝子発現解析における標準遺伝子としての利用
- 野村 佳宏,森田 重人,原田 太郎 [他],佐藤 茂
- Journal of the Japanese Society for Horticultural Science 81(4), 357-365, 2012
- カーネーションから，7 種のポリユビキチン遺伝子（DcUbq1–7）の cDNA をクローニングして構造を明らかにするとともに，それら遺伝子の開花時および老化時の花弁における発現を解析した．DcUbq1 と DcUbq2 は開花途上の特定時期に発現が増加し，さらに老化後期にも増加した．DcUbq3–7 転写産物量は開花後期に増加したが，老化時期には一定レベルで推移した．これの結果から，ユビキチン遺 …
- NAID 130004951672
- 2SH0935 Critical role of actin monomer concentration in stimulus induced actin assembly and cell extension(2SH Actin as a Cytomotive Filament,The 48th Annual Meeting of the Biophysical Society of Japan)
- 木内 泰,Mizuno Kensaku
- 生物物理 50(SUPPLEMENT_2), S16, 2010-08-15
- NAID 110008102224
Related Links
- Actin-monomer-binding proteins [edited by] Pekka Lappalainen （Molecular biology intelligence unit） Landes Bioscience/Eurekah.com , Springer Science+Business ... This book provides a comprehensive view on actin monomer ...
- Official Full-Text Publication: Actin monomer binding proteins. on ResearchGate, the professional network for scientists. ... [Show abstract] [Hide abstract] ABSTRACT: We have found 5 profilin cDNAs in cultured parsley cells ...
Related Pictures
★リンクテーブル★
| リンク元 | 「アクチン単量体」「単量体アクチン」 |
| 関連記事 | 「act」「monomer」 |
「アクチン単量体」
- 英
- actin monomer
- 関
- 単量体アクチン
「単量体アクチン」
- 英
- actin monomer
- 関
- アクチン単量体
「act」
- v.
- 作用する、行動する、働く
- n.
「monomer」