IV型コラーゲン
- 関
- collagen IV、collagen type IV
WordNet
- write by means of a keyboard with types; "type the acceptance letter, please" (同)typewrite
- a small metal block bearing a raised character on one end; produces a printed character when inked and pressed on paper; "he dropped a case of type, so they made him pick them up"
- (biology) the taxonomic group whose characteristics are used to define the next higher taxon
- a subdivision of a particular kind of thing; "what type of sculpture do you prefer?"
- all of the tokens of the same symbol; "the word `element contains five different types of character"
- printed characters; "small type is hard to read"
- identify as belonging to a certain type; "Such people can practically be typed" (同)typecast
- a paste-up made by sticking together pieces of paper or photographs to form an artistic image; "he used his computer to make a collage of pictures superimposed on a map" (同)montage
- any collection of diverse things; "a collage of memories"
- the 9th letter of the Roman alphabet (同)i
- a fibrous scleroprotein in bone and cartilage and tendon and other connective tissue; yields gelatin on boiling
- writing done with a typewriter (同)typewriting
PrepTutorEJDIC
- 〈C〉(…の)『型』,タイプ,類型,種類(kind)《+of+名》 / 〈C〉(その種類の特質を最もよく表している)『典型』,手本,模範《+of+名》 / 〈U〉《集合的に》活字;〈C〉(1個の)活字 / 〈U〉(印刷された)字体,活字 / 〈C〉(貨幣・メダルなどの)模様,図柄 / 〈C〉血液型(blood group) / …‘を'タイプに打つ / (…として)…‘を'分類する《+名+as+名(doing)》 / …‘の'型を決める / タイプライターを打つ
- コラージュ / 〈C〉画面に絵具以外のいろいろな素材を貼り付けて耕成した絵 / 〈U〉1の絵画技法
- 『私は』私が
- iodineの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/03/18 05:56:00」(JST)
[Wiki en表示]
Collagen IV (ColIV or Col4) is a type of collagen found primarily in the basal lamina. The collagen IV C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, collagen IV lacks the regular glycine in every third residue necessary for the tight, collagen helix. This makes the overall arrangement more sloppy with kinks. These two features cause the collagen to form in a sheet, the form of the basal lamina. Collagen IV is the more common usage, as opposed to the older terminology of "type-IV collagen"[citation needed].
There are six human genes associated with it:[1]
- COL4A1, COL4A2, COL4A3, COL4A4, COL4A5, COL4A6
Clinical significance
The alpha-3 subunit (COL4A3) of collagen IV is thought to be the antigen implicated in Goodpasture's Disease, wherein the immune system attacks the basement membranes of the glomeruli and the alveoli upon the antigenic site on the alpha-3 subunit becomes unsequestered due to environmental exposures.
Goodpasture's Diseasepresents with nephritic syndrome, and hemoptysis. Microscopic evaluation of biopsied renal tissue will reveal linear deposits of Immunoglobulin G by immunofluorescence. This is classically in young adult males.
Mutations to the genes coding for collagen IV lead to Alport syndrome. This will cause thinning and splitting of the glomerular basement membrane. It will present as isolated hematuria, sensorineural hearing loss, and ocular disturbances and is passed on genetically in an X-linked manner.
Liver fibrosis and cirrhosis are associated with the deposition of collagen IV in the liver. Serum Collagen IV concentrations correlate with hepatic tissue levels of collagen IV in subjects with alcoholic liver disease and hepatitis C and fall following successful therapy.[2][3]
Increased glomerular and mesangial deposition of collagen IV occurs in diabetic nephropathy and increased urinary levels are associated with the extent of renal injury.[4]
References
- ^ Khoshnoodi J, Pedchenko V, Hudson BG (May 2008). "Mammalian collagen IV". Microsc. Res. Tech. 71 (5): 357–70. doi:10.1002/jemt.20564. PMID 18219669.
- ^ Tsutsumi, M; Takase, S; Urashima, S; Ueshima, Y; Kawahara, H; Takada, A (December 1996). "Serum markers for hepatic fibrosis in alcoholic liver disease: which is the best marker, type III procollagen, type IV collagen, laminin, tissue inhibitor of metalloproteinase, or prolyl hydroxylase?". Alcoholism: Clinical and Experimental Research 20 (9): 1512–7. PMID 8986196.
- ^ Yabu, K; Kiyosawa, K; Mori, H; Matsumoto, A; Yoshizawa, K; Tanaka, E; Furuta, S (May 1994). "Serum collagen type IV for the assessment of fibrosis and resistance to interferon therapy in chronic hepatitis C.". Scandinavian journal of gastroenterology 29 (5): 474–9. PMID 7518613.
- ^ Okonogi, H; Nishimura, M; Utsunomiya, Y; Hamaguchi, K; Tsuchida, H; Miura, Y; Suzuki, S; Kawamura, T; Hosoya, T; Yamada, K (May 2001). "Urinary type IV collagen excretion reflects renal morphological alterations and type IV collagen expression in patients with type 2 diabetes mellitus.". Clinical nephrology 55 (5): 357–64. PMID 11393380.
External links
- Collagen type IV at the US National Library of Medicine Medical Subject Headings (MeSH)
Protein: scleroproteins
|
|
Extracellular matrix |
Collagen |
Fibril forming |
- type I
- type II (COL2A1)
- type III
- type V
- COL24A1
- COL26A1
|
|
Other |
- FACIT: type IX
- type XII (COL12A1)
- COL14A1
- COL16A1
- COL19A1
- COL20A1
- COL21A1
- COL22A1
- basement membrane: type IV
- COL4A1
- COL4A2
- COL4A3
- COL4A4
- COL4A5
- COL4A6
- multiplexin: COL15A1
- type XVIII
- transmembrane: COL13A1
- COL17A1
- COL23A1
- COL25A1
- other: type VI
- COL6A1
- COL6A2
- COL6A3
- COL6A5
- type VII (COL7A1)
- type VIII
- type X (COL10A1)
- type XI
- COL27A1
- COL28A1
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|
Enzymes |
- Prolyl hydroxylase/Lysyl hydroxylase
- Cartilage associated protein/Leprecan
- ADAMTS2
- Procollagen peptidase
- Lysyl oxidase
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|
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Laminin |
- alpha
- LAMA1
- LAMA2
- LAMA3
- LAMA4
- LAMA5
- beta
- gamma
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|
Other |
- ALCAM
- Elastin
- Vitronectin
- FRAS1
- FREM2
- Decorin
- FAM20C
- ECM1
- Matrix gla protein
- Tectorin
|
|
|
Other |
- Keratin/Cytokeratin
- Gelatin
- Reticulin
- Cartilage oligomeric matrix protein
|
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Positioning of the sensor cell on the sensing area using cell trapping pattern in incubation type planar patch clamp biosensor.
- Wang ZH, Takada N, Uno H, Ishizuka T, Yawo H, Urisu T.SourceNagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan; JST, CREST, K's Gobancho, 7 Gobancho, Chiyoda-ku, Tokyo 102-0076, Japan.
- Colloids and surfaces. B, Biointerfaces.Colloids Surf B Biointerfaces.2012 Aug 1;96:44-9. Epub 2012 Apr 5.
- Positioning the sensor cell on the micropore of the sensor chip and keeping it there during incubation are problematic tasks for incubation type planar patch clamp biosensors. To solve these problems, we formed on the Si sensor chip's surface a cell trapping pattern consisting of a lattice pattern w
- PMID 22526091
- Engineering endostatin-expressing cartilaginous constructs using injectable biopolymer hydrogels.
- Jeng L, Olsen BR, Spector M.SourceTissue Engineering, VA Boston Healthcare System, Boston, MA 02130, USA; Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA.
- Acta biomaterialia.Acta Biomater.2012 Jul;8(6):2203-12. Epub 2012 Feb 24.
- The release of an anti-angiogenic agent, such as type XVIII/endostatin, from an implantable scaffold may be of benefit in the repair of articular cartilage. The objectives of this study are to develop an injectable mesenchymal stem cell (MSC)-incorporating collagen-based hydrogel capable of undergoi
- PMID 22370447
Japanese Journal
- Effects of type Ⅳ collagen on myogenic characteristics of IGF-Ⅰ gene-engineered myoblasts
- Ito Akira,Yamamoto Masahiro,Ikeda Kazushi [他]
- Journal of bioscience and bioengineering 119(5), 596-603, 2015-05
- NAID 40020471548
- ONO-1301, a Sustained-Release Prostacyclin Analog, Ameliorates the Renal Alterations in a Mouse Type 2 Diabetes Model Possibly Through Its Protective Effects on Mesangial Cells
- Watatani Hiroyuki,Yamasaki Hiroko,Maeshima Yohei,Nasu Tatsuyo,Hinamoto Norikazu,Ujike Haruyo,Sugiyama Hitoshi,Sakai Yoshiki,Tanabe Katsuyuki,Makino Hirofumi
- Acta Medica Okayama 69(1), 1-15, 2015-02
- … Considering the increasing prevalence of type 2 diabetes mellitus worldwide, novel therapeutic approaches are urgently needed. … Here we examined the therapeutic effects of the intermittent administration of slow-release ONO-1301 (SR-ONO) on diabetic nephropathy in obese type 2 diabetes mice, as well as its direct effects on mesangial cells. …
- NAID 120005549937
- Intracranial Hemorrhage and Tortuosity of Veins Detected on Susceptibility-weighted Imaging of a Child with a Type IV Collagen α1 Mutation and Schizencephaly
- NIWA Tetsu,AIDA Noriko,OSAKA Hitoshi,WADA Takahito,SAITSU Hirotomo,IMAI Yutaka
- Magnetic Resonance in Medical Sciences 14(3), 223-226, 2015
- … Type IV collagen α1 (COL4A1) forms a sheet-like network beneath the endothelium and surrounding smooth muscle cells. …
- NAID 130005093236
Related Links
- Type-IV collagen is a type of collagen found primarily in the basal lamina. The type IV collagen C4 domain at the C-terminus is not removed in post-translational processing, and the fibers link head-to-head, rather than in parallel. Also, type-IV ...
- この配列は、コラーゲン様配列と呼ばれ、コラーゲンタンパク質の特徴である。例えば、I 型コラーゲンでは、この "―(グリシン)―(アミノ酸X)―(アミノ酸Y)―" が1014アミノ酸 残基繰返す配列を持っている。(アミノ酸X)としてプロリン、(アミノ酸Y)として、4(R) ...
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★リンクテーブル★
[★]
- 英
- type IV collagen
- 関
- コラーゲン、肝線維化マーカー、膜型コラーゲン
[★]
IV型コラーゲン
- 関
- collagen IV、type IV collagen
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- (windows)ファイル内容表示(linux -> cat])
- ex. type report_20111118.jp.htm | php a.php > report_20111118.jp.jp.jp.html
- 関
- form、mode、pattern、type specimen、typed
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- 関
- i.v.、intravascular、intravenous、intravenously
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- 関
- form、mode、pattern、type
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