- 同
- Interleukin-4 receptor
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2012/11/08 15:50:16」(JST)
[Wiki en表示]
Interleukin 4 receptor |
PDB rendering based on 1iar. |
Available structures |
PDB |
Ortholog search: PDBe, RCSB |
List of PDB id codes |
1IAR, 1IRS, 3BPL, 3BPN, 3BPO
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Identifiers |
Symbols |
IL4R; CD124; IL-4RA; IL4RA |
External IDs |
OMIM: 147781 MGI: 105367 HomoloGene: 7784 GeneCards: IL4R Gene |
Gene Ontology |
Molecular function |
• interleukin-4 receptor activity
• receptor signaling protein activity
• protein binding
• insulin receptor substrate binding
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Cellular component |
• extracellular region
• integral to plasma membrane
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Biological process |
• production of molecular mediator involved in inflammatory response
• immune response
• signal transduction
• interleukin-4-mediated signaling pathway
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Sources: Amigo / QuickGO |
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RNA expression pattern |
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More reference expression data |
Orthologs |
Species |
Human |
Mouse |
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Entrez |
3566 |
16190 |
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Ensembl |
ENSG00000077238 |
ENSMUSG00000030748 |
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UniProt |
P24394 |
P16382 |
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RefSeq (mRNA) |
NM_000418.3 |
NM_001008700.3 |
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RefSeq (protein) |
NP_000409.1 |
NP_001008700.1 |
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Location (UCSC) |
Chr 16:
27.32 – 27.38 Mb |
Chr 7:
125.55 – 125.58 Mb |
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PubMed search |
[1] |
[2] |
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Interleukin-4 receptor alpha chain, N-terminal |
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interleukin-4 / receptor alpha chain complex |
Identifiers |
Symbol |
IL4Ra_N |
Pfam |
PF09238 |
InterPro |
IPR015319 |
SCOP |
1iar |
SUPERFAMILY |
1iar |
Available protein structures: |
Pfam |
structures |
PDB |
RCSB PDB; PDBe |
PDBsum |
structure summary |
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Interleukin 4 receptor is a type I cytokine receptor. IL4R is its human gene.
This gene encodes the alpha chain of the interleukin-4 receptor, a type I transmembrane protein that can bind interleukin 4 and interleukin 13 to regulate IgE antibody production in B cells. Among T cells, the encoded protein also can bind interleukin 4 to promote differentiation of Th2 cells. A soluble form of the encoded protein can be produced by an alternate splice variant or by proteolysis of the membrane-bound protein, and this soluble form can inhibit IL4-mediated cell proliferation and IL5 upregulation by T-cells. Allelic variations in this gene have been associated with atopy, a condition that can manifest itself as allergic rhinitis, sinusitus, asthma, or eczema. Two transcript variants encoding different isoforms, a membrane-bound and a soluble form, have been found for this gene.[1]
Contents
- 1 See also
- 2 Interactions
- 3 Structure
- 4 References
- 5 Further reading
- 6 External links
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See also
- Cluster of differentiation
Interactions
Interleukin-4 receptor has been shown to interact with SHC1.[2][3]
Structure
The N-terminal (extracellular) portion of interleukin-4 is related in overall topology to fibronectin type III modules and folds into a sandwich comprising seven antiparallel beta sheets arranged in a three-strand and a four-strand beta-pleated sheet. They are required for binding of interleukin-4 to the receptor alpha chain, which is a crucial event for the generation of a Th2-dominated early immune response.[4]
References
- ^ "Entrez Gene: IL4R interleukin 4 receptor". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3566.
- ^ Ikizawa, K; Yanagihara Y (February 2000). "Possible involvement of Shc in IL-4-induced germline epsilon transcription in a human B cell line". Biochem. Biophys. Res. Commun. (UNITED STATES) 268 (1): 54–9. doi:10.1006/bbrc.2000.2080. ISSN 0006-291X. PMID 10652211.
- ^ Kashiwada, M; Giallourakis C C, Pan P Y, Rothman P B (December 2001). "Immunoreceptor tyrosine-based inhibitory motif of the IL-4 receptor associates with SH2-containing phosphatases and regulates IL-4-induced proliferation". J. Immunol. (United States) 167 (11): 6382–7. ISSN 0022-1767. PMID 11714803.
- ^ Hage T, Sebald W, Reinemer P (April 1999). "Crystal structure of the interleukin-4/receptor alpha chain complex reveals a mosaic binding interface". Cell 97 (2): 271–81. doi:10.1016/S0092-8674(00)80736-9. PMID 10219247.
Further reading
- Nelms K, Keegan AD, Zamorano J, et al. (1999). "The IL-4 receptor: signaling mechanisms and biologic functions.". Annu. Rev. Immunol. 17 (1): 701–38. doi:10.1146/annurev.immunol.17.1.701. PMID 10358772.
- Jiang H, Harris MB, Rothman P (2000). "IL-4/IL-13 signaling beyond JAK/STAT.". J. Allergy Clin. Immunol. 105 (6 Pt 1): 1063–70. doi:10.1067/mai.2000.107604. PMID 10856136.
PDB gallery
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1iar: INTERLEUKIN-4 / RECEPTOR ALPHA CHAIN COMPLEX
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External links
- CD124+Antigen at the US National Library of Medicine Medical Subject Headings (MeSH)
Cytokine receptors
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Chemokine receptor
(GPCRs) |
CC |
- CCR1/CCRL1
- CCR2
- CCRL2
- CCR3
- CCR4
- CCR5
- CCR6
- CCR7
- CCR8
- CCR9
- CCR10
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CXC |
- IL-8
- CXCR3
- CXCR4
- CXCR5
- CXCR6
- CXCR7
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Other |
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TNF receptor |
1-10 |
- TNFRSF1 (CD120)
- TNFRSF1A (CD120a)
- TNFRSF1B (CD120b)
- TNFRSF3 (Lymphotoxin beta receptor)
- TNFRSF4 (CD134)
- TNFRSF5 (CD40)
- TNFRSF6 (FAS)
- TNFRSF6B
- TNFRSF7 (CD27)
- TNFRSF8 (CD30)
- TNFRSF9 (CD137)
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11-20 |
- TNFRSF10A (CD261)
- TNFRSF10B (CD262)
- TNFRSF10C (CD263)
- TNFRSF10D (CD264)
- TNFRSF11A (CD265/RANK)
- TNFRSF11B (Osteoprotegerin)
- TNFRSF12A (CD266)
- TNFRSF13B (CD267)
- TNFRSF13C
- TNFRSF14 (CD268)
- TNFRSF16 (Nerve growth factor receptor)
- TNFRSF17 (CD269)
- TNFRSF18
- TNFRSF19
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21-25 |
- TNFRSF21
- TNFRSF25
- TNFRSF27
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JAK-STAT |
Type I |
γ-chain |
- Interleukin receptors
- IL2R/IL2RA/IL2RB/IL15R
- IL4R/IL13R/IL13RA1/IL13RA2
- IL7R/IL7RA
- IL9R
- IL21R
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β-chain |
- Interleukin receptors
- GM-CSF
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gp130 |
- Interleukin receptors
- IL6RA
- 11/IL11RA
- 27/IL27RA
- OSMR
- LIFR
- CNTFR
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IL12RB1 |
- Interleukin receptors
- IL12R/IL12RB1/IL12RB2
- IL23R23
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Other |
- hormone receptor: GH
- prolactin
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Type II |
- Interleukin receptors
- IL10R/IL10RA/IL10RB/IL22R/IL22RA2
- IL20R/IL20RA/IL20RB
- IL28R
- Interferon receptors
- -α/β/IFNAR1/IFNAR2
- -γ/IFNGR1/IFNGR2
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Ig superfamily |
- CSF1
- KIT
- IL1
- IL18R/IL18R1
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IL-17 family |
- IL-17
- IL17RA
- IL17RB
- IL17RC
- IL17RD
- IL17RE
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S/T |
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B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
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This article incorporates text from the public domain Pfam and InterPro IPR015319
English Journal
- An intravenous exposure mouse model for prediction of potential drug-sensitization using reporter antigens popliteal lymph node assay.
- Lin M, Sun W, Wang Y, Li X, Jin Y, Gong W, Fan X, Wang Y.SourceCollege of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China.
- Journal of applied toxicology : JAT.J Appl Toxicol.2012 Jun;32(6):395-401. doi: 10.1002/jat.1696. Epub 2011 Jul 1.
- Immune-mediated drug hypersensitivity is a particularly concerning health-safety issue among clinicians given its unpredictability and potentially life-threatening effects, especially with exposure to intravenous drugs. Therefore, the development of intravenous drug-exposure models for drug-hazard a
- PMID 21721018
- Regulation of NADPH Oxidase Gene Expression with PKA and Cytokine IL-4 in Neurons and Microglia.
- Savchenko VL.SourceDepartment of Geriatrics, University of Arkansas, Little Rock, AR, USA, vsavche1@gmail.com.
- Neurotoxicity research.Neurotox Res.2012 May 8. [Epub ahead of print]
- Neuronal excitation is mediated by the activation of NMDA receptor and associated with the formation of reactive oxygen species due to the activation of NADPH oxidase complex proteins. The activation of G(s) protein coupled receptors (GPCRs) induces neuronal activation in the cAMP-dependent protein
- PMID 22565378
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★リンクテーブル★
[★]
- 英
- interleukin-4, interleukin 4
- 同
- インターロイキン4、インターロイキン-4
- 関
- サイトカイン、インターロイキン
概念
- B細胞のIgのクラススイッチを促進(SP.251) ← IgEへのクラススイッチ
産生細胞
機能
受容体
[★]
- 同
- leucine-6, CD1A through E
種類
発現組織
- 胸腺皮質、ランゲルハンス細胞、樹状細胞、B細胞(CD1c)、腸上皮、平滑筋、血管上皮(CD1d)
分子量
機能
- MHC class I-like molecule, associated with β2-microgloulin. Has specialized role in presentation of lipid antigens