前骨髄球
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/12/21 16:59:05」(JST)
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Promyelocyte |
Identifiers |
Code |
TH H2.00.04.3.04003 |
Anatomical terminology |
Eosonophilic promyelocyte
Neutrophilic promyelocyte
A promyelocyte (or progranulocyte) is a granulocyte precursor, developing from the myeloblast and developing into the myelocyte.
Additional images
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Promyelocyte from bone marrow examination
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External links
- Promyelocyte at eMedicine Dictionary
- "Promyelocyte" at Dorland's Medical Dictionary
- Histology image: 01806loa — Histology Learning System at Boston University
- "18. Bone Marrow and Hemopoiesis: bone marrow smear, promyelocyte and erythroblasts "
- Histology at KUMC blood-blood08 "Bone marrow"
- Histology at KUMC blood-blood11 "Bone marrow"
- "White Cell Basics: Maturation" at virginia.edu
- Histology image: 75_02 at the University of Oklahoma Health Sciences Center - "Bone marrow smear"
- Promyelocyte at the US National Library of Medicine Medical Subject Headings (MeSH)
Myeloid physiology
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Hematopoiesis |
Myelopoiesis
(CFU-GEMM) |
CFU-GM |
- Granulopoiesis
- Myeloblast
- Promyelocyte
- Myelocyte
- Metamyelocyte
- Band cell
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MEP |
- Thrombopoiesis
- Megakaryoblast
- Promegakaryocyte
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- Erythropoiesis
- Proerythroblast
- Normoblast
- Reticulocyte
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General |
- Extramedullary hematopoiesis
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Hemostasis |
- Coagulation
- Clot retraction
- Platelet adhesiveness
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Other |
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cell/phys (coag, heme, immu, gran), csfs
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rbmg/mogr/tumr/hist, sysi/epon, btst
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drug (B1/2/3+5+6), btst, trns
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UpToDate Contents
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English Journal
- p70S6 kinase is a target of the novel proteasome inhibitor 3,3'-diamino-4'-methoxyflavone during apoptosis in human myeloid tumor cells.
- Piedfer M, Bouchet S, Tang R, Billard C, Dauzonne D, Bauvois B.SourceINSERM U872, Université Pierre et Marie Curie, Université Paris-Descartes, Centre de Recherche des Cordeliers, Paris, France.
- Biochimica et biophysica acta.Biochim Biophys Acta.2013 Jun;1833(6):1316-28. doi: 10.1016/j.bbamcr.2013.02.016. Epub 2013 Feb 26.
- Acute myeloid leukemia (AML) is a deadly disease characterized by the clonal expansion and accumulation of hematopoietic stem cells arrested at various stages of development. Clinical research efforts are currently focusing on targeted therapies that induce apoptosis in AML cells. Herein, the effect
- PMID 23481040
- Toll-Like Receptor 4/Stem Cell Antigen 1 Signaling Promotes Hematopoietic Precursor Cell Commitment to Granulocyte Development during the Granulopoietic Response to Escherichia coli Bacteremia.
- Shi X, Siggins RW, Stanford WL, Melvan JN, Basson MD, Zhang P.SourceDepartment of Surgery, College of Human Medicine, Michigan State University, East Lansing, Michigan, USA.
- Infection and immunity.Infect Immun.2013 Jun;81(6):2197-205. doi: 10.1128/IAI.01280-12. Epub 2013 Apr 1.
- In response to severe bacterial infection, bone marrow hematopoietic activity shifts toward promoting granulopoiesis. The underlying cell signaling mechanisms remain obscure. To study the role of Toll-like receptor 4 (TLR4)/stem cell antigen-1 (Sca-1) signaling in this process, bacteremia was induce
- PMID 23545304
- Age-Associated Changes in the Differentiation Potentials of Human Circulating Hematopoietic Progenitors to T- or NK-Lineage Cells.
- Kyoizumi S, Kubo Y, Kajimura J, Yoshida K, Imai K, Hayashi T, Nakachi K, Young LF, Moore MA, van den Brink MR, Kusunoki Y.SourceDepartment of Radiobiology/Molecular Epidemiology, Radiation Effects Research Foundation, Hiroshima 732-0815, Japan;
- Journal of immunology (Baltimore, Md. : 1950).J Immunol.2013 May 13. [Epub ahead of print]
- Age-associated changes of T and NK cell (T/NK) potential of human hematopoietic stem cells are unknown. In this study, we enumerate and characterize T/NK precursors among CD34+Lin- cell populations circulating in normal human adult peripheral blood (PB) by a limiting-dilution assay using coculture w
- PMID 23670190
Japanese Journal
- 前骨髄球断片が巨大血小板様の形態を示した急性骨髄性白血病(M2)症例
- A dominant negative retinoic acid receptor blocks neutrophil differentiation at the promyelocyte stage
Related Links
- Promyelocyte definition at Dictionary.com, a free online dictionary with pronunciation, synonyms and translation. Look it up now! Thesaurus Translator Reference Word of the Day Blog Slideshows Apps by Dictionary My Account ...
- promyelocyte /pro·my·elo·cyte/ (-mi´il-o-sīt″) a precursor in the granulocytic series, intermediate between myeloblast and myelocyte, containing a few, as yet undifferentiated, cytoplasmic granules.promyelocyt´ic pro·my·e·lo·cyte (pr-m-l ...
Related Pictures
★リンクテーブル★
[★]
- 英
- promyelocyte, promyeloblast
- 関
- 血球。好中球
- 骨髄の中に存在する
- 顆粒球系未熟細胞の中で最も大きく、径は12~20/15-25μmと大型で細胞質は広くなる(骨髄芽球より核細胞質比が低下)。
- 細胞質は好塩基性に青染するが、骨髄球の時期に近づくと淡橙色が混在してくる。
- 細胞質にはびまん性に紫赤色の粗大なアズール顆粒(一次顆粒)が増加するが、好中性顆粒(二次顆粒)は形成されない(骨髄球では好中性顆粒が産生される)。
- ミエロペルオキシダーゼ活性は分泌小器官(粗面小胞体、ゴルジ装置)と一次顆粒で強陽性を示す。
- 核は骨髄芽球と同様であるが、円形・類円形をなし、細胞質の片側に偏在して位置する傾向がみられ、かつ核小体が残存する(骨髄芽球では核小体が消失)。
臨床関連
[★]
[★]
- 関
- metamyelocyte、myeloblast、myelocyte、promyelocyte
[★]
- 関
- promyelocyte