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1. フォンヒッペル・リンダウ病の分子生物学および病因 molecular biology and pathogenesis of von hippel lindau disease
2. 非プラチナ製剤ベースの癌化学療法の神経学的合併症の概要 overview of neurologic complications of non platinum cancer chemotherapy
3. 混合性結合組織病における抗U1-RNP抗体 anti u1 rnp antibodies in mixed connective tissue disease
4. パーキンソン病の病因および発症機序 etiology and pathogenesis of parkinson disease
5. 腎不全患者に生じる抗がん剤の腎毒性と用量調整：既存の細胞障害性抗癌剤 chemotherapy nephrotoxicity and dose modification in patients with renal insufficiency conventional cytotoxic agents

Fenretinide Induces Ubiquitin-Dependent Proteasomal Degradation of Stearoyl-CoA Desaturase in Human Retinal Pigment Epithelial Cells.

Samuel W1, Kutty RK, Duncan T, Vijayasarathy C, Kuo BC, Chapa KM, Redmond TM.
Journal of cellular physiology.J Cell Physiol.2014 Aug;229(8):1028-38. doi: 10.1002/jcp.24527.
Stearoyl-CoA desaturase (SCD, SCD1), an endoplasmic reticulum (ER) resident protein and a rate-limiting enzyme in monounsaturated fatty acid biosynthesis, regulates cellular functions by controlling the ratio of saturated to monounsaturated fatty acids. Increase in SCD expression is strongly implica
PMID 24357007

UCH-L1 induces podocyte hypertrophy in membranous nephropathy by protein accumulation.

Lohmann F1, Sachs M1, Meyer TN2, Sievert H3, Lindenmeyer MT4, Wiech T5, Cohen CD4, Balabanov S6, Stahl RA1, Meyer-Schwesinger C7.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jul;1842(7):945-58. doi: 10.1016/j.bbadis.2014.02.011. Epub 2014 Feb 28.
Podocytes are terminally differentiated cells of the glomerular filtration barrier that react with hypertrophy in the course of injury such as in membranous nephropathy (MGN). The neuronal deubiquitinase ubiquitin C-terminal hydrolase L1 (UCH-L1) is expressed and activated in podocytes of human and
PMID 24583340

Curcusone D, a novel ubiquitin-proteasome pathway inhibitor via ROS-induced DUB inhibition, is synergistic with bortezomib against multiple myeloma cell growth.

Cao MN1, Zhou YB2, Gao AH1, Cao JY1, Gao LX1, Sheng L1, Xu L1, Su MB1, Cao XC1, Han MM1, Wang MK3, Li J4.
Biochimica et biophysica acta.Biochim Biophys Acta.2014 Jun;1840(6):2004-13. doi: 10.1016/j.bbagen.2014.02.006. Epub 2014 Feb 15.
BACKGROUND: Ubiquitin-proteasome pathway (UPP) plays a very important role in the degradation of proteins. Finding novel UPP inhibitors is a promising strategy for treating multiple myeloma (MM).METHODS: Ub-YFP reporter assays were used as cellular UPP models. MM cell growth, apoptosis and overall d
PMID 24534329

The N-terminal domain of N-pro of classical swine fever virus determines its stability and regulates type I IFN production

Knockdown of AT-rich interaction domain (ARID) 5B gene expression induced AMPKα2 activation in cardiac myocytes

Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells