WordNet

place signs, as along a road; "sign an intersection"; "This road has been signed"
(medicine) any objective evidence of the presence of a disorder or disease; "there were no signs of asphyxiation"
a perceptible indication of something not immediately apparent (as a visible clue that something has happened); "he showed signs of strain"; "they welcomed the signs of spring" (同)mark
a character indicating a relation between quantities; "dont forget the minus sign"
a fundamental linguistic unit linking a signifier to that which is signified; "The bond between the signifier and the signified is arbitrary"--de Saussure
a gesture that is part of a sign language
a public display of a message; "he posted signs in all the shop windows"
engage by written agreement; "They signed two new pitchers for the next season" (同)contract, sign on, sign_up
approve and express assent, responsibility, or obligation; "All parties ratified the peace treaty"; "Have you signed your contract yet?" (同)ratify
communicate silently and non-verbally by signals or signs; "He signed his disapproval with a dismissive hand gesture"; "The diner signaled the waiters to bring the menu" (同)signal, signalize, signalise
mark with ones signature; write ones name (on); "She signed the letter and sent it off"; "Please sign here" (同)subscribe
be engaged by a written agreement; "He signed to play the casino on Dec. 18"; "The soprano signed to sing the new opera"
communicate in sign language; "I dont know how to sign, so I could not communicate with my deaf cousin"
notably out of the ordinary; "the year saw one signal triumph for the Labour party"
an electric quantity (voltage or current or field strength) whose modulation represents coded information about the source from which it comes
any nonverbal action or gesture that encodes a message; "signals from the boat suddenly stopped" (同)signaling, sign
any incitement to action; "he awaited the signal to start"; "the victory was a signal for wild celebration"
(physics and chemistry) the simplest structural unit of an element or compound

PrepTutorEJDIC

(ある事実・状態・感情などの)『表れ』,印,気配,徴侯(indication);(…の)こん跡,計跡《+『of』+『名』》・『身ぶり』,手まね,合図 / 『標識』,看板 / (数学・音楽などの)記号 / (…の)『象徴』,シンボル(symbol)《+『of』+『名』》・《文》(…の)『前兆』,きざし《+『of』+『名』》・宮(きゅう)(黄道12区分の一つ) ・〈手紙・書類・作品など〉‘に'『署名する』・(…に)〈名前など〉‘を'書く《+『名』+『on』(『to』)+『名』》 / …‘を'雇う契約に署名する・…‘を'合図する,知らせる;…に合図する・署名する・契約書に署名して雇われる
(警告・指示・情報などを伝える)『信号』,合図 / (…の)きっかけ,動機,導火線《+『for』+『名』》 / 〈人・車など〉‘に'『合図する』,信号を送る / …‘を'『合図』(信号)『で知らせる』 / 『合図する』,信号する / 合図の,信号の / めざましい,顕著な
分子《略》『mol』) / (一般に)(…の)微量《+『of』+『名』》

UpToDate Contents

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1. 複合免疫不全 combined immunodeficiencies
2. リウマチ性疾患におけるサイトカインネットワーク：治療の意味 cytokine networks in rheumatic diseases implications for therapy
3. T細胞受容体シグナル伝達 t cell receptor signaling
4. ペプチドホルモンのシグナル伝達および調節 peptide hormone signal transduction and regulation
5. 肥満細胞：表面受容体とシグナル伝達 mast cells surface receptors and signal transduction

English Journal

An SH3 binding motif within the nucleocapsid protein of porcine reproductive and respiratory syndrome virus interacts with the host cellular signaling proteins STAMI, TXK, Fyn, Hck, and cortactin.

Kenney SP1, Meng XJ2.
Virus research.Virus Res.2015 Jun 2;204:31-9. doi: 10.1016/j.virusres.2015.04.004. Epub 2015 Apr 13.
Porcine reproductive and respiratory syndrome virus (PRRSV) causes an economically important global swine disease, and has a complicated virus-host immunomodulation that often leads to a weak Th2 immune response and viral persistence. In this study, we identified a Src homology 3 (SH3) binding motif
PMID 25882913

Screening of mammalian target of rapamycin inhibitors in natural product extracts by capillary electrophoresis in combination with high performance liquid chromatography-tandem mass spectrometry.

Zhang Y1, Li F1, Li M2, Kang J3.
Journal of chromatography. A.J Chromatogr A.2015 Apr 3;1388:267-73. doi: 10.1016/j.chroma.2015.02.033. Epub 2015 Feb 16.
In this study, capillary electrophoresis (CE) combined with HPLC-MS/MS were used as a powerful platform for screening of inhibitors of mammalian target of rapamycin (mTOR) in natural product extracts. The screening system has been established by using 5-carboxyfluorescein labeled substrate peptide F
PMID 25725958

DAP12-based activating chimeric antigen receptor for NK cell tumor immunotherapy.

Töpfer K1, Cartellieri M2, Michen S1, Wiedemuth R1, Müller N1, Lindemann D3, Bachmann M2, Füssel M4, Schackert G1, Temme A5.
Journal of immunology (Baltimore, Md. : 1950).J Immunol.2015 Apr 1;194(7):3201-12. doi: 10.4049/jimmunol.1400330. Epub 2015 Mar 4.
NK cells are emerging as new effectors for immunotherapy of cancer. In particular, the genetic engraftment of chimeric Ag receptors (CARs) in NK cells is a promising strategy to redirect NK cells to otherwise NK cell-resistant tumor cells. On the basis of DNAX-activation protein 12 (DAP12), a signal
PMID 25740942

Japanese Journal

Loss of hippocampal CA3 phramidal neurons in mice lacking STAM1

Molecular and cellular biology 21(11), 3807-3819, 2001-06
NAID 120000948061

Immunohistochemical Localization of Opsins and Alpha-Subunit of Transducin in the Pineal Complex and Deep Brain of the Japanese Grass Lizard, Takydromus tachydromoides(Physiology)