English Journal

Clinical significance of azathioprine metabolites for the maintenance of remission in autoimmune hepatitis.

Dhaliwal HK, Anderson R, Thornhill EL, Schneider S, McFarlane E, Gleeson D, Lennard L.SourceClinical Pharmacology Unit, Department of Human Metabolism, University of Sheffield, Sheffield, United Kingdom; Liver Unit, Royal Hallamshire Hospital, Sheffield, United Kingdom.
Hepatology (Baltimore, Md.).Hepatology.2012 Oct;56(4):1401-8. doi: 10.1002/hep.25760. Epub 2012 Sep 7.
Azathioprine (AZA) is used to maintain remission in autoimmune hepatitis (AIH), but up to 18% of patients are unresponsive. AZA is a prodrug, and the formation of active thioguanine nucleotide (TGN) metabolites varies widely. We aimed to assess the relationship between AZA metabolite concentrations
PMID 22488741

Sirolimus modulates HIVAN phenotype through inhibition of epithelial mesenchymal transition.

Yadav A, Kumar D, Salhan D, Rattanavich R, Maheshwari S, Adabala M, Ding G, Singhal PC.SourceImmunology Center, Feinstein Institute for Medical Research, North Shore-Long Island Jewish Health System, Manhasset, NY 11030, United States.
Experimental and molecular pathology.Exp Mol Pathol.2012 Aug;93(1):173-81. Epub 2012 May 2.
HIV-associated nephropathy (HIVAN) is characterized by proliferative phenotype in the form of collapsing glomerulopathy and microcystic dilatation of tubules. Recently, epithelial mesenchymal transition (EMT) of renal cells has been demonstrated to contribute to the pathogenesis of proliferative HIV
PMID 22579465