血管作動性腸管ポリペプチド
WordNet
- of or relating to or inside the intestines; "intestinal disease" (同)enteric, enteral
- a peptide containing 10 to more than 100 amino acids
PrepTutorEJDIC
- 腸[内]の
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/08/13 13:58:50」(JST)
[Wiki en表示]
| Vasoactive intestinal peptide |
| Available structures |
| PDB |
Ortholog search: PDBe, RCSB |
| List of PDB id codes |
|
2RRH, 2RRI
|
|
|
| Identifiers |
| Symbols |
VIP ; PHM27 |
| External IDs |
OMIM: 192320 MGI: 98933 HomoloGene: 2539 ChEMBL: 5737 GeneCards: VIP Gene |
| Gene ontology |
| Molecular function |
• hormone activity
• neuropeptide hormone activity
• protein binding
|
| Cellular component |
• extracellular region
• neuronal cell body
|
| Biological process |
• positive regulation of endothelial cell proliferation
• G-protein coupled receptor signaling pathway
• body fluid secretion
• learning or memory
• positive regulation of cell proliferation
• regulation of signal transduction
• positive regulation of adenylate cyclase activity involved in G-protein coupled receptor signaling pathway
• regulation of protein localization
• negative regulation of apoptotic process
• negative regulation of potassium ion transport
• positive regulation of protein catabolic process
• positive regulation of vasodilation
• negative regulation of smooth muscle cell proliferation
• regulation of sensory perception of pain
• positive regulation of penile erection
|
| Sources: Amigo / QuickGO |
|
| RNA expression pattern |
|
| More reference expression data |
| Orthologs |
| Species |
Human |
Mouse |
|
| Entrez |
7432 |
22353 |
|
| Ensembl |
ENSG00000146469 |
ENSMUSG00000019772 |
|
| UniProt |
P01282 |
P32648 |
|
| RefSeq (mRNA) |
NM_003381 |
NM_011702 |
|
| RefSeq (protein) |
NP_003372 |
NP_035832 |
|
| Location (UCSC) |
Chr 6:
153.07 – 153.08 Mb |
Chr 10:
5.64 – 5.65 Mb |
|
| PubMed search |
[1] |
[2] |
|
|
|
Vasoactive intestinal peptide also known as the vasoactive intestinal polypeptide or VIP is a peptide hormone containing 28 amino acid residues. VIP is neuropeptide that belongs to a glucagon/secretin superfamily, the ligand of class II G protein-coupled receptors.[1] VIP is produced in many tissues of vertebrates including the gut, pancreas, and suprachiasmatic nuclei of the hypothalamus in the brain.[2][3] VIP stimulates contractility in the heart, causes vasodilation, increases glycogenolysis, lowers arterial blood pressure and relaxes the smooth muscle of trachea, stomach and gall bladder. In humans, the vasoactive intestinal peptide is encoded by the VIP gene.[4]
VIP has a half-life (t½) in the blood of about two minutes.
Contents
- 1 Function
- 2 Pathology
- 3 See also
- 4 References
- 5 Further reading
- 6 External links
Function
VIP has an effect on several tissues:
- With respect to the digestive system, VIP seems to induce smooth muscle relaxation (lower esophageal sphincter, stomach, gallbladder), stimulate secretion of water into pancreatic juice and bile, and cause inhibition of gastric acid secretion and absorption from the intestinal lumen.[5] Its role in the intestine is to greatly stimulate secretion of water and electrolytes,[6] as well as stimulating contraction of enteric smooth muscle, dilating peripheral blood vessels, stimulating pancreatic bicarbonate secretion, and inhibiting gastrin-stimulated gastric acid secretion. These effects work together to increase motility.[7]
- It also has the function of stimulating pepsinogen secretion by chief cells.[8]
- It is also found in the brain and some autonomic nerves. One region of the brain includes a specific area of the suprachiasmatic nuclei (SCN), the location of the 'master circadian pacemaker'. The SCN coordinates daily timekeeping in the body and VIP plays a key role in communication between individual brain cells within this region. Further, VIP is also involved in synchronising the timing of SCN function with the environmental light-dark cycle. Combined, these roles in the SCN make VIP a crucial component of the mammalian circadian timekeeping machinery.
- VIP helps to regulate prolactin secretion;[9] it stimulates prolactin release in the domestic turkey.
- It is also found in the heart and has significant effects on the cardiovascular system. It causes coronary vasodilation[5] as well as having a positive inotropic and chronotropic effect. Research is being performed to see if it may have a beneficial role in the treatment of heart failure.
- VIP provokes vaginal lubrication in normal women, doubling the total volume of lubrication produced in one study.[10]
- The growth-hormone-releasing hormone (GH-RH) is a member of the VIP family and stimulates Growth Hormone secretion in the anterior pituitary gland.
Pathology
VIP is overproduced in VIPoma.[5] Can be associated with Multiple Endocrine Neoplasia Type 1 (Pituitary, parathyroid and pancreatic tumors). Symptoms are typically:
- Profuse non-bloody/non-mucoid diarrhea (3L+) causing dehydration and the associated electrolyte disturbances such as hypokalemia and metabolic acidosis.
- Lethargy and exhaustion may ensue
See also
- Vasoactive intestinal peptide receptor
References
- ^ Umetsu Y, Tenno T, Goda N, Shirakawa M, Ikegami T, Hiroaki H (May 2011). "Structural difference of vasoactive intestinal peptide in two distinct membrane-mimicking environments". Biochimica Et Biophysica Acta 1814 (5): 724–30. doi:10.1016/j.bbapap.2011.03.009. PMID 21439408.
- ^ Fahrenkrug J, Emson PC (September 1982). "Vasoactive intestinal polypeptide: functional aspects". British Medical Bulletin 38 (3): 265–70. PMID 6129023.
- ^ Said SI (April 1986). "Vasoactive intestinal peptide". Journal of Endocrinological Investigation 9 (2): 191–200. doi:10.1007/bf03348097. PMID 2872248.
- ^ Linder S, Barkhem T, Norberg A, et al. (January 1987). "Structure and expression of the gene encoding the vasoactive intestinal peptide precursor". Proceedings of the National Academy of Sciences of the United States of America 84 (2): 605–9. doi:10.1073/pnas.84.2.605. PMC 304259. PMID 3025882.
- ^ a b c Bowen R (1999-01-24). "Vasoactive Intestinal Peptide". Pathophysiology of the Endocrine System: Gastrointestinal Hormones. Colorado State University. Retrieved 2009-02-06.
- ^ "Vasoactive intestinal polypeptide". General Practice Notebook. Retrieved 2009-02-06.
- ^ Bergman RA, Afifi AK, Heidger PM. "Plate 6.111 Vasoactive Intestinal Polypeptide (VIP)". Atlas of Microscopic Anatomy: Section 6 - Nervous Tissue. www.anatomyatlases.org. Retrieved 2009-02-06.
- ^ Sanders MJ, Amirian DA, Ayalon A, Soll AH (November 1983). "Regulation of pepsinogen release from canine chief cells in primary monolayer culture". The American Journal of Physiology 245 (5 Pt 1): G641–6. PMID 6195927.
- ^ Kulick RS, Chaiseha Y, Kang SW, Rozenboim I, El Halawani ME (July 2005). "The relative importance of vasoactive intestinal peptide and peptide histidine isoleucine as physiological regulators of prolactin in the domestic turkey". General and Comparative Endocrinology 142 (3): 267–73. doi:10.1016/j.ygcen.2004.12.024. PMID 15935152.
- ^ Ottesen B, Pedersen B, Nielsen J, Dalgaard D, Wagner G, Fahrenkrug J (1987). "Vasoactive intestinal polypeptide (VIP) provokes vaginal lubrication in normal women". Peptides 8 (5): 797–800. doi:10.1016/0196-9781(87)90061-1. PMID 3432128.
Further reading
- Fahrenkrug J (2001). "Gut/brain peptides in the genital tract: VIP and PACAP". Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum 234: 35–9. PMID 11713978.
- Delgado M, Pozo D, Ganea D (June 2004). "The significance of vasoactive intestinal peptide in immunomodulation". Pharmacological Reviews 56 (2): 249–90. doi:10.1124/pr.56.2.7. PMID 15169929.
- Conconi MT, Spinazzi R, Nussdorfer GG (2006). "Endogenous ligands of PACAP/VIP receptors in the autocrine-paracrine regulation of the adrenal gland". International Review of Cytology 249: 1–51. doi:10.1016/S0074-7696(06)49001-X. ISBN 978-0-12-364653-8. PMID 16697281.
- Hill JM (2007). "Vasoactive intestinal peptide in neurodevelopmental disorders: therapeutic potential". Current Pharmaceutical Design 13 (11): 1079–89. doi:10.2174/138161207780618975. PMID 17430171.
- Gonzalez-Rey E, Varela N, Chorny A, Delgado M (2007). "Therapeutical approaches of vasoactive intestinal peptide as a pleiotropic immunomodulator". Current Pharmaceutical Design 13 (11): 1113–39. doi:10.2174/138161207780618966. PMID 17430175.
- "[Quaternary structure of rabbit skeletal muscle glycogen synthetase]". Doklady Akademii Nauk SSSR (in Russian) 222 (4): 997–1000. June 1975. PMID 807467.
- Kitamura K, Kangawa K, Kawamoto M, Ichiki Y, Matsuo H, Eto T (May 1992). "Isolation and characterization of peptides which act on rat platelets, from a pheochromocytoma". Biochemical and Biophysical Research Communications 185 (1): 134–41. doi:10.1016/s0006-291x(05)80966-0. PMID 1318039.
- Glowa JR, Panlilio LV, Brenneman DE, Gozes I, Fridkin M, Hill JM (January 1992). "Learning impairment following intracerebral administration of the HIV envelope protein gp120 or a VIP antagonist". Brain Research 570 (1-2): 49–53. doi:10.1016/0006-8993(92)90562-n. PMID 1617429.
- Theriault Y, Boulanger Y, St-Pierre S (March 1991). "Structural determination of the vasoactive intestinal peptide by two-dimensional H-NMR spectroscopy". Biopolymers 31 (4): 459–64. doi:10.1002/bip.360310411. PMID 1863695.
- Gozes I, Giladi E, Shani Y (April 1987). "Vasoactive intestinal peptide gene: putative mechanism of information storage at the RNA level". Journal of Neurochemistry 48 (4): 1136–41. doi:10.1111/j.1471-4159.1987.tb05638.x. PMID 2434617.
- Yamagami T, Ohsawa K, Nishizawa M, et al. (1988). "Complete nucleotide sequence of human vasoactive intestinal peptide/PHM-27 gene and its inducible promoter". Annals of the New York Academy of Sciences 527: 87–102. doi:10.1111/j.1749-6632.1988.tb26975.x. PMID 2839091.
- Bodner M, Fridkin M, Gozes I (June 1985). "Coding sequences for vasoactive intestinal peptide and PHM-27 peptide are located on two adjacent exons in the human genome". Proceedings of the National Academy of Sciences of the United States of America 82 (11): 3548–51. doi:10.1073/pnas.82.11.3548. PMC 397822. PMID 2987932.
- DeLamarter JF, Buell GN, Kawashima E, Polak JM, Bloom SR (1985). "Vasoactive intestinal peptide: expression of the prohormone in bacterial cells". Peptides 6 (Suppl 1): 95–102. doi:10.1016/0196-9781(85)90016-6. PMID 2995945.
- Linder S, Barkhem T, Norberg A, et al. (January 1987). "Structure and expression of the gene encoding the vasoactive intestinal peptide precursor". Proceedings of the National Academy of Sciences of the United States of America 84 (2): 605–9. doi:10.1073/pnas.84.2.605. PMC 304259. PMID 3025882.
- Gotoh E, Yamagami T, Yamamoto H, Okamoto H (September 1988). "Chromosomal assignment of human VIP/PHM-27 gene to 6q26----q27 region by spot blot hybridization and in situ hybridization". Biochemistry International 17 (3): 555–62. PMID 3202886.
- Yiangou Y, Di Marzo V, Spokes RA, Panico M, Morris HR, Bloom SR (October 1987). "Isolation, characterization, and pharmacological actions of peptide histidine valine 42, a novel prepro-vasoactive intestinal peptide-derived peptide". The Journal of Biological Chemistry 262 (29): 14010–3. PMID 3654650.
- Gozes I, Bodner M, Shani Y, Fridkin M (1986). "Structure and expression of the vasoactive intestinal peptide (VIP) gene in a human tumor". Peptides 7 (Suppl 1): 1–6. doi:10.1016/0196-9781(86)90156-7. PMID 3748844.
- Tsukada T, Horovitch SJ, Montminy MR, Mandel G, Goodman RH (August 1985). "Structure of the human vasoactive intestinal polypeptide gene". DNA 4 (4): 293–300. PMID 3899557.
- Heinz-Erian P, Dey RD, Flux M, Said SI (September 1985). "Deficient vasoactive intestinal peptide innervation in the sweat glands of cystic fibrosis patients". Science 229 (4720): 1407–8. doi:10.1126/science.4035357. PMID 4035357.
- Bloom SR, Christofides ND, Delamarter J, Buell G, Kawashima E, Polak JM (November 1983). "Diarrhoea in vipoma patients associated with cosecretion of a second active peptide (peptide histidine isoleucine) explained by single coding gene". Lancet 2 (8360): 1163–5. doi:10.1016/S0140-6736(83)91215-1. PMID 6139527.
External links
- Pathway at biocarta.com
- Physiology at MCG 6/6ch2/s6ch2_34
- Endocrine system:
- hormones
- Peptide hormones
- Steroid hormones
|
|
Endocrine
glands |
|
Hypothalamic-
pituitary
|
|
Hypothalamus
|
- GnRH
- TRH
- Dopamine
- CRH
- GHRH/Somatostatin
- Melanin concentrating hormone
|
|
|
Posterior pituitary
|
|
|
|
Anterior pituitary
|
- α
- FSH
- FSHB
- LH
- LHB
- TSH
- TSHB
- CGA
- Prolactin
- POMC
- CLIP
- ACTH
- MSH
- Endorphins
- Lipotropin
- GH
|
|
|
|
Adrenal axis
|
|
Adrenal cortex:
|
- aldosterone
- cortisol
- DHEA
|
|
|
Adrenal medulla:
|
- epinephrine
- norepinephrine
|
|
|
|
Thyroid axis
|
|
Thyroid:
|
- thyroid hormone
- calcitonin
|
|
|
Parathyroid:
|
|
|
|
|
Gonadal axis
|
|
Testis::
|
|
|
|
Ovary:
|
- estradiol
- progesterone
- activin and inhibin
- relaxin (pregnancy)
|
|
|
Placenta:
|
- hCG
- HPL
- estrogen
- progesterone
|
|
|
|
Islet-Acinar
Axis
|
|
Pancreas:
|
- glucagon
- insulin
- amylin
- somatostatin
- pancreatic polypeptide
|
|
|
|
Pineal gland
|
|
|
|
Other
glands |
|
Thymus:
|
- Thymosins
- Thymosin α1
- Beta thymosins
- Thymopoietin
- Thymulin
|
|
|
Digestive system:
|
|
Stomach:
|
|
|
|
Duodenum:
|
- CCK
- Incretins
- secretin
- motilin
- VIP
|
|
|
Ileum:
|
- enteroglucagon
- peptide YY
|
|
|
Liver/other
|
- Insulin-like growth factor
|
|
|
|
Adipose tissue:
|
- leptin
- adiponectin
- resistin
|
|
|
Skeleton::
|
|
|
|
Kidney:
|
- JGA (renin)
- peritubular cells
- calcitriol
- prostaglandin
|
|
|
Heart:
|
|
|
|
|
|
|
noco (d)/cong/tumr, sysi/epon
|
proc, drug (A10/H1/H2/H3/H5)
|
|
|
|
|
Peptides: neuropeptides
|
|
| Hormones |
see hormones
|
|
| Opioid peptides |
|
Dynorphins
|
- Big dynorphin
- Dynorphin A
- Dynorphin B
- Leumorphin
|
|
|
Endomorphins
|
- Endomorphin-1
- Endomorphin-2
|
|
|
Endorphins
|
- α-Endorphin
- β-Endorphin
- γ-Endorphin
- α-Neoendorphin
- β-Neoendorphin
|
|
|
Enkephalins
|
- Met-enkephalin
- Leu-enkephalin
|
|
|
Others
|
- Adrenorphin
- Amidorphin
- Nociceptin
- Opiorphin
- Spinorphin
|
|
|
Other
neuropeptides |
|
Kinins
|
- Tachykinins: mammal
- Substance P
- Neurokinin A
- Neurokinin B
- amphibian
|
|
|
Neuromedins
|
|
|
|
Other
|
- Angiotensin
- Bombesin
- Calcitonin gene-related peptide
- Carnosine
- Cocaine and amphetamine regulated transcript
- Delta sleep-inducing peptide
- FMRFamide
- Galanin
- Galanin-like peptide
- Gastrin releasing peptide
- Ghrelin
- Neuropeptide S
- Neuropeptide Y
- Neurophysins
- Neurotensin
- Pancreatic polypeptide
- Pituitary adenylate cyclase activating peptide
- RVD-Hpα
- VGF
|
|
|
|
B trdu: iter (nrpl/grfl/cytl/horl), csrc (lgic, enzr, gprc, igsr, intg, nrpr/grfr/cytr), itra (adap, gbpr, mapk), calc, lipd; path (hedp, wntp, tgfp+mapp, notp, jakp, fsap, hipp, tlrp)
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Practical considerations in analysing neuropeptides, calcitonin gene-related peptide and vasoactive intestinal peptide, by nano-electrospray ionisation and quadrupole time-of-flight mass spectrometry: monitoring multiple protonations.
- Abaye DA, Pullen FS, Nielsen BV.
- Rapid communications in mass spectrometry : RCM.2011 Apr 30;25(8):1107-16. doi: 10.1002/rcm.4961. Epub 2011 Mar 29.
- PMID 21452389
- Increasing proportions of tyrosine hydroxylase-immunoreactive interneurons colocalize with choline acetyltransferase or vasoactive intestinal peptide in the developing rat cerebral cortex.
- Asmus SE, Cocanougher BT, Allen DL, Boone JB, Brooks EA, Hawkins SM, Hench LA, Ijaz T, Mayfield MN.
- Brain research.2011 Apr 6;1383:108-19. Epub 2011 Feb 3.
- PMID 21295554
- Activation of the VIP/VPAC2 system induces reactive astrocytosis associated with increased expression of glutamate transporters.
- Nishimoto M, Miyakawa H, Wada K, Furuta A.
- Brain research.2011 Apr 6;1383:43-53. Epub 2011 Jan 31.
- PMID 21281617
Japanese Journal
- Cell type-specific inhibitory inputs to dendritic and somatic compartments of parvalbumin-expressing neocortical interneuron.
- Hioki Hiroyuki,Okamoto Shinichiro,Konno Michiteru,Kameda Hiroshi,Sohn Jaerin,Kuramoto Eriko,Fujiyama Fumino,Kaneko Takeshi
- The Journal of neuroscience : the official journal of the Society for Neuroscience 33(2), 544-555, 2013-01-09
- … We then investigated inhibitory inputs from three distinct subgroups of GABAergic interneurons by visualizing the axon terminals immunopositive for PV, somatostatin (SOM), or vasoactive intestinal polypeptide (VIP). …
- NAID 120005300466
- Colocalization of Nitric Oxide Synthase, Vasoactive Intestinal Polypeptide and Tyrosine Hydroxylase Immunoreactivities in Postganglionic Neurons of the Quail Superior Cervical Ganglion
- ITOH Katsuhito,TAKAKI Yasuhito,ANDO Koichi,SOH Tomoki,ICHINOMIYA Yasutoshi,KUSABA Haruo
- Journal of Veterinary Medical Science, 2012
- … The colocalization of immunoreactivity to nitric oxide synthase (NOS), vasoactive intestinal polypeptide (VIP) and tyrosine hydroxylase (TH) in the superior cervical ganglion (SCG) was investigated in the quail. …
- NAID 130002502190
- Neuropeptide Effects in the Trigeminal System : Pathophysiology and Clinical Relevance in Migraine
- MESSLINGER Karl,FISCHER Michael J. M.,LENNERZ Jochen K.
- Keio journal of medicine 60(3), 82-89, 2011-09-01
- … The neuropeptides substance P, calcitonin gene-related peptide (CGRP) and vasoactive intestinal polypeptide (VIP) have been considered as important mediators in migraine and other primary headaches. …
- NAID 10029624739
Related Pictures
★リンクテーブル★
[★]
- 英
- vasoactive intestinal polypeptide VIP, vasoactive intestinal peptide
- 同
- 血管作用性小腸ペプチド
- 関
- 神経伝達物質
[show details]
血管作動性腸管ポリペプチド : 63 件
血管作動性腸ペプチド : 51 件
血管作動性腸管由来ポリペプチド : 30 件
血管作用性小腸ペプチド : 約 46 件
血管作用性腸ポリペプチド : 17 件
血管作用性腸管ペプチド : 21 件
血管作用性腸管ポリペプチド : 20 件
血管活性腸管ペプチド : 24 件
血管活性腸管ポリペプチド : 13 件
血管賦活腸管ペプチド : 8 件
まとめ
- 腸管の拡張や迷走神経の刺激により胃から大腸に分布するVIP細胞から分泌され、小腸と大腸の蠕動運動を促進し、消化管による水とイオンの排出を促進する。また、胃酸分泌を抑制する。
概念
- グルカゴン・VIP：膵臓
- セクレチン：十二指腸粘膜
- VIPと関連蛋白：enteric nerve, 自律神経、中枢神経
分類
性状
産生組織
標的組織
受容体
作用
- 平滑筋弛緩作用、血管拡張作用、腸液分泌刺激作用
- 末梢血管、冠血管、肺動脈拡張 (SPC.345)
- 気管支平滑筋拡張 (SPC.345)
- 消化管平滑筋弛緩 (SPC.345)
- インスリン、グルカゴン、ソマトスタチンなど分泌促進
- 重炭酸を含む膵液の分泌促進
- ガストリンの分泌抑制
- ↑ intestinal water and electrolyte secretion
- ↑ relaxation of intestinal smooth muscle and sphincters
分泌の調整
- ↑ by distension and vagal stimulation
- ↓ by adrenergic input
分子機構
生合成
臨床関連
- VIPoma vasoavtive intestinal polypeptidescreting tumor
- VIPを産生する非α非β膵島細胞腫瘍
- WDHA症候群(水様下痢低カリウム血症無胃酸症候群)
[★]
血管作動性腸管ポリペプチド vasoactive intestinal polypeptide
[★]
血管作働性腸管ポリペプチドI型受容体
- 関
- type I vasoactive intestinal peptide receptor、VIP-1 receptor
[★]
- 関
- alimentary system、bowel、digestive system、enteric、enteric canal、entero、gastrointestinal、gastrointestinal system、GI、gut、intestinal tract、intestine
[★]
- 関
- peptide
[★]
