Leser-Trelat徴候
WordNet
- place signs, as along a road; "sign an intersection"; "This road has been signed"
- (medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
- a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
- a character indicating a relation between quantities; "dont forget the minus sign"
- a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
- a gesture that is part of a sign language
- a public display of a message; "he posted signs in all the shop windows"
- engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
- approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
- communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
- mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
- be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
- communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
- having a handwritten signature; "a signed letter"
PrepTutorEJDIC
- (ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
- =ti
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/02/09 19:32:01」(JST)
[Wiki en表示]
Many seborrheic keratosis on the back of a person with Leser–Trélat sign due to colon cancer.
The Leser-Trélat sign is the explosive onset of multiple seborrheic keratoses[1] (many pigmented skin lesions),[2]:638[3] often with an inflammatory base. This can be an ominous sign of internal malignancy as part of a paraneoplastic syndrome. In addition to the development of new lesions, preexisting ones frequently increase in size and become symptomatic.
Contents
- 1 History
- 2 Associations
- 3 References
- 4 External links
History[edit]
It is named for Edmund Leser and Ulysse Trélat.[4][5]
It has been suggested that Leser and Trélat were observing angiomas and not seborrheic keratoses, and so the credit should properly go to Hollander for his 1900 publication.[6][7][8]
Associations[edit]
Although most associated neoplasms are gastrointestinal[9] adenocarcinomas (stomach, liver, colorectal and pancreas), malignancies of the breast, lung,[10] and urinary tract,[11] as well as lymphoid tissue, have been associated with this impressive rash. It is likely that various cytokines and other growth factors produced by the neoplasm are responsible for the abrupt appearance of the seborrheic keratoses.
In some cases, paraneoplastic acanthosis nigricans (35% of patients), Florid cutaneous papillomatosis, Ichthyosis acquisita (Acquired hypertrichosis lanuginosa), Cowden syndrome, Tylosis, Acrokeratosis paraneoplastica of Bazex and Tripe palms accompanies the sign of Leser-Trélat.
References[edit]
- ^ Schwartz RA (July 1996). "Sign of Leser-Trélat". J. Am. Acad. Dermatol. 35 (1): 88–95. doi:10.1016/S0190-9622(96)90502-2. PMID 8682971.
- ^ Odom, Richard B.; Davidsohn, Israel; James, William D.; Henry, John Bernard; Berger, Timothy G.; Clinical diagnosis by laboratory methods; Dirk M. Elston (2006). Andrews' diseases of the skin: clinical dermatology. Saunders Elsevier. ISBN 0-7216-2921-0.
- ^ "eMedicine - Sign of Leser-Trelat : Article by Robert A Schwartz".
- ^ synd/3211 at Who Named It?
- ^ Leser E. Ueber ein die Krebskrankheit beim Menschen haufig begleitendes, noch wenig gekanntes Symptom. Munchener Med Wochenschr. 1901;51:2035-2036.
- ^ "Sign of Leser-Trelat". Retrieved 15 July 2011.
- ^ Hollander E. V. Beitrage zur Fruhdiagnose des Darmcarcinomas (Hereditatsverhaltnisse und Hautveranderungen. Deutsche Medicinische Wochenschrift. 1900;26:483-485.
- ^ Lock, Stephen; Last, John M.; Dunea, George (2001-12-01). The Oxford illustrated companion to medicine. Oxford University Press US. pp. 502–. ISBN 978-0-19-262950-0. Retrieved 15 July 2011.
- ^ Gregory B, Ho VC (February 1992). "Cutaneous manifestations of gastrointestinal disorders. Part I". J. Am. Acad. Dermatol. 26 (2 Pt 1): 153–66. doi:10.1016/0190-9622(92)70019-C. PMID 1552046.
- ^ Heaphy MR, Millns JL, Schroeter AL (August 2000). "The sign of Leser-Trélat in a case of adenocarcinoma of the lung". J. Am. Acad. Dermatol. 43 (2 Pt 2): 386–90. doi:10.1016/S0190-9622(00)70301-X. PMID 10901731.
- ^ Yaniv R, Servadio Y, Feinstein A, Trau H (March 1994). "The sign of Leser-Trélat associated with transitional cell carcinoma of the urinary-bladder--a case report and short review". Clin. Exp. Dermatol. 19 (2): 142–5. PMID 8050144.
External links[edit]
- New Zealand Dermatological Society Includes images
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Eponymous medical signs for integumentary system
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| Skin |
- Asboe-Hansen sign
- Auspitz's sign
- Borsari's sign
- Braverman's sign
- Crowe sign
- Dennie–Morgan fold
- Darier's sign
- Fitzpatrick's sign
- Florid cutaneous papillomatosis
- Gottron's sign
- Hutchinson's sign
- Janeway lesion
- Kerr's sign
- Koebner's phenomenon
- Koplik spots
- Leser-Trelat sign
- Nikolsky's sign
- Pastia's sign
- Russell's sign
- Wickham striae
- Wolf's isotopic response
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| Nails |
- Aldrich-Mees' lines
- Beau's lines
- Muehrcke's lines
- Terry's nails
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noco (i/b/d/q/u/r/p/m/k/v/f)/cong/tumr (n/e/d), sysi/epon
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proc, drug (D2/3/4/5/8/11)
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noco/cong/tumr, sysi/epon
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Eponymous medical signs for oncology
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| Hematological malignancy |
- Russell bodies
- Auer rod
- Bence Jones protein
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| Lymph nodes |
- Virchow's node ( Troisier's sign )
- Sister Mary Joseph nodule
- Lund's node
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| Other |
- Call-Exner bodies
- Leser–Trélat sign
- Trousseau sign of malignancy
- Courvoisier's law
- Schiller-Duval body
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Paraneoplastic syndromes
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| Endocrine |
- Hypercalcaemia
- SIADH
- Zollinger–Ellison syndrome
- Cushing's syndrome
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| Hematological |
- Granulocytosis
- Multicentric reticulohistiocytosis
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| Neurological |
- Paraneoplastic cerebellar degeneration
- Encephalomyelitis
- Limbic encephalitis
- Opsoclonus
- Polymyositis
- Transverse myelitis
- Lambert–Eaton myasthenic syndrome
- Anti-NMDA receptor encephalitis
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| Musculoskeletal |
- Dermatomyositis
- Hypertrophic osteopathy
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| Mucocutaneous |
| reactive erythema: |
- Erythema gyratum repens
- Necrolytic migratory erythema
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| papulosquamous: |
- Acanthosis nigricans
- Ichthyosis acquisita
- Acrokeratosis paraneoplastica of Bazex
- Extramammary Paget's disease
- Florid cutaneous papillomatosis
- Leser-Trélat sign
- Pityriasis rotunda
- Tripe palms
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| other/ungrouped: |
- Febrile neutrophilic dermatosis
- Pyoderma gangrenosum
- Paraneoplastic pemphigus
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UpToDate Contents
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- 1. 内臓悪性腫瘍の皮膚症状 cutaneous manifestations of internal malignancy
- 2. 皮膚の良性病変の概要 overview of benign lesions of the skin
- 3. 原発性肝細胞癌の臨床的特徴および診断 clinical features and diagnosis of primary hepatocellular carcinoma
English Journal
- Sign and Pseudo-Sign of Leser-Trelat.
- Kowalzick L, Truhm B, Eickenscheidt L.Abstract.
- Journal of drugs in dermatology : JDD.J Drugs Dermatol.2014 Jan 1;13(1):14.
- .
- PMID 24385114
- Leser-Trélat sign: does it really exist?
- Turan E, Yesilova Y, Yurt N, Koçarslan S.Author information Department of Dermatology, Faculty of Medicine, University of Harran, 63200-Sanliurfa, Turkey. enverturan@gmail.comAbstractLeser-Trélat sign is a rare cutaneous disorder that manifests with sudden emergence of seborrheic keratoses and increase in their numbers and size within weeks or months. Its concurrence with many types of malignancies, especially adenocarcinoma and lymphoma, has been reported in the literature. In this case report, a patient having Leser-Trélat sign, without any detected malignancy in spite of detailed examination and 18 months of follow up, is presented. Current literature is reviewed in relation to the debate whether Leser-Trélat is a paraneoplastic syndrome or not.
- Acta dermatovenerologica Croatica : ADC.Acta Dermatovenerol Croat.2013 Aug;21(2):123-7.
- Leser-Trélat sign is a rare cutaneous disorder that manifests with sudden emergence of seborrheic keratoses and increase in their numbers and size within weeks or months. Its concurrence with many types of malignancies, especially adenocarcinoma and lymphoma, has been reported in the literature. In
- PMID 24001422
- Eruptive seborrheic keratoses associated with adalimumab use.
- Eastman KL, Knezevich SR, Raugi GJ.Author information University of Washington School of Medicine, Seattle, WA, USA;AbstractBACKGROUND: Seborrheic keratoses are common, benign cutaneous growths, however in rare situations they can acutely erupt in large numbers. Eruptive seborrheic keratoses can be associated with internal malignancy (sign of Leser-Trelat), but may also appear in conjunction with inflammatory dermatoses and adverse drug reactions.
- Journal of dermatological case reports.J Dermatol Case Rep.2013 Jun 30;7(2):60-3. doi: 10.3315/jdcr.2013.1139. Print 2013 Jun 30.
- BACKGROUND: Seborrheic keratoses are common, benign cutaneous growths, however in rare situations they can acutely erupt in large numbers. Eruptive seborrheic keratoses can be associated with internal malignancy (sign of Leser-Trelat), but may also appear in conjunction with inflammatory dermatoses
- PMID 23858344
Japanese Journal
- 症例 食道癌が発見されたLeser-Trelat徴候の1例
- 安藤 英也,前田 正司,亀岡 伸樹,藤本 克博,坪井 俊二
- 日本臨床外科学会雑誌 = The journal of the Japan Surgical Association 67(6), 1223-1226, 2006-06-25
- NAID 10018199325
- 安藤 英也,前田 正司,亀岡 伸樹,藤本 克博,坪井 俊二
- 日本臨床外科学会雑誌 67(6), 1223-1226, 2006
- … Leser-Trélat徴候は,掻痒感を伴う脂漏性角化症が急速に出現して悪性腫瘍を合併するもの定義されている.今回われわれはL-T徴候を呈した乳癌の1例を経験したので,文献的考察を加え報告する.症例は66歳,女性.主訴は右乳房の腫瘤と乳頭異常分泌.現病歴は以前より右乳房の腫瘤を自覚していたが,平成11年7月より乳頭異常分泌が出現したため7月上旬に外来受診.現症は右乳房全体に硬い腫瘤を触知し乳頭より黄褐色の分泌物を …
- NAID 130003605045
Related Links
- The Leser-Trelat sign is the explosive onset of multiple seborrheic keratoses ( many pigmented skin lesions), :638 often with an inflammatory base. This can be an ominous sign of internal malignancy as part of a paraneoplastic syndrome. ...
★リンクテーブル★
[★]
- 英
- Leser-Trélat sign, Leser-Trelat sign
- 同
- Leser-Trélat徴候, Leser-Trelat徴候
- 関
- 脂漏性角化症、老人性疣贅
- a condition of malignant cells present in the skin, characterized by the sudden onset of multiple seborrheic keratoses, with pruritus or enlargement of preexisting keratosis in older adults. It is associated with adenocarcinoma of the stomach, breast cancer, and lung cancer.
- 加齢性疣贅(脂漏性角化症)が数ヶ月で急速に増え、掻痒を伴うもの ← 普通の脂漏性角化症では掻痒はない、はず。
- 合併する悪性腫瘍：胃癌、肺癌、乳癌、子宮癌の順に多い
参考
- http://www.nejm.org/doi/pdf/10.1056/NEJMicm062851
- http://emedicine.medscape.com/article/1097299-overview
- http://encyclopedia.thefreedictionary.com/Leser-Trelat+sign
- http://www.dermpedia.org/files/images/Picture8_8.jpg
- http://www.nejm.org/na102/home/ACS/publisher/mms/journals/content/nejm/2007/nejm_2007.356.issue-21/nejmicm062851/production/images/large/nejmicm062851_f1.jpeg
uptodate
- 1. [charged] 内臓悪性腫瘍の皮膚症状 - uptodate [1]
国試
[★]
- 関
- indication、manifestation、signature、stigma、stigmata、symptom、symptomatic
