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1. 巨核球の生物学と血小板の産生megakaryocyte biology and the production of platelets [show details]
…molecular, cellular, and pathological levels. As an example, common transcription factors exist in these two lineages and their regulatory hematopoietic cytokines, erythropoietin and thrombopoietin, are 50 …
2. 赤血球産生調節regulation of erythropoiesis [show details]
… stabilization and activation of specific transcription factors . One of these is the heterodimeric transcription factor complex hypoxia-inducible factor (HIF-1),… (type 1) because of elimination of the negative regulatory domain of the receptor that binds an inhibitory phosphatase SH-PTP-1 .…
3. 骨髄造血の制御regulation of myelopoiesis [show details]
… by expression of successive combinations of transcription factors that in turn dictate the expression of adhesion… order to meet sudden demands caused by infection has led to the evolution of an extremely complex regulatory network. Many of the factors that allow release of granulocytes from storage pools are distinct …
4. 遺伝性疾患の基本原則basic principles of genetic disease [show details]
…20 to 30 repeats to more than 100 or even 1000 repeats) and polymorphisms in regulatory factors such as transcription factors, enhancers, silencers, or insulators. Structural (chromosomal) variation …
5. 慢性関節リウマチにおける滑膜異常synovial pathology in rheumatoid arthritis [show details]
… the role of transcription factors in the pathogenesis of RA, especially since they are potential targets for therapeutic intervention. The AP-1 family of transcription factors (c-Jun,… fibroblasts may result in a return of the critical regulatory processes that such cells provide in the noninflamed state .…

English Journal

The roles of apoptosis, autophagy and unfolded protein response in arbovirus, influenza virus, and HIV infections.

Mehrbod P, Ande SR, Alizadeh J, Rahimizadeh S, Shariati A, Malek H, Hashemi M, Glover KKM, Sher AA, Coombs KM, Ghavami S.
Virulence. 2019 Dec;10(1)376-413.
Virus infection induces different cellular responses in infected cells. These include cellular stress responses like autophagy and unfolded protein response (UPR). Both autophagy and UPR are connected to programed cell death I (apoptosis) in chronic stress conditions to regulate cellular homeostasis
PMID 30966844

The Yersinia pseudotuberculosis Cpx envelope stress system contributes to transcriptional activation of rovM.

Thanikkal EJ, Gahlot DK, Liu J, Fredriksson Sundbom M, Gurung JM, Ruuth K, Francis MK, Obi IR, Thompson KM, Chen S, Dersch P, Francis MS.
Virulence. 2019 12;10(1)37-57.
The Gram-negative enteropathogen Yersinia pseudotuberculosis possesses a number of regulatory systems that detect cell envelope damage caused by noxious extracytoplasmic stresses. The CpxA sensor kinase and CpxR response regulator two-component regulatory system is one such pathway. Active Cpx signa
PMID 30518290

Induction of cystathionine gamma-lyase expression and metallothionein-1 S-sulfhydration alleviate cadmium-induced cell death in myoblast cells.

Zhang Y, Ali A, Jin Z, Pei Y, Yang G.
Ecotoxicology and environmental safety. 2019 Sep;179()222-231.
Hydrogen sulfide (HS), a multifunctional gasotransmitter, participates in a wide range of cellular signal transduction and pathophysiological processes. Cystathionine gamma-lyase (CSE) acts as a major HS-generating enzyme in peripheral organs and tissues. As a cysteine-rich and heavy metal-binding p
PMID 31048218

Japanese Journal

A regulatory module controlling stress-induced cell cycle arrest in Arabidopsis

Takahashi Naoki,Ogita Nobuo,Takahashi Tomonobu,Taniguchi Shoji,Tanaka Maho,Seki Motoaki,Umeda Masaaki
2019-04-04
… Here we report that in Arabidopsis, the NAC-type transcription factors ANAC044 and ANAC085 are required for DNA damage-induced G2 arrest. … Under genotoxic stress conditions, ANAC044 and ANAC085 enhance protein accumulation of the R1R2R3-type Myb transcription factor (Rep-MYB), which represses G2/M-specific genes. …
NAID 120006619181

Genome-wide analysis of MpBHLH12, a IIIf basic helix-loop-helix transcription factor of Marchantia polymorpha (JPR SYMPOSIUM : Regulatory networks in plant growth and development)

Arai Haruka,Yanagiura Kazuya,Toyama Yuko,Morohashi Kengo
Journal of plant research 132(2), 197-209, 2019-03
NAID 40021851833

Expression of a tobacco nicotine biosynthesis gene depends on the JRE4 transcription factor in heterogenous tomato (JPR SYMPOSIUM : Regulatory networks in plant growth and development)