uterotonic

• adj.

• 子宮収縮の

• n.

• 子宮収縮薬

関

myometrial contraction、uterine contraction

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/08/16 20:12:30」(JST)

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A uterotonic, also known as ecbolic, is an agent used to induce contraction or greater tonicity of the uterus. Uterotonics are used both to induce labor, and to reduce postpartum hemorrhage.

Some uterotonics act as analogues of oxytocin. An oxytocinergic, or oxytocic, means "having to do with oxytocin (OXT)". The oxytocin receptor (OXTR) is the binding and activation site of oxytocin.

Some agents may act as indirect oxytocinergics:

• 5-HT_1A Receptor (5-HT_1AR): A protein responsible for inducing the secretion of oxytocin
• Serotonergic: A drug which acts upon serotonin and 5-HT_1AR, resulting in oxytocin release (e.g., MDMA ("Ecstasy")
• Ergoline uterotonics include methylergonovine, ergometrine (and Syntometrine), and acetergamine
• Polypeptides include carbetocin and cargutocin
• Cloquinozine had been described as a oxytocic agent.
• Epostane is another example of a drug described as a contraceptive, oxytocic agent.
• U-69,593 inhibits the peripheral, though not central secretion of oxytocin and vasopressin in rats.

Prostaglandins

• Dinoprost
• Alprostadil
• Prostaglandin F2, prostaglandin E1, carboprost
• Fenprostalene in cattle. This compound resembles Enprostil in structure and is a long-acting analogue of PGF2α.
• Meteneprost

Analogs of oxytocin

• Urofollitropin is an analog of oxytocin possessing higher activity
• Carbetocin
• Demoxytocin
• (Thiazolidine-4-carboxylic acid)-oxytocin

Tocolytic

• Conversely, a tocolytic acts to oppose uterine contractility. These agents may be oxytocinergic in mechanism. For example, atosiban works in this way.

Natural food

• Parsley in large amount may have uterotonic effect

See also

• Goldenseal
• L-371,257
• Oxytocin
• WAY-267,464

External links

•  "Oxytocics". New International Encyclopedia. 1905. 

UpToDate Contents

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• 1. 経腟分娩後の出血管理 management of postpartum hemorrhage at vaginal delivery
• 2. 分娩第3期のマネージメントのための薬物療法 pharmacologic management of the third stage of labor
• 3. 陣痛誘発前に未成熟な頸管を熟化させる手技 techniques for ripening the unfavorable cervix prior to induction
• 4. 無傷子宮における破裂 rupture of the unscarred uterus
• 5. 陣痛の潜伏相 latent phase of labor

English Journal

• Investigation of uterotonic properties of Ananas comosus extracts.

• Monji F1, Adaikan PG2, Lau LC1, Bin Said B1, Gong Y1, Tan HM1, Choolani M1.
• Journal of ethnopharmacology.J Ethnopharmacol.2016 Dec 4;193:21-29. doi: 10.1016/j.jep.2016.07.041. Epub 2016 Jul 16.
• ETHNOPHARMACOLOGICAL RELEVANCE: In folklore medicine Ananas comosus (pineapple) is reputed to act as an abortifacient and in expectant women as a means of inducing labor. Several reports have claimed abortifacient property of A. comosus fruit (ripe or unripe). Ripe fruit has been used orally as trad
• PMID 27426506

• Peripartum hysterectomy incidence, risk factors and clinical characteristics in Ireland.

• Campbell SM1, Corcoran P1, Manning E1, Greene RA2; Irish Maternal Morbidity Advisory Group1.
• European journal of obstetrics, gynecology, and reproductive biology.Eur J Obstet Gynecol Reprod Biol.2016 Dec;207:56-61. doi: 10.1016/j.ejogrb.2016.10.008. Epub 2016 Oct 27.
• BACKGROUND: The incidence of peripartum hysterectomy (PH) shows fifty-fold variation worldwide (0.2-10.5/1000 deliveries) and risk factors include advancing maternal age and parity, previous caesarean section (CS) and abnormal placentation.OBJECTIVES: In this first national study of PH in Ireland, o
• PMID 27825028

• Carbetocin for prevention of postcesarean hemorrhage in women with severe preeclampsia: a before-after cohort comparison with oxytocin.

• Nucci B1, Aya A2, Aubry E2, Ripart J2.
• Journal of clinical anesthesia.J Clin Anesth.2016 Dec;35:321-325. doi: 10.1016/j.jclinane.2016.08.017. Epub 2016 Oct 12.
• STUDY OBJECTIVE: The aim of the study was to compare the incidence of the use of additional uterotonics before and after the change of carbetocin to oxytocin for the prevention of postpartum hemorrhage after cesarean delivery in women with severe preeclampsia.DESIGN: This was an observational retros
• PMID 27871550

Japanese Journal

• カニクイザルを用いた子宮収縮作用の評価

• 坂本 憲吾,坂口 靖江,大谷 光嗣,野村 護,下井 昭仁,佐藤 伸一
• 日本毒性学会学術年会 39.1(0), P-194, 2012
• ＜目的＞化合物の子宮運動に対する影響を評価するため，カニクザルを用いた評価系の確立を目的に実施した．＜方法＞非妊娠雌サルの月経周期を確認し，排卵前及び排卵後の性周期に該当する各2～3例に，イソフルランの麻酔下で生理食塩液，子宮収縮薬のジノプロスト（1，3，10又は30 μｇ/kg）及びオキシトシン（30，100及び300 mU/kg），子宮収縮抑制薬のリトドリン（10 μg/kg）をそれぞれ静脈内 …
• NAID 130005008798

• ダグラス窩に嵌頓した子宮筋腫合併妊娠の１例

• 高岡 亜妃,大竹 紀子,北村 幸子 [他],須賀 真美,岡田 悠子,宮本 和尚,西村 淳一,今村 裕子,山田 曜子,山田 聡,星野 達二,北 正人
• 産婦人科の進歩 63(1), 29-32, 2011
• 子宮筋腫などを合併し頸管延長を伴って過度に子宮が変形した症例では，帝王切開術の際，子宮切開部位の決定に苦慮することがある．今回，術前にMRIにて頸管の著明な延長を確認し，術中エコーにて適切な子宮筋層の切開部位を決定でき，良好な経過であった症例を経験したので報告する．症例は31歳，初産婦．妊娠38週時に子宮頸部筋腫合併妊娠，骨盤位および低置胎盤にて当科紹介受診．骨盤MRIにて子宮後下方に約9cm大の …
• NAID 130000670770

• Uterotonic effect of Harpagophytum procumbens DC (Pedaliaceae) secondary root aqueous extract on rat isolated uterine horns

• ,
• Journal of smooth muscle research = 日本平滑筋学会機関誌 45(5), 231-239, 2009-10-01
• … procumbens secondary root aqueous extract possesses spasmogenic, uterotonic action on mammalian uterine muscles. …
• NAID 10025993922

Related Pictures

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★リンクテーブル★

リンク元	「子宮収縮薬」「子宮収縮」「myometrial contraction」

「子宮収縮薬」

　　[★]

英

uterotonic, oxytocics

ラ

uterotonica

同

子宮収縮促進薬？

関

子宮収縮、分娩誘発、陣痛誘発薬、陣痛促進役

• プロスタグランジン：生理的な子宮収縮を呈する。気管支喘息、緑内障に対しては禁忌。

• プロスタグランジンE1
• プロスタグランジンE2
• プロスタグランジンF2α

• オキシトシン
• エルゴメトリン：最も強力。分娩後、子宮収縮を促す目的で使用
• メチルエルゴメトリン

「子宮収縮」

　　[★]

英

uterine contraction、myometrial contraction、uterotonic

関

子宮収縮薬、陣痛

「myometrial contraction」

　　[★]

• 子宮収縮

関

uterine contraction、uterotonic