- 関
- blood pressure lowering、blood pressure reduction、drop in blood pressure、fall in blood pressure、hypotension、low blood pressure
WordNet
- abnormally low blood pressure
- holding office; "the in party"
- to or toward the inside of; "come in"; "smash in the door" (同)inwards, inward
- currently fashionable; "the in thing to do"; "large shoulder pads are in"
- directed or bound inward; "took the in bus"; "the in basket"
- the force applied to a unit area of surface; measured in pascals (SI unit) or in dynes (cgs unit); "the compressed gas exerts an increased pressure" (同)pressure level, force per unit area
- an oppressive condition of physical or mental or social or economic distress
- the somatic sensation that results from applying force to an area of skin; "the sensitivity of his skin to pressure and temperature was normal" (同)pressure_sensation
- a force that compels; "the public brought pressure to bear on the government"
- smear with blood, as in a hunting initiation rite, where the face of a person is smeared with the blood of the kill
- temperament or disposition; "a person of hot blood"
- people viewed as members of a group; "we need more young blood in this organization"
- the fluid (red in vertebrates) that is pumped through the body by the heart and contains plasma, blood cells, and platelets; "blood carries oxygen and nutrients to the tissues and carries away waste products"; "the ancients believed that blood was the sea
- any process in which electrons are added to an atom or ion (as by removing oxygen or adding hydrogen); always occurs accompanied by oxidation of the reducing agent (同)reducing
- the act of reducing complexity (同)simplification
PrepTutorEJDIC
- 低血圧[症]
- 《具体的な場所,位置》 / …『の中に』(『で』) / …『において』,…で / 《intoの代りに移動を表す動詞と共に》…『の中へ』 / (乗り物)『に乗って』 / …『の状熊に』(『で』) / …『に従事して』,に属して / …『を身につけて』,に覆われて / 《『in』do『ing』の形で》…『するときに』,する際に(when) / 《時間》 / …『して』,…『が経過したあと』 / …『の間に』 / …『については』,…の点では / 《方法・手段・材料》…『で』 / 《人を目的語にして,性質・能力があることを示して》…の中に / …の目的で,のつもりで,として / 《比率割合》…のうちで,につき / 《過去分詞に伴って》…に[…されて] / 『中へ』(に) / 『在宅して』,帰って / (乗り物などが)『到着して』,(時期・季節が)来て / 出回って,流行して / 《俗》流行の,当世風の / 《話》特定の人々にのみ理解される
- 〈U〉『押すこと』,『押しつけること』,圧搾,圧縮;〈C〉〈U〉『圧力』,圧力の強さ / 〈U〉『圧迫』,『強制』 / 〈U〉(不快な)圧迫感 / 〈C〉〈U〉(精神的な)重荷,苦脳;(時間・金銭的)切迫 / 〈U〉多忙,あわただしさ / 《おもに米》…‘に'圧力をかける,強制する(《英》pressurise)
- 『血』,『血』液 / 流血(bloodshed);殺人 / 気質,気性,血気,血潮 / 『血統』,血縁(kinship);生まれ,家柄;《the~》王家の血統 / (人種・出身国の)系 / 〈人〉‘に'初めての経験をさせる / 〈猟犬〉‘に'初めて獲物を血を味わわせる
- 〈U〉〈C〉(…を)『減らすこと』,減少,縮小,格下げ,(…の)割り引き《+『in』+『名』》 / 〈C〉減少(縮小)した量;割引額 / 〈C〉縮図,縮写 / 〈U〉換算約分
- 純血の,純種の / 《複合語を作って》「…の血(性質)を持った」の意を表す
UpToDate Contents
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English Journal
- A new strategy for treating hypertension by blocking the activity of the brain renin-angiotensin system with aminopeptidase A inhibitors.
- Gao J1, Marc Y, Iturrioz X1, Leroux V1, Balavoine F2, Llorens-Cortes C1.Author information 1*Laboratory of Central Neuropeptides in the Regulation of Body Fluid Homeostasis and Cardiovascular Functions, CIRB, Collège de France, INSERM U1050, Paris, F-75231, France.2†Quantum Genomics, Massy, F-91300, France.AbstractHypertension affects one-third of the adult population and is a growing problem due to the increasing incidence of obesity and diabetes. Brain RAS (renin-angiotensin system) hyperactivity has been implicated in the development and maintenance of hypertension in several types of experimental and genetic hypertension animal models. We have identified in the brain RAS that APA (aminopeptidase A) and APN (aminopeptidase N), two membrane-bound zinc metalloproteases, are involved in the metabolism of AngII (angiotensin II) and AngIII (angiotensin III) respectively. The present review summarizes the main findings suggesting that AngIII plays a predominant role in the brain RAS in the control of BP (blood pressure). We first explored the organization of the APA active site by site-directed mutagenesis and molecular modelling. The development and the use in vivo of specific and selective APA and APN inhibitors EC33 and PC18 respectively, has allowed the demonstration that brain AngIII generated by APA is one of the main effector peptides of the brain RAS, exerting a tonic stimulatory control over BP in conscious hypertensive rats. This identified brain APA as a potential therapeutic target for the treatment of hypertension, which has led to the development of potent orally active APA inhibitors, such as RB150. RB150 administered orally in hypertensive DOCA (deoxycorticosteroneacetate)-salt rats or SHRs (spontaneously hypertensive rats) crosses the intestinal, hepatic and blood-brain barriers, enters the brain, generates two active molecules of EC33 which inhibit brain APA activity, block the formation of brain AngIII and normalize BP for several hours. The decrease in BP involves two different mechanisms: a decrease in vasopressin release into the bloodstream, which in turn increases diuresis resulting in a blood volume reduction that participates in the decrease in BP and/or a decrease in sympathetic tone, decreasing vascular resistance. RB150 constitutes the prototype of a new class of centrally acting antihypertensive agents and is currently being evaluated in a Phase Ib clinical trial.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Aug 1;127(3):135-48. doi: 10.1042/CS20130396.
- Hypertension affects one-third of the adult population and is a growing problem due to the increasing incidence of obesity and diabetes. Brain RAS (renin-angiotensin system) hyperactivity has been implicated in the development and maintenance of hypertension in several types of experimental and gen
- PMID 24697296
- Melatonin reduces tachycardia in postural tachycardia syndrome: a randomized, crossover trial.
- Green EA1, Black BK, Biaggioni I, Paranjape SY, Bagai K, Shibao C, Okoye MC, Dupont WD, Robertson D, Raj SR.Author information 1Division of Clinical Pharmacology, Department of Medicine, Autonomic Dysfunction Center, Vanderbilt University, Nashville, TN, USA.AbstractBACKGROUND: Postural tachycardia syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in heart rate (HR) upon standing, and many POTS patients have a hyperadrenergic state. Medications that restrain HR are a promising approach to this problem.
- Cardiovascular therapeutics.Cardiovasc Ther.2014 Jun;32(3):105-12. doi: 10.1111/1755-5922.12067.
- BACKGROUND: Postural tachycardia syndrome (POTS) induces disabling chronic orthostatic intolerance with an excessive increase in heart rate (HR) upon standing, and many POTS patients have a hyperadrenergic state. Medications that restrain HR are a promising approach to this problem.OBJECTIVE: We tes
- PMID 24495468
- Control of blood pressure in hypertensive neurological emergencies.
- Manning L1, Robinson TG, Anderson CS.Author information 1Department of Cardiovascular Sciences and NIHR Biomedical Research Unit in Cardiovascular Disease, University of Leicester, Leicester, UK, lm313@le.ac.uk.AbstractNeurological hypertensive emergencies cause significant morbidity and mortality. Most occur in the setting of ischaemic stroke, spontaneous intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH), but other causes relate to hypertensive encephalopathy and reversible cerebral vasoconstriction syndrome (RCVS). Prompt and controlled reduction of blood pressure (BP) is necessary, although there remains uncertainty as to the optimal rate of decline and ideal antihypertensive agent. There is probably no single treatment strategy that covers all neurological hypertensive emergencies. Prompt diagnosis of the underlying disorder, recognition of its severity, and appropriate targeted treatment are required. Lack of comparative-effectiveness data leaves clinicians with limited evidence-based guidance in management, although significant developments have occurred recently in the field. In this article, we review the management of specific neurological hypertensive emergencies, with particular emphasis on recent evidence.
- Current hypertension reports.Curr Hypertens Rep.2014 Jun;16(6):436. doi: 10.1007/s11906-014-0436-x.
- Neurological hypertensive emergencies cause significant morbidity and mortality. Most occur in the setting of ischaemic stroke, spontaneous intracerebral hemorrhage (ICH), or subarachnoid hemorrhage (SAH), but other causes relate to hypertensive encephalopathy and reversible cerebral vasoconstrictio
- PMID 24771058
Japanese Journal
- Effects of Landiolol Hydrochloride on Intractable Tachyarrhythmia After Pediatric Cardiac Surgery
- Tokunaga Chiho,Hiramatsu Yuji,Kanemoto Shinya,Takahashi-Igari Miho,Abe Masakazu,Horigome Hitoshi,Sakakibara Yuzuru,徳永 千穂,平松 祐司,金本 真也,高橋 実穂,堀米 仁志,榊原 謙
- The annals of thoracic surgery 95(5), 1685-1688, 2013-05-00
- … BackgroundWhile β-blockers can be effective in controlling tachyarrhythmias after pediatric cardiac surgery, a negative inotropic influence sometimes complicates their use. … Landiolol hydrochloride is a novel, ultra-short-acting β-blocker recently developed in Japan. …
- NAID 120005296346
- Safety and Efficacy of a Bolus Injection of Landiolol Hydrochloride as a Premedication for Multidetector-Row Computed Tomography Coronary Angiography
- Osawa Kazuhiro,Miyoshi Toru,Sato Shuhei,Akagi Noriaki,Morimitsu Yusuke,Nakamura Kazufumi,Kohno Kunihisa,Kusano Kengo,Kanazawa Susumu,Ito Hiroshi
- Circulation Journal 77(1), 146-152, 2013
- … Image quality and hemodynamic parameters were compared in patients before and after approval of landiolol hydrochloride. … If heart rate reduction was insufficient after premedication with an oral β-blocker, a bolus injection of landiolol hydrochloride (n=66) or other drugs (n=30) was used. … The percentage of evaluable images per segment in patients after approval of landiolol (99.3%) was greater than that in patients before approval of landiolol (97.4%, P<0.01). …
- NAID 130001870125
- 低血糖発作との鑑別が重要であった体位性起立頻脈症候群の1例
- 黒住 旭,岡田 洋右,西田 啓子 [他],山本 直,森 博子,新生 忠司,田中 良哉
- 産業医科大学雑誌 34(4), 353-361, 2012-12-01
- 症例は49歳男性.43歳時より動作時に動悸,冷汗,虚脱感が突然生じるようになり,低血糖発作(血糖50〜60mg/dl)を疑われ当科紹介.75g経口糖負荷試験で5時間後に血糖56mg/dlまで低下したが,無治療で血糖は回復.48時間絶食試験終了直前,排尿後の立位時に気分不良となり冷汗,頻呼吸を生じた.その際装着していたホルター心電図で140台の洞性頻脈を認めた.頻脈は日中活動時のみ出現し,起立時に再 …
- NAID 110009562109
Related Links
- 19 Jul 2012 ... Even a small reduction in the sodium in your diet can reduce blood pressure by 2 to 8 mm Hg. The recommendations for reducing sodium are: Limit sodium to 2,300 milligrams (mg) a day or less. A lower sodium level — 1,500 ...
★リンクテーブル★
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- 英
- hypotension、low blood pressure、reduction in blood pressure、fall in blood pressure、blood pressure lowering、blood pressure reduction、drop in blood pressure
- 関
- 低血圧、血圧下降、低血圧症、血圧降下
[★]
- 関
- blood pressure lowering、blood pressure reduction、drop in blood pressure、fall in blood pressure、hypotension、hypotensive、reduction in blood pressure
[★]
- 関
- blood pressure lowering、blood pressure reduction、fall in blood pressure、hypotension、low blood pressure、reduction in blood pressure
[★]
- 関
- blood pressure lowering、blood pressure reduction、drop in blood pressure、hypotension、low blood pressure、reduction in blood pressure
[★]
- 関
- blood pressure reduction、drop in blood pressure、fall in blood pressure、hypotension、low blood pressure、reduction in blood pressure
[★]
- 関
- decline、decrease、depression、diminish、diminution、down-regulate、down-regulation、downregulate、downregulation、drop、fall、hypoergy、loss、lower、lowering、parsimony、reduce、retrenchment
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- 関
- blood
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インジウム indium
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血液