複製因子C
- 関
- replication protein C、RFC
WordNet
- be a contributing factor; "make things factor into a companys profitability"
- any of the numbers (or symbols) that form a product when multiplied together
- an independent variable in statistics
- anything that contributes causally to a result; "a number of factors determined the outcome"
- consider as relevant when making a decision; "You must factor in the recent developments" (同)factor in, factor out
- resolve into factors; "a quantum computer can factor the number 15" (同)factor in, factor out
- an event known to have happened or something known to have existed; "your fears have no basis in fact"; "how much of the story is fact and how much fiction is hard to tell"
- a concept whose truth can be proved; "scientific hypotheses are not facts"
- a piece of information about circumstances that exist or events that have occurred; "first you must collect all the facts of the case"
- a statement or assertion of verified information about something that is the case or has happened; "he supported his argument with an impressive array of facts"
- the 3rd letter of the Roman alphabet (同)c
- (music) the keynote of the scale of C major
- a general-purpose programing language closely associated with the UNIX operating system
- (genetics) the process whereby DNA makes a copy of itself before cell division
- the repetition of an experiment in order to test the validity of its conclusion; "scientists will not believe an experimental result until they have seen at least one replication"
- (law) a pleading made by a plaintiff in reply to the defendants plea or answer
PrepTutorEJDIC
- (…の)『要因』,(…を生み出す)要素《+『in』+『名』(do『ing』)》 / 囲数,約数 / 代理人,《おもに英》仲買人 / =factorize
- 〈C〉『事実』,実際にある(あった)事 / 〈U〉真相,真実(truth) / 《the~》(法律用語で)犯行
- carbonの化学記号
- 写し,複写,複製 / 《文》(被告の訴答に対する)原告の訴答
- cesiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/01/05 16:16:21」(JST)
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This article needs additional citations for verification. Please help improve this article by adding citations to reliable sources. Unsourced material may be challenged and removed. (December 2009) |
The replication factor C, or RFC, is a five-subunit[1] protein complex that is required for DNA replication.
The subunits of this heteropentamer are named Rfc1, Rfc2, Rfc3, Rfc4, and Rfc5 (in S. cerevisiae). RFC is used in eukaryotic replication as a clamp loader, similar to the γ Complex in E. coli. Its role as clamp loader involves catalysing the loading of PCNA on to DNA. It binds to the 3' end of the DNA and uses ATP to open the ring of PCNA so that it can encircle the DNA. ATP hydrolysis causes release of RFC, with concomitant clamp loading onto DNA.
References[edit]
- ^ Replication Protein C at the US National Library of Medicine Medical Subject Headings (MeSH)
DNA replication (comparing Prokaryotic to Eukaryotic)
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Initiation |
Prokaryotic
(initiation) |
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Eukaryotic
(preparation in
G1 phase) |
- Origin recognition complex
- ORC1
- ORC2
- ORC3
- ORC4
- ORC5
- ORC6
- Minichromosome maintenance
- MCM2
- MCM3
- MCM4
- MCM5
- MCM6
- MCM7
- Autonomously replicating sequence
- Single-strand binding protein
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Both |
- Origin of replication/Ori/Replicon
- Replication fork
- Lagging and leading strands
- Okazaki fragment
- Primer
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|
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Replication |
Prokaryotic
(elongation) |
- DNA polymerase III holoenzyme
- dnaC
- dnaE
- dnaH
- dnaN
- dnaQ
- dnaT
- dnaX
- holA
- holB
- holC
- holD
- holE
- Replisome
- DNA ligase
- DNA clamp
- Topoisomerase
- Prokaryotic DNA polymerase: DNA polymerase I
|
|
Eukaryotic
(synthesis in
S phase) |
- Replication factor C
- Flap endonuclease
- Topoisomerase
- Replication protein A
- Eukaryotic DNA polymerase: delta
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Both |
- Movement: Processivity
- DNA ligase
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|
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Termination |
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See also: DNA replication and repair-deficiency disorder B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, pttl, nexn) · dnab, rnab/runp · stru (domn, 1°, 2°, 3°, 4°)
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UpToDate Contents
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English Journal
- Abscisic Acid Suppresses the Highly Occurred Somatic Homologous Recombination in Arabidopsis rfc1 Mutant.
- Yao T, Jin D, Liu Q, Gong Z.SourceState Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China.
- Journal of genetics and genomics = Yi chuan xue bao.J Genet Genomics.2013 Sep 20;40(9):465-71. doi: 10.1016/j.jgg.2013.05.006. Epub 2013 Jun 10.
- The phytohormone abscisic acid (ABA) regulates many aspects of plant growth, including seed germination, root growth and cell division. Previous study indicates that ABA treatment increases DNA damage and somatic homologous recombination (HR) in Arabidopsis abo4/pol ɛ (aba overly-sensitive 4 /DNA p
- PMID 24053948
- DNA polymerase δ stalls on telomeric lagging strand templates independently from G-quadruplex formation.
- Lormand JD, Buncher N, Murphy CT, Kaur P, Lee MY, Burgers P, Wang H, Kunkel TA, Opresko PL.SourceDepartment of Environmental and Occupational Health, University of Pittsburgh Graduate School of Public Health, 100 Technology Drive, Pittsburgh, PA 15219, USA, Department of Physics, North Carolina State University, 2401 Stinson Drive, Raleigh, NC, 27695, USA, Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY 10595, USA, Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St. Louis, MO 63110, USA and Laboratory of Molecular Genetics and Laboratory of Structural Biology, National Institute of Environmental Health Sciences, NIH, DHHS, Research Triangle Park, NC 27709, USA.
- Nucleic acids research.Nucleic Acids Res.2013 Sep 13. [Epub ahead of print]
- Previous evidence indicates that telomeres resemble common fragile sites and present a challenge for DNA replication. The precise impediments to replication fork progression at telomeric TTAGGG repeats are unknown, but are proposed to include G-quadruplexes (G4) on the G-rich strand. Here we examine
- PMID 24038470
- Assembly and Distributive Action of an Archaeal DNA Polymerase Holoenzyme.
- Bauer RJ, Wolff ID, Zuo X, Lin HK, Trakselis MA.SourceDepartment of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260, USA.
- Journal of molecular biology.J Mol Biol.2013 Sep 11. pii: S0022-2836(13)00560-3. doi: 10.1016/j.jmb.2013.09.003. [Epub ahead of print]
- The assembly and enzymatic ability of the replication DNA polymerase holoenzyme from Sulfolobus solfataricus (Sso) was investigated using presteady-state fluorescence resonance energy transfer assays coupled with functional and structural studies. Kinetic experiments reveal that ATP binding to repli
- PMID 24035812
Japanese Journal
- Uracil DNA Glycosylase Counteracts APOBEC3G-Induced Hypermutation of Hepatitis B Viral Genomes: Excision Repair of Covalently Closed Circular DNA
- Kitamura Kouichi,Wang Zhe,Chowdhury Sajeda,Simadu Miyuki,Koura Miki,Muramatsu Masamichi
- PLoS Pathogens 9(5), e1003361, 2013-05-00
- … We investigated whether uracil residues in hepadnavirus DNA were excised by uracil-DNA glycosylase (UNG), a host factor for base excision repair (BER). … To assess the effect of UNG on the cccDNA viral intermediate, we used the duck HBV (DHBV) replication model. … UNG inhibition also enhanced the APOBEC3G-mediated suppression of viral replication, including reduction of NC-DNA, pre-C mRNA, and secreted viral particle-associated DNA in prolonged culture. …
- NAID 120005304726
- Dual Programmed Cell Death Pathways Induced by p53 Transactivation Overcome Resistance to Oncolytic Adenovirus in Human Osteosarcoma Cells
- Hasei Joe,Sasaki Tsuyoshi,Tazawa Hiroshi,Osaki Shuhei,Yamakawa Yasuaki,Kunisada Toshiyuki,Yoshida Aki,Hashimoto Yuuri,Onishi Teppei,Uno Futoshi,Kagawa Shunsuke,Urata Yasuo,Ozaki Toshifumi,Fujiwara Toshiyoshi
- Molecular Cancer Therapeutics 12(3), 314-325, 2013-03-00
- … Tumor suppressor p53 is a multifunctional transcription factor that regulates diverse cell fates, including apoptosis and autophagy in tumor biology. … We previously developed a tumor-specific replication-competent oncolytic adenovirus, OBP-301, that kills human osteosarcoma cells, but some human osteosarcoma cells were OBP-301-resistant. …
- NAID 120005324798
- Development of Incurable Cancer Cell Targeted Agents Using Viral Technology
- 山村 倫子,高橋 克仁
- YAKUGAKU ZASSHI 133(3), 297-303, 2013
- … Since tumor cells present in a hypoxic environment are known to be resistant to chemotherapy and radiotherapy, we also engineered a novel oncolytic herpes virus targeting a specific tumor microenvironment, which harbors a gene encoding a fusion protein of oxygen-dependent degradation (ODD) domain of HIF1α and ICP4, a master viral transcription factor required for replication. …
- NAID 130003361914
Related Links
- The replication factor C, or RFC, is a five-subunit protein complex that is required for DNA replication. ... See also: DNA replication and repair-deficiency disorder B bsyn: dna (repl, cycl, reco, repr) · tscr (fact, tcrg, nucl, rnat, rept, ptts) · tltn (risu, ...
- This is the C-terminal domain of RFC (replication factor-C) protein of the clamp loader complex which binds to the DNA sliding clamp (proliferating cell nuclear antigen, PCNA). The five modules of RFC assemble into a right-handed spiral, ...
Related Pictures
★リンクテーブル★
[★]
- 英
- replication factor C、RFC
- 関
- 複製タンパク質C
[★]
- 関
- replication factor C
[★]
[★]
- 関
- actual、actually、in fact、in practice、indeed、practically
[★]
- 関
- element、elementary、factorial、parameter
[★]
セシウム, caesium, cesium
[★]
カドミウム
- 関
- cadmium