- 関
- replication factor C
WordNet
- the 18th letter of the Roman alphabet (同)r
PrepTutorEJDIC
- resistance / 17歳以下父兄同伴映画の表示 / rook
- radio frequency無線周波数
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/07/21 23:13:25」(JST)
[Wiki ja表示]
|
ウィキペディアにおけるRFCについてはWikipedia:コメント依頼をご覧ください。 |
RFC
- Request for Comments - IETFによる技術仕様公開形式
- ラジオ福島
- Radio Frequency Choke Coil - 高周波チョークコイル、高周波チョーク
- Radiant Fukuoka Cheers - プロバスケットボールbjリーグ、ライジング福岡のチアリーディングチーム。
- RFC落語ファイトクラブ - WOWOWライブにて2012年よりに放送される落語番組。
|
このページは曖昧さ回避のためのページです。一つの言葉や名前が二つ以上の意味や物に用いられている場合の水先案内のために、異なる用法を一覧にしてあります。お探しの用語に一番近い記事を選んで下さい。このページへリンクしているページを見つけたら、リンクを適切な項目に張り替えて下さい。 |
[Wiki en表示]
For Wikipedia requests for comment, see WP:RFC.
RFC may refer to:
Sport[edit]
- Randers FC, a Danish professional football club
- Rangers F.C., a Scottish professional football club
- Reading F.C., an English professional football club
- Richmond F.C., an English rugby union club
- Richmond Football Club, a professional Australian rules football club
- Romulus F.C., an English semi-professional football club
- Rugby Football Club, used as the last part in names such as Cardiff Rugby Football Club, cf. RFC 5513
Science and technology[edit]
- Radio frequency choke, an electronic component
- Regenerative fuel cell
- Remote function call, a procedure for data interchange between a computer client and server
- Replication factor C, a protein complex
- Request for change
- Request for change, one of the processes or documents in the ITSM/ITIL guidelines for running technology companies
- Request for Comments, an Internet Engineering Task Force memorandum on Internet standards and protocols
Politics[edit]
- The Reconstruction Finance Corporation, a branch of the US Government during the Great Depression which gave aid to state and local governments and loans to banks and other businesses, helping to lay the foundations for the New Deal.
Miscellanea[edit]
- Ramoji Film City, a film studio in Hyderabad, India
- Rainforest Cafe, a rainforest-themed chain restaurant owned by Landry's Restaurants.
- ReliabilityFirst Corporation, an electric reliability company under the North American Electric Reliability Corporation
- Residual functional capacity, a term used in the adjudication of claims for Social Security disability benefits to denote a claimant's maximum capacity to do things in spite of his or her impairments
- River Forecast Center, a US National Weather Service unit colocated with Weather Forecast Offices that makes hydrometeorological and river predictions
- Rosenberg Fund for Children, a charity
- Royal Flying Corps, a branch of the British military during World War One
See also[edit]
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Structural Determinants of Unique Properties of Human IgG4-Fc.
- Davies AM1, Rispens T2, Ooijevaar-de Heer P2, Gould HJ3, Jefferis R4, Aalberse RC2, Sutton BJ5.Author information 1Randall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, United Kingdom; Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 9RT, United Kingdom. Electronic address: anna.davies@kcl.ac.uk.2Sanquin Research, Amsterdam 1066 CX, The Netherlands; Academic Medical Centre Landsteiner Laboratory, University of Amsterdam, Amsterdam 1066 CX, The Netherlands.3Randall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, United Kingdom; Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 9RT, United Kingdom.4College of Medical and Dental Sciences, School of Immunity and Infection, University of Birmingham, Edgbaston, Birmingham B15 2TT, United Kingdom.5Randall Division of Cell and Molecular Biophysics, King's College London, London SE1 1UL, United Kingdom; Medical Research Council and Asthma UK Centre in Allergic Mechanisms of Asthma, London SE1 9RT, United Kingdom. Electronic address: brian.sutton@kcl.ac.uk.AbstractHuman IgG4, normally the least abundant of the four subclasses of IgG in serum, displays a number of unique biological properties. It can undergo heavy-chain exchange, also known as Fab-arm exchange, leading to the formation of monovalent but bispecific antibodies, and it interacts poorly with FcγRII and FcγRIII, and complement. These properties render IgG4 relatively "non-inflammatory" and have made it a suitable format for therapeutic monoclonal antibody production. However, IgG4 is also known to undergo Fc-mediated aggregation and has been implicated in auto-immune disease pathology. We report here the high-resolution crystal structures, at 1.9 and 2.35Å, respectively, of human recombinant and serum-derived IgG4-Fc. These structures reveal conformational variability at the CH3-CH3 interface that may promote Fab-arm exchange, and a unique conformation for the FG loop in the CH2 domain that would explain the poor FcγRII, FcγRIII and C1q binding properties of IgG4 compared with IgG1 and -3. In contrast to other IgG subclasses, this unique conformation folds the FG loop away from the CH2 domain, precluding any interaction with the lower hinge region, which may further facilitate Fab-arm exchange by destabilisation of the hinge. The crystals of IgG4-Fc also display Fc-Fc packing contacts with very extensive interaction surfaces, involving both a consensus binding site in IgG-Fc at the CH2-CH3 interface and known hydrophobic aggregation motifs. These Fc-Fc interactions are compatible with intact IgG4 molecules and may provide a model for the formation of aggregates of IgG4 that can cause disease pathology in the absence of antigen.
- Journal of molecular biology.J Mol Biol.2014 Feb 6;426(3):630-44. doi: 10.1016/j.jmb.2013.10.039. Epub 2013 Nov 6.
- Human IgG4, normally the least abundant of the four subclasses of IgG in serum, displays a number of unique biological properties. It can undergo heavy-chain exchange, also known as Fab-arm exchange, leading to the formation of monovalent but bispecific antibodies, and it interacts poorly with FcγR
- PMID 24211234
- A random forest classifier for lymph diseases.
- Azar AT1, Elshazly HI2, Hassanien AE3, Elkorany AM4.Author information 1Faculty of Computers and Information, Benha University, Egypt. Electronic address: ahmad.azar@fci.bu.edu.eg.2Faculty of Computers and Information, Cairo University, Egypt; Scientific Research Group in Egypt (SRGE), Egypt. Electronic address: hanosoma3002@yahoo.com.3Faculty of Computers and Information, Cairo University, Egypt; Scientific Research Group in Egypt (SRGE), Egypt. Electronic address: aboitcairo@gmail.com.4Faculty of Computers and Information, Cairo University, Egypt. Electronic address: a.korani@fci-cu.edu.eg.AbstractMachine learning-based classification techniques provide support for the decision-making process in many areas of health care, including diagnosis, prognosis, screening, etc. Feature selection (FS) is expected to improve classification performance, particularly in situations characterized by the high data dimensionality problem caused by relatively few training examples compared to a large number of measured features. In this paper, a random forest classifier (RFC) approach is proposed to diagnose lymph diseases. Focusing on feature selection, the first stage of the proposed system aims at constructing diverse feature selection algorithms such as genetic algorithm (GA), Principal Component Analysis (PCA), Relief-F, Fisher, Sequential Forward Floating Search (SFFS) and the Sequential Backward Floating Search (SBFS) for reducing the dimension of lymph diseases dataset. Switching from feature selection to model construction, in the second stage, the obtained feature subsets are fed into the RFC for efficient classification. It was observed that GA-RFC achieved the highest classification accuracy of 92.2%. The dimension of input feature space is reduced from eighteen to six features by using GA.
- Computer methods and programs in biomedicine.Comput Methods Programs Biomed.2014 Feb;113(2):465-73. doi: 10.1016/j.cmpb.2013.11.004. Epub 2013 Nov 14.
- Machine learning-based classification techniques provide support for the decision-making process in many areas of health care, including diagnosis, prognosis, screening, etc. Feature selection (FS) is expected to improve classification performance, particularly in situations characterized by the hig
- PMID 24290902
- Enhanced receptor-mediated endocytosis and cytotoxicity of a folic Acid-desacetylvinblastine monohydrazide conjugate in a pemetrexed-resistant cell line lacking folate-specific facilitative carriers but with increased folate receptor expression.
- Zhao R, Diop-Bove N, Goldman ID.Author information Departments of Medicine (R.Z., I.D.G.) and Molecular Pharmacology (R.Z., N.D.-P., I.D.G.), Albert Einstein College of Medicine, Bronx, New York.AbstractThe reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptors (FR) are folate-specific transporters. Antifolates currently in the clinic, such as pemetrexed, methotrexate, and pralatrexate, are transported into tumor cells primarily via RFC. Folic acid conjugated to cytotoxics, a new class of antineoplastics, are transported into cells via FR-mediated endocytosis. To better define the role of PCFT in antifolate resistance, a methotrexate-resistant cell line, M160-8, was selected from a HeLa subline in which the RFC gene was deleted and PCFT was highly overexpressed. These cells were cross-resistant to pemetrexed. PCFT function and the PCFT mRNA level in M160-8 cells were barely detectable, and FR-α function and mRNA level were increased as compared with the parent cells. While pemetrexed rapidly associated with FR and was internalized within endosomes in M160-8 cells, consistent with FR-mediated transport, subsequent pemetrexed and (6S)-5-formyltetrahydrofolate export into the cytosol was markedly impaired. In contrast, M160-8 cells were collaterally sensitive to EC0905, a folic acid-desacetylvinblastine monohydrazide conjugate also transported by FR-mediated endocytosis. However, in this case a sulfhydryl bond is cleaved to release the lipophilic cytotoxic moiety into the endosome, which passively diffuses out of the endosome into the cytosol. Hence, resistance to pemetrexed in M160-8 cells was due to entrapment of the drug within the endosome due to the absence of PCFT under conditions in which the FR cycling function was intact.
- Molecular pharmacology.Mol Pharmacol.2014 Feb;85(2):310-21. doi: 10.1124/mol.113.089110. Epub 2013 Nov 18.
- The reduced folate carrier (RFC), proton-coupled folate transporter (PCFT), and folate receptors (FR) are folate-specific transporters. Antifolates currently in the clinic, such as pemetrexed, methotrexate, and pralatrexate, are transported into tumor cells primarily via RFC. Folic acid conjugated t
- PMID 24249723
Japanese Journal
- ネットワーク・コーナ IoT時代の必読! 押さえておこう!技術仕様の基本 インターネット・プロトコル教科書(第1回)ネットを使うときの隠れ常識! 技術文書RFC
- OAuth2.0にSPKI権限証明書を適用した権限委譲方式の提案と実装
- ドメイン名についてのRFC821(SMTP)の正しい解釈を巡る混乱(ネットワーク研究開発テストベッド運用・利用,一般)
★リンクテーブル★
[★]
- 英
- replication factor C、RFC
- 関
- 複製タンパク質C
[★]
複製因子C
- 関
- replication protein C、RFC
[★]
[★]