WordNet
- the 20th letter of the Roman alphabet (同)t
PrepTutorEJDIC
- tritiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/11 08:43:11」(JST)
wiki en
English Journal
- NUDT15 polymorphisms are better than thiopurine S-methyltransferase as predictor of risk for thiopurine-induced leukopenia in Chinese patients with Crohn's disease.
- Zhu X1, Wang XD2, Chao K3, Zhi M3, Zheng H1, Ruan HL4, Xin S1, Ding N3, Hu PJ3, Huang M1, Gao X5.
- Alimentary pharmacology & therapeutics.Aliment Pharmacol Ther.2016 Sep 8. doi: 10.1111/apt.13796. [Epub ahead of print]
- BACKGROUND: Thiopurine-induced leukopenia is the most common dangerous adverse event in Asians. NUDT15 R139C was recently proposed to be a promising biomarker for leukopenia with thiopurine therapy in Asians, but this has not been replicated in the Chinese population.AIM: To investigate the influenc
- PMID 27604507
- Measures of 6-mercaptopurine and methotrexate maintenance therapy intensity in childhood acute lymphoblastic leukemia.
- Nielsen SN1, Grell K1,2, Nersting J1, Frandsen TL1, Hjalgrim LL1, Schmiegelow K3,4.
- Cancer chemotherapy and pharmacology.Cancer Chemother Pharmacol.2016 Sep 6. [Epub ahead of print]
- PURPOSE: Normal white blood cell counts (WBC) are unknown in children with acute lymphoblastic leukemia (ALL). Accordingly, 6-mercaptopurine (6MP) and methotrexate (MTX) maintenance therapy is adjusted by a common WBC target of 1.5-3.0 × 109/L. Consequently, the absolute degree of myelosuppressio
- PMID 27600880
- Structural and functional insight into the N-terminal domain of the clathrin adaptor Ent5 from Saccharomyces cerevisiae.
- Zhang F1, Song Y1, Ebrahimi M1, Niu L1, Teng M2, Li X3.
- Biochemical and biophysical research communications.Biochem Biophys Res Commun.2016 Sep 2;477(4):786-93. doi: 10.1016/j.bbrc.2016.06.136. Epub 2016 Jun 28.
- Clathrin-coated vesicles (CCVs) play critical roles in multiple cellular processes, including nutrient uptake, endosome/lysosome biogenesis, pathogen invasion, regulation of signalling receptors, etc. Saccharomyces cerevisiae Ent5 (ScEnt5) is one of the two major adaptors supporting the CCV-mediated
- PMID 27369074
Japanese Journal
- Trigeminal Neuralgia Caused by Nerve Compression by Dilated Superior Cerebellar Artery Associated with Cerebellar Arteriovenous Malformation: Case Report
- MORI Yoshimasa,KOBAYASHI Tatsuya,MIYACHI Shigeru,HASHIZUME Chisa,TSUGAWA Takahiko,SHIBAMOTO Yuta
- Neurologia medico-chirurgica 54(3), 236-241, 2014
- … Intracranial arteriovenous malformation (AVM) is a rare cause of trigeminal neuralgia (TGN). … In this presented case, successful resolution of AVM-related TGN following embolization and gamma knife stereotactic radiosurgery (GKRS) was obtained. … A patient suffered from TGN on the left side, which was thought to be caused by root entry zone compression by dilated superior cerebellar artery (SCA) associated with cerebellar AVM. …
- NAID 130003383248
- ARF1 and ARF4 regulate recycling endosomal morphology and retrograde transport from endosomes to the Golgi apparatus.
- Nakai Waka,Kondo Yumika,Saitoh Akina,Naito Tomoki,Nakayama Kazuhisa,Shin Hye-Won
- Molecular biology of the cell 24(16), 2570-2581, 2013-08
- … Moreover, the depletion of ARF1 and ARF4 inhibits retrograde transport of TGN38 and mannose-6-phosphate receptor from early/recycling endosomes to the trans-Golgi network (TGN) but does not affect the endocytic/recycling pathway of transferrin receptor or inhibit retrograde transport of CD4-furin from late endosomes to the TGN. …
- NAID 120005324911
- Identification of a second amphipathic lipid-packing sensor-like motif that contributes to Gcs1p function in the early endosome-to-TGN pathway
- Zendeh-boodi Zahra,Yamamoto Takaharu,Sakane Hiroshi [他]
- The journal of biochemistry 153(6), 573-587, 2013-06
- NAID 40019655688
Related Links
- 信頼性の高い専用ネットワークが、高品質・高効率をお約束します。 東京電力グループの専用ネットワーク「TGN」は、大量の情報をグループ各社で高速に連携し、情報を共有できる情報ネットワークインフラです。
- 新たなる 「TGN Complete Ninja」 進化したZRX1200 Ninjaの更なるフィーリング を求めて！ 細部まで黒に拘った大人のNinja ... ヘッドバイパスラインkit ブラックタイプ2 ブラックタイプの新たなバージョンが完成しました。ステンメッシュホース ...
Related Pictures
★リンクテーブル★
| リンク元 | 「6-メルカプトプリン」「trans-Golgi network」「トランスゴルジネットワーク」 |
| 関連記事 | 「TG」「T」「TGNs」 |
「6-メルカプトプリン」
- 英
- 6-mercaptopurine, mercaptopunne
- ラ
- 6-mercaptopurinum
- 同
- 6-MP
- 商
- ロイケリン
- 関
- アザチオプリン、制癌薬
- GOO. 134-138,1347f
- プリン代謝拮抗薬
- 抗悪性腫瘍薬
- 白血病治療薬
- プリンの6位にSが付加された物質。
代謝
- 投与された6-MPはPPRP(phosphoribosylpyrophosphateにより6-thioinosine 5'-monophosphate(TIMP)となる
- 6-thioinosine 5'-monophosphateはいくつかの代謝を経て6-thioguanosine 5'-monophosphate(TGN)となる
作用機序
- TIMPがプリン塩基の生合成を阻害する
- 本剤は、細胞増殖に重要な意義をもつ核酸の生合成を阻害する。メルカプトプリンは細胞内でinosinic acidのチオ同族体 thioinosinic acid（TIMP）に変換し、このTIMPは主としてinosinic acid からのadenylosuccinic acid 及びxanthylic acidへの転換を阻害し、adenine, guanineribonucleotideの生合成を阻害するとされている
適応
- 急性白血病、慢性骨髄性白血病
- 白血病、悪性リンパ腫以外の腫瘍に対しては効果が少なく適応されない
注意
- アロプリノールと相互作用がある →代謝抑制
重大な副作用
- 骨髄抑制
添付文書
- ロイケリン散10％
「trans-Golgi network」
「トランスゴルジネットワーク」
「TG」
「T」