同: Interleukin-4 receptor

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/11/08 15:50:16」(JST)

wiki en

Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.

This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.^[1]

Interactions

Interleukin-4 receptor has been shown to interact with SHC1.^[2]^[3]

Structure

The N-terminal (extracellular) portion of interleukin-4 is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.^[4]

References

^ "Entrez Gene: IL4R interleukin 4 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3566.
^ Ikizawa, K; Yanagihara Y (February 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. ISSN 0006-291X. PMID 10652211.
^ Kashiwada, M; Giallourakis C C, Pan P Y, Rothman P B (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. (United States) 167 (11): 6382–7. ISSN 0022-1767. PMID 11714803.
^ Hage T, Sebald W, Reinemer P (April 1999). "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface". Cell 97 (2): 271–81. doi:10.1016/S0092-8674(00)80736-9. PMID 10219247.

External links

CD124+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the public domain Pfam and InterPro IPR015319

This membrane protein-related article is a stub. You can help Wikipedia by expanding it.

English Journal

An intravenous exposure mouse model for prediction of potential drug-sensitization using reporter antigens popliteal lymph node assay.

Lin M, Sun W, Wang Y, Li X, Jin Y, Gong W, Fan X, Wang Y.SourceCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
Journal of applied toxicology : JAT.J Appl Toxicol.2012 Jun;32(6):395-401. doi: 10.1002/jat.1696. Epub 2011 Jul 1.
Immune-mediated drug hypersensitivity is a particularly concerning health-safety issue among clinicians given its unpredictability and potentially life-threatening effects, especially with exposure to intravenous drugs. Therefore, the development of intravenous drug-exposure models for drug-hazard a
PMID 21721018

Regulation of NADPH Oxidase Gene Expression with PKA and Cytokine IL-4 in Neurons and Microglia.

Savchenko VL.SourceDepartment of Geriatrics, University of Arkansas, Little Rock, AR, USA, vsavche1@gmail.com.
Neurotoxicity research.Neurotox Res.2012 May 8. [Epub ahead of print]
Neuronal excitation is mediated by the activation of NMDA receptor and associated with the formation of reactive oxygen species due to the activation of NADPH oxidase complex proteins. The activation of G(s) protein coupled receptors (GPCRs) induces neuronal activation in the cAMP-dependent protein
PMID 22565378

Related Pictures

Cecilware CD124 Slinger Disc CD124 B&M Crappie Duster 12 Ft Fishing Pole - Walmart.com Cipo & Baxx CD124 Regular Fit Jeans - Cipo & Baxx from Zutti UK Casino Uniforms - Custom Designed Casino Apparel for All Positions Matfer CD124 | Moulds | CAS Sport Trophies – Khoja Group

★リンクテーブル★

リンク元	「IL-4」
関連記事	「CD1」

「IL-4」

Interleukin-4 receptor alpha chain, N-terminal
	interleukin-4 / receptor alpha chain complex
Identifiers
Symbol	IL4Ra_N
Pfam	PF09238
InterPro	IPR015319
SCOP	1iar
SUPERFAMILY	1iar
Available protein structures:
Pfam	structures
PDB	RCSB PDB; PDBe
PDBsum	structure summary

Interleukin 4 receptor
	; PDB rendering based on 1iar.
Available structures
PDB	Ortholog search: PDBe, RCSB
List of PDB id codes
	1IAR, 1IRS, 3BPL, 3BPN, 3BPO
Identifiers
Symbols	IL4R; CD124; IL-4RA; IL4RA
External IDs	OMIM: 147781 MGI: 105367 HomoloGene: 7784 GeneCards: IL4R Gene
Gene Ontology
Molecular function	• interleukin-4 receptor activity; • receptor signaling protein activity; • protein binding; • insulin receptor substrate binding;
Cellular component	• extracellular region; • integral to plasma membrane;
Biological process	• production of molecular mediator involved in inflammatory response; • immune response; • signal transduction; • interleukin-4-mediated signaling pathway;
	Sources: Amigo / QuickGO
RNA expression pattern
	More reference expression data
Orthologs
	This box: view; talk; edit;

　　[★]

英: interleukin-4, interleukin 4
同: インターロイキン4、インターロイキン-4
関: サイトカイン、インターロイキン

概念

B細胞のIgのクラススイッチを促進(SP.251)　← IgEへのクラススイッチ

産生細胞

T細胞、肥満細胞

機能

B細胞活性化、IgEスイッチ、Th2細胞への分化誘導

受容体

CD124, CD132

「CD1」

　　[★]

同: leucine-6, CD1A through E

種類

CD1a, CD1b, CD1c, CD1d

発現組織

胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)

分子量

43-49

機能

MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens

[1] "Entrez Gene: IL4R interleukin 4 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3566.

[pmid10652211-2] Ikizawa, K; Yanagihara Y (February 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. ISSN 0006-291X. PMID 10652211.

[pmid11714803-3] Kashiwada, M; Giallourakis C C, Pan P Y, Rothman P B (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. (United States) 167 (11): 6382–7. ISSN 0022-1767. PMID 11714803.

[pmid10219247-4] Hage T, Sebald W, Reinemer P (April 1999). "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface". Cell 97 (2): 271–81. doi:10.1016/S0092-8674(00)80736-9. PMID 10219247.

匿名

検索

案内

案内

CD124