WordNet

a phosphoric ester of a nucleoside; the basic structural unit of nucleic acids (DNA or RNA) (同)base
an antineoplastic drug used to treat acute leukemias

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Impact of Genetic Polymorphisms on 6-Thioguanine Nucleotide Levels and Toxicity in Pediatric Patients with IBD Treated with Azathioprine.

Lee MN1, Kang B, Choi SY, Kim MJ, Woo SY, Kim JW, Choe YH, Lee SY.
Inflammatory bowel diseases.Inflamm Bowel Dis.2015 Dec;21(12):2897-908. doi: 10.1097/MIB.0000000000000570.
BACKGROUND: Thiopurine-related toxicity results in discontinuation of therapy in up to 30% of patients with inflammatory bowel disease. Although thiopurine S-methyltransferase (TPMT) is implicated in toxicity, not all toxicity can be attributed to TPMT polymorphisms. We investigated the effects of p
PMID 26332308

Body Mass Index and Smoking Affect Thioguanine Nucleotide Levels in Inflammatory Bowel Disease.

Poon SS1, Asher R2, Jackson R2, Kneebone A1, Collins P1, Probert C1, Dibb M1, Subramanian S3.
Journal of Crohn's & colitis.J Crohns Colitis.2015 Aug;9(8):640-6. doi: 10.1093/ecco-jcc/jjv084. Epub 2015 May 12.
INTRODUCTION: Optimal levels of the thiopurine metabolite, 6-thioguanine nucleotides [6-TGN] correlate with remission of inflammatory bowel disease [IBD]. Apart from variations in the thiopurine methyl transferase [TPMT] gene, little is known about other predictors of 6-TGN levels. Obesity adversely
PMID 25968584

Mercaptopurine metabolite levels are predictors of bone marrow toxicity following high-dose methotrexate therapy of childhood acute lymphoblastic leukaemia.

Vang SI1, Schmiegelow K, Frandsen T, Rosthøj S, Nersting J.
Cancer chemotherapy and pharmacology.Cancer Chemother Pharmacol.2015 May;75(5):1089-93. doi: 10.1007/s00280-015-2717-8. Epub 2015 Mar 19.
High-dose methotrexate (HD-MTX) courses with concurrent oral low-dose MTX/6-mercaptopurine (6MP) for childhood acute lymphoblastic leukaemia (ALL) are often followed by neutro- and thrombocytopenia necessitating treatment interruptions. Plasma MTX during HD-MTX therapy guides folinic acid rescue to
PMID 25788208

The Blood Concentration and Therapeutic Efficacy of Azathioprine in Patients Receiving Infliximab Combination Therapy for Refractory Crohn's Disease : A Clinical Study

Limited stability of thiopurine metabolites in blood samples : Relevant in research and clinical practise

DE GRAAF P.,VOS R. M.,DE BOER N. H. K.,SINJEWEL A.,JHARAP B.,MULDER C. J. J.,VAN BODEGRAVEN A. A.,VELDKAMP A. I.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 878(19), 1437-1442, 2010-06-01
NAID 10028036759