WordNet

uninterrupted in space; having no gaps or breaks; "a solid line across the page"; "solid sheets of water"
the state in which a substance has no tendency to flow under moderate stress; resists forces (such as compression) that tend to deform it; and retains a definite size and shape (同)solidness, solid_state
a three-dimensional shape
matter that is solid at room temperature and pressure
of the same color throughout; "solid color" (同)self-colored, self-coloured
of good quality and condition; solidly built; "a solid foundation"; "several substantial timber buildings" (同)strong, substantial
acting together as a single undiversified whole; "a solid voting bloc" (同)unanimous, whole
characterized by good substantial quality; "solid comfort"; "a solid base hit"
entirely of one substance with no holes inside; "a solid block of wood"
financially sound; "the bank is solid and will survive this attack"
having three dimensions; "a solid object"
impenetrable for the eye; "solid blackness"
of a substantial character and not frivolous or superficial; "work of solid scholarship"; "based on solid facts"
of definite shape and volume; firm; neither liquid nor gaseous; "ice is water in the solid state"
of one substance or character throughout; "solid gold"; "carved out of solid rock"
arrange in phases or stages; "phase a withdrawal"
(physical chemistry) a distinct state of matter in a system; matter that is identical in chemical composition and physical state and separated from other material by the phase boundary; "the reaction occurs in the liquid phase of the system" (同)form
a particular point in the time of a cycle; measured from some arbitrary zero and expressed as an angle (同)phase_angle
any distinct time period in a sequence of events; "we are in a transitional stage in which many former ideas must be revised or rejected" (同)stage
adjust so as to be in a synchronized condition; "he phased the intake with the output of the machine"
(astronomy) the particular appearance of a bodys state of illumination (especially one of the recurring shapes of the part of Earths moon that is illuminated by the sun); "the full phase of the moon"
a way of doing something, especially a systematic way; implies an orderly logical arrangement (usually in steps)
a colloid that has a continuous liquid phase in which a solid is suspended in a liquid (同)colloidal_solution, colloidal suspension
the syllable naming the fifth (dominant) note of any musical scale in solmization (同)soh, so
any of a large variety of proteins normally present in the body or produced in response to an antigen which it neutralizes, thus producing an immune response

PrepTutorEJDIC

『固体の』,『固形の』 / 『うつろでない』,中身のつまった / (物質の)密度が高い,密な;(印刷の)行の詰まった / 《名詞の前にのみ用いて》『混じりもののない』,純正の / (構造的に)『堅固な』 / (人が)『信頼できる』,堅実な / 健全な,しっかりした / 一致した,団結した / (時間が)まるまる,切れ目のない;(物が)連続した / 三次元の,立体の,立方の / 『固体』,固形物 / 立方体
(変化・発達の)『段階』,『局面』 / (物事の)『面』,様相《+『of』+『名』》 / (月・惑星などの)相 / …‘を'段階的に調整(整理)する
〈C〉(特に秩序だった)(…の)『方法』,方式《+『of』+『名』(do『ing』)》 / 〈C〉〈U〉(思考行・行為・行動の)きちょうめんさ;秩序,筋道
ソ(全音階の第5音)
ソル(ペルーの貨幣単位で青銅貨)
抗体,免疫体,抗毒素

UpToDate Contents

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1. 赤血球移植前試験 pretransfusion testing for red blood cell transfusion
2. 免疫グロブリンの機能および臨床応用 function and clinical applications of immunoglobulins
3. 肺移植における抗体媒介性拒絶反応の評価および治療 evaluation and treatment of antibody mediated lung transplant rejection
4. 抗Ro/SSA抗体および抗La/SSB抗体の抗原抗体系 the anti ro ssa and anti la ssb antigen antibody systems
5. 腎同種移植片のC4d染色および抗体媒介性拒絶反応の治療 c4d staining in renal allografts and treatment of antibody mediated rejection

English Journal

Rapid detection of trace bacteria in biofluids using porous monoliths in microchannels.

Mai J1, Abhyankar VV1, Piccini ME1, Olano JP2, Willson R3, Hatch AV4.Author information 1Department of Biotechnology and Bioengineering, Sandia National Laboratories, 7011 East Avenue, Livermore, CA 94551, USA.2University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77555, USA.3University of Houston, 4800 Calhoun Road, Houston, TX 77004, USA.4Department of Biotechnology and Bioengineering, Sandia National Laboratories, 7011 East Avenue, Livermore, CA 94551, USA. Electronic address: ahatch@sandia.gov.AbstractWe present advancements in microfluidic technology for rapid detection of as few as 10 rickettsial organisms in complex biological samples. An immuno-reactive filter, macroporous polyacrylamide monolith (PAM), fabricated within a microfluidic channel enhances solid-phase immuno-capture, staining and detection of targeted bacteria. Bacterial cells in samples flowing through the channel are forced to interact with the PAM filter surface due to size exclusion, overcoming common transport and kinetic limitations for rapid (min), high-efficiency (~100%) capture. In the process, targeted cells in sample volumes of 10 μl to >100 μl are concentrated within a sub-50 nl region at the PAM filter edge in the microchannel, thus concentrating them over 1000-fold. This significantly increases sensitivity, as the hydrophilic PAM also yields low non-specific immuno-fluorescence backgrounds with samples including serum, blood and non-targeted bacteria. The concentrated target cells are detected using fluorescently-labeled antibodies. With a single 2.0×2.0×0.3 mm PAM filter, as few as 10 rickettsial organisms per 100 µl of lysed blood sample can be analyzed within 60 min, as compared to hours or even days needed for conventional detection methods. This method is highly relevant to rapid, multiplexed, low-cost point of care diagnostics at early stages of infection where diagnostics providing more immediate and actionable test results are needed to improve patient outcomes and mitigate potential natural and non-natural outbreaks or epidemics of rickettsial diseases.
Biosensors & bioelectronics.Biosens Bioelectron.2014 Apr 15;54:435-41. doi: 10.1016/j.bios.2013.11.012. Epub 2013 Nov 12.
We present advancements in microfluidic technology for rapid detection of as few as 10 rickettsial organisms in complex biological samples. An immuno-reactive filter, macroporous polyacrylamide monolith (PAM), fabricated within a microfluidic channel enhances solid-phase immuno-capture, staining and
PMID 24316449

Feasibility assessment of a novel selective peptide derivatization strategy for sensitivity enhancement for the liquid chromatography/tandem mass spectrometry bioanalysis of protein therapeutics in serum.

Yuan L1, Mai A, Aubry AF, Arnold ME, Ji QC.Author information 1Bioanalytical Sciences, Analytical & Bioanalytical Development, Bristol-Myers Squibb, Princeton, NJ, 08543, USA.AbstractRATIONALE: Sensitivity is one major challenge limiting the application of liquid chromatography/tandem mass spectrometry (LC/MS/MS) methods for bioanalysis of proteins. A novel selective peptide derivatization (SPD) strategy was proposed to improve assay sensitivity. The main concept of the SPD strategy is to selectively derivatize surrogate peptides of the target protein in the digests, while not derivatizing the abundant background peptides, thereby improving the separation of target peptides during sample extraction and chromatography, and increasing the sensitivity. Additional benefits may help improve sensitivity include (1) increased ionization efficiency; (2) improved fragmentation pattern; and (3) increased sample extraction recovery of target peptides.
Rapid communications in mass spectrometry : RCM.Rapid Commun Mass Spectrom.2014 Apr 15;28(7):705-12. doi: 10.1002/rcm.6836.
RATIONALE: Sensitivity is one major challenge limiting the application of liquid chromatography/tandem mass spectrometry (LC/MS/MS) methods for bioanalysis of proteins. A novel selective peptide derivatization (SPD) strategy was proposed to improve assay sensitivity. The main concept of the SPD stra
PMID 24573801

Cross-sectional study: CagA-positive Helicobacter pylori infection, acute coronary artery disease and systemic levels of B-type natriuretic peptide.

Figura N1, Palazzuoli A, Vaira D, Campagna M, Moretti E, Iacoponi F, Giordano N, Clemente S, Nuti R, Ponzetto A.Author information 1Department of Medical, Surgical and Neurological Sciences, University of Siena and Policlinico S. Maria alle Scotte, , Siena, Italy.AbstractBACKGROUND: B-type natriuretic peptide (BNP) determination is routinely used to evaluate the severity of congestive heart failure, a possible consequence of coronary artery disease (CAD). CAD originates from vascular atherosclerotic processes and is stimulated by inflammatory events, which may also be triggered by chronic bacterial infections.
Journal of clinical pathology.J Clin Pathol.2014 Mar;67(3):251-7. doi: 10.1136/jclinpath-2013-201743. Epub 2013 Dec 13.
BACKGROUND: B-type natriuretic peptide (BNP) determination is routinely used to evaluate the severity of congestive heart failure, a possible consequence of coronary artery disease (CAD). CAD originates from vascular atherosclerotic processes and is stimulated by inflammatory events, which may also
PMID 24334757

Japanese Journal

分子インプリントポリマーをクリーンアップに応用したハチミツ及びローヤルゼリー中クロラムフェニコールの分析

坂本泰洋,斉藤貢一,波田梨公子 [他],方波見志織,岩崎雄介,伊藤里恵,中澤裕之
分析化学 = Japan analyst 61(5), 383-389, 2012-05-05
ハチミツ及びローヤルゼリー中クロラムフェニコール（CAP）の残留分析を行うために，クリーンアップに分子インプリントポリマー（MIP）を用いた方法を採用し，その有用性について，従来法である逆相系の固相抽出法と比較検討した．測定には，液体クロマトグラフィー/紫外吸収法（LC/UV），液体クロマトグラフィー/質量分析法（LC/MS）及び酵素免疫測定法（ELISA）を用い，クリーンアップ効果を検証した．そ …
NAID 10030316970

ポリスチレン親和性ペプチドを利用したタンパク質固定化技術の開発

熊田陽一
高分子 60(10), 751-752, 2011-10-01
NAID 10029658341

Identification of a Novel Carbohydrate-Mimicking Octapeptide from Chemical Peptide Library and Characterization as Selectin Inhibitor

Kawano Susumu,Iyaguchi Daisuke,Sasaki Yusuke [他],Sekizaki Haruo,Toyota Eiko
Biological and Pharmaceutical Bulletin 34(6), 883-889, 2011
… We found a novel octapeptide (H-YRNWFGRW-NH2) mimicking sialyl Lewis X (sLeX) carbohydrate from a chemical peptide library with anti-sLeX monoclonal antibody (MAb) 2H5. … The peptide libraries were constructed by Fmoc-based solid-phase methodology using the mix-split method. … The octapeptide sequence was determined by the iterative deconvolution method using anti-sLeX MAb 2H5. …
NAID 130000738065