organic cation transporter 1

有機カチオン輸送体1、有機カチオントランス・ーター1

関

OCT1

WordNet

1. simple and healthful and close to nature; "an organic lifestyle"
2. a fertilizer that is derived from animal or vegetable matter (同)organic fertilizer, organic fertiliser
3. being or relating to or derived from or having properties characteristic of living organisms; "organic life"; "organic growth"; "organic remains found in rock"
4. involving or affecting physiology or bodily organs; "an organic disease"
5. of or relating to foodstuff grown or raised without synthetic fertilizers or pesticides or hormones; "organic eggs"; "organic vegetables"; "organic chicken"
6. relating or belonging to the class of chemical compounds having a carbon basis; "hydrocarbons are organic compounds"
7. move something or somebody around; usually over long distances
8. an exchange of molecules (and their kinetic energy and momentum) across the boundary between adjacent layers of a fluid or across cell membranes
9. move while supporting, either in a vehicle or in ones hands or on ones body; "You must carry your camping gear"; "carry the suitcases to the car"; "This train is carrying nuclear waste"; "These pipes carry waste water into the river" (同)carry
10. transport commercially (同)send, ship
11. wind instrument whose sound is produced by means of pipes arranged in sets supplied with air from a bellows and controlled from a large complex musical keyboard (同)pipe_organ
12. a fully differentiated structural and functional unit in an animal that is specialized for some particular function
13. a government agency or instrument devoted to the performance of some specific function; "The Census Bureau is an organ of the Commerce Department"
14. a periodical that is published by a special interest group; "the organ of the communist party"
15. a long truck for carrying motor vehicles (同)car transporter
16. a crane for moving material with dispatch as in loading and unloading ships
17. a positively charged ion

PrepTutorEJDIC

1. 有機体の,生物の,生物から生じた / (動植物の)器官の / 有機肥料を用いる(を用いて育った)・有機的な,組織的な,系統的な・有機質の
2. (ある場所からある場所へ)…‘を'『輸送する』,運搬する《+名+from+名+to+名》 / 《文》《受動態で》(…で)…‘を'夢中にする,有頂天にする《+名+with+名》 / 〈罪人〉‘を'流刑にする / 〈U〉輸送,運送,輸送(交通)機関(transportation) / 〈C〉(軍隊や軍需品を運ぶ)輸送船,輸送機
3. 『オルガン』,パイプオルガン(pipe organ),リードオルガン(reed organ),電子オルガン(electronic organ),手回しオルガン(barrel organ) / (動植物の)『器官』 / (政党・会社などの)機関誌,機関紙 / 《しばしば複数形で》(行動・実施などの)組織,機関
4. 自動車運搬用大型トラック
5. 陽イオン,正イオン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/21 15:34:08」(JST)

wiki en

[Wiki en表示]

Solute carrier family 22 (organic cation transporter), member 1
Identifiers
Symbols	SLC22A1 ; HOCT1; OCT1; oct1_cds
External IDs	OMIM: 602607 MGI: 108111 HomoloGene: 20665 ChEMBL: 5685 GeneCards: SLC22A1 Gene
Gene ontology Molecular function • acetylcholine transmembrane transporter activity • dopamine transmembrane transporter activity • norepinephrine transmembrane transporter activity • protein binding • secondary active organic cation transmembrane transporter activity • organic cation transmembrane transporter activity • quaternary ammonium group transmembrane transporter activity • protein homodimerization activity Cellular component • plasma membrane • integral component of plasma membrane • membrane • basolateral plasma membrane Biological process • neurotransmitter transport • drug transmembrane transport • establishment or maintenance of transmembrane electrochemical gradient • organic cation transport • quaternary ammonium group transport • dopamine transport • norepinephrine transport • small molecule metabolic process • epinephrine transport • protein homooligomerization • transmembrane transport • ammonium transmembrane transport • acetate ester transport Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	6580	20517
Ensembl	ENSG00000175003	ENSMUSG00000023829
UniProt	O15245	O08966
RefSeq (mRNA)	NM_003057	NM_009202
RefSeq (protein)	NP_003048	NP_033228
Location (UCSC)	Chr 6: 160.12 – 160.16 Mb	Chr 17: 12.65 – 12.68 Mb
PubMed search	[1]	[2]

Solute carrier family 22 member 1 is a protein that in humans is encoded by the SLC22A1 gene.

Polyspecific organic cation transporters in the liver, kidney, intestine, and other organs are critical for elimination of many endogenous small organic cations as well as a wide array of drugs and environmental toxins. This gene is one of three similar cation transporter genes located in a cluster on chromosome 6. The encoded protein contains twelve putative transmembrane domains and is a plasma integral membrane protein. Two transcript variants encoding two different isoforms have been found for this gene, but only the longer variant encodes a functional transporter.

See also

• Solute carrier family
• Organic cation transport proteins

References

Further reading

• Berkhout B, Jeang KT (1992). "Functional roles for the TATA promoter and enhancers in basal and Tat-induced expression of the human immunodeficiency virus type 1 long terminal repeat". J. Virol. 66 (1): 139–49. PMC 238269. PMID 1727476. 
• Jeang KT; Chun R; Lin NH et al. (1993). "In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor". J. Virol. 67 (10): 6224–33. PMC 238044. PMID 7690421. 
• Liu YZ, Lania L, Latchman DS (1997). "Functional interaction between the HIV-1 Tat transactivator and the inhibitory domain of the Oct-2 cellular transcription factor". AIDS 10 (12): 1323–9. doi:10.1097/00002030-199610000-00003. PMID 8902060. 
• Liu YZ, Latchman DS (1997). "The octamer-binding proteins Oct-1 and Oct-2 repress the HIV long terminal repeat promoter and its transactivation by Tat". Biochem. J. 322 ( Pt 1) (Pt 1): 155–8. PMC 1218171. PMID 9078256. 
• Zhang L; Dresser MJ; Gray AT et al. (1997). "Cloning and functional expression of a human liver organic cation transporter". Mol. Pharmacol. 51 (6): 913–21. PMID 9187257. 
• Gorboulev V; Ulzheimer JC; Akhoundova A et al. (1997). "Cloning and characterization of two human polyspecific organic cation transporters". DNA Cell Biol. 16 (7): 871–81. doi:10.1089/dna.1997.16.871. PMID 9260930. 
• Verhaagh S, Schweifer N, Barlow DP, Zwart R (1999). "Cloning of the mouse and human solute carrier 22a3 (Slc22a3/SLC22A3) identifies a conserved cluster of three organic cation transporters on mouse chromosome 17 and human 6q26-q27". Genomics 55 (2): 209–18. doi:10.1006/geno.1998.5639. PMID 9933568. 
• Chasman D, Cepek K, Sharp PA, Pabo CO (1999). "Crystal structure of an OCA-B peptide bound to an Oct-1 POU domain/octamer DNA complex: specific recognition of a protein-DNA interface". Genes Dev. 13 (20): 2650–7. doi:10.1101/gad.13.20.2650. PMC 317104. PMID 10541551. 
• Tomilin A; Reményi A; Lins K et al. (2001). "Synergism with the coactivator OBF-1 (OCA-B, BOB-1) is mediated by a specific POU dimer configuration". Cell 103 (6): 853–64. doi:10.1016/S0092-8674(00)00189-6. PMID 11136971. 
• Hayer M, Bönisch H, Brüss M (2001). "Molecular cloning, functional characterization and genomic organization of four alternatively spliced isoforms of the human organic cation transporter 1 (hOCT1/SLC22A1)". Ann. Hum. Genet. 63 (Pt 6): 473–82. doi:10.1017/S0003480099007770. PMID 11388889. 
• Pietig G; Mehrens T; Hirsch JR et al. (2001). "Properties and regulation of organic cation transport in freshly isolated human proximal tubules". J. Biol. Chem. 276 (36): 33741–6. doi:10.1074/jbc.M104617200. PMID 11447227. 
• Pan H; Qin WX; Huo KK et al. (2001). "Cloning, mapping, and characterization of a human homologue of the yeast longevity assurance gene LAG1". Genomics 77 (1–2): 58–64. doi:10.1006/geno.2001.6614. PMID 11543633. 
• Xu XR; Huang J; Xu ZG et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. doi:10.1073/pnas.241522398. PMC 64988. PMID 11752456. 
• Schinkel AH, Jonker JW (2003). "Polymorphisms affecting function of the human organic cation transporter hOCT1 (SLC22A1): what are the consequences?". Pharmacogenetics 12 (8): 589–90. doi:10.1097/00008571-200211000-00001. PMID 12439217. 
• Kerb R; Brinkmann U; Chatskaia N et al. (2003). "Identification of genetic variations of the human organic cation transporter hOCT1 and their functional consequences". Pharmacogenetics 12 (8): 591–5. doi:10.1097/00008571-200211000-00002. PMID 12439218. 
• Schaffer A; Kim EC; Wu X et al. (2003). "Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elements". J. Biol. Chem. 278 (25): 23141–50. doi:10.1074/jbc.M212952200. PMID 12672812. 
• Shu Y; Leabman MK; Feng B et al. (2003). "Evolutionary conservation predicts function of variants of the human organic cation transporter, OCT1". Proc. Natl. Acad. Sci. U.S.A. 100 (10): 5902–7. doi:10.1073/pnas.0730858100. PMC 156299. PMID 12719534. 
• Sakata T; Anzai N; Shin HJ et al. (2004). "Novel single nucleotide polymorphisms of organic cation transporter 1 (SLC22A1) affecting transport functions". Biochem. Biophys. Res. Commun. 313 (3): 789–93. doi:10.1016/j.bbrc.2003.11.175. PMID 14697261. 
• Bottalico B; Larsson I; Brodszki J et al. (2004). "Norepinephrine transporter (NET), serotonin transporter (SERT), vesicular monoamine transporter (VMAT2) and organic cation transporters (OCT1, 2 and EMT) in human placenta from pre-eclamptic and normotensive pregnancies". Placenta 25 (6): 518–29. doi:10.1016/j.placenta.2003.10.017. PMID 15135235. 

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

UpToDate Contents

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• 1. Chapter 3C：近位尿細管における分泌経路 chapter 3c secretory pathways in proximal tubule
• 2. 猫からの人畜共通感染症 zoonoses from cats
• 3. Chapter 3B：近位尿細管におけるナトリウム輸送能の優越性 chapter 3b primacy of sodium transport in proximal function
• 4. シスプラチン腎障害 cisplatin nephrotoxicity
• 5. 喘息およびアレルギー性鼻炎の治療におけるアレルゲン回避策 allergen avoidance in the treatment of asthma and allergic rhinitis

English Journal

• Combined in Vitro-in Vivo Approach To Assess the Hepatobiliary Disposition of a Novel Oral Thrombin Inhibitor.

• Matsson EM, Eriksson UG, Palm JE, Artursson P, Karlgren M, Lazorova L, Brännström M, Ekdahl A, Dunér K, Knutson L, Johansson S, Schützer KM, Lennernäs H.SourceDepartment of Pharmacy, Uppsala University , Box 580, SE-751 23 Uppsala, Sweden.
• Molecular pharmaceutics.Mol Pharm.2013 Oct 17. [Epub ahead of print]
• Two clinical trials and a large set of in vitro transporter experiments were performed to investigate if the hepatobiliary disposition of the direct thrombin inhibitor prodrug AZD0837 is the mechanism for the drug-drug interaction with ketoconazole observed in a previous clinical study. In Study 1,
• PMID 24079718

• Interaction of Ethambutol with Human Organic Cation Transporters of the SLC22 Family Indicates Potential for Drug-Drug Interactions during Antituberculosis Therapy.

• Pan X, Wang L, Gründemann D, Sweet DH.SourceDepartment of Pharmaceutics, Virginia Commonwealth University, Richmond, Virginia, USA.
• Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2013 Oct;57(10):5053-9. doi: 10.1128/AAC.01255-13. Epub 2013 Aug 5.
• According to the 2012 WHO global tuberculosis (TB) report (http://apps.who.int/iris/bitstream/10665/75938/1/9789241564502_eng.pdf), the death rate for tuberculosis was over 1.4 million patients in 2011, with ∼9 million new cases diagnosed. Moreover, the frequency of comorbidity with human immunode
• PMID 23917312

• Differential regulation of hepatic organic cation transporter 1, organic anion-transporting polypeptide 1a4, bile-salt export pump, and multidrug resistance-associated protein 2 transporter expression in lymphocyte-deficient mice associates with interleukin-6 production.

• Bodeman CE, Dzierlenga AL, Tally CM, Mulligan RM, Lake AD, Cherrington NJ, McKarns SC.SourceCenter for Cellular and Molecular Immunology, Department of Surgery (C.E.B., C.M.T., R.M.M., S.C.M.) and Department of Microbiology and Immunology (S.C.M.), University of Missouri School of Medicine, Columbia, Missouri; and Department of Pharmacology and Toxicology, University of Arizona, Tucson, Arizona (A.L.D., A.D.L., N.J.C.).
• The Journal of pharmacology and experimental therapeutics.J Pharmacol Exp Ther.2013 Oct;347(1):136-44. doi: 10.1124/jpet.113.205369. Epub 2013 Aug 8.
• Cholestasis results from interrupted bile flow and is associated with immune-mediated liver diseases. It is unclear how inflammation contributes to cholestasis. The aim of this study was to determine whether T and B cells contribute to hepatic transporter expression under basal and inflammatory cond
• PMID 23929842

Japanese Journal

• プラチナ系抗がん剤のがん・腎臓移行を決定する分子機構 (特集 トランスポーターを利用したドラッグデリバリー)

• 米澤 淳
• Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System 27(5), 381-388, 2012-11
• NAID 40019499304

• 有機カチオン輸送系を介した白金系抗がん剤の腎毒性発現機構

• 米澤 淳
• 薬学雑誌 132(11), 2012
• … Organic cation transporter (OCT)/SLC22A, and multidrug and toxin extrusion (MATE)/SLC47A play a role in renal handling of cationic drug in the kidney. … Oxaliplatin, which was a superior substrate of the luminal efflux transporter, MATE2-K as well as OCT2, did not show nephrotoxicity. … Recent findings indicate that organic cation transporters are key to the nephrotoxicity of platinum agents. …
• NAID 130001871984

• Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

• Tamai Ikumi
• Biopharmaceutics and Drug Disposition xx(xx), 2012
• … The carnitine/organic cation transporter (OCTN) family consists of three transporter isoforms, i.e. OCTN1 (SLC22A4) and OCTN2 (SLC22A5) in humans and animals and Octn3 (Slc22a21) in mice. … Among them, OCTN2 is a sodium-dependent, high-affinity transporter of carnitine, and a functional defect of OCTN2 due to genetic mutation causes primary systemic carnitine deficiency (SCD). …
• NAID 120004997007

Related Links

• Organic Cation Transporter 1 - RightDiagnosis.com

Organic Cation Transporter 1 information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Organic Cation Transporter 1 Description of Organic Cation Transporter 1 ...

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Organic Cation Transporter 1. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is provided.

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★リンクテーブル★

リンク元	「OCT1」「有機カチオン輸送体1」「有機カチオントランスポーター1」「SLC22A1」
関連記事	「transport」「organic」「transporter」「cation transporter」「cation」

「OCT1」

　　[★]

• 有機カチオン輸送体1、有機カチオントランス・ーター1

関

organic cation transporter 1

「有機カチオン輸送体1」

　　[★]

英

organic cation transporter 1、OCT1

関

有機カチオントランス・ーター1

「有機カチオントランスポーター1」

　　[★]

英

organic cation transporter 1、OCT1

関

有機カチオン輸送体1

「SLC22A1」

　　[★]

• organic cation transporter 1

「transport」

　　[★]

• n.

• 輸送、運搬

• v.

• 輸送する、運搬する、運ぶ

関

bring、carriage、carry、convey、delivery、ship、traffic、trafficking、transportation

　 　 　 　 　

「organic」

　　[★]

• adj.

• 有機物の、有機の、有機的な、器質性の、器質的な

関

organic compound、organic matter、organized、organo

　 　 　 　 　 　 　

「transporter」

　　[★] トランスポーター

関

translocator、transport protein、transporter protein

　 　 　

「cation transporter」

　　[★]

• カチオントランス・ーター、陽イオン輸送体

関

cation transport protein

「cation」

　　[★]

• 陽イオン、カチオン

関

cationic

関

See also specific cations