Rab1 GTP-binding protein

GTP結合タンパク質Rab1

WordNet

1. executed with proper legal authority; "a binding contract"
2. the protective covering on the front, back, and spine of a book; "the book had a leather binding" (同)book binding, cover, back
3. strip sewn over or along an edge for reinforcement or decoration
4. the capacity to attract and hold something
5. any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
6. ancient Egyptian sun god with the head of a hawk; a universal creator; he merged with the god Amen as Amen-Ra to become the king of the gods (同)Re
7. the 7th letter of the Roman alphabet (同)g

PrepTutorEJDIC

1. 義務的な,拘束力ある / 〈U〉しばること;〈C〉しばる物 / 〈C〉製本,装丁 / 〈U〉縁(‘ふち')取り材料
2. 蛋白(たんばく)質
3. radiumの化学記号

UpToDate Contents

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• 1. 肥大型心筋症：遺伝子変異および臨床遺伝子検査 hypertrophic cardiomyopathy gene mutations and clinical genetic testing
• 2. プロテインＳ欠乏症 protein s deficiency
• 3. 鉄のバランス調節 regulation of iron balance
• 4. 慢性骨髄性白血病の細胞生物学および分子生物学 cellular and molecular biology of chronic myeloid leukemia
• 5. プロテインＣ欠乏症 protein c deficiency

English Journal

• TRAPPII regulates exocytic Golgi exit by mediating nucleotide exchange on the Ypt31 ortholog RabERAB11.

• Pinar M1, Arst HN Jr2, Pantazopoulou A1, Tagua VG1, de los Ríos V1, Rodríguez-Salarichs J3, Díaz JF3, Peñalva MA4.
• Proceedings of the National Academy of Sciences of the United States of America.Proc Natl Acad Sci U S A.2015 Apr 7;112(14):4346-51. doi: 10.1073/pnas.1419168112. Epub 2015 Mar 23.
• The oligomeric complex transport protein particle I (TRAPPI) mediates nucleotide exchange on the RAB GTPase RAB1/Ypt1. TRAPPII is composed of TRAPPI plus three additional subunits, Trs120, Trs130, and Trs65. Unclear is whether TRAPPII mediates nucleotide exchange on RAB1/Ypt1, RAB11/Ypt31, or both.
• PMID 25831508

• Phosphatidylinositol 4,5-bisphosphate is an HCV NS5A ligand and mediates replication of the viral genome.

• Cho NJ1, Lee C2, Pang PS3, Pham EA3, Fram B1, Nguyen K1, Xiong A1, Sklan EH2, Elazar M1, Koytak ES2, Kersten C2, Kanazawa KK4, Frank CW4, Glenn JS5.
• Gastroenterology.Gastroenterology.2015 Mar;148(3):616-25. doi: 10.1053/j.gastro.2014.11.043. Epub 2014 Dec 2.
• BACKGROUND & AIMS: Phosphoinositides (PIs) bind and regulate localization of proteins via a variety of structural motifs. PI 4,5-bisphosphate (PI[4,5]P2) interacts with and modulates the function of several proteins involved in intracellular vesicular membrane trafficking. We investigated intera
• PMID 25479136

• Analysis of several loci from genome-wide association studies in Parkinson's disease in mainland China.

• Liu ZH1, Guo JF2, Li K1, Wang YQ1, Kang JF1, Wei Y1, Sun QY3, Xu Q3, Wang DL4, Xia K4, Yan XX3, Xu CS5, Tang BS6.
• Neuroscience letters.Neurosci Lett.2015 Feb 5;587:68-71. doi: 10.1016/j.neulet.2014.12.027. Epub 2014 Dec 17.
• Large-scale meta-analyses of genome-wide association studies in Parkinson's disease (PD) have identified a number of susceptibility loci in sporadic PD. Since the characteristics of those loci in a Han Chinese population from mainland China were unknown, we performed a case-control replication study
• PMID 25528405

Japanese Journal

• Molecular Cloning of cDNA for BRab from the Brain of Bombyx mori and Biochemical Properties of BRab Expressed in Escherichia coli

• Uno Tomohide,Ueno Mayumi,Nakajima Ayumi [他],SHIRAI Yasuhito,AIZONO Yasuo
• Bioscience, biotechnology, and biochemistry 62(10), 1885-1891, 1998-10-23
• … From a brain cDNA library of Bombyx mori, we cloned cDNA for BRab, which encoded a 202-amino-acid polypeptide sharing 60-80% similarity with rab1 family members. … To characterize its biochemical properties, cDNA for BRab was inserted into an expression vector (pGEX2T) and expressed in Escherichia coli as a glutathione S-trans-ferase (GST) fusion protein. … The recombinant protein was purified to homogeneity with glutathione S-Sepharose. …
• NAID 110002679046

• Isolation and Characterization of cDNAs That Encode Eleven Small GTP-Binding Proteins from Pisum sativum

• NAGANO Yukio,MURAI Nobuhiko,MATSUNO Ryuichi,SASAKI Yukiko
• Plant and cell physiology 34(3), 447-455, 1993-04
• … Eleven cDNA clones (pra1 to pra9A, pra9B, and pra9C) were isolated from a pea (Pisum sativum) leaf cDNA library which were similar to small GTP-binding proteins. … The putative proteins included the characteristic sequences of ras-related small GTP-binding proteins: four conserved domains involved in binding of GTP/GDP; …
• NAID 110003720282

Related Links

• Rabファミリー低分子量Gタンパク質 - 脳科学辞典

Evolution of the Rab family of small GTP-binding proteins. J. Mol. Biol.: 2001, 313(4);889-901 [PubMed:11697911] [WorldCat.org] [DOI] ↑ 2.0 2.1 2.2 M Zerial, H McBride Rab proteins as membrane organizers. Nat. Rev. Mol. Cell ...

• Rab1 Small GTP-Binding Protein Regulates Cell Surface ...

The human calcium-sensing receptor (hCaR) is a family-3/C G-protein-coupled receptor that regulates Ca 2+ homeostasis by controlling parathyroid hormone secretion. Here we investigated the role of Rab1, a small GTP ...

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★リンクテーブル★

リンク元	「GTP結合タンパク質Rab1」
関連記事	「binding」「GTP」「binding protein」「G」

「GTP結合タンパク質Rab1」

　　[★]

英

Rab1 GTP-binding protein

「binding」

　　[★]

• n.

• 結合、バインディング

• adj.

• 結合性の

関

affinity、associate、bind、bond、bonding、combine、conjoin、conjugate、conjugation、conjunction、connect、connection、connective、connectivity、couple、dock、engage、engagement、join、ligate、linkage、symphysial、symphysic、union

　 　 　 　 　

「GTP」

　　[★]

• グアノシン三リン酸 guanosine triphosphate
• グルタミルトランスペプチダーゼ　→　γ-グルタミルトランスペプチダーゼ

「binding protein」

　　[★]

• 結合タンパク質、結合タンパク、結合蛋白質、結合蛋白

関

BP、carrier protein、transport protein

「G」

　　[★]

• グアニン guanine
• グアノシン guanosine
• グリシン glycine