WordNet

the connective tissue beneath mucous membrane

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/30 13:18:18」(JST)

wiki en

In the gastrointestinal tract, the submucosa is the layer of dense irregular connective tissue or loose connective tissue that supports the mucosa, as well as joins the mucosa to the bulk of overlying smooth muscle (fibers running circularly within layer of longitudinal muscle).

Structure

Blood vessels, lymphatic vessels, and nerves (all supplying the mucosa) will run through here. Tiny parasympathetic ganglia are scattered around forming the submucosal plexus (or "Meissner's plexus") where preganglionic parasympathetic neurons synapse with postganglionic nerve fibers that supply the muscularis mucosae. Histologically, the wall of the alimentary canal shows four distinct layers (from the lumen moving out): mucosa, submucosa, muscularis externa, and a serosa or adventitia.

Clinical significance

Identification of the submucosa plays an important role in diagnostic and therapeutic endoscopy, where special fibre-optic cameras are used to perform procedures on the gastrointestinal tract. Abnormalities of the submucosa, such as gastrointestinal stromal tumors, usually show integrity of the mucosal surface.

The submucosa is also identified in endoscopic ultrasound to identify the depth of tumours and to identify other abnormalities. An injection of dye, saline, or epinephrine into the submucosa is imperative in the safe removal of certain polyps.

Endoscopic mucosal resection involves removal of the mucosal layer, and in order to be done safely, a submucosal injection of dye is performed to ensure integrity at the beginning of the procedure.

Small intestinal submucosa

Small intestinal submucosa (SIS) is submucosal tissue in the small intestines of vertebrates. SIS is harvested (typically from pigs) for transplanted structural material in several clinical applications, typically biologic meshes. They have low immunogenicity. Some uses under investigation include a scaffold for intervertebral disc regeneration.^[1]^[2]

Unlike other scaffold materials, the resorbable SIS extracellular matrix (SIS-ECM) scaffold is replaced by well-organized host tissues, including differentiated skeletal muscle.^[3]

Submucosal images

Stomach.
Section of the human esophagus. Moderately magnified.
Vertical section of bladder wall.
General structure of the gut wall showing the submucosa.

References

^ Oelschlager BK, Pellegrini CA, Hunter J et al. (October 2006). "Biologic prosthesis reduces recurrence after laparoscopic paraesophageal hernia repair: a multicenter, prospective, randomized trial". Ann. Surg. 244 (4): 481–90. doi:10.1097/01.sla.0000237759.42831.03. PMC 1856552. PMID 16998356.
^ Helton WS, Fisichella PM, Berger R, Horgan S, Espat NJ, Abcarian H (June 2005). "Short-term outcomes with small intestinal submucosa for ventral abdominal hernia". Arch Surg 140 (6): 549–60; discussion 560–2. doi:10.1001/archsurg.140.6.549. PMID 15967902.
^ Badylak S, Kokini K, Tullius B, Simmons-Byrd A, Morff R (April 2002). "Morphologic study of small intestinal submucosa as a body wall repair device". J. Surg. Res. 103 (2): 190–202. doi:10.1006/jsre.2001.6349. PMID 11922734.

External links

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 消化管腫瘍の内視鏡的切除術の概要 overview of endoscopic resection of gastrointestinal tumors
2. High-frequency catheter endoscopic ultrasonography
3. 食道表在癌のマネージメント management of superficial esophageal cancer
4. 消化管における光干渉断層撮影 optical coherence tomography in the gastrointestinal tract
5. バレット食道：高度異形成および早期癌の治療のための内視鏡的切除 barretts esophagus treatment of high grade dysplasia or early cancer with endoscopic resection

English Journal

Update on Bioactive Prosthetic Material for the Treatment of Hernias.

Edelman DS, Hodde JP.SourceDepartment of Surgery, Doctors Hospital Miami,Florida.
Surgical technology international.Surg Technol Int.2012 Dec 1;XXI:135-139. [Epub ahead of print]
The use of mesh in the repair of hernias is commonplace. Synthetic mesh, like polypropylene, has been the workhorse for hernia repairs since the 1980s. Surgisis® mesh (Cook Surgical, Bloomington, IN), a biologic hernia graft material composed of purified porcine small intestinal submucosa (SIS), wa
PMID 22504982

The simultaneous presence of neuroepithelial cells and neuroepithelial bodies in the respiratory gas bladder of the longnose gar, Lepisosteus osseus, and the spotted gar, L. oculatus.

Zaccone D, Dabrowski K, Lauriano ER, de Pasquale A, Macrì D, Satora L, Lanteri G.SourceDepartment of Animal Biology and Marine Ecology, Faculty of Science, University of Messina, Italy. zacconed@unime.it
Acta histochemica.Acta Histochem.2012 Jul;114(4):370-8. Epub 2011 Aug 9.
Anatomical and functional studies on the autonomic innervation as well as the location of airway receptors in the air-bladder of lepisosteids are very fragmentary. These water-breathing fishes share in common with the bichirs the presence of a glottis (not a ductus pneumaticus) opening into the esop
PMID 21831413

Japanese Journal

Early Gastric Cancer Recurrence Following Curative Resection Presenting as Biliary Tract Dilatation, Pancreatic Duct Dilatation and Intestinal Wall Thickening

Internal Medicine 55(7), 745-750, 2016
NAID 130005141969

Experimental Reconstruction of the Trachea with Urinary Bladder Wall

Annals of Thoracic and Cardiovascular Surgery advpub(0), 2016
NAID 130005139452

Gastric endoscopic submucosal dissection using sodium carboxymethylcellulose as a new injection substance

FUKUSHIMA JOURNAL OF MEDICAL SCIENCE advpub(0), 2016
NAID 130005138563

Related Pictures

★リンクテーブル★

リンク元	「粘膜」「粘膜下組織」「SM」「粘膜下」「submucosal」
拡張検索	「endoscopic submucosal dissection」

「粘膜」

Submucosa
	; Mucosa; Submucosa; Meissner's plexus; Circular muscle; Auerbach's plexus; longitudinal muscle; Serosa or Adventitia
	Endoscopy and radial endoscopic ultrasound images of submucosal tumour in mid-esophagus. The submucosa is seen as a dark ring on the ultrasound image.
Details
Latin	tela submucosa
Identifiers
Dorlands; /Elsevier	s_27/12765896
TA	A05.3.01.028
FMA	85391 55072, 85391
	Anatomical terminology

　　[★]

英: mucosa (KL), mucous membrane (KH), endometrium (Z. L-20), mucosae (Z. P-27)
ラ: tunica mucosa
関: 粘膜固有層、粘膜筋板、粘膜下組織、筋層

消化器系、呼吸器系、泌尿器系、生殖器系

定義

上皮、粘膜固有層、粘膜筋板をまとめて粘膜と呼ぶ

粘膜

上皮 epithelium：組織型は多様
基底板
粘膜固有層 lamina propria：結合組織。血管、リンパ管、神経が豊富。消化管では
粘膜筋板 muscularis mucosae：消化管のに存在する平滑筋

粘膜下の深層にある組織

粘膜下組織(粘膜下層) submucosa：疎性結合組織。より太い血管、リンパ管、神経。消化管ではマイスナー神経叢が存在(cf.アウエルバッハ神経叢)。

「粘膜下組織」

　　[★]

英: submucosa sm, submucosa of bronchus (Z. L-21)
ラ: tela submucosa (Z. P-26)
同: 粘膜下層？
関: 粘膜、固有筋層

「SM」

　　[★]

「粘膜下」

　　[★]

英: submucosa、submucosal、submucous
関: 粘膜下層

「submucosal」

　　[★]

adj.

粘膜下の

関: submucosa、submucous

「endoscopic submucosal dissection」

　　[★] 内視鏡的粘膜下層剥離術 ESD

[1] Oelschlager BK, Pellegrini CA, Hunter J et al. (October 2006). "Biologic prosthesis reduces recurrence after laparoscopic paraesophageal hernia repair: a multicenter, prospective, randomized trial". Ann. Surg. 244 (4): 481–90. doi:10.1097/01.sla.0000237759.42831.03. PMC 1856552. PMID 16998356.

[2] Helton WS, Fisichella PM, Berger R, Horgan S, Espat NJ, Abcarian H (June 2005). "Short-term outcomes with small intestinal submucosa for ventral abdominal hernia". Arch Surg 140 (6): 549–60; discussion 560–2. doi:10.1001/archsurg.140.6.549. PMID 15967902.

[3] Badylak S, Kokini K, Tullius B, Simmons-Byrd A, Morff R (April 2002). "Morphologic study of small intestinal submucosa as a body wall repair device". J. Surg. Res. 103 (2): 190–202. doi:10.1006/jsre.2001.6349. PMID 11922734.

匿名

検索

案内

案内

submucosa