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1. 局所麻酔薬の皮下浸潤subcutaneous infiltration of local anesthetics [show details]
…arise in which local anesthesia is required for a patient with a history of a prior adverse reaction to a specific local anesthetic. True IgE-mediated allergic reactions to local anesthetic agents are rare …
2. 末梢神経ブロックの概要overview of peripheral nerve blocks [show details]
… to the risk of complications such as vasovagal events, inadvertent IV injection, and local anesthetic (LA) toxicity, as well as the possible use of sedative medication(s). Lipid emulsion 20 percent and …
3. 局所麻酔剤に対するアレルギー反応allergic reactions to local anesthetics [show details]
…idiosyncratic reactions to local anesthetics (LAs) are nonallergic in nature. Common nonallergic reactions include psychomotor responses related to anxiety, sympathetic stimulation from pain, or toxic effects …
4. 臨床使用する局所麻酔薬についてclinical use of local anesthetics in anesthesia [show details]
… injection of the anesthetic solution Increased LA dose increases the duration and the likelihood of a successful block. Baricity and other aspects of the choice of local anesthetics for spinal… idiosyncratic reactions to LAs are nonallergic in nature, but may be labelled as allergy. Symptoms of absorption or inadvertent injection of epinephrine or LA, vasovagal reactions,… have not demonstrated similar toxicity. Indeed the preservative-free form is now commonly used for brief spinal anesthetics in ambulatory patients.…
5. 局所麻酔の全身毒性local anesthetic systemic toxicity [show details]
… aspects of cardiovascular toxicity, and may relate to the mechanism for reversal of LAST with intravenous lipid emulsion (ILE). All local anesthetics (LAs) may cause LAST with toxic plasma levels. However …

English Journal

Total Syntheses and Determination of Absolute Configurations of Cep-212 and Cep-210, Predicted Biosynthetic Intermediates of Tetrodotoxin Isolated from Toxic Newt.

Adachi M, Miyasaka T, Kudo Y, Sugimoto K, Yotsu-Yamashita M, Nishikawa T.
Organic letters. 2019 02;21(3)780-784.
Total syntheses of Cep-212 and Cep-210, predicted biosynthetic intermediates of tetrodotoxin isolated from the Japanese toxic newt, have been accomplished from geraniol by an intramolecular hetero Diels-Alder reaction as a key step in a highly stereoselective manner. The success of these syntheses e
PMID 30628790

Effects of an Intraparenchymal Injection of Lidocaine in the Rat Cervical Spinal Cord.

Sisti MS, Zanuzzi CN, Nishida F, Cantet RJC, Portiansky EL.
Neurochemical research. 2018 Nov;43(11)2072-2080.
Lidocaine effects in the spinal cord have been extensively investigated over the years. Although the intrathecal route is usually used to treat insults occurring in the spinal cord, the local delivery drug via intraparenchymal infusions has gained increasing favor for the treatment of some neurodege
PMID 30196348

Cytotoxicity of local anesthetics on rabbit adipose-derived mesenchymal stem cells during early chondrogenic differentiation.

Wu T, Shi Z, Song H, Li Y, Li JH.
Experimental and therapeutic medicine. 2018 Oct;16(4)2843-2850.
Local anesthetics (LAs) are commonly used to provide peri-operative pain control in the peripheral joints. In the field of regenerative medicine, adipose-derived mesenchymal stem cells (ADMSCs) are gaining attention as a cellular source for repair and regeneration in degenerative diseases. However,
PMID 30214505