WordNet
- mark with lines; "sorrow had lined his face"
- a length (straight or curved) without breadth or thickness; the trace of a moving point
- a single frequency (or very narrow band) of radiation in a spectrum
- reinforce with fabric; "lined books are more enduring"
- a particular kind of product or merchandise; "a nice line of shoes" (同)product line, line of products, line of merchandise, business line, line of business
- the road consisting of railroad track and roadbed (同)railway line, rail line
- a commercial organization serving as a common carrier
- acting in conformity; "in line with"; "he got out of line"; "toe the line"
- something (as a cord or rope) that is long and thin and flexible; "a washing line"
- a conceptual separation or distinction; "there is a narrow line between sanity and insanity" (同)dividing_line, demarcation, contrast
- a formation of people or things one behind another; "the line stretched clear around the corner"; "you must wait in a long line at the checkout counter"
- a formation of people or things one beside another; "the line of soldiers advanced with their bayonets fixed"; "they were arrayed in line of battle"; "the cast stood in line for the curtain call"
- a fortified position (especially one marking the most forward position of troops); "they attacked the enemys line"
- a mark that is long relative to its width; "He drew a line on the chart"
- a spatial location defined by a real or imaginary unidimensional extent
- in games or sports; a mark indicating positions or bounds of the playing area
- persuasive but insincere talk that is usually intended to deceive or impress; "`let me show you my etchings is a rather worn line"; "he has a smooth line but I didnt fall for it"; "that salesman must have practiced his fast line of talk"
- text consisting of a row of words written across a page or computer screen; "the letter consisted of three short lines"; "there are six lines in every stanza"
- be in line with; form a line along; "trees line the riverbank" (同)run along
- cover the interior of; "line the gloves"; "line a chimney"
- fill plentifully; "line ones pockets"
- relating to or occurring in a term or fixed period of time; "terminal examinations"; "terminal payments"
- a contact on an electrical device (such as a battery) at which electric current enters or leaves (同)pole
- station where transport vehicles load or unload passengers or goods (同)terminus, depot
- electronic equipment consisting of a device providing access to a computer; has a keyboard and display
- being or situated at an end; "the endmost pillar"; "terminal buds on a branch"; "a terminal station"; "the terminal syllable"
- causing or ending in or approaching death; "a terminal patient"; "terminal cancer"
- of or relating to or situated at the ends of a delivery route; "freight pickup is a terminal service"; "terminal charges"
- providing something with a surface of a different material (同)facing
- a protective covering that protects an inside surface (同)liner
- the act of attaching an inside lining (to a garment or curtain etc.)
- having a lining or a liner; often used in combination; "a lined skirt"; "a silk-lined jacket"
- (used especially of skin) marked by lines or seams; "their lined faces were immeasurably sad"; "a seamed face" (同)seamed
- bordered by a line of things; "tree lined streets"
PrepTutorEJDIC
- 『線』,筋,けい / (色・縫い目などの)『線』,しま;(顔・手などの)しわ(wrinkle) / (物・人の)『列』,行列(row) / 『綱』,糸,針金 / 電線,電話線,電信線 / (文章の)『行』;(詩の)『行』 / 《しばしばa~》《話》『短い手紙』(note) / 《複数形で》輪郭,外形(outline) / 境界線(boundary);限界,限度(limit) / (鉄道・バスなどの)路線;航路,空路 / 《複数形で》せりふ / 進路,道順(course);(考えなどの)筋道,方針 / 《しばしばone's~》(活動の)分野,方面;特意 / 家系,血統,血筋 / 在庫商品,仕入れ品 / 導管,パイプライン / 《しばしば複数形で》戦線,防御線 / …‘に'『線を引く』,筋(しま,しわ)をつける / …‘に'『沿って並ぶ;』(…を)…‘に'沿って並べる《+『名』+『with』+『名』》
- (材料で)〈着物など〉‘に'裏を付ける《+『名』『with』+『名』》 / (…で)…‘を'満たす,(…を)…‘に'詰め込む《+『名』+『with』+『名』》
- 『終りの』,末端の / 毎期の,定期の;学期末の / 『死に至る』, / 末端 / (電池の)端子 / (町の中心に近い)空港バス発着場;(一般に,鉄道・バスの)終点,終着駅
- 〈U〉(服などの)裏張り,裏塗り / 〈U〉裏地,裏材
UpToDate Contents
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- 1. 末期進行癌における生存期間の推定 survival estimates in advanced terminal cancer
- 2. 心不全におけるナトリウム利尿ペプチド測定 natriuretic peptide measurement in heart failure
- 3. 急性前骨髄球性白血病の分子生物学 molecular biology of acute promyelocytic leukemia
- 4. 胸腔内圧の測定 measurement of pleural pressure
- 5. インスリン受容体の構造および機能 structure and function of the insulin receptor
English Journal
- Electrochemical detection of human papillomavirus DNA type 16 using a pyrrolidinyl peptide nucleic acid probe immobilized on screen-printed carbon electrodes.
- Jampasa S1, Wonsawat W2, Rodthongkum N3, Siangproh W4, Yanatatsaneejit P5, Vilaivan T6, Chailapakul O7.Author information 1Program in Petrochemical and Polymer Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.2Department of Chemistry, Faculty of Science and Technology, Suan Sunandha Rajabhat University, 1 U-Thong Nok Road, Dusit, Bangkok 10300, Thailand.3Metallurgy and Materials Science Research Institute, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.4Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok, Thailand.5Human Genetics Research Group, Department of Botany, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand.6Organic Synthesis Research Unit, Department of Chemistry, Faculty of Science, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand.7Electrochemistry and Optical Spectroscopy Research Unit, Department of Chemistry, Chulalongkorn University, Pathumwan, Bangkok 10330, Thailand. Electronic address: corawon@chula.ac.th.AbstractAn electrochemical biosensor based on an immobilized anthraquinone-labeled pyrrolidinyl peptide nucleic acid (acpcPNA) probe was successfully developed for the selective detection of human papillomavirus (HPV) type 16 DNA. A 14-mer acpcPNA capture probe was designed to recognize a specific 14 nucleotide region of HPV type 16 L1 gene. The redox-active label anthraquinone (AQ) was covalently attached to the N-terminus of the acpcPNA probe through an amide bond. The probe was immobilized onto a chitosan-modified disposable screen-printed carbon electrode via a C-terminal lysine residue using glutaraldehyde as a cross-linking agent. Hybridization with the target DNA was studied by measuring the electrochemical signal response of the AQ label using square-wave voltammetric analysis. The calibration curve exhibited a linear range between 0.02 and 12.0µM with a limit of detection and limit of quantitation of 4 and 14nM, respectively. This DNA sensing platform was successfully applied to detect the HPV type 16 DNA from a PCR amplified (240bp fragment of the L1 gene) sample derived from the HPV type 16 positive human cancer cell line (SiHa), and failed to detect the HPV-negative c33a cell line. The sensor probe exhibited very high selectivity for the complementary 14 base oligonucleotide over the non-complementary oligonucleotides with sequences derived from HPV types 18, 31 and 33. The proposed sensor provides an inexpensive tool for the early stage detection of HPV type 16, which is an important biomarker for cervical cancer.
- Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:428-34. doi: 10.1016/j.bios.2013.11.023. Epub 2013 Nov 20.
- An electrochemical biosensor based on an immobilized anthraquinone-labeled pyrrolidinyl peptide nucleic acid (acpcPNA) probe was successfully developed for the selective detection of human papillomavirus (HPV) type 16 DNA. A 14-mer acpcPNA capture probe was designed to recognize a specific 14 nucleo
- PMID 24300785
- EBV-encoded LMP-1 sensitizes nasopharyngeal carcinoma cells to genotoxic drugs by down-regulating Cabin1 expression.
- Chang PY, Wu ZZ, Sun NK, Chao CC.Author information Tumor Biology Laboratory, Department of Biochemistry and Molecular Biology, Chang Gung University College of Medicine, Gueishan, Taoyuan, Taiwan, Republic of China.AbstractThe oncogenic latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is involved in the pathogenesis of human nasopharyngeal carcinoma (NPC) and lymphoma. We and other authors have shown earlier that LMP1 induces apoptosis and inhibits xenograft tumor growth in mice, but the mechanism underlying these processes has not been investigated so far. In the present study, we show that knockdown of LMP1 renders the EBV-positive NPC cell line CG-1 resistant to various genotoxic drugs (cisplatin, etoposide, and adriamycin). LMP1 inhibits the expression of Cabin1, a Ca(2+) regulated protein shown earlier to inhibit calcineurin. Knockdown of calcineurin binding protein (Cabin1) with small hairpin RNA sensitizes CG-1 cells to genotoxic drugs. In contrast, LMP1 overexpression reduces Cabin1 level and renders both CG-1 cells and EBV-negative NPC cell lines sensitive to cisplatin. The c-Jun-N-terminal kinase (JNK) and ERK pathways are required for LMP1-induced suppression of Cabin1 at the transcriptional level. Chromatin immunoprecipitation assays further confirm that the JNK-activated transcription factor AP-1 mediates the LMP1-induced down-regulation of Cabin1 gene expression. LMP1 knockdown also increases the resistance of xenograph tumors to cisplatin in mice, therefore confirming the relevance of our findings in vivo. This study reveals the molecular mechanism underlying the pro-apoptotic activity of LMP1 during cisplatin-based NPC chemotherapy.
- Journal of cellular physiology.J Cell Physiol.2014 Mar;229(3):309-22. doi: 10.1002/jcp.24448.
- The oncogenic latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) is involved in the pathogenesis of human nasopharyngeal carcinoma (NPC) and lymphoma. We and other authors have shown earlier that LMP1 induces apoptosis and inhibits xenograft tumor growth in mice, but the mechanism underlyi
- PMID 23939952
Japanese Journal
- Effect of Taurine on Acinar Cell Apoptosis and Pancreatic Fibrosis in Dibutyltin Dichloride-induced Chronic Pancreatitis
- Matsushita Koki,Mizushima Takaaki,Shirahige Akinori,Tanioka Hiroaki,Sawa Kiminari,Ochi Koji,Tanimoto Mitsune,Koide Norio
- Acta Medica Okayama 66(4), 329-334, 2012-08
- … Therefore, we examined apoptosis in DBTC-chronic pancreatitis and in the AR42J pancreaticacinar cell line with/without taurine. … The AR42J pancreatic acinar cell line was incubated with/without DBTC with taurine chloramines. … Apoptosis was determined by using terminal deoxynucleotidyl transferase-mediated dUTP-digoxigenin nick end labeling (TUNEL) assay. …
- NAID 120004622481
Related Pictures
★リンクテーブル★
| リンク元 | 「分界線」 |
| 関連記事 | 「LINE」「terminal」「line」「lining」 |
「分界線」
- 英
- terminal line
- ラ
- linea terminalis (M)
定義 (M.195)
「LINE」
- 日
- 長い散在反復配列、長散在型反復配列、長い散在性反復配列、ライン、広範囲散在反復配列
- 英
- long interspersed nuclear element, long interspersed nucleotide element, long interspersed element, long interspersed repetitive elements, LINEs, long interspersed repeat sequences
- 関
- レトロトランスポゾン
- Long interspersed nuclear elements[8] are a group of genetic elements that are found in large numbers in eukaryotic genomes. They are transcribed (or are the evolutionary remains of what was once transcribed) to an RNA using an RNA polymerase II promoter that resides inside the LINE. LINEs code for the enzyme reverse transcriptase, and many LINEs also code for an endonuclease (e.g. RNase H). The reverse transcriptase has a higher specificity for the LINE RNA than other RNA, and makes a DNA copy of the RNA that can be integrated into the genome at a new site.
- The 5' UTR contains the promoter sequence, while the 3' UTR contains a polyadenylation signal (AATAAA) and a poly-A tail.[10] Because LINEs move by copying themselves (instead of moving, like transposons do), they enlarge the genome. The human genome, for example, contains about 20,000-40,000 LINEs, which is roughly 21% of the genome.
「terminal」
- n.
- adj.
- 終端の、終末の、末期の
- 関
- distal、end、end stage、ending、extremity、full-blown、terminal region、terminal stage、terminally、termini、terminus
「line」
- n.
- v.
- 裏打ちする
「lining」
- n.