RhoA GTP-binding protein

GTP結合タンパク質RhoA

WordNet

1. executed with proper legal authority; "a binding contract"
2. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
3. strip sewn over or along an edge for reinforcement or decoration
4. the capacity to attract and hold something
5. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
6. the 7th letter of the Roman alphabet (同)g

PrepTutorEJDIC

1. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
2. 蛋白(たんばく)質
3. rhodiumの化学記号

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English Journal

• Di-Ras2 Forms a Complex with SmgGDS in Brain Cytosol to Be in a Low-affinity State for Guanine Nucleotides.

• Ogita Y1, Egami S1, Ebihara A1, Ueda N1, Katada T1, Kontani K2.
• The Journal of biological chemistry.J Biol Chem.2015 Jul 6. pii: jbc.M115.637769. [Epub ahead of print]
• The Ras family of small GTPases function in a wide variety of biological processes as "molecular switches" by cycling between inactive GDP-bound and active GTP-bound forms. Di-Ras1 and Di-Ras2 were originally identified as small GTPases forming a distinct subgroup of the Ras family. Di-Ras1/Di-Ras2
• PMID 26149690

• Pigment epithelium-derived factor regulates microvascular permeability through adipose triglyceride lipase in sepsis.

• He T1, Hu J2, Yan G3, Li L1, Zhang D1, Zhang Q1, Chen B2, Huang Y1.
• Clinical science (London, England : 1979).Clin Sci (Lond).2015 Jul;129(1):49-61. doi: 10.1042/CS20140631.
• The integrity of the vascular barrier, which is essential to blood vessel homoeostasis, can be disrupted by a variety of soluble permeability factors during sepsis. Pigment epithelium-derived factor (PEDF), a potent endogenous anti-angiogenic molecule, is significantly increased in sepsis, but its r
• PMID 25700221

• Cannabinoid receptor 1 but not 2 mediates macrophage phagocytosis by G(α)i/o /RhoA/ROCK signaling pathway.

• Mai P1, Tian L, Yang L, Wang L, Yang L, Li L.
• Journal of cellular physiology.J Cell Physiol.2015 Jul;230(7):1640-50. doi: 10.1002/jcp.24911.
• Phagocytosis is critical to macrophages linking innate and adaptive immune reaction. Cannabinoid receptor 1 (CB1) and 2 (CB2) mediate immune modulation. However, the role of cannabinoid receptors in macrophage phagocytosis is undefined. In this study, we found that two murine macrophage lines (J774A
• PMID 25545473

Japanese Journal

• RhoA, a Possible Target for Treatment of Airway Hyperresponsiveness in Bronchial Asthma

• , ,
• Journal of pharmacological sciences 114(3), 239-247, 2010-11-20
• … sensitization, is mainly regulated by a monomeric GTP-binding protein, RhoA, and its downstream target Rho-kinase. … In animal models of allergic bronchial asthma, an augmented agonist-induced, RhoA-mediated contraction of bronchial smooth muscle has been suggested. … The RhoA/Rho-kinase signaling is now proposed as a novel target for the treatment of airway hyperresponsiveness in asthma. …
• NAID 10029890076

• Possible role of the RhoC/ROCK pathway in progression of clear cell renal cell carcinoma

• , , , , , , , , , , ,
• Biomedical Research 29(3), 155-161, 2008
• … To clarify the role of the Rho small GTP-binding protein (Rho) and its major downstream target, ROCK (Rho-associated serine-threonine protein kinase), in progression of renal cell carcinoma (RCC), we examined mRNA expression for Rho and ROCK genes in surgical specimen of RCC tissues from 78 Japanese patients and in the corresponding non-tumor tissues originating from the same patient using a real-time reverse transcription polymerase chain reaction (RT-PCR). …
• NAID 130004470709

• 肺動脈平滑筋のホルボールエステルによるCa非依存性収縮にはCdc42が関与する(薬理学)

• , , [他], , , , , , ,
• The journal of veterinary medical science 67(8), 787-793, 2005-08-25
• … ホルボールエステルにより発生するCa^<2+>非依存性の収縮に, 低分子GTP結合タンパク質Rho GTPaseファミリーがどのように関与するかを, ブタ肺動脈平滑筋を用いて検討した.Ca^<2+>除去溶液(1mM EGTA含む)中にCキナーゼ(PKC)活性化薬である12-deoxyphorbol 13-isobutyrate (DPB, 1μM)を投与すると持続性の収縮が発生したが, この収縮は電位依存性Ca^<2+>チャネル抑制剤verapamilおよびRhoキナーゼ阻害剤Y27632では抑制されなかった.ウ …
• NAID 110003983140

Related Links

• The GTP-binding protein Rho. - National Center for ...

1. Int J Biochem Cell Biol. 1997 Nov;29(11):1225-9. The GTP-binding protein Rho. Ridley AJ. RhoA, RhoB and RhoC are three closely related proteins, and are members of the Ras super-family of small GTP-binding ...

• RHOA Gene - GeneCards | RHOA Protein | RHOA Antibody

UniProtKB/Swiss-Prot EnzymeRegulation: GTP hydrolysis is stimulated by ARHGAP30. RHOA_HUMAN,P61586 UniProtKB/Swiss-Prot Function: Regulates a signal transduction pathway ...

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★リンクテーブル★

リンク元	「GTP結合タンパク質RhoA」
関連記事	「binding」「GTP」「binding protein」「G」「Rh」

「GTP結合タンパク質RhoA」

　　[★]

英

RhoA GTP-binding protein

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「GTP」

　　[★]

• グアノシン三リン酸 guanosine triphosphate
• グルタミルトランスペプチダーゼ　→　γ-グルタミルトランスペプチダーゼ

「binding protein」

　　[★]

• 結合タンパク質、結合タンパク、結合蛋白質、結合蛋白

関

BP、carrier protein、transport protein

「G」

　　[★]

• グアニン guanine
• グアノシン guanosine
• グリシン glycine

　

「Rh」

　　[★]

• Rh抗原 Rh antigen
• ロジウム rhodium