UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. リードスタンバーグ細胞およびホジキンリンパ腫の病因the reed sternberg cell and the pathogenesis of hodgkin lymphoma [show details]
… lurk . Humans possess an important class of negative regulatory T cells (Tregs) that express CD4, high levels of CD25, and the transcription factor FOXP3 . HRS cells express high levels of Galectin-1, …
2. 分子遺伝学の原理principles of molecular genetics [show details]
…unfolding and chromatin activation, transcription factor binding, and regulation of mRNA metabolism. RNA transcription is initiated by the binding of specific transcription factors to DNA sequence motifs flanking …
3. 全身性硬化症（強皮症）の危険因子および考えられる原因risk factors for and possible causes of systemic sclerosis scleroderma [show details]
…including the HLA locus and gene regions for CD247, interferon regulatory factor 5 (IRF5), and signal transducer and activator of transcription 4 (STAT4). Each of these SSc-susceptibility loci is involved …
4. 原発性免疫不全症の診断のためのフローサイトメトリーflow cytometry for the diagnosis of primary immunodeficiencies [show details]
…P3 gene (FOXP3) are the cause of IPEX. Foxp3 is a transcription factor that is crucial to the development, survival, and effector function of regulatory T (Treg) cells, which are essential in maintaining …
5. サルコイドーシスの病理と発症機序pathology and pathogenesis of sarcoidosis [show details]
…interleukin (IL)-2 and other cytokines, aided by T regulatory cells (Tregs) that also produce interferon-gamma . Increased expression of the transcription factor T-bet and chemokine receptor CXCR3 contribute …

English Journal

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.

Mehrbod P, Ande SR, Alizadeh J, Rahimizadeh S, Shariati A, Malek H, Hashemi M, Glover KKM, Sher AA, Coombs KM, Ghavami S.
Virulence. 2019 Dec;10(1)376-413.
Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR). Both autophagy and UPR are connected to programed cell death I (apoptosis) in chronic stress conditions to regulate cellular homeostasis
PMID 30966844

Induction of cystathionine gamma-lyase expression and metallothionein-1 S-sulfhydration alleviate cadmium-induced cell death in myoblast cells.

Zhang Y, Ali A, Jin Z, Pei Y, Yang G.
Ecotoxicology and environmental safety. 2019 Sep;179()222-231.
Hydrogen sulfide (HS), a multifunctional gasotransmitter, participates in a wide range of cellular signal transduction and pathophysiological processes. Cystathionine gamma-lyase (CSE) acts as a major HS-generating enzyme in peripheral organs and tissues. As a cysteine-rich and heavy metal-binding p
PMID 31048218

Novel miRNA, miR-sc14, promotes Schwann cell proliferation and migration.

Ji XM, Wang SS, Cai XD, Wang XH, Liu QY, Wang P, Cheng ZC, Qian TM.
Neural regeneration research. 2019 Sep;14(9)1651-1656.
MicroRNAs refer to a class of endogenous, short non-coding RNAs that mediate numerous biological functions. MicroRNAs regulate various physiological and pathological activities of peripheral nerves, including peripheral nerve repair and regeneration. Previously, using a rat sciatic nerve injury mode
PMID 31089066

Japanese Journal

A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

Takahashi Naoki,Ogita Nobuo,Takahashi Tomonobu,Taniguchi Shoji,Tanaka Maho,Seki Motoaki,Umeda Masaaki
2019-04-04
… Here we report that in Arabidopsis, the NAC-type transcription factors ANAC044 and ANAC085 are required for DNA damage-induced G2 arrest. … Under genotoxic stress conditions, ANAC044 and ANAC085 enhance protein accumulation of the R1R2R3-type Myb transcription factor (Rep-MYB), which represses G2/M-specific genes. …
NAID 120006619181

Genome-wide analysis of MpBHLH12, a IIIf basic helix-loop-helix transcription factor of Marchantia polymorpha (JPR SYMPOSIUM : Regulatory networks in plant growth and development)

Arai Haruka,Yanagiura Kazuya,Toyama Yuko,Morohashi Kengo
Journal of plant research 132(2), 197-209, 2019-03
NAID 40021851833

Expression of a tobacco nicotine biosynthesis gene depends on the JRE4 transcription factor in heterogenous tomato (JPR SYMPOSIUM : Regulatory networks in plant growth and development)