骨髄球　

WordNet

an immature leukocyte normally found in bone marrow

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/10 12:10:09」(JST)

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Basophilic^[1]

Eosinophilic^[2]

Neutrophilic^[3]

A myelocyte is a young cell of the granulocytic series, occurring normally in bone marrow (can be found in circulating blood when caused by certain diseases).

Histology

When stained with the usual dyes, the cytoplasm is distinctly basophilic and relatively more abundant than in myeloblasts or promyelocytes, even though myelocytes are smaller cells.

Numerous cytoplasmic granules are present in the more mature forms of myelocytes. Neutrophilic and eosinophilic granules are peroxidase-positive, while basophilic granules are not.

The nuclear chromatin is coarser than that observed in myelocyte, but it is relatively faintly stained and lacks a well defined membrane.

The nucleus is fairly regular in contour (not indented), and seems to be 'buried' beneath the numerous cytoplasmic granules. (If the nucleus were indented, it would likely be a metamyelocyte.)

Maturation

Myelocytes are derived from promyelocytes and give rise to metamyelocytes.

Measurement

There is an internationally agreed method of counting blasts, with results from M1 upwards.

Additional images

Hematopoiesis

References

^ Histology image:01809loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
^ Histology image:01810loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.
^ Histology image:01804loa from Vaughan, Deborah (2002). A Learning System in Histology: CD-ROM and Guide. Oxford University Press. ISBN 978-0195151732.

External links

Neutrophilic Myelocyte Presented by the University of Virginia
Eosinophilic Myelocyte Presented by the University of Virginia
Basophilic Myelocyte Presented by the University of Virginia
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1. 末梢血塗抹標本の評価evaluation of the peripheral blood smear [show details]
…Metamyelocytes, and rarely myelocytes, may be seen during infections, pregnancy, leukemoid reactions, and recovery from myelosuppression. Forms less mature than the myelocyte (eg, promyelocytes, myeloblasts) …
2. 骨髄異形成症候群の臨床症状および診断clinical manifestations and diagnosis of the myelodysplastic syndromes [show details]
…(ie, leukopenia), usually resulting from absolute neutropenia . Circulating immature neutrophils (myelocytes, promyelocytes, and myeloblasts) may be identified, but blasts constitute fewer than 20 percent …
3. 慢性骨髄性白血病の臨床症状および診断clinical manifestations and diagnosis of chronic myeloid leukemia [show details]
…neutrophils with peaks in the percent myelocytes and segmented neutrophils Blasts typically account for less than 2 percent. The presence of a greater percent of myelocytes than the more mature metamyelocytes …
4. 好中球二次顆粒欠損症neutrophil specific granule deficiency [show details]
…defect in C/EBP-epsilon appears to block the transition of neutrophils from the promyelocyte to myelocyte stage , resulting in release of cells in an abnormal state . Primary or azurophilic granule proteins …
5. 好中球増多症の患者へのアプローチapproach to the patient with neutrophilia [show details]
…refers to an increase in the percentage of band forms, generally accompanied by metamyelocytes and myelocytes. Leukemoid reaction refers to WBC >50,000/microL from causes other than leukemia, with the majority …

English Journal

Suppression of the stem cell antigen-1 response and granulocyte lineage expansion by alcohol during septicemia.

Melvan JN, Siggins RW, Bagby GJ, Stanford WL, Welsh DA, Nelson S, Zhang P.SourceFrom the Departments of Physiology (JNM, RWS, GJB, SN) and Medicine (GJB, DAW, SN), Section of Pulmonary/Critical Care Medicine, and the Comprehensive Alcohol Research Center (JNM, RWS, GJB, DAW, SN), Louisiana State University Health Sciences Center, New Orleans, LA; Sprott Centre for Stem Cell Research (WLS), Ottawa Hospital Research Institute, Ottawa, Ontario, Canada; and the Department of Surgery (PZ), College of Human Medicine, Michigan State University, East Lansing, MI.
Critical care medicine.Crit Care Med.2011 Sep;39(9):2121-30.
OBJECTIVE: : Granulocytopenia frequently occurs in alcohol abusers with severe bacterial infection, which strongly correlates with poor clinical outcome. Knowledge of the molecular mechanisms underlying the granulopoietic response to bacterial infection remains limited. This study investigated the i
PMID 21602669

Two Cases of Syndromic Neutropenia with a Report of Novel Mutation in G6PC3.

Alizadeh Z, Fazlollahi MR, Eshghi P, Hamidieh AA, Ghadami M, Pourpak Z.SourceImmunology, Asthma and Allergy Research Institute, Tehran University of Medical Sciences, Tehran, Iran. fazlollahi@tums.ac.ir.
Iranian journal of allergy, asthma, and immunology.Iran J Allergy Asthma Immunol.2011 Sep;10(3):227-30.
Severe congenital neutropenia (SCN) is a rare primary immunodeficiency. Different genes are found to be associated with SCN, including ELA2, HAX1, WAS, GFI1, G-CSFR. Also, recently G6PC3 as a rare gene in SCN has been reported. Patients with G6PC3 often have cardiac and/or urogenital malformations.
PMID 21891829

Japanese Journal

赤芽球癆を合併した胸腺腫の1例

坂部龍太郎,向田秀則,山下芳典,多幾山渉
日本呼吸器外科学会雑誌 20(5), 724-728, 2006-07-15
拡大胸腺摘出術後にCyclosporin Aを投与し,貧血を改善することができた赤芽球癆合併胸腺腫の1例を報告する.症例は75歳,男性.労作時呼吸困難を主訴に受診し,高度の貧血を指摘された.骨髄検査にて赤芽球無形成を認め,胸部CTにて前縦隔に4cm大の充実性腫瘍を認めた.赤芽球癆合併胸腺腫と診断し,輸血にて貧血を改善した後,拡大胸腺摘出術を施行した.病理組織学的にWHO分類type B1,正岡分類 …
NAID 110004750716

Peripheral Blood Stem Cell Mobilization with Chemotherapy and Granulocyte-colony Stimulating Factor in Patients with Hematological Malignancies

WATANABE Shigeki,MUKAIYAMA Taketo,OGAWA Yoshiaki,KAWADA Hiroshi,ICHIKAWA Yukinobu
Tokai journal of experimental and clinical medicine 19(3・4・5・6), 143-155, 1994-12
… We demonstrated that many cellular components of peripheral blood (PB) on the day of PBSC harvest, especially CD34+ cell, total leukocyte, myelocyte and monocyte counts, were correlated with the numbers of CFU-GM obtained in each leukapheresis. …
NAID 110004700731