WordNet

executed with proper legal authority; "a binding contract"
the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
strip sewn over or along an edge for reinforcement or decoration
the capacity to attract and hold something
any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
the 7th letter of the Roman alphabet (同)g

PrepTutorEJDIC

義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
蛋白(たんばく)質
rhodiumの化学記号

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1. ビタミンAの概要overview of vitamin a [show details]
…carrier protein levels including retinol-binding protein (RBP), due to redistribution resulting from capillary leak . In severe malnutrition, serum retinol levels are low because dietary protein,… which then combines with a membrane-bound protein called opsin to yield rhodopsin .…
2. 網膜色素変性症：臨床症状および診断retinitis pigmentosa clinical presentation and diagnosis [show details]
… 100 different rhodopsin mutations are known. Thus far, over 51 genes have been implicated in non-syndromic RP, 45 genes in syndromic RP, and 20 genes in LCA . The protein products of… Phenothiazines and chloroquine bind to melanin and concentrate in the retinal pigment epithelium.…
3. 網膜色素変性症：治療retinitis pigmentosa treatment [show details]
… Alpha-tocopherol transport protein deficiency (ataxia with vitamin E deficiency) – Alpha-tocopherol transport protein deficiency is a hereditary syndrome with RP,… outer segment membranes and may be involved in rhodopsin regeneration .…
4. 血管作動性腸管ポリペプチドvasoactive intestinal polypeptide [show details]
… in receptor coupling to G proteins. VIP binds to its specific heptahelical membrane receptor and activates the heterotrimeric G protein,… class of G protein-coupled receptors. These receptors share a significant degree of sequence homology (>50 percent), which distinguishes them from members of the rhodopsin/beta-adrenergic…
5. 腫瘍随伴性視覚症候群paraneoplastic visual syndromes [show details]
… CSF may be normal or show mild lymphocytic pleocytosis and/or elevated protein.… contain antibodies that react with the bipolar cells of the retina . Arrestin, transducing, and rhodopsin antibodies have been identified . Antiretinal antibodies are also prevalent (in as much as 69 percent) …

English Journal

The mechanisms and significance of up-regulation of RhoB expression by hypoxia and glucocorticoid in rat lung and A549 cells.

Huang GX1, Pan XY1,2, Jin YD1, Wang Y1, Song XL2, Wang CH2, Li YD1, Lu J1.
Journal of cellular and molecular medicine.J Cell Mol Med.2016 Jul;20(7):1276-86. doi: 10.1111/jcmm.12809. Epub 2016 Feb 24.
Small guanosine triphosphate (GTP)-binding protein RhoB is an important stress sensor and contributes to the regulation of cytoskeletal organization, cell proliferation and survival. However, whether RhoB is involved in the hypoxic response and action of glucocorticoid (GC) is largely unknown. In th
PMID 26915688

RASSF1A Suppresses the Invasion and Metastatic Potential of Human Non-Small Cell Lung Cancer Cells by Inhibiting YAP Activation through the GEF-H1/RhoB Pathway.

Dubois F1, Keller M1, Calvayrac O2, Soncin F3, Hoa L4, Hergovich A4, Parrini MC5, Mazières J2, Vaisse-Lesteven M6, Camonis J5, Levallet G7, Zalcman G8.
Cancer research.Cancer Res.2016 Mar 15;76(6):1627-40. doi: 10.1158/0008-5472.CAN-15-1008. Epub 2016 Jan 12.
Inactivation of the tumor suppressor gene RASSF1A by promoter hypermethylation represents a key event underlying the initiation and progression of lung cancer. RASSF1A inactivation is also associated with poor prognosis and may promote metastatic spread. In this study, we investigated how RASSF1A in
PMID 26759237

Microtubule and Actin Interplay Drive Intracellular c-Src Trafficking.

Arnette C1, Frye K1, Kaverina I1.
PloS one.PLoS One.2016 Feb 11;11(2):e0148996. doi: 10.1371/journal.pone.0148996. eCollection 2016.
The proto-oncogene c-Src is involved in a variety of signaling processes. Therefore, c-Src spatiotemporal localization is critical for interaction with downstream targets. However, the mechanisms regulating this localization have remained elusive. Previous studies have shown that c-Src trafficking i
PMID 26866809

Japanese Journal

Possible role of the RhoC/ROCK pathway in progression of clear cell renal cell carcinoma

ABE Hideyuki,KAMAI Takao,TSUJII Toshihiko,NAKAMURA Fumihiko,MASHIDORI Tomoko,MIZUNO Tomoya,TANAKA Miho,TATSUMIYA Katsuhisa,FURUYA Nobutaka,MASUDA Akinori,YAMANISHI Tomonori,YOSHIDA Ken-Ichiro
Biomedical Research 29(3), 155-161, 2008
… To clarify the role of the Rho small GTP-binding protein (Rho) and its major downstream target, ROCK (Rho-associated serine-threonine protein kinase), in progression of renal cell carcinoma (RCC), we examined mRNA expression for Rho and ROCK genes in surgical specimen of RCC tissues from 78 Japanese patients and in the corresponding non-tumor tissues originating from the same patient using a real-time reverse transcription polymerase chain reaction (RT-PCR). …
NAID 130004470709

Postnatal changes in Rho and Rho-related proteins in the mouse brain

KOMAGOME Rika,KIMURA Kazuhiro,SAITO Masayuki
Japanese Journal of Veterinary Research 47(3/4), 127-133, 2000-02-29
… To provide information on the role of Rho, a GTP-binding protein, in postnatal development of the brain cells, the change in the levels of Rho protein and Rho-related proteins was examined in the brain of mice for two weeks after birth, in parallel with the changes in the activity of marker enzymes for neuronal and glial cells. … In contrast, the levels of RhoA and RhoB in the membrane fraction were decreased during the postnatal period. …
NAID 110001079306