Cellular expression

B細胞、T細胞、NK細胞、肥満細胞、好中球

M.W.(kDa)

64

Functions

IL-2 receptor γ chain, common subunit of IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 receptor

Family

Cytokine receptor

同: common γ-chain

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2018/01/17 03:05:40」(JST)

wiki en

[Wiki en表示]

The common gamma chain (γ_c) (or CD132), also known as interleukin-2 receptor subunit gamma or IL-2RG, is a cytokine receptor sub-unit that is common to the receptor complexes for at least six different interleukin receptors: IL-2, IL-4,^[5] IL-7,^[6] IL-9, IL-15^[7] and interleukin-21 receptor. The γ_c glycoprotein is a member of the type I cytokine receptor family expressed on most lymphocyte (white blood cell) populations, and its gene is found on the X-chromosome of mammals.

This protein is located on the surface of immature blood-forming cells in bone marrow. One end of the protein resides outside the cell where it binds to cytokines and the other end of the protein resides in the interior of the cell where it transmits signals to the cell's nucleus. The common gamma chain partners with other proteins to direct blood-forming cells to form lymphocytes (a type of white blood cell). The receptor also directs the growth and maturation of lymphocyte subtypes: T cells, B cells, and natural killer cells. These cells kill viruses, make antibodies, and help regulate the entire immune system.

Gene

Cytokine receptor common subunit gamma also known as interleukin-2 receptor subunit gamma or IL-2RG is a protein that in humans is encoded by the IL2RG gene.^[8] The human IL2RG gene is located on the long (q) arm of the X chromosome at position 13.1, from base pair 70,110,279 to base pair 70,114,423.

IL-7 receptor and signaling, common γ chain (blue) and IL-7 receptor-α (green)

Structure

The γ_c chain is an integral membrane protein that contains extracellular, transmembrane, and intracellular domains.

Function

Lymphocytes expressing the common gamma chain can form functional receptors for these cytokine proteins, which transmit signals from one cell to another and direct programs of cellular differentiation.

Ligands

The γ_c chain partners with other ligand-specific receptors to direct lymphocytes to respond to cytokines including IL-2, IL-4, IL-7, IL-9, IL-15 and IL-21.^[9]

Signalling

IL2RG has been shown to interact with Janus kinase 3.^[10]^[11]

Clinical significance

X-linked severe combined immunodeficiency

X-linked severe combined immunodeficiency is caused by mutations in the IL2RG gene. More than 200 different mutations in the IL2RG gene have been identified in people with X-linked severe combined immunodeficiency (SCID).^[12] Most of these mutations involve changes in one or a few nucleotides (DNA building blocks) in the gene. These changes lead to the production of a nonfunctional version of the common gamma chain protein^{[citation needed]} or no production of protein.^[13] Without the common gamma chain, important chemical signals are not relayed to the nucleus and lymphocytes cannot develop normally. A lack of functional mature lymphocytes disrupts the immune system's ability to protect the body from infection. Sufferers have no functional immunity and can die within months after birth without successful bone marrow transplantation or alternatively, isolation from exposure to pathogens. Without important developmental signals from IL-7 and IL-15, T-cell and NK cell populations respectively fail to develop.

Experiments in animal models have shown X-SCID to occur similarly in dogs, but not in mice.^[14]

Schizophrenia

Alterations in the immune response are involved in pathogenesis of many neuropsychiatric disorders including schizophrenia. Distinct gene variants of a number of pro-inﬂammatory and chemotactic cytokines together with their receptors associate with this disorder. IL2RG represents an important signaling component of many interleukin receptors and so far, no data on the functional state of this receptor in schizophrenia have been reported. Over-expression of the IL2RG gene may be implicated in altered immune response in schizophrenia and contribute to the pathogenesis of this disorder.^[15]

References

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017
^ "Human PubMed Reference:".
^ "Mouse PubMed Reference:".
^ Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE (December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor". Science. 262 (5141): 1880–3. doi:10.1126/science.8266078. PMID 8266078.
^ Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science. 262 (5141): 1877–80. doi:10.1126/science.8266077. PMID 8266077.
^ Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM (August 1995). "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor". EMBO J. 14 (15): 3654–63. PMC 394440 . PMID 7641685.
^ Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K (July 1992). "Cloning of the gamma chain of the human IL-2 receptor". Science. 257 (5068): 379–82. doi:10.1126/science.1631559. PMID 1631559.
^ Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K (July 2001). "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex". J. Immunol. 167 (1): 1–5. doi:10.4049/jimmunol.167.1.1. PMID 11418623.
^ Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045–7. doi:10.1126/science.7973659. PMID 7973659.
^ Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID". Science. 266 (5187): 1042–5. doi:10.1126/science.7973658. PMID 7973658.
^ Vihinen M, Arredondo-Vega FX, Casanova JL, Etzioni A, Giliani S, Hammarström L, Hershfield MS, Heyworth PG, Hsu AP, Lähdesmäki A, Lappalainen I, Notarangelo LD, Puck JM, Reith W, Roos D, Schumacher RF, Schwarz K, Vezzoni P, Villa A, Väliaho J, Smith CI (2001). "Primary immunodeficiency mutation databases". Adv. Genet. 43: 103–88. doi:10.1016/s0065-2660(01)43005-7. PMID 11037300.
^ Schmalstieg FC, Leonard WJ, Noguchi M, Berg M, Rudloff HE, Denney RM, Dave SK, Brooks EG, Goldman AS (March 1995). "Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency". J. Clin. Invest. 95 (3): 1169–73. doi:10.1172/JCI117765. PMC 441454 . PMID 7883965.
^ Henthorn PS, Somberg RL, Fimiani VM, Puck JM, Patterson DF, Felsburg PJ (September 1994). "IL-2R gamma gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease". Genomics. 23 (1): 69–74. doi:10.1006/geno.1994.1460. PMID 7829104.
^ Ghazaryan H, Petrek M, Boyajyan A (2014). "Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene". Psychiatry Res. 217 (3): 158–62. doi:10.1016/j.psychres.2014.03.020. PMID 24713359.

External links

Interleukin Receptor Common gamma Subunit at the US National Library of Medicine Medical Subject Headings (MeSH)

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. X連鎖重度複合型免疫不全（SCID） x linked severe combined immunodeficiency scid
2. 重度複合型免疫不全（SCID）：特定の欠損 severe combined immunodeficiency scid specific defects
3. 原発性免疫不全症に対する遺伝子治療 gene therapy for primary immunodeficiency
4. 重度複合型免疫不全（SCID）：概要 severe combined immunodeficiency scid an overview
5. 複合免疫不全 combined immunodeficiencies

English Journal

Isolation and characterization of renal cancer stem cells from patient-derived xenografts.

Hasmim M1,2, Bruno S3, Azzi S2, Gallerne C2, Michel JG2, Chiabotto G4, Lecoz V2, Romei C5, Spaggiari GM5, Pezzolo A6, Pistoia V6, Angevin E1,7, Gad S1,8, Ferlicot S1,9, Messai Y1, Kieda C10, Clay D11, Sabatini F12, Escudier B1,7, Camussi G4, Eid P2, Azzarone B5, Chouaib S1.
Oncotarget.Oncotarget.2015 Nov 2. doi: 10.18632/oncotarget.6266. [Epub ahead of print]
As rapidly developing patient-derived xenografts (PDX) could represent potential sources of cancer stem cells (CSC), we selected and characterized non-cultured PDX cell suspensions from four different renal carcinomas (RCC). Only the cell suspensions from the serial xenografts (PDX-1 and PDX-2) of a
PMID 26551931

Thymic emigration patterns in patients with type 2 diabetes treated with metformin.

Dworacki G1, Urazayev O2, Bekmukhambetov Y2, Iskakova S3, Frycz BA4, Jagodziński PP4, Dworacka M5.
Immunology.Immunology.2015 Nov;146(3):456-69. doi: 10.1111/imm.12522. Epub 2015 Oct 5.
Recent data suggest that thymic output, which provides the naive T cells necessary for the normal functioning of T-cell-dependent immunosurveillance cellular immunity including anti-cancer protection, can be disturbed in the course of type 2 diabetes. Metformin, an anti-diabetic drug commonly confir
PMID 26271466

Immune dysregulation in Alagille syndrome: A new feature of the evolving phenotype.

Tilib Shamoun S1, Le Friec G2, Spinner N3, Kemper C2, Baker AJ4.
Clinics and research in hepatology and gastroenterology.Clin Res Hepatol Gastroenterol.2015 Oct;39(5):566-9. doi: 10.1016/j.clinre.2015.02.003. Epub 2015 May 27.
Alagille syndrome (ALGS) is a rare autosomal dominant, multi-system disease caused by mutations in one of two NOTCH signaling pathway genes. Mutations in JAG1 are found in more than 94% of patients, with associated Jagged1 defects. We previously showed that CD46, which is a complement and immune reg
PMID 26026399

Japanese Journal

Increased plasma interleukin-7 level correlates with decreased CD127 and increased CD132 extracellular expression on T cell subsets in patients with HIV-1 infection

SASSON S. C.
J. Infect. Dis. 193, 505, 2006
NAID 30017496139

X-SCID遺伝子治療における白血病発症とその対策 (特集遺伝子治療--新たな戦略)

久米晃啓
ゲノム医学 3(4), 381-385, 2003-08
NAID 40005924589

Related Pictures

Ford CD132 - NAV Module - DND Services Ltd CD132 - MST-Design Water transfer printing and varnish accessories SONY CD132 6 CD Ford Mondeo oryginalne z kodem - Sprzedajemy.pl Ford cd132-cd6 manual HD-TVI DVR 16 Channel 720p 2U Tribrid - Regal Security - Quality Security Product Supplier CD/MP3-ресивер автомагнитола 2-din Ford Sony mp3 Mondeo 3 (III

★リンクテーブル★

リンク元	「IL-2」「IL-4」
関連記事	「CD13」「CD1」

「IL-2」

IL2RG
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2B5I, 2ERJ, 3BPL, 3QAZ, 3QB7, 4GS7
Identifiers
Aliases	IL2RG, CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, interleukin 2 receptor subunit gamma
External IDs	OMIM: 308380 MGI: 96551 HomoloGene: 172 GeneCards: IL2RG
Gene location (Human)
Chr.	X chromosome (human)
End	71,112,108 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	101,268,255 bp
RNA expression pattern
	More reference expression data
Gene ontology
Molecular function	• interleukin-7 receptor activity; • interleukin-2 receptor activity; • protein binding; • cytokine receptor activity; • interleukin-4 receptor activity; • Ras guanyl-nucleotide exchange factor activity; • interleukin-2 binding;
Cellular component	• integral component of membrane; • membrane; • plasma membrane; • integral component of plasma membrane; • external side of plasma membrane; • endosome; • cytosol;
Biological process	• MAPK cascade; • immune response; • viral process; • signal transduction; • interleukin-2-mediated signaling pathway; • interleukin-4-mediated signaling pathway; • interleukin-7-mediated signaling pathway; • interleukin-15-mediated signaling pathway; • interleukin-9-mediated signaling pathway; • regulation of molecular function;
	Sources:Amigo / QuickGO
Orthologs
	3561
	16186
	ENSG00000147168
	ENSMUSG00000031304
	P31785
	P34902
	NM_000206
	NM_013563; NM_001308535
	NP_000197
	NP_001295464; NP_038591
	Wikidata
View/Edit Human	View/Edit Mouse

　　[★]

英: interleukin-2, interleukin 2
同: インターロイキン2。T細胞増殖因子 T-cell growth factor TCGF
関: インターロイキン

産生細胞

T細胞(Th1細胞？)

機能

文献によりまちまち

T細胞増殖
Th細胞の増殖、B細胞の増殖、LAK細胞の増殖
T細胞の活性化・増殖・分化。LAK細胞の活性化

受容体

CD25α、CD122β、CD132(γc)

参考

1.

http://www.i-l-fitness-jp.com/comment/img/killer-t-cell-7.JPG

2.

http://www.medicalfood.org/disease-management/listerv.html

3.

http://www.j-tajiri.or.jp/source/translation/b/03/01.html

「IL-4」

　　[★]

英: interleukin-4, interleukin 4
同: インターロイキン4、インターロイキン-4
関: サイトカイン、インターロイキン

概念

B細胞のIgのクラススイッチを促進(SP.251)　← IgEへのクラススイッチ

産生細胞

T細胞、肥満細胞

機能

B細胞活性化、IgEスイッチ、Th2細胞への分化誘導

受容体

CD124, CD132

「CD13」

　　[★]

同: MY7, Aminopeptidase N

概念

WCH.33

2型の膜タンパクでメタロプロテアーゼファミリー(CD10,CD26,CD73等)に属する。
ホモ2量体
遺伝子：15q25
分子量：150 kDa
発現：骨髄球系・単球系の細胞系統に発現。多くの急性骨髄性白血病と少数のリンパ芽球性白血病(5-10%)でみられる。骨髄細胞による細胞間接着による発現制御を受けており、in vitroではCD13は発現しない。その他の組織でも発現している(略)。
機能：RNAコロナウイルスの受容体。内皮の形態形成と細胞の移動性を制御しており、血管新生と腫瘍進展のいずれにおいても重要な役割を果たしている。

「CD1」

　　[★]

同: leucine-6, CD1A through E

種類

CD1a, CD1b, CD1c, CD1d

発現組織

胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

43-49

機能

MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000147168 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000031304 - Ensembl, May 2017

[3] "Human PubMed Reference:".

[4] "Mouse PubMed Reference:".

[pmid8266078-5] Russell SM, Keegan AD, Harada N, Nakamura Y, Noguchi M, Leland P, Friedmann MC, Miyajima A, Puri RK, Paul WE (December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor". Science. 262 (5141): 1880–3. doi:10.1126/science.8266078. PMID 8266078.

[pmid8266077-6] Noguchi M, Nakamura Y, Russell SM, Ziegler SF, Tsang M, Cao X, Leonard WJ (December 1993). "Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor". Science. 262 (5141): 1877–80. doi:10.1126/science.8266077. PMID 8266077.

[pmid7641685-7] Giri JG, Kumaki S, Ahdieh M, Friend DJ, Loomis A, Shanebeck K, DuBose R, Cosman D, Park LS, Anderson DM (August 1995). "Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor". EMBO J. 14 (15): 3654–63. PMC 394440 . PMID 7641685.

[pmid1631559-8] Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, Munakata H, Nakamura M, Sugamura K (July 1992). "Cloning of the gamma chain of the human IL-2 receptor". Science. 257 (5068): 379–82. doi:10.1126/science.1631559. PMID 1631559.

[pmid11418623-9] Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, Sugamura K (July 2001). "Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex". J. Immunol. 167 (1): 1–5. doi:10.4049/jimmunol.167.1.1. PMID 11418623.

[pmid7973659-10] Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu ZJ, Oishi I, Silvennoinen O, Witthuhn BA, Ihle JN (November 1994). "Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits". Science. 266 (5187): 1045–7. doi:10.1126/science.7973659. PMID 7973659.

[pmid7973658-11] Russell SM, Johnston JA, Noguchi M, Kawamura M, Bacon CM, Friedmann M, Berg M, McVicar DW, Witthuhn BA, Silvennoinen O (November 1994). "Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID". Science. 266 (5187): 1042–5. doi:10.1126/science.7973658. PMID 7973658.

[pmid11037300-12] Vihinen M, Arredondo-Vega FX, Casanova JL, Etzioni A, Giliani S, Hammarström L, Hershfield MS, Heyworth PG, Hsu AP, Lähdesmäki A, Lappalainen I, Notarangelo LD, Puck JM, Reith W, Roos D, Schumacher RF, Schwarz K, Vezzoni P, Villa A, Väliaho J, Smith CI (2001). "Primary immunodeficiency mutation databases". Adv. Genet. 43: 103–88. doi:10.1016/s0065-2660(01)43005-7. PMID 11037300.

[pmid7883965-13] Schmalstieg FC, Leonard WJ, Noguchi M, Berg M, Rudloff HE, Denney RM, Dave SK, Brooks EG, Goldman AS (March 1995). "Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency". J. Clin. Invest. 95 (3): 1169–73. doi:10.1172/JCI117765. PMC 441454 . PMID 7883965.

[pmid7829104-14] Henthorn PS, Somberg RL, Fimiani VM, Puck JM, Patterson DF, Felsburg PJ (September 1994). "IL-2R gamma gene microdeletion demonstrates that canine X-linked severe combined immunodeficiency is a homologue of the human disease". Genomics. 23 (1): 69–74. doi:10.1006/geno.1994.1460. PMID 7829104.

[pmid24713359-15] Ghazaryan H, Petrek M, Boyajyan A (2014). "Chronic schizophrenia is associated with over-expression of the interleukin-2 receptor gamma gene". Psychiatry Res. 217 (3): 158–62. doi:10.1016/j.psychres.2014.03.020. PMID 24713359.

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

匿名

検索

案内

CD132

Cellular expression

M.W.(kDa)

Functions

Family

Wikipedia preview

wiki en

Contents

Gene

Structure

Function

Ligands

Signalling

Clinical significance

X-linked severe combined immunodeficiency

Schizophrenia

References

Further reading

External links

UpToDate Contents

English Journal

Japanese Journal

Related Links

Related Pictures

★リンクテーブル★

「IL-2」

産生細胞

機能

受容体

参考

「IL-4」

概念

産生細胞

機能

受容体

「CD13」

概念

「CD1」

種類

発現組織

分子量

機能