WordNet

not moving quickly; taking a comparatively long time; "a slow walker"; "the slow lane of traffic"; "her steps were slow"; "he was slow in reacting to the news"; "slow but steady growth"
cause to proceed more slowly; "The illness slowed him down" (同)slow down, slow up
become slow or slower; "Production slowed" (同)slow down, slow up, slack, slacken
(used of timepieces) indicating a time earlier than the correct time; "the clock is slow"
at a slow tempo; "the band played a slow waltz"
material of a particular kind or constitution; "the immune response recognizes invading substances"
a particular kind or species of matter with uniform properties; "shigella is one of the most toxic substances known to man"
the real physical matter of which a person or thing consists; "DNA is the substance of our genes"
hypersensitivity reaction to the ingestion or injection of a substance (a protein or drug) resulting from prior contact with a substance

PrepTutorEJDIC

(速度・動作などが)『遅い』,のろい / 《補語または名詞の後にのみ用いて》(時計などが)『遅れている』 / 『ゆったりした』,あわてない / (人が)理解の遅い,頭の鈍い / (生活・パーティーなどが)『活気のない』,おもしろくない / 遅く,ゆっくり(slowly) / 『遅くなる』,速度を落とす《+『down』(『up』)》 / …‘を'『遅くする』,‘の'速度を落とす《+『名』+『down』(『up』),+『down』(『up』)+『名』》
《所有・所属》…『の』,…のものである,…に属する・《材料・要素》…『でできた』,から成る・《部分》…『の』[『中の』] ・《数量・単位・種類を表す名詞に付いて》…の・《原因・動機》…『で』,のために(because of) ・《主格関係》…『の』,による,によって・《目的格関係》…『を』,の・《同格関係》…『という』・《関係・関連》…『についての』[『の』],の点で・《抽象名詞などと共に》…の[性質をもつ] ・《『It is』+『形』+『of』+『名』+『to』 doの形で,ofの後の名詞を意味上の主語として》・《分離》…『から』・《起原・出所》…『から』[『の』](out of) ・《『名』+『of』+『a』(『an』)+『名』の形で》…のような・《『名』+『of』+『mine』(『yours, his』など独立所有格)の形で》…の…・《時》(1)《副詞句を作って》…に《形容詞句を作って》…の・《時刻》《米》…前(to,《米》before)
〈U〉『物質』,物 / 〈U〉《the~》(…の)『趣旨』,本音《+of+名》 / 〈U〉(スープなどの)濃さ,こく,中身[の詰まっていること] / 〈U〉『実質』,実 / 〈U〉《古》財産,資産
OLD French古[代]フランス語

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/28 22:09:05」(JST)

wiki en

[Wiki en表示]

LTC₄

LTD₄

LTE₄

The Slow-reacting substance of anaphylaxis or SRS-A is a mixture of the leukotrienes LTC4, LTD4 and LTE4. Mast cells secrete it during the anaphylactic reaction, inducing inflammation.^[1] It can be found in basophils.

It induces prolonged, slow contraction of smooth muscle and has a major bronchoconstrictor role in asthma.^[2] Compared to histamine, it is approximately 5000 times more potent and has a slower onset but longer duration of action.^{[citation needed]}

References

^ "Dorland's Medical Dictionary". Retrieved December 15, 2006.
^ Howard R. Morris, Graham W. Taylor, Priscilla J. Piper, John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.

External links

Slow Reacting Substance of Anaphylaxis at the US National Library of Medicine Medical Subject Headings (MeSH)

This biochemistry article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

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1. アナフィラキシー：迅速な認識および治療 anaphylaxis rapid recognition and treatment
2. アナフィラキシー：診断の確定および誘発因子の判定 anaphylaxis confirming the diagnosis and determining the triggers
3. 幼児におけるアナフィラキシー anaphylaxis in infants
4. アナフィラキシーの病態生理 pathophysiology of anaphylaxis
5. 食物性アナフィラキシー food induced anaphylaxis

English Journal

House dust mites induce proliferation of severe asthmatic smooth muscle cells via an epithelium-dependent pathway.

Trian T1, Allard B, Dupin I, Carvalho G, Ousova O, Maurat E, Bataille J, Thumerel M, Begueret H, Girodet PO, Marthan R, Berger P.
American journal of respiratory and critical care medicine.Am J Respir Crit Care Med.2015 Mar 1;191(5):538-46. doi: 10.1164/rccm.201409-1582OC.
RATIONALE: Asthma is a frequent airway disease, and asthma control determinants have been associated with indoor allergen sensitization. The most frequent allergens are house dust mites (HDM), which act in vivo on the bronchial epithelial layer. Severe asthma has also been associated with bronchial
PMID 25569771

Modulation of mast cell proliferative and inflammatory responses by leukotriene d4 and stem cell factor signaling interactions.

Al-Azzam N1, Kondeti V, Duah E, Gombedza F, Thodeti CK, Paruchuri S.
Journal of cellular physiology.J Cell Physiol.2015 Mar;230(3):595-602. doi: 10.1002/jcp.24777.
Mast cells (MCs) are important effector cells in asthma and pulmonary inflammation, and their proliferation and maturation is maintained by stem cell factor (SCF) via its receptor, c-Kit. Cysteinyl leukotrienes (cys-LTs) are potent inflammatory mediators that signal through CysLT1 R and CysLT2 R loc
PMID 25161061

Activation of calcium- and voltage-gated potassium channels of large conductance by leukotriene B4.

Bukiya AN1, McMillan J2, Liu J3, Shivakumar B3, Parrill AL2, Dopico AM4.
The Journal of biological chemistry.J Biol Chem.2014 Dec 19;289(51):35314-25. doi: 10.1074/jbc.M114.577825. Epub 2014 Nov 4.
Calcium/voltage-gated, large conductance potassium (BK) channels control numerous physiological processes, including myogenic tone. BK channel regulation by direct interaction between lipid and channel protein sites has received increasing attention. Leukotrienes (LTA4, LTB4, LTC4, LTD4, and LTE4) a
PMID 25371198

Japanese Journal

ロイコトリエン・リポキシゲナーゼ代謝系と創薬

阿部正義,吉本谷博
日本薬理学雑誌 : FOLIA PHARMACOLOGICA JAPONICA 124(4), 415-425, 2004-10-01
… ロイコトリエン・リポキシゲナーゼ系に関連した薬の中で最初に臨床的に確かな評価を得たのは，構造式の決定に長年の研究を要したslow reacting substance of anaphylaxis（SRS-A）を抑制するものであった．最初に抗喘息薬として登場したのは5-リポキシゲナーゼ阻害薬であったが，次に開発されたcysteinyl-leukotriene type 1 receptor（cysLT1R）拮抗薬が5-リ …
NAID 10025739505

トロンボキサンA2受容体拮抗薬 : セラトロダストの創製研究

寺尾秦次,白石充,松本辰美 [他],蘆田康子
藥學雜誌 119(5), 377-390, 1999-05-01
… We were interested in RCS (rabbit aorta contracting substance) and SRS-A(slow reacting substance of anaphylaxis) and their involvement in human bronchial asthma. … We synthesized a lot of chemical compounds and eventually discovered that AA-861 inhibited the generation of SRS-A from the lung tissue of actively sensitized guinea pigs. …
NAID 110003648745

Synthesis and Antiallergy Activity of [1,3,4]Thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one Derivatives. I

鈴木範夫,三輪保,相原俊三,菅野英幸,高森秀男,坪川政雄,両川祐一,塚田恒,磯田純郎
Chemical & pharmaceutical bulletin 40(2), 357-363, 1992-02-25
… A series of 6-substituted [1,3,4]thiadiazolo[3,2-a]-1,2,3-triazolo[4,5-d]pyrimidin-9(3H)-one derivatives 4a-z were synthesized from 5-substituted 1,3,4-thiadiazol-2-amines 5 by the following consecutive reactions : pyrimidine ring closure with bis(2,4,6-trichlorophenyl)malonate, nitration, chlorination, amination, hydrogenation and diazotization. …
NAID 110003629766

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★リンクテーブル★

リンク元	「アナフィラキシー遅延反応物質」「SRS-A」
拡張検索	「slow-reacting substance of anaphylaxis」
関連記事	「slow」「substance」「slowing」「anaphylaxis」

「アナフィラキシー遅延反応物質」

　　[★]

英: slow reacting substance of anaphylaxis, SRS-A, slow-reacting substance of anaphylaxis
同: アナフィラキシー遅延反応性物質

[show details]

アナフィラキシー遅延反応性物質 : 49 件
アナフィラキシー遅延反応物質 : 79 件

「SRS-A」

　　[★] アナフィラキシー遅延反応物質, slow reacting substance of anaphylaxis, slow-reacting substance of anaphylaxis

「slow-reacting substance of anaphylaxis」

　　[★] アナフィラキシー遅延反応物質, SRS-A

「slow」

　　[★]

adj.

(比較級slower-最上級slowest)緩徐な、遅い、ゆっくりとした、緩慢な

v.

遅くする

関: gradual、gradually、late、slowly、sluggish

「substance」

　　[★]

n.

物質、サブスタンス、実体

関: entity、material、matter

「slowing」

　　[★]

n.

緩徐化、徐脈化

「anaphylaxis」

　　[★] アナフィラキシー　

[1] "Dorland's Medical Dictionary". Retrieved December 15, 2006.

[2] Howard R. Morris, Graham W. Taylor, Priscilla J. Piper, John R. Tippins. "Structure of slow-reacting substance of anaphylaxis from guinea-pig lung". Retrieved December 15, 2006.

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案内

slow reacting substance of anaphylaxis