- 関
- TIMP-1
WordNet
- limit, block, or decrease the action or function of; "inhibit the action of the enzyme"; "inhibit the rate of a chemical reaction"
- control and refrain from showing; of emotions, desires, impulses, or behavior (同)bottle up, suppress
- limit the range or extent of; "Contact between the young was inhibited by strict social customs"
- a soft thin (usually translucent) paper (同)tissue_paper
- part of an organism consisting of an aggregate of cells having a similar structure and function
- a substance that retards or stops an activity
PrepTutorEJDIC
- 《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
- 〈感情・欲望・行動・作用など〉‘を'抑制する / (…しないように)〈人〉‘を'抑制する,妨げる《+『名』+『from』+『名』(do『ing』)》
- 〈U〉〈C〉(生物体の)『組織』 / 〈U〉〈C〉『薄織物』 / 〈U〉〈C〉水を吸収する柔らかな薄紙 / 〈C〉カーボンコピー用薄紙 / 〈C〉《a ~》(…を)織り交ぜて作ったもの《+of+名》 / =tissue paper
- 抑制する人(物) / 化学反応抑制剤
- OLD French古[代]フランス語
UpToDate Contents
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- 1. 糸球体半月体形成の機序 mechanisms of glomerular crescent formation
- 2. 頭頸部の扁平上皮癌化：分子学的および遺伝学的変化 head and neck squamous cell carcinogenesis molecular and genetic alterations
- 3. 冠動脈疾患患者における脂質低下薬の利益の機序 mechanisms of benefit of lipid lowering drugs in patients with coronary heart disease
- 4. 慢性関節リウマチにおける滑膜異常 synovial pathology in rheumatoid arthritis
- 5. 関節リウマチの病因 pathogenesis of rheumatoid arthritis
English Journal
- Interleukin-17A stimulates migration of periodontal ligament fibroblasts via p38 MAPK/NF-κB -dependent MMP-1 expression.
- Wu Y, Zhu L, Liu L, Zhang J, Peng B.Author information The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST) & Key Laboratory of Oral Biomedicine Ministry of Education, School and Hospital of Stomatology, Wuhan University, Wuhan, China.AbstractInterleukin-17 (IL-17) is a cytokine secreted predominantly by Th17 cells. Although IL-17 is primarily associated with the induction of tissue inflammation, the other biological functions of IL-17, including its wound-healing functions, have yet to be thoroughly explored. Fibroblast proliferation and migration play essential roles in periodontal wound-healing responses. In this study, we report that IL-17A can increase the migration and expression of matrix metalloproteinase (MMP)-1 in human periodontal ligament (PDL) fibroblasts but has no effect on PDL fibroblast proliferation. IL-17A-induced MMP-1 expression led to cell migration, which was attenuated by pre-treatment with IL-17 receptor neutralizing antibody and small interfering RNA (siRNA) for MMP-1. The IL-17A-induced cell migration was also attenuated by its tissue inhibitor of matrix metalloproteinase (TIMP)-1. In addition, a p38 mitogen-activated protein kinase (MAPK) inhibitor (SB203580) inhibited IL-17A-induced increase of the migration and MMP-1 upregulation of PDL fibroblasts. The involvement of p38 MAPK in IL-17A-induced MMP-1 expression and cell migration was further confirmed by transfection of p38α siRNA. A nuclear factor kappaB (NF-κB) inhibitor (pyrrolidine dithiocarbamate) also suppressed the cell migration and MMP-1 expression enhanced by IL-17A. Moreover, transfection with p38α siRNA inhibited IL-17A-induced NF-κB nuclear translocation as well as NF-κB binding activity. Our results suggest that IL-17A enhances the migration of PDL fibroblasts by increasing MMP-1 expression through the IL-17 receptor, p38 MAPK, and NF-κB signal transduction pathways.
- Journal of cellular physiology.J Cell Physiol.2014 Mar;229(3):292-9. doi: 10.1002/jcp.24444.
- Interleukin-17 (IL-17) is a cytokine secreted predominantly by Th17 cells. Although IL-17 is primarily associated with the induction of tissue inflammation, the other biological functions of IL-17, including its wound-healing functions, have yet to be thoroughly explored. Fibroblast proliferation an
- PMID 23929359
- The enhanced liver fibrosis test: a clinical grade, validated serum test, biomarker of overall fibrosis in systemic sclerosis.
- Abignano G, Cuomo G, Buch MH, Rosenberg WM, Valentini G, Emery P, Del Galdo F.Author information Leeds Institute of Rheumatic and Musculoskeletal Medicine, University of Leeds, , Leeds, UK.AbstractOBJECTIVES: The absence of a serological surrogate outcome measure of fibrosis in systemic sclerosis (SSc) is a major deficiency for intervention studies and clinical management. An algorithm including the serum concentration of procollagen-III aminoterminal-propeptide, tissue inhibitor of matrix metalloproteinase-1 and hyaluronic acid, has recently been validated as predictive of severity and clinical outcome in chronic liver diseases (enhanced liver fibrosis (ELF) test) and implemented as a clinical grade test available for physicians. We evaluated the ELF test as a surrogate outcome measure in SSc.
- Annals of the rheumatic diseases.Ann Rheum Dis.2014 Feb 1;73(2):420-7. doi: 10.1136/annrheumdis-2012-202843. Epub 2013 Mar 19.
- OBJECTIVES: The absence of a serological surrogate outcome measure of fibrosis in systemic sclerosis (SSc) is a major deficiency for intervention studies and clinical management. An algorithm including the serum concentration of procollagen-III aminoterminal-propeptide, tissue inhibitor of matrix me
- PMID 23511226
- Activation of extracellular signal-regulated kinase 1/2 and Sp1 may contribute to the expression of tissue inhibitor of metalloproteinases-1 induced by transforming growth factor-β1 in human pulmonary arterial smooth muscle cells.
- Tang W1, Yang J2, Zhang F3, Guo H4, Peng F4, Wang X5.Author information 1Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing City, Zhejiang, PR China; Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou City, Zhejiang, PR China.2Department of Cardiology, Zhejiang Traditional Chinese Medical Hospital, Hangzhou City, Zhejiang, PR China.3Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou City, Zhejiang, PR China.4Department of Cardiology, Shaoxing People's Hospital (Shaoxing Hospital of Zhejiang University), Shaoxing City, Zhejiang, PR China.5Department of Cardiology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou City, Zhejiang, PR China. Electronic address: Wangxx0571@yahoo.com.cn.AbstractBACKGROUND AIMS: Tissue inhibitor of metalloproteinases-1 (TIMP-1) plays an important role in the development of pulmonary arterial hypertension. However, the molecular regulatory mechanisms of TIMP-1 in the pulmonary arteries are not fully understood, especially in human pulmonary arterial smooth muscle cells (HPASMCs). We investigated the signaling pathway involved in the regulation of TIMP-1 in HPASMCs induced by transforming growth factor (TGF)-β1.
- Cytotherapy.Cytotherapy.2014 Feb;16(2):225-33. doi: 10.1016/j.jcyt.2013.08.009. Epub 2013 Oct 8.
- BACKGROUND AIMS: Tissue inhibitor of metalloproteinases-1 (TIMP-1) plays an important role in the development of pulmonary arterial hypertension. However, the molecular regulatory mechanisms of TIMP-1 in the pulmonary arteries are not fully understood, especially in human pulmonary arterial smooth m
- PMID 24113427
Japanese Journal
- Rhein Inhibits Integrin-Linked Kinase Expression and Regulates Matrix Metalloproteinase-9/Tissue Inhibitor of Metalloproteinase-1 Ratio in High Glucose-Induced Epithelial-Mesenchymal Transition of Renal Tubular Cell
- Peng Linlin,Yang Jiayi,Ning Chen,Zhang Jing,Xiao Xiangcheng,He Dan,Wang Xiaoyuan,Li Zhiping,Fu Shuangshuang,Ning Jianping
- Biological and Pharmaceutical Bulletin 35(10), 1676-1685, 2012
- … Studies have found overexpressed integrin-linked kinase (ILK) and disturbed matrix metalloproteinase-9/tissue inhibitor of metalloproteinase-1 (MMP-9/TIMP-1) ratio in diabetic nephropathy epithelial-mesenchymal transition (EMT). … However, the underlying mechanisms of EMT and the inhibiting effect of rhein need further understanding. …
- NAID 130001872356
- Kalopanaxsaponin A Inhibits the Invasion of Human Oral Squamous Cell Carcinoma by Reducing Metalloproteinase-9 mRNA Stability and Protein Trafficking
- Hwang Young Sun,Park Kwang-Kyun,Chung Won-Yoon
- Biological and Pharmaceutical Bulletin 35(3), 289-300, 2012
- … An inability to control cancer cell invasion and metastasis is the leading cause of death in patients with cancer. … The present study was performed to determine the anti-invasive effect of Kalopanaxsaponin A (KPS-A) on matrix metalloproteinase-9 (MMP-9)-meidated invasion in phorbol 12-myristate 13-acetate (PMA)-stimulated human oral squamous cell carcinoma (OSCC) cells and a murine xenograft model of human OSCC. …
- NAID 130001872308
Related Links
- The matrix metalloproteinases are inhibited by specific endogenous tissue inhibitors of metalloproteinases (TIMPs), which comprise a family of four protease inhibitors: TIMP1, ... The role of the pro-MMP-9/TIMP-1 complex is still unknown.
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★リンクテーブル★
| リンク元 | 「TIMP-1」「組織メタロプロテアーゼ阻害物質1」 |
| 関連記事 | 「inhibit」「inhibitor」「metalloproteinase」「metalloproteinases」 |
「TIMP-1」
「組織メタロプロテアーゼ阻害物質1」
「inhibit」
- v.
- 抑制する、阻害する、阻止する
- 関
- abrogate、block、depress、depression、deter、inhibition、interdict、prevent、prevention、repress、repression、restrain、restraint、suppress、suppression
「inhibitor」
- n.